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    LIPOBEADS AND THEIR PRODUCTION
    42.
    发明申请
    LIPOBEADS AND THEIR PRODUCTION 审中-公开
    LIPOBEADS及其生产

    公开(公告)号：WO2003015701A2

    公开(公告)日：2003-02-27

    申请号：PCT/US2002/026056

    申请日：2002-08-15

    申请人： POLYTECHNIC UNIVERSITY

    发明人： KAZAKOV, Sergey ,  KAHOLEK, Marian ,  LEVON, Kalle

    IPC分类号： A61K

    CPC分类号： A61K9/5138 ,  A61K9/127 ,  A61K9/1273 ,  B01J13/02 ,  B82Y5/00 ,  C08J3/075 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989 ,  Y10T428/2991

    摘要： Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide- co -l-vinylimidazole) lipobeads were produced and characterized.

    摘要翻译： Lipobeads（脂质体包封的水凝胶）结合水凝胶和脂质体的特性，以创建对环境条件敏感的系统，并以快速时间尺度响应这些状况的变化。 脂质体可以通过在脂质体内聚合锚定或未锚定的水凝胶或通过将锚定或未锚定的水凝胶与脂质体混合来制备。 巨型脂蛋白可以通过在脂珠体中收缩未溶解的纳米凝胶并使所得脂质体聚集体缩短，锚定或未锚定脂肪细胞的长期老化或将锚定或未锚定的聚集的纳米凝胶与脂质体混合而产生。 制备聚（丙烯酰胺），聚（N-异丙基丙烯酰胺）和聚（N-异丙基丙烯酰胺 - 间 - 乙烯基咪唑）脂珠和表征。

    PARTICLES
    43.
    发明申请
    PARTICLES 审中-公开
    粒子

    公开(公告)号：WO02036258A2

    公开(公告)日：2002-05-10

    申请号：PCT/EP2001/012209

    申请日：2001-10-23

    IPC分类号： B01J13/02 ,  B01F17/00 ,  B01J13/16 ,  C08F2/00 ,  C08G69/28 ,  C08G85/00

    CPC分类号： B01F17/0028 ,  B01F17/0035 ,  B01F17/005 ,  B01J13/16 ,  G06F8/65 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： A particulate composition comprising particles having a core comprising a hydrophobic polymer within a shell, characterised in that the shell comprises a semi-permeable membrane. Particulate composition can be used for making a stable dispersion of particles uniformly distributed throughout a first hydrophobic liquid, wherein the particles comprise a core within a shell and the core comprises a hydrophobic polymer into has been imbibed a second hydrophobic liquid. Compositions can be used to encapsulate active substances and may be used in sustained release mechanisms.

    摘要翻译： 一种颗粒组合物，其包含具有包含壳内的疏水性聚合物的芯的颗粒，其特征在于，所述壳包含半透膜。 颗粒组合物可用于使均匀分布在整个第一疏水性液体中的颗粒的稳定分散，其中颗粒包含壳内的芯，并且芯包含疏水性聚合物已被吸收第二疏水性液体。 组合物可用于包封活性物质并可用于持续释放机制。

    PARTICULATE ENCAPSULATION OF LIQUID BEADS
    44.
    发明申请
    PARTICULATE ENCAPSULATION OF LIQUID BEADS 审中-公开
    液珠的颗粒包封

    公开(公告)号：WO0185138A3

    公开(公告)日：2002-03-28

    申请号：PCT/US0115012

    申请日：2001-05-10

    申请人： AVEKA INC

    发明人： HAMER MONICA A ,  HENDRICKSON WILLIAM A ,  MARTI JAMES J

    IPC分类号： A61K8/11 ,  A61K8/25 ,  A61K8/67 ,  A61K9/50 ,  A61Q19/00 ,  B01J13/02

    CPC分类号： A61K8/11 ,  A61K8/25 ,  A61K8/676 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5089 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/02 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Various materials, including generally non-compatible materials may be provided from a single delivery system by a unique encapsulation system. An encapsulation system is advantageously constructed as a core of aqueous liquid having at least 5 % by weight water therein, and an encapsulant surrounding the core to form a stable encapsulated particle, the encapsulant comprising at least one layer of hydrophobic particles in contact with and surrounding the core, the core and hydrophobic particles providing an encapsulated system that has an average weight average particle diameter of from 0.05 to 25 micrometers and can support its own weight. The encapsulation system may be provided by a novel method of manufacture comprising providing a mass of hydrophobic particles having average mass diameter size of between 0.05 and 25 micrometers, providing droplets of an aqueous medium to the mass of particles, gently mixing the fine particles of aqueous medium and the hydrophobic particles to form a stable encapsulant system of droplets of the aqueous medium encapsulated by a shell of particles.

