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    EFFICIENT DELIVERY OF MULTI-SITE PACING
    2.
    发明申请
    EFFICIENT DELIVERY OF MULTI-SITE PACING 审中-公开
    高效地交付多地点

    公开(公告)号：WO2016172566A1

    公开(公告)日：2016-10-27

    申请号：PCT/US2016/028965

    申请日：2016-04-22

    Applicant: MEDTRONIC, INC.

    Inventor： SCHROCK, Anthony W. ,  HUDSON, Jean E. ,  KLECKNER, Karen J. ,  WAHLSTRAND, John D. ,  HEINKS, Michael W. ,  HUDZIAK, Michael L. ,  GHOSH, Subham ,  SAMBELASHVILI, Aleksandre T.

    IPC: A61N1/362 ,  A61N1/368 ,  A61N1/37

    CPC classification number: A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36571 ,  A61N1/3686 ,  A61N1/3712

    Abstract: An implantable device and associated is disclosed. The device comprises a set of electrodes spatially separated from one another and all coupled to an implantable pulse generator. The device comprises a processor configured for forming a first pacing vector and a second pacing vector. The pulse generator is configured to deliver first pacing pulses to the first pacing vector and delivering second pacing pulses to the second pacing vector. The pulse generator generates a recharging current for recharging a first coupling capacitor over a first recharge time period and another recharging current for recharging a first coupling capacitor over a second recharging time period. An order of recharging the first and second coupling capacitors is dependent upon one of ventricular pacing mode, left ventricle to right ventricle delay (V-V) pace delay, multiple point LV delay and latest delivered pacing pulses to one of the first and second pacing vectors.

    Abstract translation: 公开了一种可植入装置和相关联的装置。 该装置包括彼此空间分离并且全部耦合到可植入脉冲发生器的一组电极。 该设备包括被配置用于形成第一起搏向量和第二起搏向量的处理器。 脉冲发生器被配置为将第一起搏脉冲传送到第一起搏矢量并将第二起搏脉冲传送到第二起搏矢量。 脉冲发生器产生再充电电流，用于在第一再充电时间段内为第一耦合电容器再充电，另一个再充电电流用于在第二充电时间周期内为第一耦合电容器再充电。 对第一和​​第二耦合电容器再充电的顺序取决于心室起搏模式，左心室到右心室延迟（V-V）步速延迟，多点LV延迟和最近发出的起搏脉冲之一到第一和第二起搏矢量之一。

    SYSTEM FOR OPTIMIZING MULTI-SITE PACING USING HEART SOUNDS
    3.
    发明申请
    SYSTEM FOR OPTIMIZING MULTI-SITE PACING USING HEART SOUNDS 审中-公开
    使用心脏声音优化多地点的系统

    公开(公告)号：WO2016061176A1

    公开(公告)日：2016-04-21

    申请号：PCT/US2015/055446

    申请日：2015-10-14

    Applicant: CARDIAC PACEMAKERS, INC.

    Inventor： AN, Qi ,  THAKUR, Pramodsingh Hirasingh ,  YU, Yinghong

    IPC: A61N1/05 ,  A61N1/362 ,  A61N1/365

    CPC classification number: A61N1/36585 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3686

    Abstract: An example of a system for pacing through multiple electrodes in a ventricle includes a sensing circuit to sense cardiac signal(s), a pacing output circuit to deliver pacing pulses, a heart sound sensor to sense a heart sound signal, and a control circuit to control the delivery of the pacing pulses. The control circuit includes a heart sound detector to detect heart sounds using the heart sound signal, an electrical event detector to detect cardiac electrical events using the cardiac signal(s), a measurement module to measure an optimization parameter using the detected heart sounds, and an optimization module to approximately optimize one or more pacing parameters using the measured optimization parameter. The one or more pacing parameters include an electrode configuration parameter specifying one or more electrodes selected from the multiple electrodes in the ventricle for delivering ventricular pacing pulses to that ventricle.

