Abstract:
A process for the preparation of ethanolamines comprising reacting a water-ammonia solution with ethylene oxide to form an effluent reaction mixture comprising unreacted ammonia, water and ethanolamines. This effluent reaction mixture is then subjected to a succession of steps to, inter alia, separate the ethanolamines.
Abstract:
The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (la) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of : these novel salts and use thereof.
Abstract:
The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications. The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications.
Abstract:
The present invention relates to processes for the manufacture of one or more ethanolamines and one or more ethyleneamines starting from the reaction of ethylene oxide with ammonia to produce one or more ethanolamines and the conversion of the ethanolamine(s) to ethyleneamine(s). The present invention also relates to separating alkylethyleneamines from ethyleneamines.
Abstract:
La dégradation d'une solution absorbante comportant des composés organiques munis d'une fonction aminé en solution aqueuse est sensiblement réduite en présence d'une faible quantité d'agents inhibiteurs de dégradation soufrés dérivés d'un acide aminé, définis par la formule générale : (I) La solution absorbante est mise en oeuvre pour désacidifier un effluent gazeux.
Abstract:
The present invention provides methods of carrying out the safe and reliable preparation of lipids comprising quaternary amines. Such lipids are especially suited for introducing therapeutic agents into cells or organisms. In particular, the lipids of the invention are suitable for the efficient transfer of gene therapy agents into mammalian cells or organisms in a cell type specific or tissue specific manner.
Abstract:
The present invention generally relates to a process for preparing the alkoxylated alkylamines and/or alkyl ether amines. The process consists of three stages, and utilizes an alkali catalyst. The alkoxylated alkyl amines and alkoxylated alkyl ether amines prepared by the process possess the peaked distribution and contain less hazardous by-product.
Abstract:
The present invention relates to a process for decolourising triethanolamine (TEA) characterized in that a coloured TEA is exposed to electromagnetic radiation of wavelength chosen within the range from 100 to 1200 nanometres (nm), for a time long enough to reduce the colour of the TEA. The process can be carried out continuously. The invention also related to a process for continuously manufacturing a colourless TEA comprising a step for synthesing TEA by bringing ammonia into contact with ethylene oxide in aqueous medium, a step for separating water and ammonia from a crude TEA comprising TEA as a mixture with other ethanolamines produced during the TEA synthesis, and a step for isolating a purified TEA by distilling the crude TEA. In an additional step, the crude or purified TEA is continuously exposed to the electromagnetic radiation for a time long enough to obtain a colourless TEA. The invention also relates to a device for manufacturing a purified and colourless TEA comprising a reaction zone (A) for synthetising TEA, a zone (B) for separating the crude TEA, a zone (C) for isolating the purified TEA and a zone (D) for storing the purified TEA. The device also comprises at least one radiation zone capable of delivering the electromagnetic radiation, the radiation zone being placed at any point in the device downstream of the zone (B).
Abstract:
The invention relates to a method for producing at least one alkanolamine by reacting ammonia with alkylene oxide in a reaction chamber in the presence of a catalyst, to obtain monoalkanolamine, dialkanolamine or trialkanolamine, or a mixture of two or three of said compounds, whereby the distribution of the different alkanolamines in the produced spectrum is controlled using the temperature in the reaction chamber. The method is characterised in that the temperature is adjusted by regulating the temperature profile in the reaction chamber.
Abstract:
Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.