Abstract:
The invention is directed to a method and a surgical instrument, typically a surgical stapler that is configured for performing anastomosis of a first gastro-intestinal tract section to a second gastro-intestinal tract section, both gastro-intestinal tract sections comprising a superficial layer and an intermediate layer. Said method comprises contacting the superficial layers of said gastro-intestinal tract sections and compressing the contacted sections between a first pressure area and a second pressure area, wherein the sum of the first pressure area and the second pressure increases during the compression such that the superficial layers are pressed aside and the intermediate layers are contacted.
Abstract:
The invention relates to the fields of medicine and drug development, more particularly to drugs that are capable of mimicking calorie restriction (CR), and to screening tools and screening methods for identifying the same. Provided is a dual reporter plasmid system comprising a first nucleic acid sequence encoding a Renilla luciferase transcript and a second nucleic acid sequence encoding a firefly luciferase transcript, wherein said nucleic acid sequences are both under control of the C/EBPβ-5'UTR-uORF. Also provided is adefovir or a prodrug thereof for use in a method for improving the metabolic health in a subject.
Abstract:
The invention relates to the field of medicine, in particular to means and methods for the treatment of the devastating skin blistering disease Recessive dystrophic epidermolysis bullosa (RDEB). Provided is an isolated antisense oligonucleotide (AON) of 14 to 35 nucleotides in length capable of binding to a target sequence of exon 105 in the COL7A1 gene, said target sequence comprising a stretch of at least 17 contiguous nucleotides of the exon 105 sequence and comprising at least one of the nucleotide sequences 5'-CCUGGUA-3' and 5'-AGGAG-3'.
Abstract:
This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of feed or food compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.
Abstract:
This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of food and/or feed compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.
Abstract:
The invention is directed to a coating, and to an article comprising said coating and to a method of forming a coating. More in particular, the invention relates to a coating that relates to an antifouling, cell-binding and antimicrobial coating. The coating of the invention comprises a) an inner coating layer formed from an inner coating composition, the inner coating composition comprising, i) an inner polymerisable compound comprising a polymerisable group, ii) an antimicrobial agent, and iii) an initiator, and b) an outer coating layer formed from an outer coating composition, the outer coating composition comprising i) inorganic particles with a polymerisable group and a hydrophilic polymer chain attached to one or more of the inorganic particles, ii) a cell-binding moiety, iii) an initiator, and iv) optionally, an outer polymerisable compound comprising a polymerisable group.
Abstract:
An imaging method and system for verification of a treatment plan (A). A phantom volume (V) is provided consisting of a material (10m) having dose absorbing properties similar to a biological tissue according to the treatment plan (A). Dose parameters (Q) of a hadron beam (B) are set according to the treatment plan (A). The hadron beam (B) is directed into the phantom volume (V) according to the dose parameters (Q). Light (L) emitted from the phantom volume (V) is measured. A dose distribution (D) of the hadron beam (B) in the phantom volume (V) is calculated based on the measured light (L). The light (L) is measured by imaging a lateral side (14,15) of the phantom volume (V) while the material (10m) of the phantom volume (V) comprises at least 90 mass percent water.
Abstract:
The present invention relates to a 6,7-dioxyalkyltetrahydroisoquinoline compound, or a salt or solvate thereof according to formula I: (formula I), (I) wherein R represents hydrogen or a fluorinated alkyl group, and R 2 and R 3 independently represents hydrogen or an alkyl group.
Abstract:
The invention relates to in vitro methods for isolating and characterizing human salivary gland cells for stem cell transplantation, and to the therapeutic use of the cells, in particular for treating or preventing xerostomia.
Abstract:
Title: Geranyl geranyl acetone analogs and uses thereof. Abstract The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula wherein R 1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C- atoms; and X is selected from the group consisting of moieties X 1 , X 2 , X 3 , X 4 , X 5 and X 6 . Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.