公开(公告)号：WO2011047238A1

公开(公告)日：2011-04-21

申请号：PCT/US2010/052808

申请日：2010-10-15

Applicant: GLAXOSMITHKLINE LLC ,  DUMBLE, Melissa ,  KUMAR, Rakesh ,  LAQUERRE, Sylvie ,  LEBOWITZ, Peter

Inventor： DUMBLE, Melissa ,  KUMAR, Rakesh ,  LAQUERRE, Sylvie ,  LEBOWITZ, Peter

IPC: A01N43/90 ,  A61K31/519

CPC classification number: A61K31/519 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

Abstract: A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf is beneficial, eg. cancer.

Abstract translation: 包含MEK抑制剂N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）6,8-二甲基-2,4,7-三氧代-3,4,6 ，7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂合物与B-Raf抑制剂，特别是N- {3- [5- （2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐，药物组合物 包括相同的方法和使用这些组合和组合物来治疗MEK和/或B-Raf的抑制是有益的条件，例如， 癌症。

公开(公告)号：WO2011038082A1

公开(公告)日：2011-03-31

申请号：PCT/US2010/049946

申请日：2010-09-23

Applicant: GLAXOSMITHKLINE LLC ,  DUMBLE, Melissa ,  GILMER, Tona ,  KUMAR, Rakesh ,  LEBOWITZ, Peter, F. ,  MORRIS, Shannon, Renae ,  LAQUERRE, Sylvie

Inventor： DUMBLE, Melissa ,  GILMER, Tona ,  KUMAR, Rakesh ,  LEBOWITZ, Peter, F. ,  MORRIS, Shannon, Renae ,  LAQUERRE, Sylvie

IPC: A01N43/54 ,  A61K31/415 ,  A61K31/505

CPC classification number: A61K31/519 ,  A61K9/145 ,  A61K9/2054 ,  A61K31/4155 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N -{(1 S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1 H -pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于此类治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）-6,8-二甲基-2,4,7- 三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物，和N - {（1S） 2-氨基-1 - [（3,4-二氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺，或 其药学上可接受的盐给有需要的人。

公开(公告)号：WO2010097811A4

公开(公告)日：2010-11-04

申请号：PCT/IN2010000110

申请日：2010-02-25

Applicant: COUNCIL SCIENT IND RES ,  SINHA ARUN KUMAR ,  SHARMA ABHISHEK ,  KUMAR RAKESH ,  SHARMA NAINA

Inventor： SINHA ARUN KUMAR ,  SHARMA ABHISHEK ,  KUMAR RAKESH ,  SHARMA NAINA

IPC: C07C45/30 ,  C07C47/228 ,  C07C47/23 ,  C07C47/24 ,  C07C47/277 ,  C07C311/49 ,  C07D317/54

CPC classification number: C07C45/28 ,  C07C45/30 ,  C07C249/16 ,  C07C311/49 ,  C07D317/54 ,  C07C47/228 ,  C07C47/24 ,  C07C47/23 ,  C07C47/277

Abstract: The present invention provides a process for the preparation of some novel 2-aryl and 2,2-diaryl aldehydes and analogues which are privileged intermediates for commercially important nonsteroidal anti-inflammatory drugs including naproxen, flurbiprofen and potent anticancer drug candidates, including phenstatin through a unique single step synthetic methodology utilizing easily available substrates in the form of aryl alkenes as well as environmentally benign aqueous reaction conditions in the form of solvents such as mixtures of water and DMSO or Dioxane and reagents N-bromosuccinimide, N- iodosuccinimide, N-cholorosuccinimide and phase transfer catalyst such as cetyltrimethyl ammonium bromide, N-hexyl ammonium chloride for a reaction time varying from 1min- 30min, depending upon microwave or conventional heating, without using expensive transition metal catalysts or lewis acids/bases with yield varying from 35-55 %, depending upon the solvent and substrate used. The developed method provides a clean and convenient alternative to access a diverse range of medicinally important 2-aryl and 2,2- diaryl aldehyde based scaffolds in lieu of the conventional multistep protocols employing expensive and hazardous transition metal catalysts and lewis acids/bases.

