公开(公告)号：WO2017049199A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/052303

申请日：2016-09-16

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： HWU, Patrick ,  MCKENZIE, Jodi, A. ,  MBOFUNG, Rina, N. ,  AMARIA, Rodabe ,  MALU, Shruti

IPC: A61K9/127

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K31/4745 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/76 ,  A61K2300/00

Abstract: The present disclosure relates to compositions and methods for treating cancer, more specifically to methods and compositions comprising a Topoisomerase I inhibitor and an α- PD-L1 antibody

Abstract translation: 本公开涉及用于治疗癌症的组合物和方法，更具体地涉及包含拓扑异构酶I抑制剂和α-PD-L1抗体的方法和组合物

公开(公告)号：WO2017004359A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/040364

申请日：2016-06-30

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： LEWIS, Richard, Thomas ,  JONES, Philip ,  PETROCCHI, Alessia ,  REYNA, Naphtali ,  HAMILTON, Matthew ,  SOTH, Michael, J. ,  HEFFERNAN, Timothy ,  HAN, Michelle ,  BURKE, Jason, P.

IPC: A61K31/501 ,  C07D417/14 ,  C07D207/00

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  A61K2300/00

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLSl mediated diseases, such as cancer, having the structure of Formula (I). Methods of inhibition GLSl activity in a human or animal subject are also provided.

Abstract translation: 本文公开了可用于治疗具有式（I）结构的GLS1介导的疾病例如癌症的化合物和组合物。 还提供了抑制人或动物受试者的GLS1活性的方法。

公开(公告)号：WO2012151362A2

公开(公告)日：2012-11-08

申请号：PCT/US2012/036255

申请日：2012-05-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  VISHWANATH, Sriram ,  BANK, Seth R. ,  APPAIAH, Kumar

Inventor： VISHWANATH, Sriram ,  BANK, Seth R. ,  APPAIAH, Kumar

IPC: H04B10/13 ,  H04J14/02

CPC classification number: H04B10/2581 ,  H04L1/0643

Abstract: Various method and apparatus embodiments that implement multi-input, multi-output (MIMO) techniques in optical communications systems that utilize mutli-mode optical fiber are disclosed. The techniques may include dispersion compensation, adaptive modulation, and optimization of modal coupling diversity. Using these techniques may increase the performance (in terms distance and/or bandwidth) of optical communications systems based on multi-mode fibers.

Abstract translation: 公开了在采用多模光纤的光通信系统中实现多输入多输出（MIMO）技术的各种方法和设备实施例。 这些技术可以包括色散补偿，自适应调制和模态耦合分集的优化。 使用这些技术可以增加基于多模光纤的光通信系统的性能（以距离和/或带宽计）。

公开(公告)号：WO2011041304A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/050532

申请日：2010-09-28

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  MONASH UNIVERSITY ,  MEDICINES FOR MALARIA VENTURE ,  PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  CHARMAN, Susan, A. ,  FLOYD, David ,  BURROWS, Jeremy ,  MATTHEWS, David ,  MARWAHA, Alka ,  GUJAR, Ramesh ,  COTERON-LOPEZ, Jose

Inventor： PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  CHARMAN, Susan, A. ,  FLOYD, David ,  BURROWS, Jeremy ,  MATTHEWS, David ,  MARWAHA, Alka ,  GUJAR, Ramesh ,  COTERON-LOPEZ, Jose

IPC: C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC classification number: C07D487/04

Abstract: Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

Abstract translation: 寄生虫二氢乳清酸脱氢酶（DHOD）抑制剂是治疗疟疾的候选治疗剂。 说明性的这种治疗剂包括符合式（IX）的化合物和三唑并嘧啶类化合物：及其溶剂化物，立体异构体，互变异构体和药学上可接受的盐。

公开(公告)号：WO2010065550A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066275

申请日：2009-12-01

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM ,  HAMRA, F., Kent

Inventor： HAMRA, F., Kent

IPC: A01K67/027

CPC classification number: A01K67/0271 ,  A01K67/02 ,  A01K67/0275 ,  A01K2217/07 ,  A01K2227/10 ,  A01K2227/105 ,  C12N5/061 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2800/90

Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.

Abstract translation: 来源于具有所需遗传背景的大鼠睾丸的精原干细胞系可以作为细胞移植到与精原细胞系免疫相容的雄性不育受体动物的来源。 因此移植的大鼠细胞很容易发育成受精能力的单倍体雄性配子，雄性不育接受者的睾丸产生的内源性精子竞争很少或没有。 构建用于在所需遗传背景下产生突变大鼠的来自体外培养的大鼠精原细胞系的第一载体系统影响来自移植的精原细胞的供体单倍型的最大种系传播。

公开(公告)号：WO2008134085A1

公开(公告)日：2008-11-06

申请号：PCT/US2008/005616

申请日：2008-05-01

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  ZHONG, Guangming

Inventor： ZHONG, Guangming

IPC: A61K39/118

CPC classification number: A61K39/118 ,  G01N33/56927 ,  G01N2333/295

Abstract: The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.

