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    HYBRID NANOMATERIALS AS MULTIMODAL IMAGING CONTRAST AGENTS
    44.
    发明申请
    HYBRID NANOMATERIALS AS MULTIMODAL IMAGING CONTRAST AGENTS 审中-公开
    混合纳米材料作为多模式成像对比剂

    公开(公告)号：WO2007124131A2

    公开(公告)日：2007-11-01

    申请号：PCT/US2007009796

    申请日：2007-04-20

    Applicant: UNIV NORTH CAROLINA ,  LIN WENBIN ,  RIETER WILLIAM ,  TAYLOR KATHRYN ,  KIM JASON

    Inventor： LIN WENBIN ,  RIETER WILLIAM ,  TAYLOR KATHRYN ,  KIM JASON

    IPC: A61K49/00

    CPC classification number: A61K49/12 ,  A61K49/0002 ,  A61K49/0019 ,  A61K49/0043 ,  A61K49/0093 ,  A61K49/183 ,  A61K49/1854 ,  A61K49/1857

    Abstract: The presently disclosed subject matter provides hybrid nanomaterials for use as magnetic resonance imaging (MRI), optical and/or multimodal contrast imaging agents. The hybrid nanomaterials comprise a polymeric matrix material and a plurality of coordination complexes, each coordination complex comprising a functionalized chelating group and a paramagnetic metal ion. The nanoparticle can further comprise a luminophore. Methods of synthesizing and using the nanoparticles are provided. The nanoparticles can be used to diagnose diseases, including cancer, cardiovascular disease, and diseases related to inflammation.

    Abstract translation: 目前公开的主题提供用作磁共振成像（MRI），光学和/或多模式造影剂的混合纳米材料。 混合纳米材料包含聚合物基体材料和多个配位络合物，每个配位络合物包含官能化螯合基团和顺磁金属离子。 纳米颗粒还可以包含发光体。 提供了合成和使用纳米颗粒的方法。 纳米颗粒可用于诊断疾病，包括癌症，心血管疾病和与炎症有关的疾病。

    MAGNETIC NANOPARTICLES COMPOSITIONS AND USES THEREOF
    45.
    发明申请
    MAGNETIC NANOPARTICLES COMPOSITIONS AND USES THEREOF 审中-公开
    磁性纳米材料组合物及其用途

    公开(公告)号：WO2007118884A1

    公开(公告)日：2007-10-25

    申请号：PCT/EP2007/053761

    申请日：2007-04-18

    Applicant: NANOBIOTIX ,  LEVY, Laurent

    Inventor： LEVY, Laurent

    IPC: A61K9/14 ,  A61K49/06 ,  A61K33/26 ,  A61P35/00

    CPC classification number: A61K33/26 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K41/0052 ,  A61K49/0002 ,  A61K49/183 ,  A61K49/1845 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

    Abstract: The present invention relates to the use of a biocompatible nanoparticle or nanoparticle aggregate, in combination with an external non-oscillating magnetic field, wherein said nanoparticle comprises a) a core comprising magnetic material; b) a biocompatible shell surrounding the core, and, optionally, c) a labelling agent, wherein the outer diameter of the shell is less than about 100 nm, to prepare a composition, wherein the composition is deprived of any cell targeting means. The present invention further relates to the compositions thus obtained and to their uses in the field of human health, for the treatment of cancer, or in diagnostic (imaging for example), for the monitoring of tumor evolution.

    Abstract translation: 本发明涉及生物相容纳米颗粒或纳米颗粒聚集体与外部非振荡磁场的组合的用途，其中所述纳米颗粒包括a）包含磁性材料的芯; b）围绕所述芯的生物相容性壳，以及任选地c）标记试剂，其中所述壳的外径小于约100nm，以制备组合物，其中所述组合物被剥夺任何细胞靶向手段。 本发明还涉及由此获得的组合物及其在人类健康领域，用于治疗癌症或诊断（例如成像）中用于监测肿瘤进展的用途。

    SYSTEM AND METHOD FOR THE TREATMENT OF DISEASE USING NANOPARTICLES
    47.
    发明申请
    SYSTEM AND METHOD FOR THE TREATMENT OF DISEASE USING NANOPARTICLES 审中-公开
    使用纳米颗粒治疗疾病的系统和方法

    公开(公告)号：WO2017015659A1

    公开(公告)日：2017-01-26

    申请号：PCT/US2016/043858

    申请日：2016-07-25

    Applicant: NOVATHER, INC. ,  BATCHU, Jayanth Venkata Nagendra S.

    Inventor： BATCHU, Jayanth Venkata Nagendra S.

