公开(公告)号：WO2006114441A1

公开(公告)日：2006-11-02

申请号：PCT/EP2006/061883

申请日：2006-04-27

Applicant: DSM IP ASSETS B.V. ,  EDENS, Luppo ,  ROOS, DE, Andre Leonardus ,  VAN PLATERINK, Christianus, Jacobus

Inventor： EDENS, Luppo ,  ROOS, DE, Andre Leonardus ,  VAN PLATERINK, Christianus, Jacobus

IPC: A61K38/06 ,  A61P9/12

CPC classification number: A61K38/06 ,  C12P21/06

Abstract: The present invention describes the tripeptide MAP and/or the tripeptide ITP and/or a salt thereof.

Abstract translation: 本发明描述了三肽MAP和/或三肽ITP和/或其盐。

公开(公告)号：WO2006114439A2

公开(公告)日：2006-11-02

申请号：PCT/EP2006061874

申请日：2006-04-27

Applicant: DSM IP ASSETS BV ,  EDENS LUPPO ,  WOLFRAM SWEN ,  VAN PLATERINK CHRISTIANUS JACO ,  GERHARDT CINDERELLA CHRISTINA

Inventor： EDENS LUPPO ,  WOLFRAM SWEN ,  VAN PLATERINK CHRISTIANUS JACO ,  GERHARDT CINDERELLA CHRISTINA

IPC: A61K38/06 ,  A61P3/10 ,  A61P9/12

CPC classification number: A61Q19/00 ,  A23J3/344 ,  A23K20/147 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/64 ,  A61K38/06 ,  C07K5/0808 ,  C07K5/081 ,  C12Y304/15001 ,  A23V2200/328 ,  A23V2250/0626 ,  A23V2250/0648 ,  A23V2250/064 ,  A23V2200/326 ,  A23V2250/0632 ,  A23V2250/0604

Abstract: The present invention describes the use of MAP and/or ITP or a salt thereof as a nutraceutical, preferably a medicament.

Abstract translation: 本发明描述了MAP和/或ITP或其盐作为营养食品，优选药物的用途。

公开(公告)号：WO2006089921A1

公开(公告)日：2006-08-31

申请号：PCT/EP2006/060198

申请日：2006-02-23

Applicant: DSM IP Assets B.V. ,  ROOS, DE, Andre Leonardus ,  BROECKE, VAN DEN,, Pieter Marinus ,  EDENS, Luppo

Inventor： ROOS, DE, Andre Leonardus ,  BROECKE, VAN DEN,, Pieter Marinus ,  EDENS, Luppo

IPC: C12P21/02 ,  C12P21/06

CPC classification number: C12P21/06 ,  C12P21/02

Abstract: A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P- present than -V-P-P- (molar basis) which comprises hydrolysing the protein source to liberate at least 40% of the I-P-P- sequence 10 into the peptide IPP and whereby a proteolytic enzyme is used which cleaves at the carboxy-terminus of proline residues present in the protein source, the enzyme is preferably a proline specific endoprotease or proline specific oligopeptidase, more preferably a proline specific endoprotease, and optionally an amino peptidase.

Abstract translation: 从蛋白质源产生IPP的方法，其中蛋白源包含具有-IPP序列并且在蛋白质氨基酸序列中的蛋白质比-PP-（摩尔基）存在至少6倍以上的蛋白质，其包括水解 蛋白质来源，将至少40％的IPP序列10释放到肽IPP中，由此使用在蛋白质源中存在的脯氨酸残基的羧基末端切割的蛋白水解酶，该酶优选是脯氨酸特异性内切蛋白酶 或脯氨酸特异性寡肽酶，更优选脯氨酸特异性内切蛋白酶，和任选的氨基肽酶。

公开(公告)号：WO2006067163A3

公开(公告)日：2006-06-29

申请号：PCT/EP2005/057000

申请日：2005-12-21

Applicant: DSM IP Assets B.V. ,  EDENS, Luppo ,  ROOS, DE, Andre Leonardus ,  SCHOUTEN, Olaf Leonardus ,  DEEN, Philippus Antonius

Inventor： EDENS, Luppo ,  ROOS, DE, Andre Leonardus ,  SCHOUTEN, Olaf Leonardus ,  DEEN, Philippus Antonius

IPC: A61K38/06 ,  C12P21/06

Abstract: A process to produce IPP and VPP from a protein source that comprises the -I- P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino- peptidase preferably in a single enzymatic step.

