公开(公告)号：WO2012047095A1

公开(公告)日：2012-04-12

申请号：PCT/NL2011/050665

申请日：2011-10-03

Applicant: AVANTIUM HOLDING B.V. ,  MOONEN, Roelandus Hendrikus Wilhelmus

Inventor： MOONEN, Roelandus Hendrikus Wilhelmus

IPC: B01J19/00 ,  C40B60/12 ,  G01N31/10 ,  G01F1/00

CPC classification number: F16L41/02 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00389 ,  B01J2219/00585 ,  B01J2219/00594 ,  B01J2219/00698 ,  B01J2219/00747 ,  C40B60/12 ,  Y10T137/87265

Abstract: The invention relates to a system for measuring flow rates of fluid flows to parallel reactors, comprising: - a common feed line, - a plurality of reactor feed lines for receiving a reactor fluid flow, - a measurement line, and - a valve system, comprising one or more valves and a valve control unit for controlling the one or more valves, the valve system being arranged and/or adapted such that it can assume a measurement setting in which the valves redirect one of the reactor feed flows such that it flows through the measurement line.

Abstract translation: 本发明涉及一种用于测量流向并联反应器的流体流量的系统，包括： - 公共进料管线， - 用于接收反应器流体流的多个反应器进料管线， - 测量管线和 - 阀门系统， 包括一个或多个阀和用于控制所述一个或多个阀的阀控制单元，所述阀系统被布置和/或适配成使得其可以采取测量设置，其中所述阀重新定向所述反应器进料流中的一个，使得其流动 通过测量线。

公开(公告)号：WO2008108639A1

公开(公告)日：2008-09-12

申请号：PCT/NL2008/000076

申请日：2008-03-07

Applicant: AVANTIUM HOLDING B.V. ,  RAS, Erik-Jan

Inventor： RAS, Erik-Jan

IPC: C07D223/26 ,  A61K31/55 ,  A61P25/08

CPC classification number: C07D223/26

Abstract: The present invention provides a novel crystalline form of a cocrystal of carbamazepine : glycolamide and of a co-crystal of carbamazepine : lactamide. The invention further provides methods for the preparation of a co-crystal of carbamazepine: glycolamide and and/or carbamazepine : lactamide, as well as their use in pharmaceutical applications, in particular in medicaments for he treatment of epilepsy, bipolar disorder, schizophrenia and/or trigeminal neuralgia. The co-crystalline form of carbamazepine: glycolamide and/ or carbamazepine : lactamide can be used in combination with other medicaments.

Abstract translation: 本发明提供了一种新型的卡马西平：乙二醇酰胺和卡马西平：乳酰胺共结晶的结晶形式。 本发明还提供了用于制备卡马西平：乙二醇酰胺和/或卡马西平：乳酰胺的共晶体的方法，以及它们在药物应用中的用途，特别是用于治疗癫痫，双相性精神障碍，精神分裂症和/ 或三叉神经痛。 卡马西平：乙二醇酰胺和/或卡马西平：乳酰胺的共晶形式可以与其他药物组合使用。

公开(公告)号：WO2017112900A1

公开(公告)日：2017-06-29

申请号：PCT/US2016/068424

申请日：2016-12-22

Applicant: AVANTIUM HOLDING B.V.

Inventor： COLE, Emily, Barton ,  PARAJULI, Rishi ,  TANIELYAN, Setrak ,  MORE, Santosh, R. ,  MIRYALA, Balaraju

IPC: H01M4/86 ,  H01M4/88 ,  H01M4/96 ,  H01M8/10 ,  H01M4/62 ,  H01M8/04089 ,  H01M8/24 ,  C25B15/08 ,  C25B9/20

CPC classification number: C25B9/20 ,  C25B1/00 ,  C25B1/10 ,  C25B3/04 ,  C25B9/08 ,  C25B11/035 ,  C25B11/0415 ,  C25B11/0447 ,  C25B15/08 ,  H01M4/8605 ,  H01M4/8668 ,  H01M4/8807 ,  H01M4/9041 ,  H01M4/9083 ,  Y02E60/366

