公开(公告)号：WO2011158166A1

公开(公告)日：2011-12-22

申请号：PCT/IB2011/052553

申请日：2011-06-13

Applicant: GOPINATHAN, Venugopal ,  DUTTA, Goutam ,  PATIL, Nitin ,  PATKI, Abhijit ,  SUBRAMANIYAN, Raghavan

Inventor： GOPINATHAN, Venugopal ,  DUTTA, Goutam ,  PATIL, Nitin ,  PATKI, Abhijit ,  SUBRAMANIYAN, Raghavan

IPC: A61B5/053 ,  A61B5/00

CPC classification number: A61B5/0535 ,  A61B5/0538 ,  A61B5/204 ,  A61B5/6823 ,  A61B5/6831 ,  A61B5/6847 ,  A61B5/6868 ,  A61B2576/023 ,  A61N1/36521 ,  A61N1/3962

Abstract: Systems and methods for measurements of anatomical parameters in a region of interest in a subject are provided. A diagnostic device comprises one or more pairs of electrodes for transmitting an electrical signal in the volume of interest and for receiving the voltage signals from the region of interest. A method of using electrical measurements, such as voltage or current, across a range of frequencies derived from data representative of the voltage signals is also provided. These measurements may be used to determine parameters of one or more anatomical features of the subject.

Abstract translation: 提供了用于测量受试者感兴趣区域中的解剖学参数的系统和方法。 诊断装置包括一对或多对电极，用于传输感兴趣体积中的电信号，并用于从感兴趣区域接收电压信号。 还提供了在表示电压信号的数据导出的频率范围内使用诸如电压或电流之类的电测量的方法。 这些测量可用于确定受试者的一个或多个解剖特征的参数。

公开(公告)号：WO2011134499A1

公开(公告)日：2011-11-03

申请号：PCT/EP2010/055639

申请日：2010-04-27

Applicant: ST. JUDE MEDICAL AB ,  BJÖRLING, Anders ,  HOLLMARK, Malin ,  SVENSSON, Tomas ,  HJELM, Stefan ,  NORÉN, Kjell ,  JÄRVERUD, Karin

Inventor： BJÖRLING, Anders ,  HOLLMARK, Malin ,  SVENSSON, Tomas ,  HJELM, Stefan ,  NORÉN, Kjell ,  JÄRVERUD, Karin

IPC: A61B5/0452 ,  A61B5/053 ,  A61N1/365

CPC classification number: A61B5/0452 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/7257 ,  A61B5/7264 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36585 ,  A61N1/3962

Abstract: An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during multiple cardiac cycles. A transform processor (132) generates a spectrum signal by applying a time- to-frequency transform to the cardiogenic impedance signal. The spectrum signal is processed by a distribution processor (133) configured to calculate a distribution parameter indicative of a distribution in at least a portion of the spectrum signal. The calculated distribution parameter is of high diagnostic value and is employed by an arrhythmia classifier (134) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.

Abstract translation: 可植入医疗装置（100）被配置为在多个心动周期期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源阻抗信号。 变换处理器（132）通过对心源性阻抗信号进行时间 - 频率变换来产生频谱信号。 频谱信号由分配处理器（133）处理，分配处理器（133）被配置为计算指示频谱信号的至少一部分中的分布的分布参数。 计算出的分布参数具有很高的诊断价值，并被心律失常分类器（134）采用，以便将检测到的心脏心律不齐（10）进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

公开(公告)号：WO2011097164A1

公开(公告)日：2011-08-11

申请号：PCT/US2011/023146

申请日：2011-01-31

Applicant: MEDTRONIC, INC. ,  KELLY, Kevin J. ,  MICHAELS, Matthew J. ,  MOLNAR, Gregory F. ,  WERDER, Jonathan C.

Inventor： KELLY, Kevin J. ,  MICHAELS, Matthew J. ,  MOLNAR, Gregory F. ,  WERDER, Jonathan C.

