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    GENETIC IMMUNIZATION BY MEANS OF MULTIPLE EXPRESSION STRUCTURES IN ORDER TO PRODUCE MONOCLONAL ANTIBODIES
    71.
    发明申请
    GENETIC IMMUNIZATION BY MEANS OF MULTIPLE EXPRESSION STRUCTURES IN ORDER TO PRODUCE MONOCLONAL ANTIBODIES 审中-公开
    与多表达基因免疫构建了产生单克隆抗体

    公开(公告)号：WO2004087216A3

    公开(公告)日：2004-11-25

    申请号：PCT/DE2004000649

    申请日：2004-03-26

    Applicant: GENOVAC GMBH ,  LOHRMANN JENS ,  ZIMMERMANN WOLFGANG ,  THOMPSON JOHN ,  GRUNERT FRITZ

    Inventor： LOHRMANN JENS ,  ZIMMERMANN WOLFGANG ,  THOMPSON JOHN ,  GRUNERT FRITZ

    IPC: C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40

    CPC classification number: C07K16/38 ,  C07K16/00 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/3007 ,  C07K16/40

    Abstract: The invention relates to a method for producing monoclonal antibodies by means of genetic immunization with several nucleic acids coding several polypeptides such that antibodies against different polypeptides are produced at the same time. The inventive method allows a plurality of monoclonal antibodies having a defined specificity against any number of target molecules to be produced at a high throughput. Said method especially allows antibodies against polypeptides to be produced, which are provided only with low immunogenic properties when being solely immunized, i.e. which are normally not suitable for producing antibodies. Moreover, it is possible to induce antibodies against polypeptide complexes consisting of several individual polypeptides, which can be done only because according to the inventive method, the DNA coding for all subunits of the polypeptide complex are introduced into one and the same cell.

    Abstract translation: 本发明涉及一种用于生产单克隆抗体通过基因免疫与多个不同的编码多肽的核酸，其在针对不同的多肽相同的时间产生的抗体的方法。 这种方法允许并行生产各种在高通量方法任意数量的目标分子的特异性所定义的单克隆抗体。 特别地，该方法使得有可能产生抗体多肽单独使用免疫时是弱免疫原性的，即 不适合下产生抗体的正常的情况下。 此外，有可能诱导抗体针对由多个个体多肽的Polypeptidkomplexen。 这仅仅是可能的，因为用这种方法，编码该多肽复合物的亚基在一个DNA和相同的细胞被引入。

    INTER ALPHA TRYPSIN INHIBITOR BIOPOLYMER MARKERS INDICATIVE OF INSULIN RESISTANCE
    72.
    发明申请
    INTER ALPHA TRYPSIN INHIBITOR BIOPOLYMER MARKERS INDICATIVE OF INSULIN RESISTANCE 审中-公开
    国际ALPHA TRYPSIN抑制剂生物标志物显示胰岛素抵抗

    公开(公告)号：WO2003046010A1

    公开(公告)日：2003-06-05

    申请号：PCT/CA2002/001664

    申请日：2002-10-31

    Applicant: SYN.X PHARMA, INC.

    Inventor： JACKOWSKI, George ,  MARSHALL, John

    IPC: C07K16/38

    CPC classification number: C07K14/8114

    Abstract: The present invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic strategies against said disease.

    Abstract translation: 本发明涉及使用与质谱法和飞行时间检测程序相结合的准备步骤的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后参照其在证据至少一种特定疾病状态的能力来观察在这样的样品内验证的生物聚合物队列，从而使得诊断者获得表征所述至少一种疾病状态相对于识别的存在或不存在的能力 所述生物聚合物的存在和/或不存在，预测疾病风险评估，并开发针对所述疾病的治疗策略。

    ZCYS7: A MEMBER OF THE CYSTATIN SUPERFAMILY
    75.
    发明申请
    ZCYS7: A MEMBER OF THE CYSTATIN SUPERFAMILY 审中-公开
    ZCYS7：CYSTATIN SUPERFAMILY的成员

    公开(公告)号：WO0194389A3

    公开(公告)日：2002-07-11

    申请号：PCT/US0117784

    申请日：2001-06-01

    Applicant: ZYMOGENETICS INC

    Inventor： PRESNELL SCOTT R ,  GAO ZEREN

    IPC: C07K14/81 ,  C12N15/15 ,  C07K16/38 ,  C12Q1/68 ,  G01N33/68

    CPC classification number: C07K14/8139

    Abstract: The cystatin superfamily includes inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys7 is a new member of this superfamily.