Abstract: A system and method for reducing carbon dioxide in an electrochemical cell comprising a first cell compartment, a second cell compartment, and a membrane positioned between the first cell compartment and the second cell compartment is disclosed. The method may include introducing a feed containing a carbon dioxide gas and a feed of catholyte at a cathode positioned in the first cell compartment, in which the cathode contains a gas diffusion electrode comprising a carbon cloth or graphitized carbon weave and wherein the carbon dioxide gas is directed through carbon fibers of the carbon cloth or graphitized carbon weave. The method may further include introducing a feed of anolyte at an anode positioned in the second cell compartment and applying an electrical potential between the anode and the cathode of the electrochemical cell to thereby reduce the carbon dioxide to a reduction product.

Abstract translation: 公开了用于减少电化学电池中的二氧化碳的系统和方法，所述电化学电池包含第一细胞隔室，第二细胞隔室和位于第一细胞隔室和第二细胞隔室之间的隔膜。 该方法可以包括在位于第一电池室中的阴极处引入含有二氧化碳气体和阴极电解液供给的进料，其中阴极含有包含碳布或石墨化碳织物的气体扩散电极，并且其中二氧化碳气体 通过碳布或石墨化碳织物的碳纤维引导。 该方法可以进一步包括在位于第二电池室中的阳极处引入阳极电解液进料，并且在电化学电池的阳极和阴极之间施加电势，从而将二氧化碳还原成还原产物。

公开(公告)号：WO2010107302A2

公开(公告)日：2010-09-23

申请号：PCT/NL2010/000044

申请日：2010-03-16

Applicant: AVANTIUM HOLDING B.V. ,  BODENSTAFF, Emilio, René ,  MOONEN, Roelandus, Hendrikus, Wilhelmus

Inventor： BODENSTAFF, Emilio, René ,  MOONEN, Roelandus, Hendrikus, Wilhelmus

IPC: G05D7/06 ,  F15C1/04

CPC classification number: G05D7/0694 ,  F15C1/04 ,  F16K99/0001 ,  F16K99/0021 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  Y10T137/6416

Abstract: The invention pertains to a flow controller assembly for microfluidic applications, which flow controller assembly comprises at least one microfluidic flow controller, which microfluidic flow controller comprises: - a microfluidic chip, which microfluidic chip comprises a channel for accommodating a fluid flow, which channel runs through said microfluidic chip and has a channel inlet that is connectable to a fluid source and a channel outlet that is connectable to a further fluid conduit, - a thermal energy transmitter, which thermal energy transmitter is adapted for heating and/or cooling at least a part of the channel by producing a thermal output, thereby influencing the flow rate of fluid that is present in said channel, - a flow sensor for measuring the flow rate of a fluid running through the flow controller, said flow sensor being adapted to produce flow rate measurement data, - a data control unit, which is connected to the flow sensor by a first data connection which first data connection allows the data control unit to receive flow rate measurement data from the flow sensor, which data control unit is connected to the thermal energy transmitter by a second data connection, which second data connection allows the data control unit to influence the thermal output of the thermal energy transmitter, which data control unit comprises a data processing unit that is adapted to determine the difference between the measured flow rate and a preset desired flow rate and to regulate the thermal output of the thermal energy transmitter in order to obtain or maintain the desired flow rate.

