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    FLOW ASSEMBLY FOR CELLS
    81.
    发明申请
    FLOW ASSEMBLY FOR CELLS 审中-公开
    流动装置用于细胞

    公开(公告)号：WO2016164244A1

    公开(公告)日：2016-10-13

    申请号：PCT/US2016/025188

    申请日：2016-03-31

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

    Inventor： JONES, Lisa M. ,  RINAS, Aimee

    IPC: C12M1/34 ,  C40B30/06 ,  G01N33/50

    CPC classification number: C12M23/16 ,  C01B15/00 ,  C12M1/34 ,  C12M29/00 ,  C12M33/00 ,  C12M41/46 ,  G01N33/487

    Abstract: In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in a single-file orientation and the buffer generally surrounds the single-file orientation of the plurality of cells when in the third flow path.

    Abstract translation: 在一个实施例中，用于小区的流组件包括被配置为接收多个小区的第一流路径，被配置为接收缓冲器的第二流路径和被配置为接收多个小区和缓冲器的第三流路。 多个单元格处于单文件方向，并且当在第三流动路径中时，缓冲器通常围绕多个单元格的单个文件取向。

    HIGH TORQUE DENSITY ELECTRIC MOTOR AND/OR GENERATOR
    82.
    发明申请
    HIGH TORQUE DENSITY ELECTRIC MOTOR AND/OR GENERATOR 审中-公开
    高扭矩密度电机和/或发电机

    公开(公告)号：WO2016130467A1

    公开(公告)日：2016-08-18

    申请号：PCT/US2016/016978

    申请日：2016-02-08

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

    Inventor： RUBIN, Matthew

    IPC: H02K7/12

    CPC classification number: H02K7/12 ,  H02K1/325 ,  H02K9/19 ,  H02K2201/03 ,  H02K2213/09

    Abstract: An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor about a central axis, and one of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor along the central axis in response to thermal expansion of at least one of the stator and the rotor to maintain the width of the gap.

    Abstract translation: 公开了一种电动机，包括定子和相对于定子安装的转子，以在定子的表面和转子的表面之间形成间隙，该间隙具有宽度。 定子和转子中的一个被安装成围绕中心轴线相对于定子和转子中的另一个运动，并且定子和转子中的一个被安装成相对于定子和转子中的另一个沿着 响应于定子和转子中的至少一个的热膨胀而保持间隙的宽度的中心轴线。

    METHODS AND SYSTEMS FOR PREDICTING BLEEDING RISK AND DOSE OF PLASMINOGEN ACTIVATOR
    83.
    发明申请
    METHODS AND SYSTEMS FOR PREDICTING BLEEDING RISK AND DOSE OF PLASMINOGEN ACTIVATOR 审中-公开
    预测激素释放风险和剂量的方法和系统

    公开(公告)号：WO2016118723A1

    公开(公告)日：2016-07-28

    申请号：PCT/US2016/014279

    申请日：2016-01-21

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  KLINE, Jeffrey

    Inventor： KLINE, Jeffrey

    IPC: A61B5/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50

    CPC classification number: G01N33/86 ,  A61B5/021 ,  A61B5/0402 ,  A61B5/14542 ,  G01N2800/224 ,  G01N2800/226 ,  G01N2800/52 ,  G06F19/704 ,  G16H50/30

    Abstract: The present disclosure provides a method and system for estimating the clinical responsiveness of a patient to a dose of a plasminogen activating agent to treat a thrombosis, comprising determining a concentration of α2-antiplasmin in a blood sample of the patient, determining a concentration of activated fibrinolysis inhibitor ("TAFI") in the blood sample, determining a concentration of plasminogen activator Inhibitor 1 ("PAI-1") in the blood sample, computing a clot lysis time ("CLT") based on the concentrations of a2-antiplasmin, TAFI and PAI-1 using the equation CLT = -2,813.6 +31.1 * a2-antiplasmin (percent activity) +31.1 * TAFI (percent activity) +1.49 PAI-1 (ug/L), and determining that the patient is at increased risk of hemorrhage when the computed CLT is less than a first predetermined cutoff time.

    Abstract translation: 本公开提供了一种用于估计患者对纤维蛋白溶酶原激活剂剂量以治疗血栓形成的临床响应性的方法和系统，包括测定患者血液样品中α2-抗血纤维素的浓度，确定活化的血液中浓度 血液样品中的纤维蛋白溶解抑制剂（“TAFI”），确定血液样品中纤溶酶原激活物抑制剂1（“PAI-1”）的浓度，基于a2-抗血清敏感素的浓度计算凝块溶解时间（“CLT” ，TAFI和PAI-1，使用方程式CLT = -2,813.6 +31.1 * a2-antiplasmin（活性百分比）+31.1 * TAFI（活性百分比）+1.49 PAI-1（ug / L），并确定患者增加 当计算的CLT小于第一预定截止时间时出血的风险。

    SYSTEM AND METHOD FOR REDUCING BIOLOGICAL DAMAGE IN PROTON THERAPY
    87.
    发明申请
    SYSTEM AND METHOD FOR REDUCING BIOLOGICAL DAMAGE IN PROTON THERAPY 审中-公开
    降低生物损伤的系统和方法在PROTON治疗

    公开(公告)号：WO2016014972A1

    公开(公告)日：2016-01-28

    申请号：PCT/US2015/042051

    申请日：2015-07-24

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

    Inventor： BUCHSBAUM, Jeffrey

    IPC: G01T1/02

    CPC classification number: A61N5/1067 ,  A61N5/1031 ,  A61N2005/1087

    Abstract: Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor, wherein a characteristic of the beam can be adjusted based on the measured relative biological effectiveness are disclosed. Methods of treatment comprising measuring, by a processor capable of detecting potential biological hot spots, a relative biological effectiveness of a beam on a region of a human body, designing a beam therapy treatment plan based on the measured relative biological effectiveness, and applying a beam to a patient with a region in need of beam therapy with a beam applicator in electrical communication with the processor capable of detecting potential biological hot spots are also disclosed.

    Abstract translation: 系统包括与有形的非暂时性存储器电通信的处理器，其响应于处理器的执行使得处理器测量在人体区域上的束的相对生物学效力，以及光束施加器 与处理器进行电连通，其中可以基于所测量的相对生物学效力来调整光束的特性。 治疗方法包括通过能够检测潜在生物热点的处理器测量束在人体区域上的相对生物学效力，基于所测量的相对生物学效力设计束疗法治疗计划，以及应用束 还公开了具有需要光束治疗的区域的患者，其中能够与能够检测潜在的生物学热点的处理器电通信的射束施加器。

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