公开(公告)号：WO2013081363A1

公开(公告)日：2013-06-06

申请号：PCT/KR2012/010145

申请日：2012-11-28

Applicant: 에스디 바이오센서 주식회사

Inventor： 임태규 ,  조영식 ,  이효근 ,  황희영 ,  최형길

IPC: G01N27/30 ,  G01N33/49 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  G01N27/4166 ,  G01N33/49

Abstract: 본 발명에 따른 당화헤모글로빈 측정용 바이오센서는 기준전극; 및 집전체 상에, 당화헤모글로빈에 특이적 결합가능한 부위를 포함하고 외부로부터 전압 및 전류의 공급없이 당화헤모글로빈 결합에 의해 산화환원 반응전위가 변하는 분자들이 정렬된 변이전극을 구비한 측정부; 전위차분석법(Potentiometry)에 의해 변이전극과 기준전극 사이의 전위차를 측정하기 위한, 전위차 측정회로 또는 전위차 적정장치; 및 선택적으로 상기 변이전극과 기준전극 사이의 전위차이값 또는 이를 시료내 당화헤모글로빈의 량 또는 농도로 환산시켜 표시하는 표시부를 구비한다. 본 발명에 따른 당화헤모글로빈 측정용 바이오센서는 시료내의 당화헤모글로빈의 농도를 빠르고 정확하게 측정할 수 있는 효과가 있으며, 당화헤모글로빈의 농도측정시 헤모글로빈과 당화헤모글로빈의 분리단계를 거치지 않고 동시에 두 물질의 농도를 측정하여 그 비율을 구할 수 있다.

Abstract translation: 根据本发明的用于测量糖基化血红蛋白的生物传感器包括：测量单元，包括参考电极，并且包括修改的电极，其上设置有分子，所述分子包含能够与糖基化血红蛋白特异性结合的位点，并且其氧化还原反应电位由于 在集电器上不从外部提供电压和电流的糖基化血红蛋白结合; 电位差测量电路或电位滴定装置，用于通过电位法测量改性电极和参考电极之间的电位差; 以及显示单元，用于选择性地实现改变电极和参考电极之间的电位差的值的显示，或者当该值被计算为样品内的糖基化血红蛋白的量或浓度时的结果。 根据本发明的用于测量糖基化血红蛋白的生物传感器具有使得可以快速且准确地测量样品中糖基化血红蛋白的浓度的效果，并且可以通过测量血红蛋白和糖基化血红蛋白的浓度 两种物质同时测量糖化血红蛋白浓度时不经过分离步骤。

公开(公告)号：WO2013057515A1

公开(公告)日：2013-04-25

申请号：PCT/GB2012/052609

申请日：2012-10-19

Applicant: BIO NANO CONSULTING LTD

Inventor： CASS, Anthony Edward George ,  SANTINI, Joanne ,  JOHNSON, Christopher James

IPC: C12N9/00 ,  C12Q1/00 ,  C12Q1/26

CPC classification number: C12Q1/005 ,  C12N9/0004 ,  C12Q1/26 ,  C12Y120/09001 ,  C12Y120/99001 ,  G01N27/327 ,  G01N27/4166 ,  G01N27/447 ,  G01N2333/902

Abstract: The present invention provides an arsenite oxidase enzyme modified to prevent translocation by modification of a translocation signal sequence. A microorganism modified to express the heterologous arsenite oxidase enzyme is also provided by the invention, together with a device for detecting the presence of arsenite in a sample.

Abstract translation: 本发明提供通过修饰易位信号序列修饰以防止易位的亚砷酸盐氧化酶。 本发明还提供了用于表达异源亚砷酸氧化酶的微生物以及用于检测样品中亚砷酸盐存在的装置。

公开(公告)号：WO2013039672A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/052317

申请日：2012-08-24

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC. ,  THOMPSON, David, R.

Inventor： THOMPSON, David, R.

