公开(公告)号：WO2006041972A2

公开(公告)日：2006-04-20

申请号：PCT/US2005035912

申请日：2005-10-06

Applicant: COOK INC ,  OSBORNE THOMAS A ,  FLAGLE JACOB A ,  CASE BRIAN C ,  OBERMILLER JOSEPH F ,  PAUL RAM H

Inventor： OSBORNE THOMAS A ,  FLAGLE JACOB A ,  CASE BRIAN C ,  OBERMILLER JOSEPH F ,  PAUL RAM H

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2230/0026 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2230/0095 ,  A61F2250/0067

Abstract: Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

Abstract translation: 提供具有一种或更多生物活性剂的医疗装置用于调节通过身体血管的流体流动。 根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。

公开(公告)号：WO2005115118A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/018442

申请日：2005-05-25

Applicant: CHESTNUT MEDICAL TECHNOLOGIES, INC. ,  BEREZ, Aaron, Lee ,  TRAN, Quang, Quoc

Inventor： BEREZ, Aaron, Lee ,  TRAN, Quang, Quoc

IPC: A61B17/12 ,  A61F2/82 ,  A61F2/90

CPC classification number: A61B17/12022 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12118 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/90 ,  A61F2002/823 ,  A61F2230/001 ,  A61F2230/0078 ,  A61F2230/0091 ,  A61F2230/0095

Abstract: A vascular occluding device for modifying blood flow in a vessel, while maintaining blood flow to the surrounding tissue. The occluding device includes a flexible, easily compressible and bendable occluding device that is particularly suited for treating aneurysms in the brain. The neurovascular occluding device and be deployed using a micro-catheter. The occluding device can be formed braiding wires in a helical fashion and can have varying lattice densities along the length of the occluding device. The occluding device could also have different lattice densities for surfaces on the same radial plane.

Abstract translation: 一种血管阻塞装置，用于改变血管中的血流，同时保持血液流向周围组织。 闭塞装置包括柔性，易压缩和可弯曲的闭塞装置，其特别适用于治疗脑中的动脉瘤。 神经血管闭塞装置并使用微导管部署。 闭塞装置可以以螺旋方式形成编织线，并且沿着阻塞装置的长度可以具有变化的晶格密度。 闭塞装置对于同一径向平面上的表面也可以具有不同的晶格密度。

公开(公告)号：WO2005037078A3

公开(公告)日：2005-06-30

申请号：PCT/US2004034221

申请日：2004-10-15

Applicant: SPINECORE INC

Inventor： ZUBOK RAFAIL ,  DUDASIK MICHAEL W ,  ERRICO JOSEPH P

IPC: A61B17/17 ,  A61B17/70 ,  A61B17/80 ,  A61B17/86 ,  A61B17/88 ,  A61F2/00 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46 ,  A61B17/56

CPC classification number: A61F2/4425 ,  A61B17/1728 ,  A61B17/1757 ,  A61B17/7059 ,  A61B17/8042 ,  A61B17/8625 ,  A61B17/866 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/30301 ,  A61F2002/30578 ,  A61F2002/30616 ,  A61F2002/3065 ,  A61F2002/30841 ,  A61F2002/449 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4629 ,  A61F2230/0095

Abstract: An intervertebral disc replacement trial (1200) includes a shaft (1202) having a handle at a proximal end (1206), and a head (1208) disposed at a distal end (1204) of the shaft. The head includes first and second surfaces (1210, 1212) that are spaced apart and sized for insertion into at least one intervertebral disc space defined by respective endplates of an adjacent pair of vertebral bones of a spinal column. The trial facilitates distraction of the vertebral bones in a direction along a longitudinal axis of the spinal column.

Abstract translation: 椎间盘置换试验（1200）包括在近端（1206）具有手柄的轴（1202）和设置在轴的远端（1204）的头部（1208）。 头部包括第一和第二表面（1210,1212），第一和第二表面（1210,1212）被间隔开并且尺寸适于插入由脊柱的相邻一对椎骨的相应端板限定的至少一个椎间盘间隙中。 该试验有利于沿着脊柱纵轴的方向分离椎骨。

公开(公告)号：WO2005037078A2

公开(公告)日：2005-04-28

申请号：PCT/US2004/034221

申请日：2004-10-15

Applicant: SPINECORE, INC.

