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公开(公告)号：WO2012061432A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058842
申请日：2011-11-01
Applicant: CODEXIS, INC. , DHAWAN, Ish, Kumar , BAIDYAROY, Dipnath , SHAW, Andrew , TANCHAK, Oleh , HILL, Christopher , LIU, Chengsong , CHOKSHI, Amala , SCOTT, Brian, R.
Inventor： DHAWAN, Ish, Kumar , BAIDYAROY, Dipnath , SHAW, Andrew , TANCHAK, Oleh , HILL, Christopher , LIU, Chengsong , CHOKSHI, Amala , SCOTT, Brian, R.
CPC classification number: C12P19/14 , C12N9/0006 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2203/00 , C12Y101/99018 , C13K1/02 , Y02E50/16
Abstract: The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.
Abstract translation: 本申请提供了经遗传修饰的真菌生物体，其产生显示纤维素材料对葡萄糖的增强水解，由遗传修饰的真菌生物体产生的酶混合物的酶混合物，以及使用这种酶混合物从纤维素生产葡萄糖的方法。
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公开(公告)号：WO2010099500A3
公开(公告)日：2011-03-03
申请号：PCT/US2010025683
申请日：2010-02-26
Applicant: CODEXIS INC , BAIDYAROY DIPNATH , CLARK LOUIS , NEWMAN LISA M , CHING CHARLENE
Inventor： BAIDYAROY DIPNATH , CLARK LOUIS , NEWMAN LISA M , CHING CHARLENE
CPC classification number: C12N9/2445 , C12Y302/01021
Abstract: The invention provides variants of the Thermoanaerobacter brockii CglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in industrial applications.
Abstract translation: 本发明提供了与野生型酶相比具有改善的β-葡糖苷酶活性的热厌氧杆菌CglTβ-葡糖苷酶的变体。 本发明还提供编码变体的多核苷酸，以及产生变体的方法，包含变体的酶组合物，以及在工业应用中使用该变体的方法。
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公开(公告)号：WO2012061382A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058780
申请日：2011-11-01
Applicant: CODEXIS, INC. , BAIDYAROY, Dipnath , DHAWAN, Ish, Kumar
Inventor： BAIDYAROY, Dipnath , DHAWAN, Ish, Kumar
CPC classification number: C12N9/0006 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/12 , C12P19/14 , C12P2203/00 , C12Y101/99018 , C12Y302/01021 , C13K1/02 , Y02E50/16 , Y02P20/52
Abstract: The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose. The present invention also provides a fungal cell that has been genetically modified to reduce the amount of endogenous cellobiose dehydrogenase activity that is secreted by the cell, wherein the fungal cell is from the family Chaetomiaceae, wherein said cell comprises a deletion in the cellobiose dehydrogenase 1 ( cdhl ) gene.
Abstract translation: 本发明提供改良的真菌菌株。 在一些实施方案中，改进的真菌菌株用于将纤维素材料水解成葡萄糖。 本发明还提供已被遗传修饰以减少由细胞分泌的内源性纤维二糖脱氢酶活性的量的真菌细胞，其中真菌细胞来自毛科科科，其中所述细胞包含纤维二糖脱氢酶1中的缺失 （cdhl）基因。
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公开(公告)号：WO2004097027A3
公开(公告)日：2006-04-20
申请号：PCT/US2004012446
申请日：2004-04-22
Applicant: DOW GLOBAL TECHNOLOGIES INC , SUBRAMANIAN VENKITESWARAN , RASOCHOVA LADA , LI KAI , BAIDYAROY DIPNATH , CONBOY CLAIRE B
Inventor： SUBRAMANIAN VENKITESWARAN , RASOCHOVA LADA , LI KAI , BAIDYAROY DIPNATH , CONBOY CLAIRE B
IPC: C12N15/00 , A01H1/04 , C12N9/14 , C12N9/20 , C12N9/78 , C12N15/09 , C12N15/29 , C12N15/52 , C12N15/82 , C12Q20060101 , C12Q1/00 , C12Q1/02 , C12Q1/25 , C12Q1/68
CPC classification number: C12N15/8257 , A01H1/04 , C12N9/14 , C12N9/20 , C12N9/78
Abstract: The present invention relates to compositions and methods for the screening of biocatalysts. In particular, the present invention relates to methods of screening novel plant biocatalysts in plants and plant products.
