中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.019 seconds)

    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION
    1.
    发明申请
    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION 审中-公开
    通过发酵生产低聚葡萄糖苷和低聚果糖苷的方法

    公开(公告)号：WO2013182206A1

    公开(公告)日：2013-12-12

    申请号：PCT/DK2013/050182

    申请日：2013-06-07

    Applicant: GLYCOM A/S

    Inventor： PELTIER-PAIN, Pauline ,  DEKANY, Gyula ,  DUREAU, Remy ,  RISINGER, Christian ,  HEDEROS, Markus ,  CHAMPION, Elise

    IPC: C12P19/44 ,  C07H3/06 ,  C07H5/04 ,  C07H5/08 ,  C07H15/18 ,  C12P19/28 ,  C12P19/64

    CPC classification number: C07H3/06 ,  C07H5/04 ,  C07H15/10 ,  C07H15/14 ,  C07H15/18 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64 ,  Y02P20/55

    Abstract: The application discloses a method for producing anomerically protected glycosidic oligosaccharide derivatives comprising the step of culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor. The application further discloses a method for producing an oligosaccharide comprising the steps of: (a) culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor to produce an anomerically protected glycosidic oligosaccharide derivative, then (b) removing/deprotecting the anomeric protective group.

    Abstract translation: 本申请公开了一种用于制备异头保护的糖苷寡糖衍生物的方法，其包括在含有异头保护的乳糖受体的培养基中培养具有编码可转移糖基残基的糖基转移酶的重组基因的遗传修饰细胞的步骤 活化的糖核苷酸与所述乳糖受体。 本申请进一步公开了一种生产寡糖的方法，包括以下步骤：（a）在含有异头保护的乳糖受体的培养基中培养具有编码可转移糖基残基的糖基转移酶的重组基因的遗传修饰细胞 的活性糖核苷酸与所述乳糖受体产生异头保护的糖苷寡糖衍生物，然后（b）去除/去保护端基异构保护基。

    PREPARATION AND USE OF ISOLACTOSAMINE AND INTERMEDIATES THEREFOR
    3.
    发明申请
    PREPARATION AND USE OF ISOLACTOSAMINE AND INTERMEDIATES THEREFOR 审中-公开
    异烟肼及其中间体的制备和使用

    公开(公告)号：WO2013083136A1

    公开(公告)日：2013-06-13

    申请号：PCT/DK2012/050449

    申请日：2012-12-07

    Applicant: GLYCOM A/S

    Inventor： HEDEROS, Markus ,  RISINGER, Christian ,  BOUTET, Julien ,  DEKANY, Gyula

    IPC: C07H5/06 ,  C07H1/00

    CPC classification number: C07H15/12 ,  C07H1/00 ,  C07H5/06 ,  C07H15/18 ,  Y02P20/55

    Abstract: The invention relates to providing isolactosamine (Galβ1-3GlcN 2 , formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. Isolactosamine derivatives of formula 2, the synthesis of isolactosamine by hydrogenolysis of said derivatives and the use of isolactosamine in the synthesis of lacto- N -biose containing oligosaccharides, through the steps of masking the amino group of isolactosamine with a suitable protecting group, protecting the OH-groups, activating the anomeric position to obtain a lacto- N -biosyl donor and coupling the lacto- N- biosyl donor to a desired sugar moiety, are also disclosed.

    Abstract translation: 本发明涉及以异头物或其混合物的形式提供异乳糖胺（Galbeta1-3GlcN2，式1）及其盐，以及游离碱及其盐的水合物或溶剂合物。 式2的异乳糖胺衍生物，通过所述衍生物的氢解合成异乳糖胺，以及在合成含有乳-N-降糖的寡糖中使用异乳糖胺，通过用合适的保护基掩蔽异乳糖胺的氨基，保护 OH基团，活化端基异构体位置以获得乳-N-生物基供体并将乳-N-生物基供体偶联到所需的糖部分。

Patent Agency Ranking