IPC: A61N1/36 ,  A61B5/053 ,  A61N1/365 ,  A61N1/372

CPC classification number: A61B5/053 ,  A61N1/00 ,  A61N1/3614 ,  A61N1/36521 ,  A61N1/3702

Abstract: Implantable medical devices switch from a constant current mode of operation to a constant voltage mode of operation. The switching may be based on the device determining that tissue impedance stability has occurred. The determination may be a measurement of output voltage stability of the constant current source or based on other factors such as an amount of time that has elapsed. The switching may be as the result of an externally generated request such as by a clinician via an external device. The implantable medical device may begin constant voltage mode by utilizing stimulation parameters based on those initially programmed for constant current mode and based upon a measurement of voltage amplitude being output by the constant current source prior to the switch.

Abstract translation: 可植入医疗设备从恒定电流工作模式切换到恒压工作模式。 切换可以基于确定发生了组织阻抗稳定性的设备。 该确定可以是恒定电流源的输出电压稳定性的测量，或者基于其他因素，例如已经经过的时间量。 切换可能是外部产生的请求的结果，例如由临床医生经由外部设备。 可植入医疗装置可以通过利用基于最初为恒定电流模式编程的刺激参数并且基于在切换之前由恒定电流源输出的电压幅度的测量来开始恒定电压模式。

公开(公告)号：WO2011084635A1

公开(公告)日：2011-07-14

申请号：PCT/US2010/060839

申请日：2010-12-16

Applicant: CARDIAC PACEMAKERS, INC. ,  STAHMANN, Jeffrey E. ,  QUERIMIT, Michael A. ,  HOPPER, Donald L. ,  LARSON, Brian Ralph ,  EMERSON, Paul F. ,  O'BRIEN, Daniel

Inventor： STAHMANN, Jeffrey E. ,  QUERIMIT, Michael A. ,  HOPPER, Donald L. ,  LARSON, Brian Ralph ,  EMERSON, Paul F. ,  O'BRIEN, Daniel

IPC: A61N1/365

CPC classification number: A61N1/36521 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/37264

Abstract: A rate adaptive pacemaker and a method for its operation in which the response factor for a minute ventilation sensor or other type of exertion level sensor is automatically set (A5) during a parameter adjustment mode that utilizes (A3) an activity level measurement to determine when the patient is at a target activity level with which is associated an appropriate target pacing rate. In a preferred embodiment, the target activity level corresponds to casual walking (e.g., 0.9 m/s at a 4% grade) with a target pacing rate selected as appropriate for that level of activity in the individual patient.

Abstract translation: 速率自适应起搏器及其操作方法，其中在参数调整模式期间自动设置分钟通气传感器或其他类型的运动水平传感器的响应因子（A5），所述参数调整模式利用（A3）活动水平测量来确定何时 患者处于与目标活动水平相关联的目标起搏速度。 在优选实施例中，目标活动水平对应于休闲步行（例如，在4％等级为0.9m / s），其中针对个体患者中的该活动水平选择适合的目标起搏速率。

公开(公告)号：WO2011025617A1

公开(公告)日：2011-03-03

申请号：PCT/US2010/043539

申请日：2010-07-28

Applicant: MEDTRONIC, INC. ,  CHOW, Theodore

Inventor： CHOW, Theodore

IPC: A61B5/053 ,  A61N1/362 ,  A61N1/368 ,  A61N1/365 ,  A61N1/372 ,  G06F19/00

CPC classification number: A61N1/3622 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/1102 ,  A61B5/6846 ,  A61B5/7275 ,  A61B2560/0468 ,  A61N1/36521 ,  A61N1/368 ,  A61N1/37247

Abstract: In general, this disclosure provides techniques for heart monitoring. In accordance with the techniques described in this disclosure, an implantable medical device (IMD) may assess cardiac wall motion using impedance measurements through cardiac leads. As an example, the IMD may calculate an amount or rate of change in impedance due to the motion of a wall of the heart during at least a portion of one cardiac cycle, e.g., systole, in order to assess the strength of systolic contraction.

