公开(公告)号：WO2017040153A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/048444

申请日：2016-08-24

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： KANE, Michael J. ,  LINDER, William J. ,  JUFFER, Lance Eric ,  HAASL, Benjamin J. ,  SCHMIDT, Brian L. ,  HUELSKAMP, Paul ,  MAILE, Keith R.

IPC: A61N1/375 ,  A61N1/378 ,  A61B5/11 ,  A61N1/365

CPC classification number: A61N1/36535 ,  A61B5/1116 ,  A61B5/1118 ,  A61B2560/0209 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/37247 ,  A61N1/3756 ,  A61N1/378

Abstract: Systems, devices, and methods for adjusting functionality of an implantable medical device based on posture are disclosed. In some instances, a method for operating a leadless cardiac pacemaker implanted into a patient, where the patient has two or more predefined behavioral states, may include detecting a change in the behavioral state of the patient, and in response, changing a sampling rate of a sensor signal generated by a sensor of the leadless cardiac pacemaker. In some embodiments, the method may further include using the sampled sensor signal to determine an updated pacing rate of the leadless cardiac pacemaker and providing pacing to the patient at the updated pacing rate.

Abstract translation: 公开了用于基于姿势来调整可植入医疗装置的功能的系统，装置和方法。 在一些情况下，用于操作植入患者中的无引线心脏起搏器的方法，其中患者具有两个或更多个预定义的行为状态，可以包括检测患者的行为状态的变化，并且作为响应，改变患者的行为状态的变化 由无引线心脏起搏器的传感器产生的传感器信号。 在一些实施例中，该方法还可以包括使用采样的传感器信号来确定无引线心脏起搏器的更新的起搏速率并且以更新的起搏速率向患者提供起搏。

公开(公告)号：WO2016130492A1

公开(公告)日：2016-08-18

申请号：PCT/US2016/017056

申请日：2016-02-09

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： THAKUR, Pramodsingh Hirasingh ,  AN, Qi ,  YU, Yinghong ,  NYQUIST, Benjamin J.

IPC: A61N1/368

CPC classification number: A61N1/3686 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36585 ,  A61N1/3684

Abstract: An energy efficient system is described for delivering electrostimulation to a patient's heart. The system may be configured to switch, in some cases dynamically, between a multi-site electrostimulation configuration and a single-site electrostimulation configuration for delivering electrostimulation to a single heart chamber (e.g. left ventricle) based upon one or more triggers and/or a predefined schedule to reduce the energy expenditure of the system while still providing the benefits of multi-site electrostimulation.

Abstract translation: 描述了一种节能系统，用于向患者的心脏递送电刺激。 该系统可以被配置为在一些情况下动态地在多位点电刺激配置和单站点电刺激配置之间切换，用于基于一个或多个触发器将电刺激递送到单个心室（例如左心室）和/或 预定义的时间表，以减少系统的能量消耗，同时仍然提供多站点电刺激的好处。

公开(公告)号：WO2015191893A3

公开(公告)日：2016-04-14

申请号：PCT/US2015035389

申请日：2015-06-11

Applicant: CARDIAC PACEMAKERS INC

Inventor： KANE MICHAEL J ,  STAHMANN JEFFREY E ,  MAILE KEITH R

IPC: A61N1/365 ,  A61N1/05 ,  A61N1/368 ,  A61N1/372 ,  G06F17/30

CPC classification number: A61N1/36585 ,  A61N1/0563 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3684 ,  A61N1/37288 ,  A61N1/3756

Abstract: Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (LCP) that is implanted within or proximate the heart. From this location, the LCP may provide pacing therapy to the heart based at least in part on the sensed cardiac electrical data. An implantable medical device located remotely from the heart may sense patient activity, and may wirelessly communicate patient activity data from the implantable medical device to the LCP, sometimes using conducted communication. The LCP may be then determine an adjustment to the provided pacing therapy (e.g. adjust the pacing rate) based at least in part on the received patient activity data signal.

Abstract translation: 用于向患者的心脏提供速率响应起搏治疗的系统和方法。 用于提供速率响应起搏治疗的一个示例性方法包括用植入心脏内或心脏附近的无引线心脏起搏器（LCP）来感测心脏电数据。 从该位置，LCP可以至少部分地基于所感测的心脏电数据来向心脏提供起搏治疗。 位于远离心脏的可植入医疗装置可以感测患者活动，并且可以有时使用进行的通信将患者活动数据从可植入医疗装置无线地传送到LCP。 然后，LCP可以至少部分地基于所接收的患者活动数据信号来确定对所提供的起搏治疗的调整（例如调整起搏速率）。

公开(公告)号：WO2016004009A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/038495

申请日：2015-06-30

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： AVERINA, Viktoria A. ,  THAKUR, Pramodsingh Hirasingh ,  SWEENEY, Robert J.

