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    NON-RADIOACTIVE NUCLEIC ACID PROBES
    51.
    发明申请
    NON-RADIOACTIVE NUCLEIC ACID PROBES 审中-公开
    非放射性核酸探针

    公开(公告)号：WO1988004289A1

    公开(公告)日：1988-06-16

    申请号：PCT/US1987003243

    申请日：1987-12-07

    Applicant: NATIONAL DISTILLERS AND CHEMICAL CORPORATION

    Inventor： NATIONAL DISTILLERS AND CHEMICAL CORPORATION ,  FORD, John, P. ,  ERLANGER, Bernard, F. ,  BLEWETT, C., William

    IPC: C07C113/04

    CPC classification number: C12Q1/6827 ,  C12Q1/6816 ,  Y10S436/804 ,  Y10S436/828

    Abstract: A diazonium compound of formula (I), wherein Z is selected from the group consisting of biotin, an antigen, an antibody, a photoreactive group, a fluorescent group and heavy metal-containing compounds; X is an alkylene group containing up to 18 carbon atoms in the principle chain and a total of up to 24 carbon atoms or a substituted alkylene group containing up to 18 carbon atoms in the principle chain with substituents selected from the group consisting of solubility-enhancing groups and cleavable -S-S- containing moieties; Ar is an unsubstituted or substituted aryl or heteroaryl; and Y is an anion and n is an integer from 1-3.

    Abstract translation: 式（I）的重氮化合物，其中Z选自生物素，抗原，抗体，光反应性基团，荧光基团和含重金属的化合物; X是在原则链中含有至多18个碳原子的亚烷基，在原理链中含有至多24个碳原子或含有至多18个碳原子的取代的亚烷基，所述取代基选自溶解度增强 基团和可切割的含-SS的部分; Ar是未取代或取代的芳基或杂芳基; Y为阴离子，n为1-3的整数。

    SENSITIVE TESTS FOR MALIGNANCIES BASED ON DNA DETECTION
    54.
    发明申请
    SENSITIVE TESTS FOR MALIGNANCIES BASED ON DNA DETECTION 审中-公开
    基于DNA检测的恶性肿瘤敏感性检测

    公开(公告)号：WO1984000037A1

    公开(公告)日：1984-01-05

    申请号：PCT/US1983000946

    申请日：1983-06-17

    Applicant: IMREG, INC.

    Inventor： IMREG, INC. ,  GOTTLIEB, A., Arthur, M.D

    IPC: C12N11/00

    CPC classification number: G01N33/574 ,  C12N15/00 ,  C12Q1/6886 ,  Y10S436/804 ,  Y10S436/813 ,  Y10S436/815

    Abstract: An improved, more convenient, more sensitive test for detection of certain malignancies in human and animal subjects. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated matrix. Sera from normal and cancerous subjects react differently with the matrix, permitting a diagnosis of the subject.

    Abstract translation: 公开了一种用于检测人和动物受试者中某些恶性肿瘤的改进的，更方便的，更灵敏的检测方法。 在酶共轭树脂的存在下，将来自测试受试者的血清与标记的DNA混合。 来自正常和癌症受试者的血清与树脂的反应不同，允许对受试者进行诊断。

    PROBE CONTAINING A MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND UTILIZATION OF SAID PROBE TO TEST FOR AND CHARACTERIZE AN HOMOLOGOUS DNA SEQUENCE
    55.
    发明申请
    PROBE CONTAINING A MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND UTILIZATION OF SAID PROBE TO TEST FOR AND CHARACTERIZE AN HOMOLOGOUS DNA SEQUENCE 审中-公开
    包含被特异性抗体识别的修饰的核酸的探针和用于测试和表征同源物DNA序列的所述探针的利用

    公开(公告)号：WO1983002286A1

    公开(公告)日：1983-07-07

    申请号：PCT/FR1982000220

    申请日：1982-12-23

    Applicant: INSTITUT PASTEUR ,  TCHEN, Paul ,  CAMI, Anne, Brigitte ,  LENG, Marc ,  KOURILSKY, Philippe

    Inventor： INSTITUT PASTEUR

    IPC: C12Q01/68

    CPC classification number: C12Q1/6804 ,  G01N33/5308 ,  Y10S435/81 ,  Y10S436/804 ,  Y10S436/808 ,  Y10S436/828

    Abstract: Method for detecting the presence of a nucleic acid sequence such as a gene or a gene fragment in a composition or sample which is supposed to contain it. It is characterized in that said composition is contacted with a probe containing a nucleic acid complementary of the nucleic acid sequence or of the gene searched for in certain conditions enabling particularly such hybridation, the probe carrying at least a N-2-acetylaminofluorene group fixed covalently to at least one of the bases of said probe, the possible presence of the nucleic acid sequence or the gene searched for being then revealed by the action of efficient antibodies in relation to the N-2-(guanosine-8-yl)-acetylaminofluorene or antibodies which have been previously prepared in relation to the probe carrying acetylaminofluorene residues.

