公开(公告)号：WO2023019108A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/074666

申请日：2022-08-08

Applicant: PULSE BIOSCIENCES, INC.

Inventor： MOSS, Kevin, L. ,  DANITZ, David, J. ,  CONNOLLY, Richard, J. ,  WEILBACHER, Katherine, P. ,  HINMAN, Cameron, D.

IPC: A61N1/32 ,  A61B18/14

Abstract: Treatment applicators and methods including treatment applicators for delivering electrical energy to a target tissue that are configured to reduce or eliminate arcing as well as provide enhance targeting to tissue surfaces or regions just below the surface of the tissue.

公开(公告)号：WO2020191301A1

公开(公告)日：2020-09-24

申请号：PCT/US2020/023882

申请日：2020-03-20

Applicant: PULSE BIOSCIENCES, INC.

Inventor： EBBERS, Edward, A. ,  UECKER, Darrin, R. ,  NUCCITELLI, Richard, L.

IPC: A61B18/14 ,  A61B17/00 ,  A61N5/06 ,  A61B18/20 ,  A61N7/02 ,  A61N1/04

Abstract: Described herein are methods and apparatuses for the application of electric energy treatment(s) to skin tissue to alter pigmentation, and in particular to remove a tattoo. These methods and apparatuses may deliver pulsed electrical energy having a pulse duration in submicrosecond pulse range to provide high-field strength pulses that may effectively release tattoo ink and allow removal of tattoo ink regardless of ink color or composition.

公开(公告)号：WO2020168214A1

公开(公告)日：2020-08-20

申请号：PCT/US2020/018321

申请日：2020-02-14

Applicant: PULSE BIOSCIENCES, INC.

Inventor： DANITZ, David J. ,  MOSS, Kevin L. ,  JOE, Wesley C. ,  FOSTER, Christopher J. ,  BOSECK, Gary L. ,  SOTO-SIDA, Xitlalic Y. ,  MASTON, Robert ,  LUNSFORD, John P.

IPC: A61B18/14 ,  A61B18/12 ,  A61M25/01 ,  A61B18/00

Abstract: Described herein are flexible catheters adapted to be inserted into a body to deliver highvoltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue. Also disclosed herein systems including these catheters and method of using them to treat tissue.

公开(公告)号：WO2019143577A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/013545

申请日：2019-01-14

Applicant: PULSE BIOSCIENCES, INC.

Inventor： DANITZ, David, J. ,  HINMAN, Cameron, D. ,  KRIEG, Kenneth, R. ,  MOSS, Kevin, L. ,  FOSTER, Christopher, J. ,  UECKER, Darrin, R.

IPC: A61B34/30 ,  A61B18/14 ,  A61N1/36 ,  A61N1/40 ,  A61B18/00

CPC classification number: A61N1/0502 ,  A61B18/1445 ,  A61B34/32 ,  A61B34/37 ,  A61B2018/1425 ,  A61B2018/1432 ,  A61N1/40

Abstract: Described herein are methods and systems for using the treatment tip apparatuses and high-voltage connectors with robotic surgical systems. For example, retractable treatment tip apparatuses (e.g., devices, systems, etc.) including one or a plurality of electrodes that are protected by a housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment, are disclosed. In particular, these apparatuses may include a plurality of treatment electrodes and may be configured for the delivery of nanosecond pulsed electric fields. Also described herein are high-voltage connectors configured to provide high-voltage energy, such as nsPEF pulses, from a generator to the retractable treatment tip apparatuses.

公开(公告)号：WO2017201394A1

公开(公告)日：2017-11-23

申请号：PCT/US2017/033522

申请日：2017-05-19

Applicant: PULSE BIOSCIENCES, INC.

Inventor： NUCCITELLI, Richard ,  MALLON, Zachary R. ,  MCDANIEL, Amanda H. ,  DANITZ, David J. ,  ATHOS, Brian G. ,  KREIS, Mark P. ,  UECKER, Darrin R. ,  NUCCITELLI, Pamela S.

IPC: A61N1/36 ,  A61B18/00

CPC classification number: A61B18/14 ,  A61B5/055 ,  A61B2018/00613 ,  A61B2018/1405 ,  A61N1/327 ,  A61N1/36002

Abstract: An optimization of electrical characteristics for treatments of tumor or other abnormal cells in culture with sub-microsecond, high-electric field electrical pulses is disclosed. The voltages, pulse widths, and number of pulses are chosen such that the treatment energy is 10-20 J/mL. That is, U = n * Δt * V * I / volume is 10-20 J/mL, in which n is the number of pulses, Δt is the duration of each pulse, V is the voltage, I is current, and volume is the area of parallel electrodes times the distance between them. V divided by the distance between the electrodes can be in an effective range of 6 kV/cm to 30 kV/cm, 60 kV/cm, 100 kV/cm, or higher intensities. Rows of needle electrodes, blade electrodes, or other configurations of electrodes can approximate parallel electrodes.