Abstract translation: 本发明涉及用于筛选生物催化剂的组合物和方法。 特别地，本发明涉及在植物和植物产品中筛选新型植物生物催化剂的方法。
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公开(公告)号：WO2010099500A8
公开(公告)日：2014-04-24
申请号：PCT/US2010025683
申请日：2010-02-26
Applicant: CODEXIS INC , BAIDYAROY DIPNATH , CLARK LOUIS , NEWMAN LISA M , CHING CHARLENE
Inventor： BAIDYAROY DIPNATH , CLARK LOUIS , NEWMAN LISA M , CHING CHARLENE
CPC classification number: C12N9/2445 , C12Y302/01021
Abstract: The invention provides variants of the Thermoanaerobacter brockii CglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in industrial applications.
Abstract translation: 本发明提供了与野生型酶相比具有改善的β-葡糖苷酶活性的热厌氧杆菌CglTβ-葡糖苷酶的变体。 本发明还提供编码变体的多核苷酸，以及产生变体的方法，包含变体的酶组合物，以及在工业应用中使用该变体的方法。
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Patent Agency Ranking6.发明申请RECOMBINANT LIGNOCELLULOSE DEGRADATION ENZYMES FOR THE PRODUCTION OF SOLUBLE SUGARS FROM CELLULOSIC BIOMASS 审中-公开用于从细胞生物量生产可溶性糖的重组纤维素降解酶
公开(公告)号：WO2012027282A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048659
申请日：2011-08-22
Applicant: CODEXIS, INC. , CLARK, Louis , BAIDYAROY, Dipnath
Inventor： CLARK, Louis , BAIDYAROY, Dipnath
CPC classification number: C12N9/2402 , C12N9/0004 , C12N9/16 , C12N9/2437 , C12P19/00 , C12P19/14
Abstract: The invention relates to C1 lignocellulose degradation enzyme nucleic acid and protein sequences and expression of recombinant C1 lignocellulose degradation enzymes. The invention provides methods for degrading a cellulosic biomass by contacting the biomass with a recombinant C1 lignocellulose degradation enzyme of the invention.
Abstract translation: 本发明涉及C1木质纤维素降解酶核酸和蛋白质序列以及重组C1木质纤维素降解酶的表达。 本发明提供了通过使生物质与本发明的重组C1木质纤维素降解酶接触来降解纤维素生物质的方法。
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公开(公告)号：WO2010148148A3
公开(公告)日：2011-03-31
申请号：PCT/US2010038902
申请日：2010-06-16
Applicant: CODEXIS INC , ZHANG XIYUN , YANG JIE , BAIDYAROY DIPNATH , POSTLETHWAITE SALLY RHIANNON , ANDOR ATTILA , CLARK LOUIS , NEWMAN LISA M
Inventor： ZHANG XIYUN , YANG JIE , BAIDYAROY DIPNATH , POSTLETHWAITE SALLY RHIANNON , ANDOR ATTILA , CLARK LOUIS , NEWMAN LISA M
CPC classification number: C12N9/2445 , C12N9/2482 , C12Y302/01021 , Y02E50/17
Abstract: The invention relates to recombinantly produced ß-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant ß-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target ß- glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
Abstract translation: 本发明涉及与天然存在的蛋白质相比具有增强的热活性的重组产生的β-葡糖苷酶变体。 本发明还提供了通过鉴定靶β-葡糖苷酶多肽中的性能敏感位置并用热活性增强残基取代该位置的残基来生产具有改进的热活性的变体β-葡糖苷酶多肽的方法。
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8.发明申请GH61 GLYCOSIDE HYDROLASE PROTEIN VARIANTS AND COFACTORS THAT ENHANCE GH61 ACTIVITY 审中-公开GH61甘油三酯水解蛋白变体和增强GH61活性的因子
公开(公告)号：WO2013028701A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051750
申请日：2012-08-21
Applicant: CODEXIS, INC. , YANG, Jie , ZHANG, Xiyun , YOON, Jungjoo , RAO, Kripa , GRATE, John, H. , ELGART, David , BAIDYAROY, Dipnath
Inventor： YANG, Jie , ZHANG, Xiyun , YOON, Jungjoo , RAO, Kripa , GRATE, John, H. , ELGART, David , BAIDYAROY, Dipnath
CPC classification number: C12N9/2434 , C12N9/242 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
Abstract: The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.
