公开(公告)号：WO2021233932A1

公开(公告)日：2021-11-25

申请号：PCT/EP2021/063180

申请日：2021-05-18

Applicant: ATTOMARKER LIMITED ,  SHAW, Andrew, M.

Inventor： SHAW, Andrew, M.

IPC: G01N33/68 ,  G01N33/569

Abstract: A system and method for characterizing viral infection in a human or animal patient, in particular coronavirus infection, involves providing fluid from a body sample of the patient to a biosensor array comprising an array of sensor elements bearing one or more antigens of a target virus, to perform assays. The assays comprise a first group to sense a collective immune response and a second group to selectively sense an immunoglobulin IgM response and an immunoglobulin IgG response to the antigens. The collective immune response detects presence of the target virus and the levels of the immunoglobulin IgM and IgG response are compared to determine a stage of the immune response to the target virus.

公开(公告)号：WO2012010871A3

公开(公告)日：2012-03-15

申请号：PCT/GB2011051335

申请日：2011-07-15

Applicant: UNIV EXETER ,  SHAW ANDREW MARK

Inventor： SHAW ANDREW MARK

IPC: G06F19/00

CPC classification number: G01N33/54373 ,  G01N33/564 ,  G01N2333/4716 ,  G01N2333/4724 ,  G01N2800/52 ,  G06F19/18 ,  G06F19/34 ,  G16H50/50

Abstract: We describe a system/method for predicting the outcome of a medical procedure on a patient. The system/method uses using complement cascade data representing levels of a set of complement cascade markers in the patient at a succession of peri-operative time intervals, determining deviations from a model of the response to provide a pre-symptomatic prediction of the outcome. In embodiments the complement cascade pathways include the lytic pathway and at least one of the lectin pathway, the classical pathway and the alternative pathway, and the biomarkers include at least C3. The system may include an electroluminescence or plasmon-resonance multianalyte detector to analyse a blood sample from the patient.

Abstract translation: 我们描述一种用于预测患者的医疗程序结果的系统/方法。 系统/方法使用补体级联数据来表示患者中连续的围手术期间隔的一组补体级联标记的水平，确定与反应模型的偏差以提供结果的预先症状预测。 在实施方案中，补体级联途径包括溶解途径和凝集素途径，经典途径和替代途径中的至少一种，生物标志物至少包括C3。 该系统可以包括电致发光或等离子体共振多分析仪检测器以分析来自患者的血液样品。

公开(公告)号：WO2011154160A1

公开(公告)日：2011-12-15

申请号：PCT/EP2011/002897

申请日：2011-06-13

Applicant: BRITANNIA PHARMACEUTICALS LIMITED ,  NOWAK, Rachael ,  SHAW, Andrew ,  MARTIN, Graham, John

Inventor： NOWAK, Rachael ,  SHAW, Andrew ,  MARTIN, Graham, John

IPC: A61M5/14 ,  A61M5/142

CPC classification number: A61M5/002 ,  A61M5/003 ,  A61M5/1413 ,  A61M5/14244 ,  A61M5/14566 ,  A61M2005/14264 ,  A61M2005/14268 ,  A61M2205/582 ,  A61M2205/6045 ,  A61M2209/06 ,  A61M2209/088

Abstract: An apparatus for infusion equipment comprising a vessel having a tubular bore and a separate actuator pump for the vessel. The apparatus comprises a holder shaped and dimensioned to hold the vessel and a pump attachment to which the holder can be securely fitted. The attachment is shaped and dimensioned to be removeably engagable with an actuator pump, to thereby, when the holder is fitted to the pump attachment, removeably hold the pump and vessel in mutual fixed relation such that the actuator pump is operably engaged with a piston of the vessel without attaching the vessel to the pump. Embodiments of a case, a kit and a method are also described.

Abstract translation: 一种用于输注设备的装置，包括具有管状孔的容器和用于容器的单独的致动器泵。 该装置包括保持器的形状和尺寸的保持器，以及保持器可以牢固地装配到其上的泵附件。 附件的形状和尺寸被设计成与致动器泵可移除地接合，由此当保持器安装到泵附件时，可移除地将泵和容器保持在相互固定的关系中，使得致动器泵可操作地与活塞 该容器不将容器附接到泵。 还描述了壳体，套件和方法的实施例。

公开(公告)号：WO2009058303A3

公开(公告)日：2010-01-07

申请号：PCT/US2008012276

申请日：2008-10-28

Applicant: DANISCO US INC GENENCOR DIV ,  ESTELL DAVID A ,  HOMMES RONALDUS W J ,  LIU AMY D ,  SHAW ANDREW

Inventor： ESTELL DAVID A ,  HOMMES RONALDUS W J ,  LIU AMY D ,  SHAW ANDREW

IPC: C12N9/54

CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38618 ,  C11D3/38636 ,  C12Y304/24027

Abstract: The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.

