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    SYNTHETIC COMPOSITION AND METHOD FOR MODULATING BRAIN FUNCTION AND BEHAVIOUR
    81.
    发明申请
    SYNTHETIC COMPOSITION AND METHOD FOR MODULATING BRAIN FUNCTION AND BEHAVIOUR 审中-公开
    用于调节脑功能和行为的合成组合物和方法

    公开(公告)号：WO2017071715A1

    公开(公告)日：2017-05-04

    申请号：PCT/DK2016/050344

    申请日：2016-10-28

    Applicant: GLYCOM A/S

    Inventor： MCCONNELL, Bruce ,  ELISON, Emma ,  VIGSNÆS, Louise Kristine

    IPC: A61K31/702

    CPC classification number: A61K31/702 ,  A61K2300/00

    Abstract: A synthetic composition for use in improving one or more co‐morbid mental disorder symptoms of a patient with IBS, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.

    Abstract translation: 用于改善患有IBS的患者的一种或多种合并病态精神障碍症状的合成组合物，其特征在于所述组合物含有有效量的一种或多种中性人乳低聚糖

    SYNTHESIS OF DEOXYAMINO SUGARS
    85.
    发明申请
    SYNTHESIS OF DEOXYAMINO SUGARS 审中-公开
    去氧山梨糖苷的合成

    公开(公告)号：WO2014128660A1

    公开(公告)日：2014-08-28

    申请号：PCT/IB2014/059159

    申请日：2014-02-21

    Applicant: GLYCOM A/S

    Inventor： KHANZHIN, Nikolay ,  CHASSAGNE, Pierre ,  MATWIEJUK, Martin ,  HORVÁTH, Ferenc ,  DEKANY, Gyula

    IPC: C07H5/06 ,  C07H15/12

    CPC classification number: C07H15/18

    Abstract: The invention relates to methods for making an α-amino-aldehyde, preferably a 2-amino-2-deoxy sugar derivative, from an α-hydroxy-aldehyde, preferably an aldose. Intermediary 1-amino-1-deoxy-ketose derivatives, and their use as synthetic intermediates, are also described.

    Abstract translation: 本发明涉及由α-羟基醛，优选醛糖制备α-氨基醛，优选2-氨基-2-脱氧糖衍生物的方法。 中间体1-氨基-1-脱氧酮酮衍生物及其作为合成中间体的用途也被描述。

    PREPARATION AND USE OF ISOLACTOSAMINE AND INTERMEDIATES THEREFOR
    87.
    发明申请
    PREPARATION AND USE OF ISOLACTOSAMINE AND INTERMEDIATES THEREFOR 审中-公开
    异烟肼及其中间体的制备和使用

    公开(公告)号：WO2013083136A1

    公开(公告)日：2013-06-13

    申请号：PCT/DK2012/050449

    申请日：2012-12-07

    Applicant: GLYCOM A/S

    Inventor： HEDEROS, Markus ,  RISINGER, Christian ,  BOUTET, Julien ,  DEKANY, Gyula

    IPC: C07H5/06 ,  C07H1/00

    CPC classification number: C07H15/12 ,  C07H1/00 ,  C07H5/06 ,  C07H15/18 ,  Y02P20/55

    Abstract: The invention relates to providing isolactosamine (Galβ1-3GlcN 2 , formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. Isolactosamine derivatives of formula 2, the synthesis of isolactosamine by hydrogenolysis of said derivatives and the use of isolactosamine in the synthesis of lacto- N -biose containing oligosaccharides, through the steps of masking the amino group of isolactosamine with a suitable protecting group, protecting the OH-groups, activating the anomeric position to obtain a lacto- N -biosyl donor and coupling the lacto- N- biosyl donor to a desired sugar moiety, are also disclosed.

    Abstract translation: 本发明涉及以异头物或其混合物的形式提供异乳糖胺（Galbeta1-3GlcN2，式1）及其盐，以及游离碱及其盐的水合物或溶剂合物。 式2的异乳糖胺衍生物，通过所述衍生物的氢解合成异乳糖胺，以及在合成含有乳-N-降糖的寡糖中使用异乳糖胺，通过用合适的保护基掩蔽异乳糖胺的氨基，保护 OH基团，活化端基异构体位置以获得乳-N-生物基供体并将乳-N-生物基供体偶联到所需的糖部分。

    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE
    88.
    发明申请
    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE 审中-公开
    从D-葡萄糖制备L-赖氨酸前体的方法

    公开(公告)号：WO2013046180A1

    公开(公告)日：2013-04-04

    申请号：PCT/IB2012/055210

    申请日：2012-09-28

    Applicant: GLYCOM A/S ,  BOUTET, Julien ,  KHANZHIN, Nikolay ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    Inventor： BOUTET, Julien ,  KHANZHIN, Nikolay ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    IPC: C07H9/04 ,  C07H3/02 ,  C07H13/04 ,  C07H13/08

    CPC classification number: C07H9/02 ,  C07H1/00 ,  C07H3/02 ,  C07H9/04 ,  C07H11/00 ,  C07H13/04 ,  C07H13/08 ,  Y02P20/55

    Abstract: A method that can be used to make a precursor of L-fiicose from D-glucose, that comprises the steps of: a) making a compound of formula (1) from D-glucose, formula (1) wherein R 1 is acyloxy, and Q is a group (a), (b), (c) or (d), Formula (a) (b) (c) (d) or wherein R 1 is OH, and Q is a group (e), (f) or (g): Formula (e) (f) (g) wherein R 2 is acyloxy and R 3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step (a), characterized in that the moiety is a highly lipophilic protecting group; compounds according to formula I, and use of a compound according to formula (1) are provided.

    Abstract translation: 一种可用于制备D-葡萄糖的L-糖衣原体的方法，其包括以下步骤：a）由D-葡萄糖制备式（1）化合物，式（1）其中R 1为酰氧基，和 Q是式（a），（b），（c）或（d），式（a）（b）（c）（d）或其中R 1是OH，Q是基团（e） ）或（g）：式（e）（f）（g）其中R2是酰氧基，R3是磺酰基离去基团; 和b）从步骤（a）中形成的式（1）化合物制备6-脱氧-L-托洛糖，其特征在于所述部分是高亲脂性保护基; 提供了根据式I的化合物，以及使用式（1）化合物。

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