公开(公告)号：WO2016041988A1

公开(公告)日：2016-03-24

申请号：PCT/EP2015/071134

申请日：2015-09-15

Applicant: ANABIO TECHNOLOGIES LIMITED ,  SOLVOTRIN THERAPEUTICS LIMITED

Inventor： BLEIEL, Sinead ,  LEDWIDGE, Mark

IPC: A23L1/304 ,  A23L1/305 ,  A23L1/00 ,  A23L1/22 ,  A61K9/16 ,  B01J13/02

CPC classification number: A61K33/26 ,  A23L27/72 ,  A23L33/16 ,  A23L33/19 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/0095 ,  A61K9/5052 ,  A61K9/5089

Abstract: A preparation of microspheres comprises a multiplicity of discrete microspheres, in which the microspheres comprise iron entrapped within a protein matrix, and in which the protein in the protein matrix is at least partially denatured. The protein of the protein matrix comprises denatured, de-calcified, whey protein. Methods for making the preparation of microspheres are also described.

Abstract translation: 微球的制备包括多个离散的微球，其中微球包含被包埋在蛋白质基质内的铁，并且其中蛋白质基质中的蛋白质至少部分地变性。 蛋白质基质的蛋白质包括变性，去钙化的乳清蛋白。 还描述了制备微球的方法。

公开(公告)号：WO2016096931A1

公开(公告)日：2016-06-23

申请号：PCT/EP2015/079905

申请日：2015-12-15

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead

IPC: A61K9/50 ,  A61K38/56 ,  A61K38/57

CPC classification number: A61K9/5052 ,  A23L33/185 ,  A23L33/19 ,  A23P10/30 ,  A23V2002/00 ,  A61K35/20 ,  A61K36/48 ,  A61K38/168 ,  A23V2200/224 ,  A23V2200/332 ,  A23V2250/54252 ,  A23V2250/5428 ,  A23V2250/548

Abstract: A cold-gelated mono-nuclear microencapsulate comprises a unitary liquid core encapsulated within a gastro-resistant, ileal-sensitive, polymerized denatured protein membrane shell, wherein the liquid core comprises a GLP-1 release stimulating agent in a substantially solubilised form. The GLP-1 release stimulating agent is a native protein selected from native dairy protein, native vegetable protein or native egg protein.

Abstract translation: 冷凝的单核微胶囊包含包封在耐胃，回肠敏感的聚合变性蛋白质膜壳内的单一液芯，其中液芯包含基本上溶解形式的GLP-1释放刺激剂。 GLP-1释放刺激剂是选自天然乳蛋白，天然植物蛋白或天然卵蛋白的天然蛋白质。

公开(公告)号：WO2022200635A1

公开(公告)日：2022-09-29

申请号：PCT/EP2022/058174

申请日：2022-03-28

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead

IPC: A23L33/115 ,  A23L33/21 ,  A23G3/36 ,  A23G3/48 ,  A23D9/007 ,  A23D9/05 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16

Abstract: Food, beverage and nutritional supplements containing microparticles containing stabilised CBD oil, and methods for the production thereof" Food, beverage and nutritional supplements that containing microparticles are described. The microparticles contain CBD oil stabilized in an acacia or inulin fibre or cyclodextrin matrix. Methods for the production of the compositions comprise making the microparticles by providing an oil-in-water microemulsion comprising CBD oil, water, acacia/inulin fibre and optionally maltodextrin or cyclodextrin, and freeze- drying the microemulsion to remove water and provide a preparation of dried microparticles. The dried microparticles comprise a dispersed phase of stabilized microdroplets of CBD oil disposed in a continuous solid matrix comprising acacia or inulin fibre. The preparation of microcapsules contains less than 10% free CBD oil and exbibit improved pharmacokinetics and bioavailability of CBD.

公开(公告)号：WO2021165516A1

公开(公告)日：2021-08-26

申请号：PCT/EP2021/054238

申请日：2021-02-19

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead ,  KENT, Robert ,  SEVERIC, Maja

IPC: B01J13/22 ,  A23P10/35 ,  A23P20/10 ,  A23P30/10 ,  B01J13/04

Abstract: A method of producing coated microcapsules comprises the steps of producing microcapsules by cold gelation having a denatured or hydrolysed protein matrix and an active agent contained within the matrix, and drying the microcapsules. A meltable coating composition comprising wax and oil and configured to have a melting point of about 70°C to about 100°Cis heated to a temperature above the melting point of the meltable coating composition to melt the meltable coating composition, and the microcapsules are coated with the melted meltable coating composition.