    IPC: A61K9/51 ,  A61K9/00 ,  A61K49/10 ,  A61K41/00

    CPC classification number: A61K9/00 ,  A61K9/51 ,  A61K41/0052 ,  A61K47/6425 ,  A61K47/6923 ,  A61K49/183 ,  A61K49/1866

    Abstract: This invention provides SPIONs. The SPIONs can be coated as appropriately required for the disease—in the case of cancer treatment, (SPION Super Complex synthesis process) SPION Super Complexes will be the resulting coating-SPION structure. The SPION Super Complexes can also be formed through variations of the SPION Super Complex synthesis process. The NPVD synthesis process uses a combination of nanoimprinting lithography and reactive ion etching to create and isolate the NPVDs. Then the NPVDs can be coated as appropriate for the disease—in the case of cancer treatment, (NPVD Super Complex synthesis process) NPVD Super Complexes will be the resulting coating-NPVD structure. The NPVD Super Complexes can also be formed through the NPVD Super Complex Synthesis Process according to various techniques.

    Abstract translation: 本发明提供了SPION。 SPION可以适用于疾病的涂层 - 在癌症治疗的情况下（SPION超级复合物合成工艺），SPION Super Complexes将是所得到的涂层-SPION结构。 SPION超级复合物也可以通过SPION Super Complex合成过程的变化形成。 NPVD合成方法使用纳米压印光刻和反应离子蚀刻的组合来产生和隔离NPVD。 然后NPVD可以适当地涂覆疾病 - 在癌症治疗的情况下，（NPVD超级复合物合成过程）NPVD超级复合物将是所得涂层NPVD结构。 NPVD超复合物也可以通过NPVD超复合物合成工艺根据各种技术形成。

    MULTIFUNCTIONAL SUPERPARAMAGNETIC NANOSYSTEM AS CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING AND ITS PRODUCTION METHOD
    50.
    发明申请
    MULTIFUNCTIONAL SUPERPARAMAGNETIC NANOSYSTEM AS CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING AND ITS PRODUCTION METHOD 审中-公开
    多功能超声波纳米粒子作为磁共振成像的对比剂及其生产方法

    公开(公告)号：WO2015026252A1

    公开(公告)日：2015-02-26

    申请号：PCT/PT2014/000054

    申请日：2014-08-20

    Applicant: INSTITUTO SUPERIOR TECNICO ,  FACULDADE DE CIENCIAS E TECNOLOGIA DA UNIVERSIDADE NOVA DE LISBOA ,  UNIVERSIDADE DE LISBOA

    Inventor： GONCALVES, MARIA Clara Henriques Baptista ,  FORTES, Luis Miguel Amante ,  MARTINS, Maria Barbara Dos Anjos Figueira ,  CARVALHO, Alexandra Maria Fonseca Castelo Dias De ,  FEIO, Antonio Gabriel Malagueta

    IPC: A61K49/18 ,  B82Y15/00

    CPC classification number: A61K49/183 ,  A61K49/1848 ,  A61K49/1866 ,  A61K49/1875

    Abstract: The present invention concerns a multifunctional superparamagnetic nanosystem and its production method for nano-biomedical imaging, human and animal, intended to be used as contrast agent (CA) for Magnetic Resonance Imaging (MRI). Furthermore, it can be associated with therapies such as hyperthermia, and to the transport and targeted release of selected drugs, by conjugation with biomolecules. The multifunctional superparamagnetic nanosystem can be used as negative contrast agent, reducing the T2 value of tissues in MRI, found on the extremely high magnetic moment, under the action of a magnetic field. It can also be used as positive contrast agent. Its efficiency as MRI contrast agent allows for the usage of clinical dosages that are much lower than the ones currently administered to patients who undergo this diagnosis technique. The multifunctional superparamagnetic nanosystem provides a technological platform for several applications in nano- biomedical imaging. It is biocompatible and biodegradable, and its production is free of organic compounds and surfactants.

    Abstract translation: 本发明涉及旨在用作磁共振成像（MRI）的造影剂（CA）的多功能超顺磁性纳米系统及其用于纳米生物医学成像，人和动物的生产方法。 此外，它可以与诸如热疗的疗法相关联，并且可以通过与生物分子缀合而与所选药物的转运和靶向释放相关。 多功能超顺磁纳米系统可用作阴性造影剂，在磁场作用下，在极高磁矩下发现MRI降低组织的T2值。 也可以作为阳性造影剂使用。 其作为MRI造影剂的效率允许使用比目前对经历该诊断技术的患者施用的临床剂量低的临床剂量。 多功能超顺磁纳米系统为纳米生物医学成像中的多种应用提供了技术平台。 它是生物相容的和可生物降解的，其生产不含有机化合物和表面活性剂。

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