Abstract translation: 本发明涉及用于微流体应用的流量控制器组件，该流量控制器组件包括至少一个微流体流量控制器，该微流体流量控制器包括： - 微流体芯片，该微流体芯片包括用于容纳流体流动的通道，该通道运行 通过所述微流体芯片并且具有可连接到流体源的通道入口和可连接到另外的流体导管的通道出口， - 热能发射器，所述热能发射器适于加热和/或冷却至少一个 通过产生热输出的一部分通道，从而影响存在于所述通道中的流体的流速;流量传感器，用于测量流过流量控制器的流体的流量，所述流量传感器适于产生流量 速率测量数据， - 数据控制单元，其通过第一数据连接与第一数据连接到流量传感器 连接允许数据控制单元从流量传感器接收流量测量数据，该数据控制单元通过第二数据连接连接到热能发射器，该第二数据连接允许数据控制单元影响热输出 所述热能发射器，所述数据控制单元包括数据处理单元，所述数据处理单元适于确定所测量的流量与预设的所需流速之间的差异，并且调节所述热能发射器的热输出以获得或维持 所需流速。

公开(公告)号：WO2017118712A1

公开(公告)日：2017-07-13

申请号：PCT/EP2017/050234

申请日：2017-01-05

Applicant: AVANTIUM HOLDING B.V.

Inventor： KACZUR, Jerry J. ,  LAKKARAJU, Prasad ,  KRASOVIC, Julia

IPC: C25B11/03 ,  C25B15/08 ,  C25B3/04 ,  C25B9/08

CPC classification number: C25B3/04 ,  C25B9/08 ,  C25B11/035 ,  C25B15/08

Abstract: The invention relates to a method for the production of carboxylic acid based chemicals, such as carboxylic acids and salts, the method including: - receiving an anolyte feed at an anolyte region of an electrochemical cell including an anode, wherein the anode comprises or consists of a hydrogen depolarized gas diffusion anode; and - receiving a catholyte feed including carbon dioxide and an alkali metal bicarbonate at a catholyte region of the electrochemical cell including a cathode; and - applying an electrical potential between the anode and the cathode sufficient to reduce the carbon dioxide to at least one reduction product. and a system for the same. The invention further relates to a membrane-electrode assembly, comprising a metal gas diffusion electrode, hot pressed or coated with a, preferably hydrophobic, cation exchange membrane on one side.

Abstract translation: 本发明涉及用于生产基于羧酸的化学品（例如羧酸和盐）的方法，所述方法包括： - 在电化学电池的阳极电解液区域接收阳极电解液进料，所述电化学电池包括阳极 其中所述阳极包含氢气去极化的气体扩散阳极或由其组成; 和 - 在包括阴极的电化学电池的阴极电解液区域接收包含二氧化碳和碱金属碳酸氢盐的阴极电解液供给源; 和 - 在阳极和阴极之间施加足以将二氧化碳还原成至少一种还原产物的电势。 以及用于该系统的系统。 本发明进一步涉及一种膜电极组件，其包括金属气体扩散电极，在一侧热压或涂覆有优选疏水的阳离子交换膜。

公开(公告)号：WO2010082817A3

公开(公告)日：2010-07-22

申请号：PCT/NL2010/000005

申请日：2010-01-15

Applicant: AVANTIUM HOLDING B.V. ,  VAN BANNING, Stephan, Olivier ,  COETZEE, Anita ,  BODENSTAFF, Emilio René

Inventor： VAN BANNING, Stephan, Olivier ,  COETZEE, Anita ,  BODENSTAFF, Emilio René

IPC: B01F13/08 ,  B01F15/00

Abstract: The invention relates to a stir system (1) for stirring a liquid in a vial (5). The system is provided with a top (3) for at least partially closing the vial (5) and a stirrer (9) rotatable mounted in the top. The stirrer extends from the top into the vial and the stirrer is being connected with a magnet (11), which is rotatable during use by a rotating magnet field so as to rotate the stirrer in the vial. The system is further provided with a holder (30) for holding the vial (5) and a cover (31) for covering the vial in the holder.