公开(公告)号：WO2020188108A1

公开(公告)日：2020-09-24

申请号：PCT/EP2020/057883

申请日：2020-03-20

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead ,  KENT, Robert ,  MORENA MARRO, Olga

IPC: A61K9/16

Abstract: "Microcapsules containing curcumin, and methods for the production thereof" A microcapsule suitable for delivery intact to the mammalian lower intestine via an oral route and having curcumin homogenously distributed in pockets within a crosslinked functional matrix, in which the microcapsule comprises at least 30% curcumin (w/w). Matrices formed of pea protein or Shellac have been proposed, using both spray-drying and cold gelation methods. Microcapsules of the invention are resistant to degradation in the stomach and release curcumin slowly in the ileum, and exhibit improved resistance of encapsulated curcumin to thermal and high/low pH environments.

公开(公告)号：WO2014198787A1

公开(公告)日：2014-12-18

申请号：PCT/EP2014/062154

申请日：2014-06-11

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： DOHERTY, Sinead ,  BLEIEL, Jens

IPC: A61K9/50 ,  A61K31/00

CPC classification number: A61K9/5052 ,  A23L33/10 ,  A23L33/105 ,  A23L33/175 ,  A23P10/30 ,  A61K9/5089 ,  A61K31/198 ,  A61K36/67

Abstract: A process for producing microencapsulates comprising an active component such as creatine encapsulated within a polymerised hydro lysed whey protein matrix is described. The method comprises the steps of providing a suspension of hydro lysed whey protein and an active component in a carboxylic ester, treating the suspension to generate droplets of the suspension, and immediately curing the droplets by immersion in a basic curing solution, wherein the ester in the suspension reacts with the basic curing solution to release a salt that polymerises the hydrolysed whey protein encapsulating the active component in the presence of black pepper extract, glycerol, phosphate and optionally, astaxanthin and alpha lipoic acid.

Abstract translation: 描述了包含活性成分如包封在聚合的水解乳清蛋白质基质内的肌酸的微胶囊的方法。 该方法包括以下步骤：将水解乳清蛋白和活性组分的悬浮液提供在羧酸酯中，处理悬浮液以产生悬浮液液滴，并通过浸入碱性固化溶液中立即固化液滴，其中酯 悬浮液与碱性固化溶液反应以释放在黑胡椒提取物，甘油，磷酸盐和任选的虾青素和α硫辛酸存在下聚合包封活性成分的水解乳清蛋白的盐。

公开(公告)号：WO2016193373A1

公开(公告)日：2016-12-08

申请号：PCT/EP2016/062500

申请日：2016-06-02

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead

IPC: A23P10/30 ,  A61K9/48 ,  A23P10/35 ,  A23P30/25 ,  A23L27/00

CPC classification number: A61K9/5036 ,  A23L27/72 ,  A23L29/275 ,  A23L33/115 ,  A23L33/12 ,  A23P10/30 ,  A23P10/35 ,  A23P30/25 ,  A23V2002/00 ,  A23V2250/1862 ,  A23V2250/1868 ,  A23V2250/511 ,  A23V2250/5114 ,  A23V2250/616 ,  A23V2250/628 ,  A61K9/1075 ,  A61K35/612 ,  A61K47/44

Abstract: The invention provides a gelated mono-nuclear microencapsulate comprising a lipid emulsion core encapsulated within a gastro-resistant, ileal sensitive, polymerized chitosan membrane shell, wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate. In one embodiment of the invention, the emulsion is a micro-emulsion, and typically comprises a surfactant and a co-surfactant or at least two carbohydrates, for example sucrose and a maltodextrin. In one embodiment of the invention, the lipid is a marine derived lipid such as fish oil, krill oil, or nutraceutical fatty acids. In other embodiment, the lipid is a fatty acid such as DHA or ARA, or a lipid derived from seeds, nuts or eggs.