    Abstract translation: 半胱氨酸蛋白酶抑制剂超家族包括半胱氨酸蛋白酶抑制剂，其在内源蛋白酶的各种病理作用方面具有保护作用。 Zcys7是这个超家族的新成员。

    METHODS OF DIAGNOSING OR PROGNOSTICATING AGE-RELATED MACULAR DEGENERATION
    77.
    发明申请
    METHODS OF DIAGNOSING OR PROGNOSTICATING AGE-RELATED MACULAR DEGENERATION 审中-公开
    诊断或预后相关性变异的方法

    公开(公告)号：WO01016364A3

    公开(公告)日：2002-03-14

    申请号：PCT/EP2000/008554

    申请日：2000-09-01

    IPC: C07K14/81 ,  C12Q1/68 ,  G01N33/68 ,  C07K14/47 ,  C07K16/18 ,  C07K16/38 ,  C12N9/64

    CPC classification number: C07K14/8139 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    Abstract: A method for diagnosing or prognosing age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said activity, of at least one substance which is selected from the group consisting of a transcription product of a Cystatin C gene, a translation product of a Cystatin C gene, a fragment of said translation product, an amyloid protein, and a transcription product of a gene coding for an amyloid protein in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of at least one of said substances to a reference value representing a known disease or health status, thereby diagnosing or prognosing said age-related macular degeneration in said subject, or determining whether said subject is at increased risk of developing age-related macular degeneration or monitoring the progression of said age-related macular degeneration in said subject.

    Abstract translation: 用于诊断或预测受试者中年龄相关性黄斑变性的方法，或确定受试者是否处于发展年龄相关性黄斑变性的风险增加或监测受试者中年龄相关性黄斑变性的进展的方法，包括：确定水平 ，或活性，或所述水平和所述活性两者，选自Cystatin C基因的转录产物，半胱氨酸蛋白酶抑制蛋白C基因的翻译产物，所述翻译产物的片段的至少一种物质 ，淀粉样蛋白，以及来自所述受试者的样品中编码淀粉样蛋白的基因的转录产物; 以及将所述物质的至少一种的所述水平或所述活性或所述水平和所述活性两者比较为代表已知疾病或健康状况的参考值，从而诊断或预测所述受试者中所述年龄相关性黄斑变性， 或确定所述受试者是否处于发展年龄相关性黄斑变性的风险增加或监测所述受试者中所述年龄相关性黄斑变性的进展。

    KUNITZ DOMAIN POLYPEPTIDE ZKUN11
    78.
    发明申请
    KUNITZ DOMAIN POLYPEPTIDE ZKUN11 审中-公开

    公开(公告)号：WO0146230A3

    公开(公告)日：2002-01-03

    申请号：PCT/US0034581

    申请日：2000-12-18

    Applicant: ZYMOGENETICS INC

    Inventor： HOLLOWAY JAMES L

    IPC: C07K14/81 ,  C07K16/38 ,  C07K16/42 ,  C12N5/10 ,  C12N15/15

    CPC classification number: C07K14/8114

    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine protease is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.

    Abstract translation: 丝氨酸蛋白酶家族的成员在精心控制的过程中起作用，例如血液凝固，纤维蛋白溶解，补体激活，受精和激素生成。 丝氨酸蛋白酶的酶活性部分由包含Kunitz结构域的蛋白酶抑制剂调节。 Zkun11是Kunitz域蛋白家族的新成员。

    HUMAN SERPIN
    79.
    发明申请
    HUMAN SERPIN 审中-公开
    人类SERPIN

    公开(公告)号：WO0138534A3

    公开(公告)日：2002-01-03

    申请号：PCT/US0032100

    申请日：2000-11-20

    Applicant: ZYMOGENETICS INC

    Inventor： HOLLOWAY JAMES L

    IPC: C07K14/81 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/15 ,  C07K16/38 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/68

    CPC classification number: C07K14/8121

    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by serpins, serine protease inhibitors. Serpin dysfunction is associated with various disorders, including emphysema, blood clotting disorders, cirrhosis, Alzheimer disease, and Parkinson disease. Zserp 11 is a new member of the serine protease inhibitor family.

    Abstract translation: 丝氨酸蛋白酶家族的成员在精心控制的过程中起作用，例如血液凝固，纤维蛋白溶解，补体激活，受精和激素生成。 丝氨酸蛋白酶的酶活性部分由丝氨酸蛋白酶抑制剂丝氨酸蛋白酶抑制剂调节。 丝氨酸蛋白酶功能障碍与各种疾病有关，包括肺气肿，凝血障碍，肝硬化，阿尔茨海默病和帕金森病。 Zserp 11是丝氨酸蛋白酶抑制剂家族的新成员。

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