IPC: A61B5/00

CPC classification number: G01N27/416 ,  G01N27/06 ,  G01N27/4166 ,  G01N33/49

Abstract: Verification of patient sample electrolyte results using a separate quantitative measurement of sample resistivity. Sample resistivity may be used to measure small differences in resistivity of one sample to the next, and in comparison to a standard solution, in order to verify the results of sample electrolyte measurements being measured at the same time by, for example, individual ion selective electrodes (ISE) in a clinical analyzer. Providing a separate or secondary quantitative means for verification of the measured results of sample electrolytes using sample resistivity solves the problem of electrolyte result variability in sample electrolyte measurements. The process may compare a measured sample resistivity to an expected resistivity value as a verification of the accuracy of individual electrolyte results. Suspect samples - e.g., where the electrolyte resistivity results do not fit the expected resistivity - may be flagged. This separate verification step provides added confidence in the measured electrolyte results and can identify when problems occur or interferences are present in real time.

Abstract translation: 使用样品电阻率的单独定量测量验证患者样品电解质结果。 可以使用样品电阻率来测量一个样品与下一个样品的电阻率的小差异，并且与标准溶液相比较，以验证通过例如单个离子选择性同时测量的样品电解质测量的结果 电极（ISE）。 提供使用样品电阻率来验证样品电解质的测量结果的单独的或次要的定量方法，解决了样品电解质测量中电解液结果变异性的问题。 该过程可以将测量的样品电阻率与预期电阻率值进行比较，以验证单个电解质结果的精度。 可疑的样品 - 例如，电解质电阻率结果不符合预期电阻率 - 可能被标记。 这个单独的验证步骤为测量的电解质结果提供了更多的信心，并且可以确定何时出现问题或干扰实时存在。

公开(公告)号：WO2012034084A3

公开(公告)日：2012-06-28

申请号：PCT/US2011051098

申请日：2011-09-09

Applicant: S E A MEDICAL SYSTEMS INC ,  MATSIEV LEONID F ,  WEICKERT MICHAEL J ,  BENNETT JAMES W ,  SMITH MATTHEW F ,  LITVINTSEVA SVETLANA ,  BLANKE KIT

Inventor： MATSIEV LEONID F ,  WEICKERT MICHAEL J ,  BENNETT JAMES W ,  SMITH MATTHEW F ,  LITVINTSEVA SVETLANA ,  BLANKE KIT

IPC: A61M5/172 ,  G01N27/06 ,  G01N27/08 ,  G01N27/416 ,  G06Q50/00

CPC classification number: G01N27/026 ,  A61M5/142 ,  A61M2205/0244 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/6018 ,  G01N27/4166 ,  Y02A90/26

Abstract: Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.

Abstract translation: 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的特性，药物的浓度以及使用导纳光谱法的稀释剂类型。 这些装置，系统和方法对于描述身份以及在一些变型中特别可用于浓缩医疗液体如静脉内液体的一种或多种组分。 特别地，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了通过模式识别来识别复合导纳光谱仪图案以确定液体的组成的方法。

公开(公告)号：WO2011100248A1

公开(公告)日：2011-08-18

申请号：PCT/US2011/024061

申请日：2011-02-08

Applicant: DIONEX CORPORATION ,  CHENG, Jun ,  JANDIK, Petr ,  POHL, Christopher, A.

Inventor： CHENG, Jun ,  JANDIK, Petr ,  POHL, Christopher, A.

IPC: H01M14/00 ,  G01N27/26

CPC classification number: G01N27/30 ,  G01N27/301 ,  G01N27/4166 ,  G01N30/64

Abstract: A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.

Abstract translation: 用于色谱系统的检测电池包括具有入口，出口和对电极的电池体，工作电极，在入口和出口之间延伸并与计数器和工作电极流体接触的样品流动通道，以及 钯/贵金属参考电极系统。 还描述了使用检测单元的方法。

公开(公告)号：WO2011014635A2

公开(公告)日：2011-02-03

申请号：PCT/US2010/043683

申请日：2010-07-29

Applicant: CATERPILLAR INC. ,  REBINSKY, Douglas, A. ,  TIAN, Yong ,  LIU, Xiaodong ,  ZEMSKOVA, Svetlana

Inventor： REBINSKY, Douglas, A. ,  TIAN, Yong ,  LIU, Xiaodong ,  ZEMSKOVA, Svetlana

IPC: G01N27/30 ,  G01N27/416 ,  G01N27/406

CPC classification number: G01N27/4166 ,  G01N33/287

Abstract: This disclosure relates to sulfur sensors that utilize sensing materials that can be used to detect ultra low concentrations of sulfur in liquids, such as below even 15 ppm. The sulfur sensors comprise a sensing electrode having a material that contributes an electrical element to the analysis and a material that contributes an ionic element to the analysis.