Abstract translation: 通常，本公开提供了用于心脏监测的技术。 根据本公开中描述的技术，可植入医疗装置（IMD）可以使用通过心脏引线的阻抗测量来评估心脏壁运动。 作为示例，IMD可以计算由于在一个心动周期（例如收缩期）的至少一部分期间心脏壁的运动引起的阻抗变化量或速率，以便评估收缩期收缩的强度。

公开(公告)号：WO2010131998A1

公开(公告)日：2010-11-18

申请号：PCT/SE2009/000244

申请日：2009-05-13

Applicant: ST. JUDE MEDICAL AB ,  BLOMQVIST, Andreas

Inventor： BLOMQVIST, Andreas

IPC: A61B5/053 ,  A61N1/368

CPC classification number: A61B5/1102 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6869 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

Abstract: The present invention generally relates to implantable medical devices, such as bi-ventricular pacemakers, and, in particular, to techniques for such devices for detecting and monitoring mechanical dyssynchronicity of the heart. A dyssynchronicity measure indicating a degree of mechanical dyssynchronicity of a heart of a patient is calculated. A first intracardiac impedance set is measured using electrodes placed such that the first intracardiac impedance set substantially reflects a mechanical activity of the left side of the heart and a second intracardiac impedance set is measure using electrodes placed such that the second intracardiac impedance set substantially reflects a mechanical activity of the right side of the heart. The measure of a dyssynchronicity is calculated based on a resulting parameter set from a comparison between at least a subset of the first and the second impedance sets, respectively, the subsets containing information of the mechanical systole, wherein a reduced dyssynchronicity measure corresponds to an improved synchronicity between the right side and the left side of heart.

Abstract translation: 本发明一般涉及诸如双心室起搏器的可植入医疗装置，特别涉及用于检测和监测心脏的机械不同步性的这种装置的技术。 计算表示患者心脏的机械不同步度的不同步性度量。 使用放置使得第一心内阻抗设定基本上反映心脏左侧的机械活动的电极来测量第一心内阻抗集，并且使用放置的第二心内阻抗设定的电极来测量第二心内阻抗集， 心脏右侧的机械活动。 基于从第一和第二阻抗组的至少一个子集之间的比较的结果参数集计算包含机械收缩信息的子集，其中减少的不同步度测量对应于改进的 心脏右侧和左侧的同步性。

公开(公告)号：WO2010127164A2

公开(公告)日：2010-11-04

申请号：PCT/US2010033040

申请日：2010-04-29

Applicant: PROTEUS BIOMEDICAL INC ,  ZDEBLICK MARK

Inventor： ZDEBLICK MARK

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/08 ,  A61B5/0538 ,  A61B5/085 ,  A61B5/6855 ,  A61B5/6871 ,  A61B5/6874 ,  A61N1/36135 ,  A61N1/36521 ,  A61N1/368

Abstract: An apparatus having at least one implantable lead, e.g., two leads, three leads, etc., is provided. In one example, the apparatus includes at least two satellites electrically coupled to a common implantable pulse generator by at least two conductors extending from the common implantable pulse generator to each of the at least two satellites. Each satellite, for example, is associated with a respective tissue site such as a cardiac wall.

Abstract translation: 提供了具有至少一个可植入引线的装置，例如两个引线，三个引线等。 在一个示例中，该装置包括至少两个卫星，该至少两个卫星通过从公共可植入脉冲发生器延伸到至少两个卫星中的每个卫星的至少两个导体电耦合到公共可植入脉冲发生器。 每个卫星例如与相应的组织部位如心脏壁相关联。

公开(公告)号：WO2010115214A1

公开(公告)日：2010-10-07

申请号：PCT/US2010/030497

申请日：2010-04-09

Applicant: CARDIOCOM, LLC ,  COSENTINO, Daniel, L. ,  COSENTINO, Louis, C. ,  GOLDEN, Brian, A. ,  YOUNG, Todd

Inventor： COSENTINO, Daniel, L. ,  COSENTINO, Louis, C. ,  GOLDEN, Brian, A. ,  YOUNG, Todd

IPC: G06Q50/00 ,  G06F17/00

CPC classification number: G06F19/322 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0402 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/4869 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/37211 ,  A61N1/37264 ,  A61N1/37282 ,  G01G19/4146 ,  G01G19/44 ,  G01G23/3735 ,  G01G23/3742 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3475 ,  G06F19/3481 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60 ,  G16H40/40

Abstract: In general, this disclosure describes techniques for remotely monitoring the health of an ambulatory patient. As described herein, an ambulatory patient may interact with a monitoring device that is located at the patient's home. The monitoring device may prompt the patient to provide responses to health-related questions or requests for physiological characteristics and may upload the responses. A health care professional may then use the responses to evaluate the health of the patient. A set of firmware instructions stored on the monitoring device may cause the monitoring device to perform these functions. These firmware instructions remain the same even when the monitoring device downloads new prompts.