    摘要翻译： 可以通过独特的封装系统从单个递送系统提供各种材料，包括通常不兼容的材料。 封装系统有利地被构造为具有至少5重量％水中的水的含水液体核心，以及包围核心以形成稳定的包封颗粒的密封剂，所述密封剂包含至少一层接触和环绕的疏水性颗粒 芯，芯和疏水性颗粒提供具有0.05至25微米的平均重量平均粒径并且可以支撑其自身重量的封装体系。 包封系统可以通过一种新的制造方法提供，包括提供大量平均质量直径尺寸为0.05至25微米的疏水性颗粒，向颗粒物质提供水性介质的液滴，轻轻地将水性微粒 介质和疏水性颗粒以形成由颗粒壳包封的水性介质的液滴的稳定的密封剂系统。

    A METHOD FOR INDUCING IMMUNITY COMPRISING PHAGOCYTIC PARTICLES AND ATP RECEPTORS
    45.
    发明申请
    A METHOD FOR INDUCING IMMUNITY COMPRISING PHAGOCYTIC PARTICLES AND ATP RECEPTORS 审中-公开
    一种诱导包含PHAGOCYTIC PARTICLES和ATP受体的免疫的方法

    公开(公告)号：WO02020042A1

    公开(公告)日：2002-03-14

    申请号：PCT/US2001/028171

    申请日：2001-09-07

    IPC分类号： A61K9/127 ,  A61K39/385 ,  A61P37/04 ,  C12N15/88 ,  A61K39/00 ,  C12N15/00 ,  C12N15/85 ,  C12N15/86

    CPC分类号： A61K39/385 ,  A61K9/127 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/6056 ,  C12N15/88 ,  Y10T428/2984

    摘要： The invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention invention also provides methods of delivering an antigen to an Class II or class I MHC receptor to supress immunity against the antigen in a subject having a disease. The ligand-binding APCs to bind to the ligand-coated Ag/ATP-filled particles and APC phagolysosomes to ingest the ligand-coated Ag(ATP-filled particles to facilitate transfer of the ingested antigen from the phagolysosomes into cytoplasm such that the angigen is delivered to a Class II MHC receptor and is expressed on the surface of the APCs (Ag-APCs), d) incubating the Ag-APCs of step (c) with lymphocytes previously removed from the subject having the disease; and e) administering the incubated lymphocytes of step (d) to the subject so as induce Class II MHC presentation and elicit suppressor T-lymphocytes so to supress immunity against the angiten in the subject.

    摘要翻译： 本发明提供将抗原递送至I类或​​II类MHC受体以在具有疾病的受试者中诱导针对抗原的免疫的方法。 本发明还提供了将抗原递送至II类或I类MHC受体以抑制具有疾病的受试者中抗原的免疫的方法。 配体结合的APC结合配体包被的Ag / ATP填充的颗粒和APC噬菌粒体以摄取配体包被的Ag（ATP填充的颗粒以促进摄取的抗原从吞噬细胞转移到细胞质中，使得Angigen 递送到II类MHC受体并且在APC表面（Ag-APC）上表达，d）将步骤（c）的Ag-APC与先前从具有该疾病的受试者中去除的淋巴细胞孵育; 和e）将受试者的步骤（d）的培养的淋巴细胞施用于受试者，以便诱导II类MHC呈递和引发抑制性T淋巴细胞，从而抑制对受试者的angiten的免疫。

    POLYMERIC NANOPARTICLES INCLUDING OLFACTIVE COMPONENTS
    48.
    发明申请
    POLYMERIC NANOPARTICLES INCLUDING OLFACTIVE COMPONENTS 审中-公开
    包括奥氏体组分的聚合纳米粒子

    公开(公告)号：WO01079303A1

    公开(公告)日：2001-10-25

    申请号：PCT/EP2001/003986

    申请日：2001-04-06

    IPC分类号： A61K8/00 ,  A61K8/02 ,  A61K8/18 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q13/00 ,  A61Q19/00 ,  C08F2/00 ,  C08F2/24 ,  C08F2/44 ,  C11D3/50 ,  C11D17/00 ,  A61K7/00 ,  A61K7/06 ,  A61K7/46 ,  A61K7/48

    CPC分类号： B82Y5/00 ,  A61K8/02 ,  A61K2800/413 ,  A61Q13/00 ,  C08F2/44 ,  C11D3/505 ,  C11D17/0039 ,  Y10T428/2984

    摘要： The polymeric nanoparticles including olfactive components have a glass temperature of >50 DEG C. They are obtainable by continuously adding a monomer component and an olfactive component to an aqueous solution. The aqueous solution comprises a first initiator and an emulsifier. The added components are distributed in the aqueous solution to obtain reaction mixture while the polymerization of the monomer component is started at the first temperature. The liquid monomer component and the olfactive component are added continuously while a second initiator is added dropwise to the reaction mixture and the first temperature is maintained. After terminating the addition of liquid monomer component and the olfactive component the temperature of the reaction mixture is increased to a second temperature and a third initiator is added dropwise.

    摘要翻译： 包含嗅觉组分的聚合物纳米颗粒具有> 50℃的玻璃温度。它们可通过将单体组分和嗅觉组分连续加入到水溶液中而获得。 水溶液包含第一引发剂和乳化剂。 添加的组分分布在水溶液中以获得反应混合物，同时单体组分的聚合在第一个温度下开始。 连续加入液体单体组分和嗅觉组分，同时将第二引发剂滴加到反应混合物中并保持第一温度。 在终止液体单体组分和嗅觉组分的加入后，将反应混合物的温度升至第二温度，并滴加第三引发剂。