Abstract translation: 本发明提供了制备一些新的2-芳基和2,2-二芳基醛和类似物的方法，所述醛和类似物是用于商业上重要的非甾体抗炎药，包括萘普生，氟比洛芬和有效的抗癌候选药物包括苯抑制素通过 采用芳基烯烃形式的容易获得的底物以及溶剂形式的环境友好的水性反应条件，例如水和DMSO或二氧六环的混合物和试剂N-溴代琥珀酰亚胺，N-碘代琥珀酰亚胺，N-氯代琥珀酰亚胺 和相转移催化剂如十六烷基三甲基溴化铵，N-己基氯化铵，反应时间从1分钟至30分钟不等，取决于微波或常规加热，而不使用昂贵的过渡金属催化剂或路易斯酸/碱，产率从35-55变化 ％，取决于所用的溶剂和基材。 所开发的方法提供了一种干净而方便的替代方案，以取代使用昂贵且危险的过渡金属催化剂和路易斯酸/碱的常规多步骤方案的各种医学上重要的基于2-芳基和2,2-二芳基醛的支架。

公开(公告)号：WO2010044746A1

公开(公告)日：2010-04-22

申请号：PCT/SG2008/000398

申请日：2008-10-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  RANGANATHAN, Nagarajan ,  KUMAR, Rakesh ,  ZHANG, Qingxin ,  LIAO, Ebin ,  BLIZNETSOV, Vladimir ,  PREMACHANDRAN, Chirayarikathuveedu, Sankarapillai

Inventor： RANGANATHAN, Nagarajan ,  KUMAR, Rakesh ,  ZHANG, Qingxin ,  LIAO, Ebin ,  BLIZNETSOV, Vladimir ,  PREMACHANDRAN, Chirayarikathuveedu, Sankarapillai

IPC: G02B6/12 ,  H01L27/14

CPC classification number: H01L27/144 ,  G02B6/12004 ,  G02B6/305 ,  G02B6/3636 ,  G02B6/3652 ,  G02B6/3692 ,  G02B6/4232 ,  G02B2006/12061 ,  G02B2006/12123 ,  G02B2006/12142

Abstract: According to one embodiment of the present invention, an integrated assembly is provided. The integrated assembly includes a substrate with an integrated circuit, an interconnect structure disposed above the substrate, wherein the interconnect structure comprises a metallization plane; a first dielectric cavity is formed through the interconnect structure and at least a part of the substrate to accommodate a first optical component; wherein the integrated circuit and the first optical component are provided on the same side of the substrate. A method of manufacturing an integrated assembly is also provided.

Abstract translation: 根据本发明的一个实施例，提供了一种集成组件。 集成组件包括具有集成电路的衬底，布置在衬底上方的互连结构，其中互连结构包括金属化平面; 通过所述互连结构形成第一介电腔，并且至少部分所述衬底以容纳第一光学部件; 其中所述集成电路和所述第一光学部件设置在所述基板的同一侧。 还提供了一种制造集成组件的方法。

公开(公告)号：WO2007081554A2

公开(公告)日：2007-07-19

申请号：PCT/US2006049333

申请日：2006-12-27

Applicant: SPECIALTY COATING SYSTEMS INC ,  KUMAR RAKESH

Inventor： KUMAR RAKESH

IPC: B32B1/08

CPC classification number: C07C25/22 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B05D1/60 ,  C07C23/18 ,  C09D165/04 ,  H01L21/0212 ,  H01L21/02263 ,  H01L21/3127 ,  H05K3/284 ,  Y10T428/1393

Abstract: Conformal coatings are disclosed. A fluorinated thin film, for example, is formed by vapor phase polymerization on a variety of sensitive surfaces that may include electronic and automotive sensors, biochips, implantable sensors and biomedical devices.

Abstract translation: 公开了保形涂层。 氟化薄膜例如通过气相聚合在各种敏感表面上形成，这些敏感表面可以包括电子和汽车传感器，生物芯片，可植入传感器和生物医学装置。

公开(公告)号：WO2007035327A2

公开(公告)日：2007-03-29

申请号：PCT/US2006/035465

申请日：2006-09-12

Applicant: MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. ,  BUFORD, John ,  KUMAR, Rakesh ,  ROSS, Keith ,  PERKINS, Gregory, M.

