公开(公告)号：WO2009129210A3

公开(公告)日：2009-10-22

申请号：PCT/US2009/040453

申请日：2009-04-14

Applicant: MEDTRONIC, Inc. ,  WARSAW ORTHOPEDIC, INC. ,  WOHABREBBI, Amira ,  KING, Vanja, Margareta ,  MCKAY, William, F.

Inventor： WOHABREBBI, Amira ,  KING, Vanja, Margareta ,  MCKAY, William, F.

IPC: A61K9/16 ,  A61K9/20

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

公开(公告)号：WO2009129149A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040240

申请日：2009-04-10

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

Inventor： MCKAY WILLIAM F

IPC: A61K9/20 ,  A61K31/485 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K9/7007 ,  A61K9/0002 ,  A61K9/0024 ,  A61K31/135 ,  A61K31/192 ,  A61K31/366 ,  A61K31/4168 ,  A61K31/485 ,  A61K31/573 ,  A61K31/58 ,  A61K31/655

Abstract: Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain.

Abstract translation: 提供有效的疼痛和/或炎症治疗。 通过在靶位点处或附近施用有效量的至少止痛剂和/或至少一种抗炎剂，可以减少，预防或治疗炎症和疼痛。

公开(公告)号：WO2008063949A3

公开(公告)日：2009-08-27

申请号：PCT/US2007084411

申请日：2007-11-12

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  ZANELLA JOHN M

Inventor： MCKAY WILLIAM F ,  ZANELLA JOHN M

IPC: A61L27/36 ,  A61L27/30 ,  A61L27/34 ,  A61L27/40 ,  A61L27/46 ,  A61L27/54

CPC classification number: A61L27/365 ,  A61L27/3608 ,  A61L27/3847 ,  A61L27/40

Abstract: A method for enhancing the binding of growth factors and/or cells to an allograft structure by applying an effective quantity of a coating material to the surface of the allograft structure, producing a thin coated allograft structure, administering to the thin coated allograft structure a growth factor, cells or a combination thereof, and implanting the thin coated allograft structure into a host bone.

Abstract translation: 一种通过将有效量的涂层材料施用于同种异体移植物结构的表面来增强生长因子和/或细胞与同种异体移植物结构的结合的方法，产生薄涂层的同种异体移植结构，向薄涂层的同种异体移植结构施用生长 因子，细胞或其组合，以及将薄涂层的同种异体移植物结构植入宿主骨中。

公开(公告)号：WO2008076671A3

公开(公告)日：2009-05-14

申请号：PCT/US2007086771

申请日：2007-12-07

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

Inventor： MCKAY WILLIAM F

IPC: A61L24/00 ,  A61L27/44 ,  A61L27/46

CPC classification number: A61L24/0015 ,  A61C8/0006 ,  A61F2/28 ,  A61F2/2803 ,  A61F2/2846 ,  A61F2/44 ,  A61F2002/2817 ,  A61F2002/2825 ,  A61F2002/2853 ,  A61F2002/2892 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2310/00179 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/02 ,  A61L24/046 ,  A61L24/102 ,  A61L27/12 ,  A61L27/18 ,  A61L27/24 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/62 ,  C08L67/04

Abstract: A biomedical implant is disclosed with osteogenic factors and a solid impermeable membrane occluding a portion of its surface for the generation of new bone growth at the target site of the implant. The implant is porous, bioresorbable, and forms a three dimensional architectural scaffold for the formation of new bone tissue. The implant is formed with a polymer or collagen, bone morphogenetic protein and ceramic particles.

Abstract translation: 公开了一种生物医学植入物，其具有成骨因素，并且固体不渗透膜封闭其表面的一部分，用于在植入物的靶位点产生新的骨生长。 植入物是多孔的，生物可再吸收的，并且形成用于形成新骨组织的三维建筑支架。 植入物由聚合物或胶原，骨形态发生蛋白和陶瓷颗粒形成。

公开(公告)号：WO2008109807A3

公开(公告)日：2008-12-18

申请号：PCT/US2008056169

申请日：2008-03-07

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

Inventor： MCKAY WILLIAM F

IPC: A61L27/46 ,  A61L27/22

CPC classification number: A61L27/24 ,  A61L27/12 ,  A61L27/46 ,  A61L27/505 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/258 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/64

Abstract: A novel composition and kit for a bone void filler are provided. The improved bone void filler includes a porous, collagen scaffolding admixed with calcium phosphate and at least one stabilizer agent. Optionally, the bone void filler further includes at least one bioactive agent.