IPC: A61N1/362

CPC classification number: A61B5/7275 ,  A61B5/0205 ,  A61B5/0537 ,  A61B5/091 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/4857 ,  A61B7/04 ,  A61N1/36114 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/39 ,  G06F19/00

Abstract: Systems are provided for using stored physiologic information about a subject to detect a previous treatment event. Physiologic information can be sensed from a subject using one or more sensors. Using a detection circuit, a change in the sensed physiologic information, such as a change from reference physiologic information, can be used to identify a candidate previous treatment event. An alert or other information about the candidate treatment event can be provided to a patient or clinician. In an example, a candidate treatment event can include a heart failure or diuresis treatment that is identified using information about a change in one or more of a subject's circadian pattern, a subject's thoracic impedance, or a subject's respiration status.

Abstract translation: 系统被提供用于使用存储的关于受试者的生理信息来检测先前的治疗事件。 可以使用一个或多个传感器从对象感测生理信息。 使用检测电路，可以使用感测到的生理信息（例如从参考生理信息的变化）的变化来识别候选的先前治疗事件。 关于候选治疗事件的警报或其他信息可以提供给患者或临床医师。 在一个示例中，候选治疗事件可以包括使用关于受试者的昼夜节律模式，受试者的胸部阻抗或受试者的呼吸状态中的一种或多种的变化的信息来识别的心力衰竭或利尿治疗。

公开(公告)号：WO2015191893A2

公开(公告)日：2015-12-17

申请号：PCT/US2015/035389

申请日：2015-06-11

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： KANE, Michael J. ,  STAHMANN, Jeffrey E. ,  MAILE, Keith R.

CPC classification number: A61N1/36585 ,  A61N1/0563 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3684 ,  A61N1/37288 ,  A61N1/3756

Abstract: Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (LCP) that is implanted within or proximate the heart. From this location, the LCP may provide pacing therapy to the heart based at least in part on the sensed cardiac electrical data. An implantable medical device located remotely from the heart may sense patient activity, and may wirelessly communicate patient activity data from the implantable medical device to the LCP, sometimes using conducted communication. The LCP may be then determine an adjustment to the provided pacing therapy (e.g. adjust the pacing rate) based at least in part on the received patient activity data signal.

Abstract translation: 用于向患者的心脏提供速率响应起搏治疗的系统和方法。 用于提供速率响应起搏治疗的一个示例性方法包括用植入心脏内或心脏附近的无引线心脏起搏器（LCP）来感测心脏电数据。 从该位置，LCP可以至少部分地基于所感测的心脏电数据来向心脏提供起搏治疗。 位于远离心脏的可植入医疗装置可以感测患者活动，并且可以有时使用进行的通信将患者活动数据从可植入医疗装置无线地传送到LCP。 然后，LCP可以至少部分地基于所接收的患者活动数据信号来确定对所提供的起搏治疗的调整（例如调整起搏速率）。

公开(公告)号：WO2015095581A9

公开(公告)日：2015-10-08

申请号：PCT/US2014071253

申请日：2014-12-18

Applicant: CARDIAC PACEMAKERS INC

Inventor： ROCKWEILER HOLLY E ,  SAHA SUNIPA ,  HERRMANN KEITH L ,  YU YINGHONG ,  KRUEGER JOEL A

IPC: A61N1/372 ,  A61N1/36 ,  A61N1/368 ,  A61N1/37

CPC classification number: A61N1/3686 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/371 ,  A61N1/37247

Abstract: Some systems and methods may facilitate selection of a vector for delivering electrical stimulation to a patient's heart. One method may include displaying a plurality of vectors on a display screen wherein each vector represents a different combination of three or more electro-stimulation electrodes, determining an electrical impedance for each of the plurality of vectors, displaying on the display screen the electrical impedance for each of the plurality of vectors, receiving a selection of a set of the plurality of vectors, determining, for each of the vectors in the set of vectors, a capture threshold, displaying on the display screen the capture threshold for each of the vectors in the set of vectors, receiving a selection of a vector from the set of vectors for delivery of electrical stimulation to the patient's heart, and programming the electro-stimulation device electrical stimulation to the patient's heart via the selected vector.

Abstract translation: 一些系统和方法可以有助于选择用于向患者的心脏递送电刺激的载体。 一种方法可以包括在显示屏上显示多个矢量，其中每个矢量表示三个或更多个电刺激电极的不同组合，确定多个矢量中的每一个的电阻抗，在显示屏上显示用于 所述多个矢量中的每一个接收对所述多个矢量的集合的选择，针对所述矢量集合中的每个矢量确定捕获阈值，在显示屏幕上显示每个矢量的捕获阈值， 该组矢量从用于向患者的心脏递送电刺激的矢量集合中接收矢量的选择，并且经由选择的矢量将电刺激设备电刺激编程到患者的心脏。

公开(公告)号：WO2015109028A1

公开(公告)日：2015-07-23

申请号：PCT/US2015/011474

申请日：2015-01-14

Applicant: KAISER, Daniel, Walter ,  KAISER, Clayton, Allen

Inventor： KAISER, Daniel, Walter ,  KAISER, Clayton, Allen

IPC: A61B5/024 ,  A61B5/0295 ,  A61B5/0402

CPC classification number: A61N1/3627 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/1459 ,  A61B17/1204 ,  A61B17/12122 ,  A61B17/12136 ,  A61B2017/00022 ,  A61F2/2475 ,  A61F2/2487 ,  A61F2002/068 ,  A61F2250/0003 ,  A61F2250/0013 ,  A61M1/1008 ,  A61M1/1018 ,  A61M1/106 ,  A61M1/1074 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/3684 ,  A61N1/3962

Abstract: Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume. The device includes an adjustable member that may create a mean pressure differential in order to manifest an effective "mechanical diuresis" by sequestering extraneous blood volume to the high-capacitance of the venous vasculature. The system is therefore designed to reduce intracardiac filling pressures while maintaining or even increasing cardiac output.