Inventor： ZUBOK, Rafail ,  DUDASIK, Michael, W. ,  ERRICO, Joseph, P.

IPC: A61B

CPC classification number: A61F2/4425 ,  A61B17/1728 ,  A61B17/1757 ,  A61B17/7059 ,  A61B17/8042 ,  A61B17/8625 ,  A61B17/866 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/30301 ,  A61F2002/30578 ,  A61F2002/30616 ,  A61F2002/3065 ,  A61F2002/30841 ,  A61F2002/449 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4629 ,  A61F2230/0095

Abstract: An intervertebral disc replacement trial (1200) includes a shaft (1202) having a handle at a proximal end (1206), and a head (1208) disposed at a distal end (1204) of the shaft. The head includes first and second surfaces (1210, 1212) that are spaced apart and sized for insertion into at least one intervertebral disc space defined by respective endplates of an adjacent pair of vertebral bones of a spinal column. The trial facilitates distraction of the vertebral bones in a direction along a longitudinal axis of the spinal column.

Abstract translation: 椎间盘置换试验台（1200）包括在近端（1206）处具有手柄的轴（1202）和设置在所述轴的远端（1204）处的头部（1208）。 头包括第一和第二表面（1210,1212），所述第一表面和第二表面被间隔开并且尺寸设置成用于插入由脊柱的相邻一对脊椎骨的相应端板限定的至少一个椎间盘空间中。 该试验有助于沿着脊柱的纵向轴线的方向使椎骨的牵引。

公开(公告)号：WO2004080352A1

公开(公告)日：2004-09-23

申请号：PCT/US2004/007219

申请日：2004-03-10

Applicant: COOK INCORPORATED ,  OSBORNE, Thomas, A. ,  CASE, Brian, C. ,  BLEYER, Mark, W.

Inventor： OSBORNE, Thomas, A. ,  CASE, Brian, C. ,  BLEYER, Mark, W.

IPC: A61F2/24

CPC classification number: A61F2/2475 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0026 ,  A61F2230/0095

Abstract: A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame (410) and a valve leaflet (446, 448), and includes at least one opening (480) that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration.

Abstract translation: 提供了一种用于调节通过身体容器的流体流动的人造瓣膜。 阀包括可膨胀支撑框架（410）和阀小叶（446,448），并且包括至少一个开口（480），当阀处于关闭构型时允许控制量的逆流流过阀。

公开(公告)号：WO2004075789A2

公开(公告)日：2004-09-10

申请号：PCT/US2004005750

申请日：2004-02-26

Applicant: COOK INC ,  CASE BRIAN C ,  FLAGLE JACOB A ,  GARRISON MICHAEL L ,  HOFFA ANDREW K ,  LEONARD RAY II

Inventor： CASE BRIAN C ,  FLAGLE JACOB A ,  GARRISON MICHAEL L ,  HOFFA ANDREW K ,  LEONARD RAY II

IPC: A61B19/00 ,  A61F2/00 ,  A61F2/06 ,  A61F2/24 ,  A61F2/02

CPC classification number: A61F2/2475 ,  A61B90/39 ,  A61F2/2418 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0098

Abstract: A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.

Abstract translation: 一种具有可成像结构的可扩张假体，其包括可由外部（例如，射线照相或超声）成像系统在视觉上区分的一个或多个元件，所述结构围绕与假体的结构特征对应的第一轴定位，所述第一轴被配置为执行 特定于该轴的特定功能。 可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。 在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣结构的孔，使得孔可以在成像下具有特定的解剖特征，诸如 将孔与容器的长轴对齐。 在另一个实施例中，可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征（例如分支血管开口）定向。 本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。

公开(公告)号：WO2004058098A3

公开(公告)日：2004-08-26

申请号：PCT/US0340086

申请日：2003-12-15

Applicant: AMEDICA CORP

Inventor： KHANKDAR ASHOK C ,  BRODKE DARREL S ,  LAKSHMINARAYANAN RAMASWAMY

IPC: A61F20060101 ,  A61F2/00 ,  A61F2/30 ,  A61F2/44

CPC classification number: A61F2/4425 ,  A61F2/30767 ,  A61F2002/30224 ,  A61F2002/30301 ,  A61F2002/30365 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30878 ,  A61F2002/30934 ,  A61F2002/443 ,  A61F2220/0033 ,  A61F2230/0069 ,  A61F2230/0095 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00317 ,  Y10S606/907