Abstract translation: 提供了一种用于骨空隙填充剂的新型组合物和试剂盒。 改进的骨空隙填料包括与磷酸钙和至少一种稳定剂混合的多孔的胶原支架。 任选地，骨空隙填料还包括至少一种生物活性剂。

公开(公告)号：WO2008079672A2

公开(公告)日：2008-07-03

申请号：PCT/US2007087117

申请日：2007-12-12

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  PECKHAM STEVEN M

Inventor： MCKAY WILLIAM F ,  PECKHAM STEVEN M

CPC classification number: A61K38/1875 ,  A61B17/00491 ,  A61B50/30 ,  A61B2017/00495 ,  A61K9/10

Abstract: A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

Abstract translation: 提供用于更快的骨修复和早期矫形植入物固定的组合物。 该组合物包含嵌入载体浆液中的骨诱导或骨生物活性生物因子。 通过用生物相容性流体润湿生物可降解聚合物和磷酸钙颗粒来制备浆料。 该组合物可以应用于骨折部位，整形外科植入物或手术过程中的两者。 该组合物利用低剂量的生物因子，因此常规使用具有成本效益。

公开(公告)号：WO2008070273A2

公开(公告)日：2008-06-12

申请号：PCT/US2007080932

申请日：2007-10-10

Applicant: WARSAW ORTHOPEDIC INC ,  BODEN SCOTT D ,  MCKAY WILLIAM F ,  TITUS FRANCIS L ,  SANGADALA SREEDHARA

Inventor： BODEN SCOTT D ,  MCKAY WILLIAM F ,  TITUS FRANCIS L ,  SANGADALA SREEDHARA

IPC: C12N5/00 ,  A61K35/12 ,  A61K48/00 ,  A61L27/38 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C12N5/08

CPC classification number: A61L27/3856 ,  A61K35/12 ,  A61K35/13 ,  A61K48/00 ,  A61K2121/00 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C12N2799/022

Abstract: Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein. Transfection may be accomplished in vitro, ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid.

Abstract translation: 描述了在哺乳动物细胞中表达LIM矿化蛋白的方法。 还描述了在原核和非哺乳动物真核细胞中表达LIM矿化蛋白和评估LIM矿化蛋白的糖基化的方法。 该方法涉及用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 转染可以通过体外，离体或体内通过直接注射病毒或裸DNA或通过非病毒载体如质粒完成。

公开(公告)号：WO2008067088A1

公开(公告)日：2008-06-05

申请号：PCT/US2007/082600

申请日：2007-10-26

Applicant: WARSAW ORTHOPEDIC, INC ,  MCKAY, William F.

Inventor： MCKAY, William F.

IPC: A61F2/30

CPC classification number: A61F2/30756 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0642 ,  A61B2017/0647 ,  A61F2002/30062 ,  A61F2002/30761 ,  A61F2002/30766 ,  A61F2210/0004

Abstract: The invention herein generally refers to an in situ cartilage repair implant. The implant (1a) promotes cartilage repair by providing a sealed barrier (2a) that prevents the flow of synovial fluid and inflammatory cytokines into a surgically prepared hole that accommodates the implant. Optionally, additives are associated with the implant to promote cartilage repair.

Abstract translation: 本文中的发明通常涉及原位软骨修复植入物。 植入物（1a）通过提供防止滑液和炎性细胞因子流入容纳植入物的手术准备的孔的密封屏障（2a）来促进软骨修复。 可选地，添加剂与植入物相关联以促进软骨修复。

公开(公告)号：WO2006102417A3

公开(公告)日：2008-06-05

申请号：PCT/US2006010419

申请日：2006-03-22

Applicant: WARSAW ORTHOPEDIC INC ,  MARX JEFFREY C ,  MCKAY WILLIAM F ,  BODEN SCOTT D

Inventor： MARX JEFFREY C ,  MCKAY WILLIAM F ,  BODEN SCOTT D

IPC: A61K38/00 ,  A61P19/08 ,  A61P19/10

CPC classification number: A61K38/1709 ,  A61K38/1875 ,  A61K2300/00

Abstract: The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.

Abstract translation: 本发明涉及用于治疗受损骨患者的方法和组合物。 具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。

公开(公告)号：WO2007130753A3

公开(公告)日：2008-02-14

申请号：PCT/US2007064755

申请日：2007-03-23

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  SCIFERT JEFFREY L

Inventor： MCKAY WILLIAM F ,  SCIFERT JEFFREY L

IPC: A61L24/02 ,  A61L24/10 ,  A61L27/24 ,  A61L27/46

CPC classification number: A61L27/24 ,  A61F2/02 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1652 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/02 ,  A61L24/10 ,  A61L24/102 ,  A61L27/02 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/38

Abstract: Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body is disruptable upon wetting with a biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material, and wherein the body defines one or more reservoirs for receiving amounts of the biocompatible liquid.

Abstract translation: 描述了一种包括三维主体的医学上有用的制品，所述三维主体包括一种或多种可植入物质，其中所述主体在用生物相容性液体润湿以形成适合的可植入材料例如腻子，糊剂或更易流动的湿润植入物材料时是可破坏的， 其中所述主体限定用于接收一定量的所述生物相容性液体的一个或多个储存器。