    Abstract translation: 用于起搏通过心室中的多个电极的系统的示例包括用于感测心脏信号的感测电路，用于输送起搏脉冲的起搏输出电路，用于感测心脏声音信号的心脏声音传感器，以及控制电路 控制起搏脉冲的输送。 控制电路包括使用心音信号检测心音的心脏声音检测器，使用心脏信号检测心脏电气事件的电子事件检测器，使用检测到的心脏声音来测量优化参数的测量模块，以及 优化模块，以使用所测量的优化参数近似优化一个或多个起搏参数。 一个或多个起搏参数包括指定从心室中的多个电极中选择的一个或多个电极的电极配置参数，用于将心室起搏脉冲输送到心室。

    METHOD AND APPARATUS FOR ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY EMPLOYING A MULTIPOLAR LEFT VENTRICULAR LEAD
    7.
    发明申请
    METHOD AND APPARATUS FOR ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY EMPLOYING A MULTIPOLAR LEFT VENTRICULAR LEAD 审中-公开
    自适应心脏再生治疗方法和装置采用多孔左心室导联

    公开(公告)号：WO2013078010A1

    公开(公告)日：2013-05-30

    申请号：PCT/US2012/064029

    申请日：2012-11-08

    Applicant: MEDTRONIC, INC.

    Inventor： STADLER, Robert W. ,  SAMBELASHVILI, Aleksandre T. ,  SPLETT, Vincent E.

    IPC: A61N1/362 ,  A61N1/368

    CPC classification number: A61N1/3627 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3688

    Abstract: A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.

    Abstract translation: 医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗 心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。 在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。 响应于激活时间确定选择第一起搏站点。 该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。

    FAULT TOLERANT SYSTEM FOR AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR OR PULSE GENERATOR
    8.
    发明申请
    FAULT TOLERANT SYSTEM FOR AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR OR PULSE GENERATOR 审中-公开
    用于可植入式变频器或脉冲发生器的容错系统

    公开(公告)号：WO2012102872A1

    公开(公告)日：2012-08-02

    申请号：PCT/US2012/021151

    申请日：2012-01-13

    Applicant: MEDTRONIC, INC. ,  CRUTCHFIELD, Randolph E. ,  CABELKA, Lonny V.

    Inventor： CRUTCHFIELD, Randolph E. ,  CABELKA, Lonny V.

    IPC: A61N1/08 ,  A61N1/39

    CPC classification number: A61N1/3931 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3782 ,  A61N1/3962 ,  A61N1/3981

    Abstract: The disclosure describes circuits for providing therapy in an implantable medical device. The illustrative circuits include features that provide fault tolerance with graceful degradation as well as switching control methods that reduce component count and improves reliability. Fault detection circuit 130 functions to monitor the components of output circuits (such as hold capacitors 102, or tip capacitors 106) in order to detect any abnormalities associated with the operation of the components. In response to detecting a component abnormally, fault detection circuitry 130 transmits a signal to a controller/timer circuit, with the signal being utilized in one embodiment to reconfigure the coupling of the components in the output circuits such that the component (s) that are determined to exhibit an abnormality are switched out of the output circuits.

    Abstract translation: 本公开描述了用于在可植入医疗装置中提供治疗的电路。 示例性电路包括提供具有优雅劣化的容错性以及减少组件数量并提高可靠性的开关控制方法的特征。 故障检测电路130用于监视输出电路（例如保持电容器102或尖端电容器106）的组件，以便检测与组件的操作相关联的任何异常。 响应于异常检测到组件，故障检测电路130将信号发送到控制器/定时器电路，在一个实施例中使用信号来重新配置输出电路中的组件的耦合，使得组件 确定为出现异常的信号被切换出输出电路。

    PRIORITIZED PROGRAMMING OF MULTI-ELECTRODE PACING LEADS
    9.
    发明申请
    PRIORITIZED PROGRAMMING OF MULTI-ELECTRODE PACING LEADS 审中-公开
    多电极光源的优先编程

    公开(公告)号：WO2012044370A1

    公开(公告)日：2012-04-05

    申请号：PCT/US2011/033564

    申请日：2011-04-22

    Applicant: MEDTRONIC, INC. ,  SCHOTZKO, Elizabeth, A. ,  SCHELL, Jon, D.