Abstract: A total disc implant (TDI) is provided for total replacement of a spinal disc or discs in a human patient or other mammal, wherein the TDI is designed to maintain a substantially full range of natural motion (ROM) following implantation. The TDI generally comprises, in one preferred form, upper (10) and lower (12) end plates for affixation to adjacent vertebral bodies, with an intervening insert disposed therebetween. The end plates each include elongated part-cylindrical surfaces (22-24) oriented generally perpendicular to each other, with one of said surfaces extending in an anterior-posterior direction and the other extending in a medial-lateral direction. The intervening insert (20) defines concave upper (26) and lower (28) part-cylindrical seats oriented for respectively engaging these part-cylindrical surfaces, wherein these part-cylindrical seats are defined by offset radii to include a somewhat flattened central base region merging smoothly with upwardly curving radiused sides.

Abstract translation: 全盘植入物（TDI）被提供用于人类患者或其他哺乳动物中的脊椎盘或椎间盘的完全替换，其中TDI被设计成在植入后保持基本上全部的自然运动范围（ROM）。 TDI通常包括一个优选形式的上（10）和下（12）端板，用于固定到相邻的椎体，其间插入插入的插入物。 端板各自包括大致垂直于彼此定向的细长部分圆柱形表面（22-24），其中一个所述表面沿前后方向延伸，另一个在内侧方向上延伸。 所述中间插入件（20）限定为分别接合这些部分圆柱形表面的凹形上部（26）和下部（28）部分圆柱形座，其中这些部分圆柱形座由偏移半径限定以包括稍微平坦化的中心基部区域 顺利地与向上弯曲的圆角融合。

公开(公告)号：WO2004016150A2

公开(公告)日：2004-02-26

申请号：PCT/US2003/025430

申请日：2003-08-15

Applicant: THRAMANN, Jeffrey, M., D.

Inventor： THRAMANN, Jeffrey, M., D. ,  FULTON, Michael, M., D.

IPC: A61B

CPC classification number: A61F2/91 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61B2017/12068 ,  A61F2/852 ,  A61F2/915 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/30329 ,  A61F2002/30545 ,  A61F2002/30599 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/91508 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2002/9665 ,  A61F2220/0025 ,  A61F2230/0095 ,  A61F2250/001 ,  A61F2250/0063 ,  A61F2250/0071

Abstract: The present invention relates to an aneurysm stent having a base and connector. The base has a vessel facing side and an aneurysm facing side, and is shaped to cover an aneurysm sufficiently. The connector is coupled to the aneurysm facing side of the base such that when deployed the connector is adapted to extend partially into the aneurysm to anchor the base about the aneurysm and inhibit flow into the aneurysm.

Abstract translation: 本发明涉及具有基座和连接器的动脉瘤支架。 基部具有面向血管的侧面和面向动脉瘤的侧面，并且被成形为充分覆盖动脉瘤。 连接器联接到基部的面向动脉瘤侧，使得当展开时，连接器适于部分地延伸到动脉瘤中，以使基部围绕动脉瘤锚定并阻止流入动脉瘤。

公开(公告)号：WO2003090649A1

公开(公告)日：2003-11-06

申请号：PCT/US2003/012500

申请日：2003-04-23

Applicant: FERREE, Bret, A.

Inventor： FERREE, Bret, A.

IPC: A61F2/44

CPC classification number: A61F2/4425 ,  A61B17/86 ,  A61F2/30767 ,  A61F2/44 ,  A61F2002/30016 ,  A61F2002/3008 ,  A61F2002/30135 ,  A61F2002/302 ,  A61F2002/30245 ,  A61F2002/30301 ,  A61F2002/30324 ,  A61F2002/30327 ,  A61F2002/30507 ,  A61F2002/30518 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30632 ,  A61F2002/30649 ,  A61F2002/30769 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/30919 ,  A61F2002/30934 ,  A61F2002/443 ,  A61F2002/448 ,  A61F2220/0025 ,  A61F2230/0004 ,  A61F2230/0065 ,  A61F2230/0071 ,  A61F2230/0095 ,  A61F2250/0019 ,  A61F2250/0039 ,  A61F2250/0098 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00293 ,  A61F2310/00395 ,  A61F2310/0058 ,  A61F2310/00592