Abstract translation: 公开了用亚微秒高电场电脉冲治疗肿瘤或其他异常细胞的电特性的优化。 选择电压，脉冲宽度和脉冲数以使处理能量为10-20J / mL。 也就是说，U = n *Δt* V * I /体积为10-20 J / mL，其中n为脉冲数，Δt为每个脉冲的持续时间，V为电压，I为电流，体积 平行电极的面积乘以它们之间的距离。 V除以电极之间的距离可以处于6kV / cm至30kV / cm，60kV / cm，100kV / cm或更高强度的有效范围内。 针电极，刀片电极或其他电极配置的行可以接近平行电极。

公开(公告)号：WO2022192459A1

公开(公告)日：2022-09-15

申请号：PCT/US2022/019636

申请日：2022-03-09

Applicant: PULSE BIOSCIENCES, INC.

Inventor： LEVINSON, Mitchell, Elliott ,  TUROVSKIY, Roman ,  DANITZ, David, J. ,  CONNOLLY, Richard, J.

IPC: A61B18/12 ,  A61B18/14 ,  A61B18/00 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00345

Abstract: Methods and apparatuses are disclosed for providing pulsed electrical treatment (including high voltage, sub-microsecond pulsed electric energy) to body lumens for treatment and/or prevention of restenosis.

公开(公告)号：WO2022026359A1

公开(公告)日：2022-02-03

申请号：PCT/US2021/043127

申请日：2021-07-26

Applicant: PULSE BIOSCIENCES, INC.

Inventor： KRIEG, Kenneth R. ,  SCHAADT, Gregory P. ,  HUANG, Chaofeng

IPC: A61B18/12 ,  A61N1/32 ,  A61B18/00 ,  A61N1/08 ,  A61N1/40

Abstract: Described herein are apparatuses (e.g., systems and devices) and methods of delivering nanosecond pulsed electrical fields (nsPEF). In particular, these apparatuses and methods may provide enhanced safety and robust operation over even very short (e.g., nanosecond and sub-nanosecond pulses) and high voltage pulsing; these benefits may be accomplished by multifunctional isolation of various subsystems and components of the apparatus, even including the low-voltage, control and command portions of the apparatus with extremely low capacitance, high voltage isolation. The methods and apparatuses described herein for delivering high voltage, nanosecond pulses may include an applicator, which may be configured as a handle, that is connected by a cable to a controller and nanosecond pulse generator. One or more safety features, including robust electrical isolation, may be included to protect both the apparatus and the user. For example, the apparatus may include multi-functional isolation within the pulse generator, as well as multifunctional isolation between the applicator, such as a handpiece (e.g., delivery tool), a delivery cable connecting the handpiece to the pulse generator, and the pulse generator.

公开(公告)号：WO2020077019A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/055486

申请日：2019-10-09

Applicant: PULSE BIOSCIENCES, INC.

Inventor： JAUREGUI JOHNSTON, Lauren M. ,  EBBERS, Edward A. ,  DANITZ, David J. ,  NUCCITELLI, Richard L. ,  UECKER, Darrin R. ,  MOSS, Kevin L. ,  HINMAN, Carmeron D.

IPC: A61N1/36 ,  A61N1/05 ,  A61B18/14 ,  A61B18/00

Abstract: Described herein are methods and apparatuses for reducing or eliminating skin glands (e.g., sebaceous, eccrine and apocrine) with an electric treatment. Also described herein are methods for treating and/or preventing a disorder of a skin gland. For example, described herein are methods of treating sebaceous hyperplasia.

公开(公告)号：WO2017151261A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/015884

申请日：2017-01-31

Applicant: PULSE BIOSCIENCES, INC.

Inventor： XIAO, Shu ,  ATHOS, Brian G. ,  KREIS, Mark P. ,  DANITZ, David J. ,  UECKER, Darrin R.

IPC: H03K3/02

Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.

Abstract translation: 公开了一种亚微秒脉冲电场发生器。 场发生器包括产生电源控制信号并产生脉冲发生器控制信号的控制器，以及接收电源控制信号并基于接收的电源控制信号产生一个或多个电源电压的电源。 场发生器还包括脉冲发生器，其接收功率电压和脉冲发生器控制信号，并基于功率电压并基于脉冲发生器控制信号产生一个或多个脉冲。 控制器接收表示脉冲特征值或脉冲结果值的反馈信号，并基于接收到的反馈信号产生电源控制信号和脉冲发生器控制信号中的至少一个。

公开(公告)号：WO2017151260A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/015881

申请日：2017-01-31

Applicant: PULSE BIOSCIENCES, INC.

Inventor： ATHOS, Brian G. ,  UECKER, Darrin R. ,  XIAO, Shu

IPC: H03K3/02 ,  H03K3/00 ,  H03K5/00 ,  H03K5/01 ,  H03K5/12

Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.

Abstract translation: 公开了一种脉冲发生器放电电路。 该电路包括一个或多个放电级，每个放电级包括多个控制输入端子。 该电路还包括第一和第二放电端子以及电连接在第一和第二放电端子之间的多个串联连接的开关，其中每个开关的导通状态由控制信号控制。 该电路还包括多个电感元件，该多个电感元件被配置成为串联连接的开关产生控制信号，其中每个电感元件被配置为响应于一个或多个输入信号为一个串联连接的开关产生控制信号， 更多的控制输入端子，并且其中每个串联连接的开关被配置为接收来自相应的一个电感元件的控制信号。