Abstract translation: 本发明提供衣原体蛋白质和用于诊断和检测测定以及治疗和免疫方案的方法。

公开(公告)号：WO2007117572A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/008536

申请日：2007-04-06

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  FELDMAN, Marc, D. ,  MILNER, Thomas, E. ,  KIM, Jihoon ,  OH, Jung-hwan ,  SANGHI, Pramod ,  MANCUSO, Jake ,  JOHNSTON, Keith, P. ,  MA, Leo ,  EMELIANOV, Stanislav

Inventor： FELDMAN, Marc, D. ,  MILNER, Thomas, E. ,  KIM, Jihoon ,  OH, Jung-hwan ,  SANGHI, Pramod ,  MANCUSO, Jake ,  JOHNSTON, Keith, P. ,  MA, Leo ,  EMELIANOV, Stanislav

IPC: A61B6/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/416 ,  A61N1/403 ,  A61N2/02 ,  G01N21/1717 ,  G01N21/4795

Abstract: Provided herein are systems, methods and compositions for the use of optical coherence tomography for detection of cells and for killing detected cells.

Abstract translation: 本文提供了使用光学相干断层摄影术来检测细胞和杀死检测到的细胞的系统，方法和组合物。

公开(公告)号：WO2007056551A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/043722

申请日：2006-11-08

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  HAMMER, Robert, E. ,  HAMRA, F., Kent ,  CRONKHITE, Jennifer, T.

Inventor： HAMMER, Robert, E. ,  HAMRA, F., Kent ,  CRONKHITE, Jennifer, T.

IPC: A01K67/027 ,  C12N5/06

CPC classification number: C12N5/0611 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/115 ,  C12N2533/54

Abstract: A transgenic rat expresses a gene of interest, such as EGFP, exclusively in the germ cells of both males and females. From such a transgenic rat one can isolate a line of spermatogonial stem cells, which can renew and proliferate in culture.

Abstract translation: 转基因大鼠仅在雄性和雌性的生殖细胞中表达目的基因，例如EGFP。 从这样的转基因大鼠可以分离一系列精原干细胞，其可以在培养物中更新和增殖。

公开(公告)号：WO2006130152A2

公开(公告)日：2006-12-07

申请号：PCT/US2005/023830

申请日：2005-07-06

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  UNITED STATES OF AMERICA represented by THE SECRETARY OF THE AIR FORCE ,  AHUJA, Sunil, K. ,  DOLAN, Matthew, J. ,  KULKARNI, Hemant ,  GONZALEZ, Enrique

Inventor： AHUJA, Sunil, K. ,  DOLAN, Matthew, J. ,  KULKARNI, Hemant ,  GONZALEZ, Enrique

CPC classification number: C12Q1/6883 ,  C12Q1/703 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The present invention provides compositions and methods for identifying persons at an increased risk of infection by, transmission of, or accelerated progression of a disease caused by an HIV-1 virus. Diagnostic and therapeutic kits are also provided.

Abstract translation: 本发明提供用于鉴定由HIV-1病毒引起的疾病的感染，传播或加速进展的风险增加的人的组合物和方法。 还提供了诊断和治疗试剂盒。

公开(公告)号：WO2006110367A2

公开(公告)日：2006-10-19

申请号：PCT/US2006/012266

申请日：2006-03-31

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BASEMAN, Joel, Barry ,  KANNAN, Thirumalai, Rengasamy

Inventor： BASEMAN, Joel, Barry ,  KANNAN, Thirumalai, Rengasamy

IPC: C07K16/12 ,  C07K16/30

CPC classification number: A61K39/0011 ,  A61K47/6829 ,  A61K47/6851 ,  A61K2039/6037 ,  C07K14/30

Abstract: The present invention provides Mycoplasma toxins, biologically active fragments/domains of the toxins, antibodies to the toxins, therapeutic fusion proteins comprising the toxins and/or biologically active fragments/domains of the toxins and nucleic acids encoding the toxins and fusion proteins. Also provided are methods of treating and/or preventing diseases and disorders using the compositions provided herein.

Abstract translation: 本发明提供了支原体毒素，毒素的生物活性片段/结构域，毒素抗体，包含毒素的毒素和/或生物活性片段/结构域的治疗性融合蛋白和编码 毒素和融合蛋白。 还提供了使用本文提供的组合物治疗和/或预防疾病和病症的方法。