    Inventor： SCHOTZKO, Elizabeth, A. ,  SCHELL, Jon, D.

    IPC: A61N1/368 ,  A61N1/372

    CPC classification number: A61N1/3684 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371 ,  A61N1/372 ,  A61N1/37247 ,  A61N1/37276

    Abstract: Various techniques are disclosed for facilitating selection of at least one vector from among a plurality of vectors for pacing a chamber of a heart. In one example, a method includes presenting, by a computing device, a plurality of criteria by which each of the plurality of vectors may be prioritized, selecting at least one criterion from among a plurality of criteria by which each of the plurality of vectors may be prioritized, measuring the at least one selected criterion for each of the plurality of vectors, and automatically prioritizing, by the computing device, the plurality of vectors based on the measurement of the at least one selected criterion.

    Abstract translation: 公开了各种技术，用于便于从用于起搏心脏的室的多个向量中选择至少一个载体。 在一个示例中，一种方法包括由计算设备呈现多个准则，通过该标准可以对多个向量中的每一个进行优先排序，从多个标准中选择至少一个准则，通过该标准中的每个向量可以 被优先考虑，测量所述多个向量中的每一个的所述至少一个选择的标准，并且由所述计算设备基于所述至少一个所选标准的测量来自动优先化所述多个向量。

    HEART STIMULATING DEVICE WITH SELECTING OPTIMAL ELECTRODE CONFIGURATION
    10.
    发明申请
    HEART STIMULATING DEVICE WITH SELECTING OPTIMAL ELECTRODE CONFIGURATION 审中-公开
    选择最佳电极配置的心脏刺激装置

    公开(公告)号：WO2011040842A1

    公开(公告)日：2011-04-07

    申请号：PCT/SE2009/000431

    申请日：2009-09-30

    Applicant: ST. JUDE MEDICAL AB ,  SIVARD, Åke ,  LINDGREN, Anders ,  KARLSSON, Andreas

    Inventor： SIVARD, Åke ,  LINDGREN, Anders ,  KARLSSON, Andreas

    IPC: A61N1/362 ,  A61N1/05 ,  A61N1/08 ,  A61N1/37

    CPC classification number: A61N1/368 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3702

    Abstract: Heart stimulating device comprising a stimulation pulse generator arranged in a stimulator housing (2), where the heart stimulating device being connectable to a plurality of stimulation and sensing electrodes (5, 6, 7, 8, 9, 10, 11, 12) arranged at one or many leads (3, 4, 13), the electrodes being adapted to be arranged in connection with the heart to stimulate the heart. The device further comprises a sensing unit adapted to sense electrical heart tissue responses to applied electrical stimulation pulses via said electrodes. The pulse generator is adapted to generate stimulation pulses to be applied to the heart tissue by different electrodes, and for each of the applied pulses resulting in a depolarization wave in the heart tissue a depolarization wave velocity, or a depolarization wave velocity measure, of the wave is determined by the sensing unit and stored in a memory unit. The stored wave velocities, or velocity measures, related to different stimulating electrodes, are compared to each other in a comparison unit and the comparison is used to adapt a stimulation mode when stimulating the heart to optimize the hemodynamic performance of the heart.

    Abstract translation: 心脏刺激装置包括布置在刺激器壳体（2）中的刺激脉冲发生器，其中心脏刺激装置可连接到多个刺激和感测电极（5,6,7,8,9,10,11,12），其布置 在一个或多个引线（3,4,13）处，所述电极适于与心脏连接地布置以刺激心脏。 该装置还包括感测单元，其适于感测通过所述电极施加的电刺激脉冲的电心脏组织反应。 脉冲发生器适于产生由不同电极施加到心脏组织的刺激脉冲，并且对于每个施加的脉冲，导致心脏组织中的去极化波，去极化波速度或去极化波速度测量 波由感测单元确定并存储在存储单元中。 在比较单元中将与不同刺激电极相关的存储的波速度或速度测量值进行比较，并且比较用于在刺激心脏时优化刺激模式以优化心脏的血液动力学性能。

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