公开(公告)号：WO2009145614A2

公开(公告)日：2009-12-03

申请号：PCT/NL2009/000122

申请日：2009-05-26

Applicant: Avantium Holding B.V. ,  MOONEN, Roelandus Hendrikus Wilhelmus ,  BODENSTAFF, Emilio René ,  SMIT, Martin

Inventor： MOONEN, Roelandus Hendrikus Wilhelmus ,  BODENSTAFF, Emilio René ,  SMIT, Martin

IPC: G05D7/06

CPC classification number: G05D7/0635 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00418 ,  B01J2219/00587 ,  G05D11/132 ,  Y10T137/2514

Abstract: The invention pertains to reaction systems in which at least one capillary unit is applied. The capillary unit comprises: - a unit inlet for receiving a fluid flow, - a unit outlet for releasing said fluid flow, - a capillary, which capillary is arranged between the unit inlet and the unit outlet such that said fluid flow passes through the capillary, - a heater and/or a cooler for adjusting the temperature of the capillary and therewith influencing the flow rate of the fluid flow passing through said capillary, - a housing for accommodating at least the capillary and heater and/or cooler of said capillary unit, which housing provides thermal insulation of the capillary, - a flow sensor for measuring the flow rate of the fluid flow through the capillary unit, which flow sensor can be arranged either inside or outside the housing, A capillary unit is combined with or further has a flow adjustment unit for adjusting the flow rates of the secondary fluid flows, which flow adjustment unit comprises a temperature control device for individually controlling the heater and/or cooler of each capillary unit in response to the flow rate that is measured by the flow sensor of that capillary unit.

Abstract translation: 本发明涉及应用至少一个毛细管单元的反应系统。 毛细管单元包括： - 用于接收流体流的单元入口， - 用于释放所述流体流的单元出口， - 毛细管，毛细管布置在单元入口和单元出口之间，使得所述流体流动通过毛细管 ， - 加热器和/或冷却器，用于调节毛细管的温度并因此影响通过所述毛细管的流体流的流速; - 用于至少容纳所述毛细管单元的毛细管和加热器和/或冷却器的壳体 ，该壳体提供毛细管的热绝缘， - 流量传感器，用于测量通过毛细管单元的流体流量的流量，该流量传感器可以布置在壳体的内部或外部。毛细管单元结合或进一步具有 用于调节二次流体流量的流量调节单元，该流量调节单元包括用于单独控制加热器和/或冷却器的温度控制装置 每个毛细管单元响应于由该毛细管单元的流量传感器测量的流量。

公开(公告)号：WO2010056109A1

公开(公告)日：2010-05-20

申请号：PCT/NL2009/000208

申请日：2009-11-02

Applicant: AVANTIUM HOLDING B.V. ,  McKAY, Benjamin ,  BENTSCHAP KNOOK, Dirk, François ,  VAN BANNING, Srephan, Olivier ,  COETZEE, Anita

Inventor： McKAY, Benjamin ,  BENTSCHAP KNOOK, Dirk, François ,  VAN BANNING, Srephan, Olivier ,  COETZEE, Anita

IPC: G01N21/51 ,  G01N21/03 ,  G01N15/02 ,  G01N21/82 ,  G01N21/65 ,  G01N21/53

CPC classification number: G01N21/51 ,  G01N15/0227 ,  G01N21/0332 ,  G01N21/532 ,  G01N21/534 ,  G01N21/82 ,  G01N2021/651 ,  G01N2201/062 ,  G01N2201/063

Abstract: The invention relates to a sample analysis apparatus. The apparatus comprises: a radiation system to irradiate the sample in a vial and an analyser with a camera to analyse the radiation received from the sample in the vial. The apparatus is provided with a holder to releasable hold the vial and with an optical path for the radiation system to irradiate the sample and for the camera to make images of the sample. The radiation system can be used for front lighting of the sample in the vial or for back lighting of the sample in the vial. The camera may be provided with a telecentric lens.

Abstract translation: 样本分析装置技术领域本发明涉及一种样本分析装置。 该设备包括：辐射系统，用于照射小瓶中的样品和具有照相机的分析仪，以分析从小瓶中的样品接收到的辐射。 该设备设置有保持器，该保持器可释放地保持小瓶并且具有用于辐射系统照射样本并且用于相机制作样本图像的光路。 辐射系统可用于小瓶中样品的正面照明或小瓶中样品的背面照明。 相机可能配有远心镜头。