Abstract: This invention improves upon prior aft total disc replacements (TDRs) by more closely replicating the kinematics of a natural disc. The preferred embodiments feature two or more fixed centers of rotation (CORs) and an optional variable COR (VCOR) as the artificial disk replacement (ADR) translates from a fixed posterior COR that lies posterior to the COR of the TDR to facilitate normal disc motion. The use of two or more CORs allows more flexion and more extension than permitted by the facet joints and the artificial facet (AF). AF joint-like components may also be incorporated into the design to restrict excessive translation, rotation, and/or lateral bending.

Abstract translation: 本发明通过更紧密地复制天然圆盘的运动学来改进先前的后总盘替代（TDR）。 优选实施例具有两个或更多个固定的旋转中心（COR）和可选的可变的COR（VCOR），因为人造盘替换（ADR）从位于TDR的COR后面的固定的后COR转换，以便于正常的盘运动 。 使用两个或多个COR允许比小面关节和人造小面（AF）允许的更多的屈曲和更多的延伸。 AF关节部件也可以结合到设计中以限制过度的平移，旋转和/或横向弯曲。

公开(公告)号：WO2002086180A2

公开(公告)日：2002-10-31

申请号：PCT/US2002/010678

申请日：2002-04-04

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： MCNALLAN, Michael, J. ,  ERSOY, Daniel ,  GOGOTSI, Yury ,  WELZ, Sascha

IPC: C23C

CPC classification number: C04B41/009 ,  A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3845 ,  A61F2/3859 ,  A61F2/3877 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4059 ,  A61F2/4081 ,  A61F2/4241 ,  A61F2/4261 ,  A61F2002/30253 ,  A61F2002/30301 ,  A61F2002/30626 ,  A61F2002/30649 ,  A61F2002/30685 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30925 ,  A61F2002/30957 ,  A61F2002/3611 ,  A61F2002/4018 ,  A61F2002/4258 ,  A61F2002/4271 ,  A61F2002/4631 ,  A61F2230/0076 ,  A61F2230/0095 ,  A61F2310/00269 ,  A61F2310/00281 ,  A61F2310/00574 ,  A61F2310/0058 ,  A61F2310/00586 ,  A61L27/303 ,  B01J3/065 ,  B01J21/18 ,  B01J27/22 ,  B01J37/24 ,  B01J2203/0655 ,  C04B35/62839 ,  C04B35/62884 ,  C04B35/62897 ,  C04B41/4584 ,  C04B41/5001 ,  C04B41/5002 ,  C04B41/5346 ,  C04B41/85 ,  C04B41/91 ,  C04B2111/00353 ,  C04B2111/0081 ,  C04B2111/00836 ,  C04B2111/94 ,  C04B2235/3826 ,  C04B2235/383 ,  C04B2235/3834 ,  C23F1/00 ,  F16C11/0619 ,  F16C33/043 ,  F16C33/16 ,  F16C33/30 ,  C04B41/0072 ,  C04B41/4519 ,  C04B41/4556 ,  C04B35/565 ,  C04B35/56

Abstract: A process for the synthesis of carbon coatings on the surface of metal carbides, preferably SiC, by etching in a halogen-containing gaseous etchant, and optionally hydrogen gas, leading to the formation of a carbon layer on the metal carbide. The reaction is performed in gas mixtures containing 0 to two moles of hydrogen for every two moles of halogen gas, preferably about 0.5 to one mole of hydrogen gas for eery two moles of halogen gas, at temperatures from about 100° C to about 4,000° C. preferably about 800° C to about 1,000° C, over any time range, maintaining a pressure of preferably about one atmosphere.

Abstract translation: 通过在含卤素的气体蚀刻剂和任选的氢气中蚀刻，在金属碳化物，优选SiC的表面上合成碳涂层的方法，导致在金属碳化物上形成碳层。 反应在含有0至2摩尔氢气的气体混合物中进行，每2摩尔卤素气体，优选约0.5至1摩尔氢气用于2摩尔卤素气体，温度为约100至约4,000度 优选约800℃至约1000℃，在任何时间范围内，保持优选约1个大气压。