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    METHOD FOR PRODUCTION OF MICROCAPSULES
    57.
    发明申请
    METHOD FOR PRODUCTION OF MICROCAPSULES 审中-公开
    微生物生产方法

    公开(公告)号：WO00064575A1

    公开(公告)日：2000-11-02

    申请号：PCT/EP2000/003587

    申请日：2000-04-20

    IPC分类号： A61K9/50 ,  A61K47/02 ,  A61K47/30 ,  A61K47/38 ,  B01J13/08 ,  B01J13/10 ,  B01J13/06

    CPC分类号： B01J13/10

    摘要： The invention provides a process for microencapsulating a pharmaceutical substrate comprising the steps of: a) adding insoluble or sparingly soluble particles of the substrate to be microencapsulated to a stable buffer solution having a high ionic strength; b) dissolving a membrane-forming ionic polymer in the buffer; c) forming a coacervate by adding a water-complexing compound causing phase separation of the resulting mixture; and d) allowing the deposition of the coacervate onto the substrate so as to create a coating of polymer around the substrate.

    摘要翻译： 本发明提供了一种用于微胶囊化药物底物的方法，包括以下步骤：a）将待微胶囊化的底物的不溶性或微溶性颗粒加入到具有高离子强度的稳定缓冲溶液中; b）将形成膜的离子聚合物溶解在缓冲液中; c）通过加入导致所得混合物相分离的水络合化合物形成凝聚层; 和d）允许将凝聚层沉积到基底上，以便在基底周围形成聚合物涂层。

    SLOW RELEASE MICROCAPSULES
    59.
    发明申请
    SLOW RELEASE MICROCAPSULES 审中-公开
    选择延迟释放微囊

    公开(公告)号：WO99048479A1

    公开(公告)日：1999-09-30

    申请号：PCT/EP1999/001625

    申请日：1999-03-12

    IPC分类号： A61K8/11 ,  A61K8/73 ,  A61K9/16 ,  A61K9/50 ,  A61K47/36 ,  A61Q13/00 ,  B01J13/02 ,  B01J13/10

    CPC分类号： A61K8/11 ,  A61K8/736 ,  A61K9/1652 ,  A61K2800/412 ,  A61Q13/00 ,  B01J13/10

    摘要： The inventive method for producing microcapsules is characterised in that a) in one step, liquid drops of an aqueous solution (1) containing at least one water-soluble polyanion are added to an aqueous solution (2) containing the following: 0.1 to 5 wt. % calcium cations; and 0.1 to 5 wt. % hydrolyzed chitosan with a number average molecular weight of between 2,200 and 40,000 g/mol., obtained by partial hydrolysis of a chitosan with a number average molecular weight of more than 50,000 g/mol. in an aqueous solution containing 0.1 to 4 N HCl at a temperature of between 50 and 95 DEG C for 0.5 to 8 hours, the weight ratio of the solution containing HCl to usual commercial chitosan being between 1 and 50 and the product of normality of the HCl solution and the duration of hydrolysis in hours being between 0.1 and 7; and in that b) once the addition of solution 1 is complete, the resulting microcapsules remain in solution 2 for a duration of 15 to 360 minutes, preferably 60 to 180 minutes.

    摘要翻译： 一种用于制备微胶囊的方法，其特征在于在含有至少一种水溶性聚阴离子的水溶液中1）的一个）（在一个工艺步骤液滴，被引入到（2）含有的水溶液：0.1％〜5重量 ％钙阳离子; 和0.1〜5重量％的水解的壳聚糖具有数均分子量从2200至40,000克/摩尔，通过具有大于50,000克/摩尔的在含有0.1〜4的水溶液的数均分子量的脱乙酰壳多糖的部分水解获得的 含有在50和95摄氏度的温度下溶液当量盐酸一段0.5至8小时之间，其特征在于，含有HCl的溶液的重量比为1和50和HCl溶液和的正常性的产品之间的商业壳聚糖 水解时间是在0.1-7小时; 和b保持）加入溶液1的一段15至360分钟后，特别是用于一个周期为60至180分钟，在该溶液（2）如此得到的微胶囊。

    MICROENCAPSULATION PROCESS
    60.
    发明申请
    MICROENCAPSULATION PROCESS 审中-公开
    微孔过程

    公开(公告)号：WO1996032191A1

    公开(公告)日：1996-10-17

    申请号：PCT/US1996003731

    申请日：1996-03-19

    申请人： MONSANTO COMPANY

    发明人： MONSANTO COMPANY ,  JASON, Mark, Edward ,  KALOTA, Dennis, Jerome

    IPC分类号： B01J13/10

    CPC分类号： B01J13/02

    摘要： There is disclosed a process for microencapsulation of materials by means of complex coacervation employing gelatin and polyaspartic acid. Material to be encapsulated is emulsified in an aqueous solution of gelatin. Polyaspartic acid or a salt thereof is employed to provide a counter ion to the gelatin which, when induced to precipitate from solution by cooling and/or pH change forms a wall around the material. The wall is hardened by crosslinking to form a stable microcapsule containing the material.

    摘要翻译： 公开了通过使用明胶和聚天冬氨酸的复合凝聚来微胶囊化材料的方法。 要包封的材料在明胶水溶液中乳化。 聚天冬氨酸或其盐用于向明胶提供抗衡离子，当通过冷却和/或pH变化诱导从溶液中沉淀出来时，其形成围绕材料的壁。 通过交联使壁硬化以形成含有该材料的稳定的微胶囊。