Abstract translation: 本公开涉及使用可用于检测液体中超低浓度硫的感测材料的硫传感器，例如甚至低于15ppm。 硫传感器包括感测电极，其具有有助于分析的电元件的材料和有助于分析的离子元件的材料。

公开(公告)号：WO2010111531A3

公开(公告)日：2011-01-20

申请号：PCT/US2010028726

申请日：2010-03-25

Applicant: SENOVA SYSTEMS INC ,  LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

Inventor： LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

IPC: G01N27/30 ,  G01N27/26 ,  G01N27/416 ,  G01N33/18

CPC classification number: G01N27/4166 ,  G01N27/302 ,  G01N27/4167

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Abstract translation: 用于在工作电极上检测包含氧化还原活性分析物敏感材料的分析物的设备以及计算机辅助信号采集和处理。

公开(公告)号：WO2010151592A1

公开(公告)日：2010-12-29

申请号：PCT/US2010/039664

申请日：2010-06-23

Applicant: BAYER HEALTHCARE LLC ,  SUN, Hoi-Cheong, Steve ,  CHARLTON, Steven, C. ,  CHINNAYELKA, Swetha ,  CREAVEN, John, P. ,  EDELBROCK, Andrew, J. ,  HOLZER, Matthew, B. ,  PARASNIS, Narasinha, C. ,  REYNOLDS, Jeffery, S. ,  RIPLEY, Paul, M. ,  WANG, Xin ,  WU, Mu

Inventor： SUN, Hoi-Cheong, Steve ,  CHARLTON, Steven, C. ,  CHINNAYELKA, Swetha ,  CREAVEN, John, P. ,  EDELBROCK, Andrew, J. ,  HOLZER, Matthew, B. ,  PARASNIS, Narasinha, C. ,  REYNOLDS, Jeffery, S. ,  RIPLEY, Paul, M. ,  WANG, Xin ,  WU, Mu

IPC: G01K3/08 ,  G01K7/01 ,  G01K7/02 ,  G01K7/16 ,  A61B5/00 ,  G01N33/487 ,  G01K13/00

CPC classification number: G01N27/4166 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  G01K3/08 ,  G01K7/01 ,  G01K7/02 ,  G01K7/16 ,  G01K13/00 ,  G01N27/26 ,  G01N27/308 ,  G01N27/3272 ,  G01N27/3274 ,  Y10T29/49155

Abstract: A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.

Abstract translation: 测试传感器包括主体，第一导电迹线，第二导电迹线和第三导电迹线。 主体包括具有流体接收区域的第一区域，与第一区域分离的第二区域以及设置在流体接收区域处或邻近流体接收区域的第一温度感测界面。 流体接收区域接收样品。 第一迹线设置在主体上，并且第一迹线的至少一部分设置在第一区域中。 第二和第三迹线设置在身体上。 第三个痕迹从第一个区域延伸到第二个区域。 第三个迹线连接到第一个温度检测界面的第一条迹线。 第三个跟踪包含与第一个跟踪不同的材料。 在第一温度感测界面处形成第一热电偶。 热电偶提供温度数据以确定分析物浓度。

公开(公告)号：WO2007037970A1

公开(公告)日：2007-04-05

申请号：PCT/US2006/035382

申请日：2006-09-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： SHAH, Rajiv ,  GOTTLIEB, Rebecca, K.

IPC: A61B5/00 ,  C12Q1/00 ,  G01N33/487

CPC classification number: A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

Abstract translation: 提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。 传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。 传感器电极层大致彼此上下配置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。 电极层由电介质层分离。

公开(公告)号：WO2006109278A3

公开(公告)日：2007-03-29

申请号：PCT/IB2006051181

申请日：2006-04-15

Applicant: AGAMATRIX INC ,  DIAMOND STEVEN ,  HARDING IAN ,  IYENGAR SRIDHAR ,  WEI BAOGUO

Inventor： DIAMOND STEVEN ,  HARDING IAN ,  IYENGAR SRIDHAR ,  WEI BAOGUO

IPC: G01N27/49 ,  C12Q1/00

CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the current peak-time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

Abstract translation: 提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时 在高原地区。 动态确定进行测量的当前峰值时间允许每个条带在最短的适当时间范围内运行，从而避免使用可能长于某些条带所需的平均测量时间，而对于其他条带来说太短。