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    METHODS AND KITS FOR PREDICTING OR ASSESSING THE SEVERITY OF INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUS
    32.
    发明申请
    METHODS AND KITS FOR PREDICTING OR ASSESSING THE SEVERITY OF INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUS 审中-公开
    用于预测或评估由金黄色葡萄球菌引起的多种感染的方法和试剂盒

    公开(公告)号：WO2017194735A1

    公开(公告)日：2017-11-16

    申请号：PCT/EP2017/061458

    申请日：2017-05-12

    Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE RENNES 1 ,  CHU DE RENNES

    Inventor： FELDEN, Brice ,  BORDEAU, Valérie ,  TATTEVIN, Pierre ,  REVEST, Matthieu ,  DONNIO, Pierre-Yves

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/112 ,  C12Q2600/158

    Abstract: The invention relates to methods and kits for predicting or assessing the severity of infections caused by Staphylococcus aureus . Staphylococcus aureus is a commensal and a pathogen, and uncovering the identifying markers of the 'colonization to disease' transition is very useful. Several S. aureus small RNAs regulate virulence. The presence/absence and expression of eight sRNAs were investigated in 83 strains from 42 sepsis or shock patients, and 41 carriers. These isolates were characterized by MLST and spa typing and monitored for virulence and resistance. RNAIII expression was lower in strains from shock patients than from colonizing strains. Noteworthy, when RNAIII was associated with SprD, colonizing strains were significantly discriminated from those from patients with bloodstream infections, including sepsis and shock. Isolates associated with colonization may have different sRNA and sRNA target expressions than disease isolates. Monitoring RNAIII and SprD expressions could inform about infection severity. Thus, the invention relates to a method of assessing of predicting or assessing severity of an infection caused by Staphylococcus aureus comprising quantifying the RNAIII and/or SprD expression level in bacteria recovered from a culture obtained from the patient.

    Abstract translation: 本发明涉及用于预测或评估由金黄色葡萄球菌引起的感染严重程度的方法和试剂盒。 金黄色葡萄球菌是一种共生和病原体，揭示'定植到疾病'转变的鉴定标记是非常有用的。 几种金黄色葡萄球菌小RNA调节毒力。 在来自42个脓毒症或休克患者的83个菌株和41个携带者中研究了8种sRNA的存在/缺失和表达。 这些分离物通过MLST和spa分型来表征并监测毒力和抗性。 来自休克患者的RNAIII表达低于定植菌株。 值得注意的是，当RNAIII与SprD相关时，殖民化菌株与血流感染患者（包括败血症和休克）的患者显着区别开来。 与定植相关的分离物可能具有与疾病分离物不同的sRNA和sRNA靶标表达。 监测RNAIII和SprD表达可以了解感染严重程度。 因此，本发明涉及评估由金黄色葡萄球菌引起的感染的预测或评估严重性的方法，包括量化从患者获得的培养物中回收的细菌中的RNAIII和/或SprD表达水平。

    METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MUCOSAL INFLAMMATORY DISEASES
    38.
    发明申请
    METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MUCOSAL INFLAMMATORY DISEASES 审中-公开

    公开(公告)号：WO2020070240A1

    公开(公告)日：2020-04-09

    申请号：PCT/EP2019/076804

    申请日：2019-10-03

    Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE RENNES 1 ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  ENIOS APPLICATIONS PRIVATE LIMITED COMPANY