Abstract translation: 提供了设备，系统和方法，用于优化心力衰竭，传导疾病和心房颤动患者的心脏内填充压力和心输出量。 该系统能够通过调节心率和总体积体积的有效量来调节和优化心内灌注压和心输出量。 该装置包括可调节构件，其可以产生平均压力差，以通过将外来血液体积隔离到静脉血管的高电容来显示有效的“机械利尿”。 因此，该系统旨在减少心内充盈压力，同时保持甚至增加心输出量。

公开(公告)号：WO2013059048A3

公开(公告)日：2014-05-30

申请号：PCT/US2012059546

申请日：2012-10-10

Applicant: ADMITTANCE TECHNOLOGIES INC ,  UNIV TEXAS ,  FELDMAN MARC D ,  LARSON ERIK R ,  PEARCE JOHN A ,  VALVANO JONATHAN W ,  PORTERFIELD JOHN

Inventor： FELDMAN MARC D ,  LARSON ERIK R ,  PEARCE JOHN A ,  VALVANO JONATHAN W ,  PORTERFIELD JOHN

IPC: A61N1/365

CPC classification number: A61N1/3925 ,  A61N1/36521

Abstract: An apparatus for treating a patient's heart includes a sensor for measuring hemodynamics of the heart. The apparatus includes a processing unit which receives the hemodynamics from the sensor and uses the hemodynamics to determine whether to shock the heart. A method for treating a patient's heart. The method includes the steps of measuring hemodynamics of the heart with a sensor. There is the step of receiving the hemodynamics from the sensor at a processing unit which uses the hemodynamics to determine whether to shock the heart.

Abstract translation: 用于治疗患者心脏的装置包括用于测量心脏血液动力学的传感器。 该装置包括处理单元，其接收来自传感器的血流动力学，并使用血液动力学来确定是否震动心脏。 一种治疗患者心脏的方法。 该方法包括用传感器测量心脏的血液动力学的步骤。 在使用血液动力学来确定是否震动心脏的处理单元处，从传感器接收血液动力学的步骤。

公开(公告)号：WO2012082698A2

公开(公告)日：2012-06-21

申请号：PCT/US2011/064560

申请日：2011-12-13

Applicant: CARDIAC PACEMAKERS, INC. ,  THAKUR, Pramodsingh Hirasingh ,  PATANGAY, Abhilash

Inventor： THAKUR, Pramodsingh Hirasingh ,  PATANGAY, Abhilash

IPC: A61N1/368

CPC classification number: A61B5/0538 ,  A61B5/0205 ,  A61B5/103 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869 ,  A61B2560/0462 ,  A61N1/36521 ,  A61N1/36535 ,  G06F19/00

Abstract: Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.

Abstract translation: 可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。 可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。 在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。 可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。 可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

公开(公告)号：WO2012058118A1

公开(公告)日：2012-05-03

申请号：PCT/US2011/057361

申请日：2011-10-21

Applicant: MEDTRONIC, INC. ,  WAHLSTRAND, John, D. ,  ST. MARTIN, James, J.

Inventor： WAHLSTRAND, John, D. ,  ST. MARTIN, James, J.

IPC: A61N1/05 ,  A61N1/08 ,  A61N1/365 ,  A61N1/372

CPC classification number: A61N1/05 ,  A61N1/36521 ,  A61N1/37288 ,  A61N2001/083

Abstract: Example techniques for communicating between two medical devices are described. One medical device may be an implantable medical device. Another medical device may be a lead-borne implantable medical device. The lead-borne implantable medical device may be referred to as a satellite. The implantable medical device may measure impedance of a path including at least two electrodes, at least one of which is on the lead, using an impedance measurement module. In some example implementations of this disclosure, the implantable medical device may also use the impedance measurement module to communicate with the satellite on the lead.

Abstract translation: 描述用于在两个医疗设备之间通信的示例技术。 一种医疗装置可以是可植入医疗装置。 另一种医疗装置可以是铅笔可植入医疗装置。 铅笔可植入医疗器械可以称为卫星。 可植入医疗装置可以使用阻抗测量模块来测量包括至少两个电极的路径的阻抗，其中至少一个电极在引线上。 在本公开的一些示例性实施方案中，可植入医疗装置还可以使用阻抗测量模块与导线上的卫星通信。