公开(公告)号：WO2006067163A2

公开(公告)日：2006-06-29

申请号：PCT/EP2005057000

申请日：2005-12-21

Applicant: DSM IP ASSETS BV ,  EDENS LUPPO ,  ROOS DE ANDRE LEONARDUS ,  SCHOUTEN OLAF LEONARDUS ,  DEEN PHILIPPUS ANTONIUS

Inventor： EDENS LUPPO ,  ROOS DE ANDRE LEONARDUS ,  SCHOUTEN OLAF LEONARDUS ,  DEEN PHILIPPUS ANTONIUS

CPC classification number: C12P21/06 ,  A23J3/344 ,  A23L33/11 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A61K38/00 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2200/326 ,  A23V2250/54246 ,  A23V2250/2136 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/7056

Abstract: A process to produce IPP and VPP from a protein source that comprises the -I- P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino- peptidase preferably in a single enzymatic step.

Abstract translation: 从其蛋白质序列中包含-I-PP-和-VPP-序列的蛋白质源产生IPP和VPP的过程，并且其中存在于蛋白质源中的-IPP-序列的至少40％被转化为肽IPP 并且存在于蛋白质源中的至少40％的-VPP-序列被转化为肽VPP，其包括优选在单个酶促步骤中使用脯氨酸特异性内切蛋白酶和氨基肽酶。

公开(公告)号：WO2005117595A1

公开(公告)日：2005-12-15

申请号：PCT/EP2005/052533

申请日：2005-06-02

Applicant: DSM IP Assets B.V. ,  EDENS, Luppo ,  HILLE, Jan Dirk Rene

Inventor： EDENS, Luppo ,  HILLE, Jan Dirk Rene

IPC: A21D8/04

CPC classification number: A21D8/042 ,  A21D13/00

Abstract: The present invention describes the use of a proline-specific endoprotease to improve the flavour of baked cereal products. The invention also relates to novel compositions comprising a proline-specific endoprotease and an exopeptidase and dough comprising such composition suitable for improving flavour in baked cereal products, a method for improving flavour in baked products, and to baked products having an improved flavour.

Abstract translation: 本发明描述了脯氨酸特异性内切蛋白酶用于改善烘焙谷物产品风味的用途。 本发明还涉及包含脯氨酸特异性内切蛋白酶和外肽酶和面团的新型组合物，其包含适合于改善烘焙谷物产品中风味的组合物，改善焙烤产品中风味的方法，以及具有改善风味的烘焙产品。

公开(公告)号：WO2005082160A1

公开(公告)日：2005-09-09

申请号：PCT/EP2005/002159

申请日：2005-02-28

Applicant: DSM IP ASSETS B.V. ,  STREEKSTRA, Hugo ,  EDENS, Luppo

Inventor： STREEKSTRA, Hugo ,  EDENS, Luppo

IPC: A23L1/015

CPC classification number: A23K10/14 ,  A21D8/042 ,  A21D13/22 ,  A23L5/25 ,  A23L5/28 ,  A23L19/18 ,  C12Y305/01 ,  C12Y305/01001 ,  C12Y305/01002

Abstract: Process for the production of a food or feed product, comprising adding an enzyme to the surface of an intermediate form of the food or feed product, and subsequently applying at least one heating step, whereby the enzyme is capable of modifying amino acids present in the intermediate form of the food or feed product. The invention also relates to food or feed products obtained by the process of the invention.

Abstract translation: 用于生产食品或饲料产品的方法，包括向中间形式的食品或饲料产品的表面添加酶，随后施加至少一个加热步骤，由此该酶能够修饰存在于 中间形式的食品或饲料产品。 本发明还涉及通过本发明的方法获得的食品或饲料产品。

公开(公告)号：WO1998027827A1

公开(公告)日：1998-07-02

申请号：PCT/EP1997007292

申请日：1997-12-22

Applicant: GIST-BROCADES B.V. ,  EDENS, Luppo ,  SCHUURHUIZEN, Paul ,  SIMONETTI, Arthur, Louis, Maria

Inventor： GIST-BROCADES B.V.