Inventor： BUFORD, John ,  KUMAR, Rakesh ,  ROSS, Keith ,  PERKINS, Gregory, M.

IPC: G06F15/16

CPC classification number: H04L63/12 ,  G06F9/468 ,  G06F21/50 ,  G06F21/54 ,  H04L63/0428 ,  H04L67/104

Abstract: A system is provided for composition trust binding in a peer-to-peer network environment. The system includes: a service requestor residing on a peer in the network and able to invoke a service residing on another peer in the network. The service requestor is also able to communicate a composition trust binding to the peer hosting the service, where the composition trust binding is a set of rules that define a collection of allowable software components which may be invoked by the service. A validation agent ensures that the service executes in accordance with the binding.

Abstract translation: 在对等网络环境中提供用于组合信任绑定的系统。 该系统包括：驻留在网络中的对等体上并能够调用驻留在网络中另一对等体上的服务的服务请求者。 服务请求者还能够将组合信任绑定到托管服务的对等体，其中组合信任绑定是定义可由服务调用的允许的软件组件的集合的一组规则。 验证代理确保服务根据绑定执行。

公开(公告)号：WO2007018523A2

公开(公告)日：2007-02-15

申请号：PCT/US2005/027085

申请日：2005-07-28

Applicant: SARNOFF CORPORATION ,  AGGARWAL, Manoj ,  HANNA, Keith ,  KALOKITIS, David ,  KUMAR, Rakesh ,  PATTERSON, David R. ,  SAWHNEY, Harpreet ,  ZHAO, Tao

Inventor： AGGARWAL, Manoj ,  HANNA, Keith ,  KALOKITIS, David ,  KUMAR, Rakesh ,  PATTERSON, David R. ,  SAWHNEY, Harpreet ,  ZHAO, Tao

IPC: H04N5/225

CPC classification number: G01S5/16 ,  G01S3/7864 ,  G01S5/0294 ,  G01S13/767 ,  G06K9/00295 ,  G06K9/00335 ,  G06K9/32 ,  G06K9/6289 ,  G06T7/97 ,  G07C9/00087 ,  G07C9/00111 ,  G08B13/19604 ,  G08B13/19608 ,  G08B13/19641 ,  G08B13/19673 ,  G08B13/19691 ,  G08B13/19697 ,  G08B13/2462 ,  H04N13/243 ,  H04N13/368 ,  H04N2013/0085

Abstract: A unified approach, a fusion technique, a space-time constraint, a methodology, and system architecture are provided. The unified approach is to fuse the outputs of monocular and stereo video trackers, RFID and localization systems and biometric identification systems. The fusion technique is provided that is based on the transformation of the sensory information from heterogeneous sources into a common coordinate system with rigorous uncertainties analysis to account for various sensor noises and ambiguities. The space-time constraint is used to fuse different sensor using the location and velocity information. Advantages include the ability to continuously track multiple humans with their identities in a large area. The methodology is general so that other sensors can be incorporated into the system. The system architecture is provided for the underlying real-time processing of the sensors.

Abstract translation: 提供统一的方法，融合技术，时空约束，方法和系统架构。 统一的方法是融合单眼和立体视频追踪器，RFID和定位系统以及生物识别系统的输出。 提供的融合技术基于将来自不同来源的感知信息转换为通用坐标系统，并进行严格的不确定性分析，以解决各种传感器噪声和模糊问题。 空间 - 时间约束用于使用位置和速度信息来融合不同的传感器。 其优势包括能够在大面积范围内持续跟踪多个人的身份。 该方法是通用的，因此可以将其他传感器结合到系统中。 系统架构提供用于传感器的基础实时处理。

公开(公告)号：WO2006121457A2

公开(公告)日：2006-11-16

申请号：PCT/US2005/029313

申请日：2005-08-18

Applicant: SARNOFF CORPORATION ,  KUMAR, Rakesh ,  SAWHNEY, Harprett ,  VERMA, Vivek ,  HSU, Stephen Charles

Inventor： VERMA, Vivek ,  HSU, Stephen Charles

IPC: G06T15/00 ,  G09G5/00

CPC classification number: G06T17/20 ,  G06T17/00

Abstract: A method and apparatus for automatically generating a three-dimensional computer model from a "point cloud" of a scene produced by a laser radar (LIDAR) system. Given a point cloud of an indoor or outdoor scene, the method extracts certain structures from the imaged scene, i.e., ceiling, floor, furniture, rooftops, ground, and the like, and models these structures with planes and/or prismatic structures to achieve a three-dimensional computer model of the scene. The method may then add photographic and/or synthetic texturing to the model to achieve a realistic model.