Abstract translation: 本发明提供了一种凝胶化单核微胶囊，其包含包封在耐胃回肠敏感的聚合壳聚糖膜壳内的脂质乳剂核，其中所述脂质乳剂核心包含变性或水解蛋白质和碳水化合物。 在本发明的一个实施方案中，乳液是微乳液，并且通常包含表面活性剂和助表面活性剂或至少两种碳水化合物，例如蔗糖和麦芽糖糊精。 在本发明的一个实施方案中，脂质是海洋衍生的脂质，例如鱼油，磷虾油或营养食品脂肪酸。 在另一个实施方案中，脂质是脂肪酸如DHA或ARA，或衍生自种子，坚果或卵的脂质。

公开(公告)号：WO2016185053A1

公开(公告)日：2016-11-24

申请号：PCT/EP2016/061622

申请日：2016-05-23

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead ,  PEREZ GOMEZ DE CADINANOS, Maria Luz ,  KENT, Robert

IPC: A23L33/185 ,  B01J13/04 ,  C08J3/12 ,  A23P10/00 ,  A23L33/19

CPC classification number: A23P10/40 ,  A23L29/20 ,  A23L29/238 ,  A23L29/256 ,  A23L33/185 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/228 ,  A23V2250/282 ,  A23V2250/5036 ,  A23V2250/506 ,  A24F47/008 ,  A61M11/042 ,  A61M15/06 ,  C08J3/122 ,  C08J2389/00 ,  H01M10/0525 ,  H01M10/42 ,  H02J7/345

Abstract: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5- 15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.

Abstract translation: 通过喷雾干燥生产微粒的方法包括以下步骤：提供包含水，挥发性二价金属盐，弱酸，5-15％乳制品或植物蛋白（w / v）和1-20％活性的喷雾干燥原料溶液 代理商（w / v）。 将原料溶液调节至具有挥发性二价金属盐基本上不溶的pH。 然后将原料溶液在升高的温度下喷雾干燥以提供雾化的液滴，由此挥发性二价金属盐在升高的温度下分解，以释放在雾化液滴中交联并聚集蛋白质的二价金属离子，以产生具有交联聚集体 蛋白质基质和活性剂分散在整个基质中。

公开(公告)号：WO2016096929A1

公开(公告)日：2016-06-23

申请号：PCT/EP2015/079903

申请日：2015-12-15

Applicant: ANABIO TECHNOLOGIES LIMITED

Inventor： BLEIEL, Sinead ,  KENT, Robert

IPC: A23J3/14 ,  A23J3/26 ,  A23L5/00 ,  A23L5/30

CPC classification number: A23J3/26 ,  A23J1/14 ,  A23J3/14 ,  A23L5/32 ,  A23P10/30 ,  A23P30/20 ,  A23V2002/00 ,  A23V2250/548 ,  A23V2300/08 ,  A23V2300/16

Abstract: A method of producing a denatured pea protein solution comprises the steps of mixing pea protein with an alkali solvent to provide a 1-10% pea protein solution (w/v) having a pH of at least 10, resting the pea protein solution for at least 15 minutes, heating the pea protein solution under conditions sufficient to heat-denature the pea protein without causing gelation of the pea protein solution, and rapidly cooling the denatured pea protein solution to prevent gelation, wherein at least 90% of the pea protein in the denatured pea protein solution is soluble. Also described is a method of producing microparticles having a denatured pea protein matrix, the method comprising the steps of providing a denatured pea protein solution according to the invention, treating the denatured pea protein solution to form microdroplets; and cross-linking and chelating the droplets to form microparticles.

Abstract translation: 生产变性豌豆蛋白溶液的方法包括以下步骤：将豌豆蛋白与碱性溶剂混合以提供pH至少为10的1-10％豌豆蛋白溶液（w / v），将豌豆蛋白溶液置于 至少15分钟，在足以使豌豆蛋白热变性而不引起豌豆蛋白溶液凝胶化的条件下加热豌豆蛋白溶液，并迅速冷却变性豌豆蛋白溶液以防止凝胶化，其中至少90％的豌豆蛋白质 变性豌豆蛋白溶液是可溶的。 还描述了生产具有变性豌豆蛋白质基质的微粒的方法，所述方法包括以下步骤：提供根据本发明的变性豌豆蛋白溶液，处理变性豌豆蛋白溶液以形成微滴; 并交联并螯合液滴以形成微粒。