    Inventor： CHEVET, Eric ,  OGIER-DENIS, Eric ,  CHATZIIOANNOU, Aristotelis

    IPC: C07K16/18 ,  C12N15/113 ,  G01N33/53 ,  A61P37/06

    Abstract: The mucosa is an integrated network of tissues, cells and effector molecules that protect the host from environmental insults and infections. Dysregulation of immunity at mucosal surfaces is thought to lead to mucosal inflammatory diseases such as those affecting the gastrointestinal system (Crohn's disease, ulcerative colitis and irritable bowel syndrome) and respiratory system (asthma, allergy and chronic obstructive pulmonary disorder). Anterior Gradient 2 (AGR2) is a dimeric Protein Disulfide Isomerase (PDI) family member involved in the regulation of protein quality control in the Endoplasmic Reticulum (ER). Its deletion in the mouse intestine increases tissue inflammation and promotes the development of inflammatory bowel disease (IBD). Now the inventors demonstrate that modulation of AGR2 dimer formation yields pro-inflammatory phenotypes notably though the secretion of AGR2 (eAGR2) that promotes monocyte attraction. The inventors show that in IBD and specifically in Crohn's disease, the levels of AGR2 dimerization modulators are selectively deregulated, and this correlates with severity of disease. The inventors thus demonstrate that AGR2 represent systemic alarm signals for pro-inflammatory responses in mucosa. Accordingly, the present invention relates to a method of treating a mucosal inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent which neutralizes the pro-inflammatory activity of eAGR2.

    METHOD, DEVICE AND PROGRAM FOR DETERMINING A DISEASE SCORE
    39.
    发明申请
    METHOD, DEVICE AND PROGRAM FOR DETERMINING A DISEASE SCORE 审中-公开

    公开(公告)号：WO2019149910A1

    公开(公告)日：2019-08-08

    申请号：PCT/EP2019/052548

    申请日：2019-02-01

    Applicant: UNIVERSITÉ DE RENNES 1 ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

    Inventor： HASSAN, Mahmoud ,  WENDLING, Fabrice ,  KABBARA, Aya

    IPC: G16H50/20 ,  A61B5/00 ,  G16H20/40

    CPC classification number: G16H20/40 ,  A61B5/4094 ,  G16H50/20 ,  G16H50/30

    Abstract: The invention relates to a method of constructing a value representative of an interaction between a plurality of brain regions, the method being implemented by an electronic device, said electronic device comprising a processor and a memory. According to the invention, the method comprises: - obtaining (10), in the form of connectivity matrices, dynamic functional networks, which are representative of electrical signals measured for a predetermined number of points of interest, called nodes, within a cerebral cortex during a given time period; - determining (20), from at least one of said connectivity matrices, a global efficiency (GE) score and at least one clustering coefficient score (Cc) for each node of said at least one of said connectivity matrices; - calculating (30) a value representative of an interaction between the plurality of brain networks in the form of a distribution ratio (Dl) using said global efficiency score and said clustering coefficient scores (Cc).

    DISPOSITIF D'ECLAIRAGE FACILITANT LA LECTURE
    40.
    发明申请
    DISPOSITIF D'ECLAIRAGE FACILITANT LA LECTURE 审中-公开

    公开(公告)号：WO2019097128A1

    公开(公告)日：2019-05-23

    申请号：PCT/FR2018/052012

    申请日：2018-08-03

    Applicant: LE FLOCH, Albert ,  UNIVERSITÉ DE RENNES 1

    Inventor： LE FLOCH, Albert ,  ROPARS, Guy

    IPC: H05B33/08

    Abstract: L'invention concerne un dispositif d'éclairage (LIGHT) d'un contenu graphique et/ou textuel représenté sur un support quelconque et notamment de type papier.Le dispositif d'éclairage (LIGHT) est configuré pour activer et désactiver périodiquement ledit faisceau d'éclairage selon des cycles successifs opérés à une fréquence Fd prédéterminée. Chaque cycle présente une durée T et comprend une période d'activation du faisceau lumineux de durée T1 suivie d'une période de désactivation du faisceau lumineux de durée T2 ou inversement. La fréquence Fd est comprise dans un intervalle de valeurs allant de 60 à 90 Hz et la durée T1 des périodes d'activation du faisceau lumineux est comprise dans un intervalle de valeurs allant de 15 à 30% de la durée T des cycles.

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