Abstract translation: 一种用于通过激光雷达（LIDAR）系统产生的场景的“点云”自动生成三维计算机模型的方法和装置。 给定室内或室外景点的点云，该方法从成像场景（即，天花板，地板，家具，屋顶，地面等）中提取某些结构，并且利用平面和/或棱柱结构对这些结构进行建模以实现 一个三维计算机模型的现场。 然后，该方法可以向模型添加照相和/或合成纹理，以实现真实的模型。

公开(公告)号：WO2006105541A2

公开(公告)日：2006-10-05

申请号：PCT/US2006/012777

申请日：2006-03-30

Applicant: SARNOFF CORPORATION ,  SHAN, Ying ,  SAWHNEY, Harprett, Singh ,  KUMAR, Rakesh

Inventor： SHAN, Ying ,  SAWHNEY, Harprett, Singh ,  KUMAR, Rakesh

IPC: G06K9/00

CPC classification number: G06K9/3241 ,  G06K9/00791 ,  G06K9/6211 ,  G06K2209/23

Abstract: A system and method for identifying objects, particularly vehicles, between two non-overlapping cameras. More specifically, the method and system determines whether a vehicle depicted in an image captured by a first camera is the same vehicle or a different vehicle than a vehicle depicted in an image captured by a second camera. This intra-camera analysis determines whether the vehicle viewed by the first camera is the same as the vehicle viewed by the second camera, without directly matching the two vehicle images, thus eliminating the problems and inaccuracies caused by disparate environmental conditions acting on the two cameras, such as dramatic appearance and aspect changes.

Abstract translation: 用于识别两个非重叠相机之间的对象，特别是车辆的系统和方法。 更具体地，该方法和系统确定由第一照相机拍摄的图像中描绘的车辆是否与由第二相机拍摄的图像中描绘的车辆相同的车辆或不同的车辆。 这种相机内分析确定第一相机观看的车辆是否与由第二相机观看的车辆相同，而不直接匹配两个车辆图像，从而消除了由两个相机作用的不同环境条件引起的问题和不准确 ，如戏剧性的外观和方面的变化。

公开(公告)号：WO2006086051A2

公开(公告)日：2006-08-17

申请号：PCT/US2005/043837

申请日：2005-12-05

Applicant: SARNOFF CORPORATION ,  GUO, Yanlin ,  SAWHNEY, Harpreet ,  KUMAR, Rakesh ,  HSU, Stephen, Charles ,  SHAN, Ying

Inventor： GUO, Yanlin ,  SAWHNEY, Harpreet ,  KUMAR, Rakesh ,  HSU, Stephen, Charles ,  SHAN, Ying

IPC: G06K9/00 ,  H04N5/225

CPC classification number: G06K9/3241 ,  G06K9/00711 ,  G06K2209/23 ,  G06T7/20 ,  G06T7/246 ,  G06T7/33

Abstract: A method and apparatus for tracking a movable object using a plurality of images, each of which is separated by an interval of time is disclosed. The plurality of images includes first and second images. The method and apparatus include elements for aligning the first and second images as a function of (i) at least one feature of a first movable object captured in the first image, and (ii) at least one feature of a second movable object captured in the second image; and after aligning the first and second images, comparing at least one portion of the first image with at least one portion of the second image.

Abstract translation: 公开了一种使用多个图像跟踪可移动物体的方法和装置，每个图像间隔一段时间。 多个图像包括第一和第二图像。 所述方法和装置包括用于将第一和第二图像对准的元件作为（i）在第一图像中捕获的第一可移动物体的至少一个特征的功能，以及（ii）捕获在第一图像中的第二可移动物体的至少一个特征 第二个图像; 并且在对准所述第一和第二图像之后，将所述第一图像的至少一部分与所述第二图像的至少一部分进行比较。