IPC: A23J03/34

CPC classification number: A23J3/346 ,  A23J3/341 ,  A23L33/18

Abstract: This invention relates to a process for obtaining enzymatically hydrolysed proteinaceous material for human consumption. The process involves the use of essentially only one exopeptidase, in combination with one or more suitable endopeptidases, to obtain improved taste characteristics and process economics under conditions which minimise microbial contamination.

Abstract translation: 本发明涉及获得用于人类消费的酶促水解的蛋白质物质的方法。 该方法包括与一种或多种合适的内肽酶组合使用基本上仅一种外肽酶，以在微生物污染最小化的条件下获得改善的味道特征和方法经济性。

公开(公告)号：WO1995028092A1

公开(公告)日：1995-10-26

申请号：PCT/EP1995001461

申请日：1995-04-18

Applicant: GIST-BROCADES B.V. ,  EDENS, Luppo ,  MEIJER, Dirk ,  VAN PARIDON, Petrus, Andreas

Inventor： GIST-BROCADES B.V.

IPC: A23K01/16

CPC classification number: C12N9/00 ,  A23K20/174 ,  A23K20/179 ,  A23K20/189 ,  A23K40/30 ,  A23K50/75 ,  A23L29/06 ,  A23L29/10 ,  A23L33/15 ,  A23L35/10 ,  A23V2002/00 ,  A61K8/06 ,  A61K8/064 ,  A61K8/345 ,  A61K8/375 ,  A61K8/60 ,  A61K8/66 ,  A61Q19/00 ,  C12Y301/00 ,  C12Y301/01003 ,  C12Y301/03 ,  C12Y302/00 ,  C12Y304/00 ,  A23V2250/154 ,  A23V2250/30 ,  A23V2250/642 ,  A23V2250/18 ,  A23V2200/222 ,  A23V2250/192 ,  A23V2250/6406 ,  A23V2250/032 ,  A23V2250/708

Abstract: The present invention describes stable water-in-oil emulsions comprising the following components: water, oil, a labile compound of interest, a stabilizing agent and an emulsifier. The labile compound present in the water phase is stabilized by addition of a stabilizing agent which preferably is a polyol. Specific emulsifiers are described which give rise to stable emulsions in the presence of high amounts of a polyol.

Abstract translation: 本发明描述了稳定的油包水乳液，其包含以下组分：水，油，感兴趣的不稳定化合物，稳定剂和乳化剂。 存在于水相中的不稳定化合物通过加入优选为多元醇的稳定剂来稳定。 描述了在大量多元醇存在下产生稳定乳液的特定乳化剂。

公开(公告)号：WO2010037695A1

公开(公告)日：2010-04-08

申请号：PCT/EP2009/062488

申请日：2009-09-28

Applicant: DSM IP ASSETS B.V. ,  EDENS, Luppo ,  ROOS, DE, Andre Leonardus

Inventor： EDENS, Luppo ,  ROOS, DE, Andre Leonardus

IPC: A61K9/48 ,  A61K38/48 ,  A61P1/18

CPC classification number: A61K9/2054 ,  A61K38/4813

Abstract: The present invention relates to a composition of at least one protease and a mode of application for treating patients suffering from pancreatic enzyme insufficiency, pancreatitis or cystic fibrosis. The composition of enzymes comprises at least one protease which has a pH optimum below 5.0 and wherein said protease is further active in the presence of pepsin. In a preferred embodiment, said protease is of microbial origin.

Abstract translation: 本发明涉及至少一种蛋白酶的组合物和用于治疗患有胰腺酶不足，胰腺炎或囊性纤维化的患者的应用模式。 酶的组成包含至少一种蛋白酶，其最适pH低于5.0，并且其中所述蛋白酶在胃蛋白酶存在下进一步具有活性。 在优选的实施方案中，所述蛋白酶是微生物来源的。