Abstract translation: 本发明提供了包含各种氨基酸取代的各种GH61蛋白质变体。 GH61蛋白质变体具有改善的与纤维素酶协同作用的能力，从而提高通过生物质糖化获得的可发酵糖的产量。 在一些实施方案中，从糖化获得的糖被发酵以产生许多终产物，包括但不限于醇。
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9.发明申请RECOMBINANT LIGNOCELLULOSE DEGRADATION ENZYMES FOR THE PRODUCTION OF SOLUBLE SUGARS FROM CELLULOSIC BIOMASS 审中-公开重组木质纤维素降解酶用于从纤维素生物质生产可溶性糖的研究
公开(公告)号：WO2012027282A3
公开(公告)日：2012-07-12
申请号：PCT/US2011048659
申请日：2011-08-22
Applicant: CODEXIS INC , CLARK LOUIS , BAIDYAROY DIPNATH
Inventor： CLARK LOUIS , BAIDYAROY DIPNATH
CPC classification number: C12N9/2402 , C12N9/0004 , C12N9/16 , C12N9/2437 , C12P19/00 , C12P19/14
Abstract: The invention relates to C1 lignocellulose degradation enzyme nucleic acid and protein sequences and expression of recombinant C1 lignocellulose degradation enzymes. The invention provides methods for degrading a cellulosic biomass by contacting the biomass with a recombinant C1 lignocellulose degradation enzyme of the invention.
Abstract translation: 本发明涉及C1木质纤维素降解酶核酸和蛋白质序列以及重组C1木质纤维素降解酶的表达。 本发明提供了通过使生物质与本发明的重组C1木质纤维素降解酶接触来降解纤维素生物质的方法。
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10.发明申请RECOMBINANT C1 B-GLUCOSIDASE FOR PRODUCTION OF SUGARS FROM CELLULOSIC BIOMASS 审中-公开用于从细胞生物量生产糖的重组C1B-葡萄糖苷酶
公开(公告)号：WO2011041594A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050982
申请日：2010-09-30
Applicant: CODEXIS, INC. , CLARK, Louis , BAIDYAROY, Dipnath , SZABO, Lorand
Inventor： CLARK, Louis , BAIDYAROY, Dipnath , SZABO, Lorand
IPC: C12P21/06
CPC classification number: C12P19/14 , C12N9/2445 , C12P19/02 , C12Y302/01021
Abstract: The invention relates to expression of a recombinant C1 β-glucosidase. The invention also provides methods for producing a fermentable sugar from cellobiose by contacting celiobiose with a recombinant host cell comprising a polynucleotide sequence encoding C1 β-glucosidase, operably linked to heterologous promoter, under conditions in which β- glucosidase is expressed and secreted by the cell and the cellobiose is enzymatically converted by said β-glucosidase to glucose. Methods of the invention may be used for conversion of a biomass substrate to a fermentable sugar, and ultimately to ethanol or other biofuel.
Abstract translation: 本发明涉及重组C1β-葡糖苷酶的表达。 本发明还提供了从纤维二糖生产可发酵糖的方法，其通过使细胞生长因子与重组宿主细胞接触，所述重组宿主细胞在编码β-葡萄糖苷酶的多核苷酸序列中可操作地连接到异源启动子，其中β-葡糖苷酶由细胞表达和分泌 并且纤维二糖由所述β-葡糖苷酶酶转化成葡萄糖。 本发明的方法可用于将生物质底物转化为可发酵的糖，最终转化为乙醇或其他生物燃料。
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