Abstract translation: 一般来说，本公开描述了用于远程监测移动患者的健康的技术。 如本文所述，流动患者可与位于病人家中的监测装置相互作用。 监测装置可以提示患者对健康相关问题或生理特征的请求提供响应，并且可以上传响应。 然后，医护人员可以使用答复来评估患者的健康状况。 存储在监视设备上的一组固件指令可能导致监视设备执行这些功能。 即使监控设备下载新的提示，这些固件指令仍然保持不变。

公开(公告)号：WO2010088533A1

公开(公告)日：2010-08-05

申请号：PCT/US2010/022609

申请日：2010-01-29

Applicant: MEDTRONIC, INC. ,  ZHOU, Xiahong ,  DONOFRIO, William, T. ,  KRAUSE, Paul, G ,  BURNES, John, E.

Inventor： ZHOU, Xiahong ,  DONOFRIO, William, T. ,  KRAUSE, Paul, G ,  BURNES, John, E.

IPC: A61N1/36 ,  A61N1/365

CPC classification number: A61N1/3601 ,  A61N1/36135 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36592

Abstract: Neurostimulation to mitigate lung wetness is delivered to a patient based on a sensed parameter indicative of lung wetness. The neurostimulation is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient. In some examples, a patient response to the neurostimulation therapy may be detected to modify the neurostimulation therapy. The patient response may include, for example, changes in the contractility of a heart of the patient, changes in the heart rate, heart rate variability or blood pressure of the patient, changes in a bladder size of the patient, changes in bladder functional activity of the patient, changes in urine flow, changes in lung function, changes in lung composition, or changes in the nerve activity of the patient.

Abstract translation: 基于指示肺湿度的感测参数将减轻肺湿润的神经刺激递送给患者。 神经刺激被配置成在患者体内增加副交感神经活动或减少交感神经活动中的至少一种。 在一些实例中，可以检测患者对神经刺激疗法的反应以修饰神经刺激疗法。 患者反应可以包括例如患者的心脏的收缩性变化，心率的改变，患者的心率变异性或血压，患者的膀胱尺寸的变化，膀胱功能活动的变化 的患者，尿流量的变化，肺功能的变化，肺组成的变化或患者的神经活动的变化。

公开(公告)号：WO2010088347A1

公开(公告)日：2010-08-05

申请号：PCT/US2010/022352

申请日：2010-01-28

Applicant: MEDTRONIC, INC. ,  SOWELAM, Sameh

Inventor： SOWELAM, Sameh

IPC: A61B5/053 ,  A61B5/08 ,  A61N1/365

CPC classification number: A61B5/0205 ,  A61B5/0245 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/4836 ,  A61B5/4878 ,  A61B5/7275 ,  A61N1/36521 ,  A61N1/3962 ,  G06F19/00

Abstract: A medical device monitors a level of fluid accumulation, e.g., pulmonary edema, and one or more respiratory parameters of the patient to detect worsening heart failure. The medical device may use intrathoracic impedance measurements to monitor both the fluid accumulation and the one or more respiratory parameters. Respiration rate and volume, also referred to as the tidal volume, are examples of respiratory parameters. The medical device examines the one or more respiratory parameters after determining that the fluid accumulation indicates worsening heart failure. In this manner, the medical device uses the one or more respiratory parameters to confirm a determination of worsening heart failure that was made based on the fluid accumulation.

Abstract translation: 医疗设备监测患者的液体积聚水平，例如肺水肿和一个或多个呼吸参数，以检测恶化的心力衰竭。 医疗装置可以使用胸内阻抗测量来监测流体积聚和一个或多个呼吸参数。 呼吸速率和体积（也称为潮气量）是呼吸参数的实例。 在确定流体积聚指示恶化的心力衰竭之后，医疗装置检查一个或多个呼吸参数。 以这种方式，医疗装置使用一个或多个呼吸参数来确认基于流体积聚而进行的恶化的心力衰竭的确定。