    Abstract translation: 用于检测假定含有它的组合物或样品中核酸序列如基因或基因片段的存在的方法。 其特征在于，使所述组合物与包含核酸序列互补的核酸的探针或在特定条件下进行特异性检测的基因进行接触，所述探针携带至少一个共价固定的N-2-乙酰氨基芴基 到所述探针的至少一个碱基，通过与N-2-（鸟苷-8-基） - 乙酰氨基芴相关的有效抗体的作用，所述核酸序列或所搜索的基因的可能存在被显示出来 或相对于携带乙酰氨基芴残基的探针预先制备的抗体。

    A METHOD OF DETECTING OR DETERMINING HISTAMINE IN HISTAMINE CONTAINING MATERIALS, PARTICULARLY BODY FLUIDS AND AN ANALYTICAL MEANS FOR USE IN SUCH METHOD
    56.
    发明申请
    A METHOD OF DETECTING OR DETERMINING HISTAMINE IN HISTAMINE CONTAINING MATERIALS, PARTICULARLY BODY FLUIDS AND AN ANALYTICAL MEANS FOR USE IN SUCH METHOD 审中-公开
    含有组胺的材料，特别是身体液体中的组胺的检测方法和用于此类方法的分析方法

    公开(公告)号：WO1983000229A1

    公开(公告)日：1983-01-20

    申请号：PCT/DK1982000064

    申请日：1982-07-06

    Applicant: SKOV, Per, Stahl ,  NORN, Svend ,  WEEKE, Bent

    IPC: G01N33/50

    CPC classification number: G01N33/5091 ,  G01N33/5308 ,  G01N33/6863 ,  G01N33/74 ,  Y10S436/804 ,  Y10S436/807 ,  Y10S436/808 ,  Y10S436/81 ,  Y10S436/811 ,  Y10T436/147777 ,  Y10T436/25375

    Abstract: L'histamine est détectée ou déterminée de manière sélective dans un échantillon en provoquant le contact entre l'échantillon et des microfibres de verre dans une proportion quantitative telle qu'elle permet à l'histamine présente de se lier aux fibres. La quantité d'histamine liée aux fibres peut être déterminée par détermination compétitive en présence d'histamine marquée sur la base d'une courbe standard, ou peut être déterminée directement par des réactions conventionnelles de couplage. Ce procédé est simple et particulièrement utile pour des diagnostics d'allergies, étant donné qu'il présente une bonne corrélation avec les procédés fluorométriques connus.

    Abstract translation: 组胺通过使样品与玻璃微纤维以定量比例接触来检测或选择性地测定，这将允许存在的组胺结合纤维。 结合组胺的量可以通过基于标准曲线的标记组胺存在下的竞争性测定来确定，或者可以通过常规偶联反应直接测定。 该方法简单，对于过敏诊断特别有用，因为它与已知的荧光测定方法具有良好的相关性。

    A METHOD OF DIAGNOSIS
    57.
    发明申请
    A METHOD OF DIAGNOSIS 审中-公开
    一种诊断方法

    公开(公告)号：WO1982001593A1

    公开(公告)日：1982-05-13

    申请号：PCT/GB1981000232

    申请日：1981-10-23

    Applicant: PARRATT DAVID

    IPC: G01N33/54

    CPC classification number: G01N33/564 ,  Y10S435/971 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/821 ,  Y10S436/823 ,  Y10S436/827

    Abstract: A method of diagnosis using an attached material for binding to an immune complex, by treating the bound complex with a series of different reagents or mixtures thereof and detecting the presence or absence of reaction in each case, this method being based on immune complexes produced in the body during infection and allowing much earlier detection and diagnosis of infection thereby providing the facility for treatment to reduce the damage caused to the body by the formation of complex.

    Abstract translation: 一种使用附着材料结合免疫复合物的方法，通过用一系列不同的试剂或其混合物处理结合的复合物并检测每种情况下是否存在反应，该方法基于在 感染期间的身体，并且允许更早地检测和诊断感染，从而提供治疗设施，以通过形成复合物减少对身体的损害。

    RADIO RECEPTOR ASSAY FOR BENZODIZAPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS
    59.
    发明申请
    RADIO RECEPTOR ASSAY FOR BENZODIZAPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS 审中-公开
    放射性受体测定在等离子体和其他生物样本中的苯二甲酸

    公开(公告)号：WO1980000750A1

    公开(公告)日：1980-04-17

    申请号：PCT/US1979000437

    申请日：1979-06-12

    Applicant: US COMMERCE

    Inventor： US COMMERCE ,  PAUL S ,  SKOLNICK P

    IPC: G01N33/60 ,  G01N33/94 ,  B01J1/22 ,  G21H5/02

    CPC classification number: G01N33/948 ,  G01N33/60 ,  Y10S436/804 ,  Y10S436/816 ,  Y10S436/819 ,  Y10S436/826

    Abstract: A rapid, sensitive and specific radioreceptor assay for measuring benzodiazepines in plasma and other biological specimens without sophisticated equipement or methodology. This method is based on the competition between [ sH] diazepam or tritiated flunitrazepam and pharmacologically active benzodiazepines present in plasma, for binding sites on rat brain synaptosomal membranes. No interference is obtained with drag-free plasma or plasma samples containing high concentrations of other commonly used drugs. High correlations (r = 0.98;p

    Abstract translation: 一种用于测量血浆和其他生物样本中苯并二氮杂没有复杂设备或方法的快速，灵敏和特异性的放射性受体测定。 该方法基于[s3> sH]地西泮或氚标记的氟硝西泮与存在于血浆中的药理学活性苯并二氮杂卓之间的竞争，用于大鼠脑突触体膜上的结合位点。 使用含高浓度其他常用药物的无抗血浆或血浆样品无干扰。 使用放射性受体测定法测定血浆中的“地西泮当量”与通过气液色谱法得到的地西泮和N-去甲基地西泮的含量之间的高相关性（r = 0.98; p <001）。 放射性受体测定法可用于监测治疗和毒理学目的的血液苯二氮卓含量。

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