Abstract translation: 本发明提供包含至少一种具有改善的储存稳定性和/或催化活性的嗜热菌蛋白酶样中性蛋白酶的方法和组合物。 在一些实施方案中，嗜热菌蛋白酶可用于清洁和其它包含洗涤剂的应用。 在一些特别优选的实施方案中，本发明提供包含热溶菌素的方法和组合物，其配制和/或工程化以抵抗洗涤剂诱导的失活。

公开(公告)号：WO2009100138A2

公开(公告)日：2009-08-13

申请号：PCT/US2009/033087

申请日：2009-02-04

Applicant: DANISCO US INC., GENENCOR DIVISION ,  PEPSIN, Michael, J. ,  RAMER, Sandra, W. ,  SHAW, Andrew

Inventor： PEPSIN, Michael, J. ,  RAMER, Sandra, W. ,  SHAW, Andrew

IPC: C12N9/28 ,  C12N15/31

CPC classification number: C12N9/2417 ,  Y02E50/17

Abstract: Described are variants of alpha (?)-amylases having altered starch hydrolysis profiles. The variants have improved thermostability and increased specific activity, resulting in reduced peak viscosity and altered final viscosity during starch liquefaction. The amylase variants are useful, e.g., in liquefaction and other starch degradation processes.

Abstract translation: 描述了具有改变的淀粉水解曲线的α（α） - 淀粉酶的变体。 这些变体具有改善的热稳定性和增加的比活性，导致在淀粉液化期间降低的峰值粘度和改变的最终粘度。 淀粉酶变体是有用的，例如在液化和其它淀粉降解过程中。

公开(公告)号：WO2009058661A1

公开(公告)日：2009-05-07

申请号：PCT/US2008/080972

申请日：2008-10-23

Applicant: DANISCO US INC., GENENCOR DIVISION ,  HOMMES, Ronaldus, W. J. ,  LIU, Amy ,  SHAW, Andrew ,  WALLACE, Louise

Inventor： HOMMES, Ronaldus, W. J. ,  LIU, Amy ,  SHAW, Andrew ,  WALLACE, Louise

IPC: C12N9/54

CPC classification number: C11D3/38618 ,  C12N9/54

Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis.

Abstract translation: 本发明提供包含至少一种在金属螯合剂存在下具有改善的稳定性的中性金属蛋白酶的方法和组合物。 在一些实施方案中，中性金属蛋白酶可用于清洁和其它包含柠檬酸盐的应用。 在一些特别优选的实施方案中，本发明提供了包含改变为抗柠檬酸盐诱导的自溶的变体中性金属蛋白酶的方法和组合物。

公开(公告)号：WO2008153934A2

公开(公告)日：2008-12-18

申请号：PCT/US2008/007113

申请日：2008-06-06

Applicant: DANISCO US, INC., GENENCOR DIVISION ,  AEHLE, Wolfgang ,  CASCAO-PEREIRA, Luis Gustavo ,  KELLIS, JR., James T. ,  SHAW, Andrew

Inventor： AEHLE, Wolfgang ,  CASCAO-PEREIRA, Luis Gustavo ,  KELLIS, JR., James T. ,  SHAW, Andrew

IPC: C12N15/10 ,  C12N15/01 ,  C12N15/52

CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38681 ,  C12N9/2411 ,  C12N9/2417 ,  C12N15/1034 ,  C12Y302/01001 ,  C12Y304/21062

Abstract: The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes {e.g., metalloproteases or serine proteases) to obtain enzyme variants that demonstrate improved performance in detergent formulations as compared to the starting or parent enzyme.

Abstract translation: 本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。 在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。 在一些优选的实施方案中，本发明提供了用于改变酶（例如金属蛋白酶或丝氨酸蛋白酶）的净表面电荷和/或表面电荷分布的方法，以获得与起始或母体相比在洗涤剂配方中表现出改善的性能的酶变体 酶。

公开(公告)号：WO2008094440A1

公开(公告)日：2008-08-07

申请号：PCT/US2008/000926

申请日：2008-01-24

Applicant: MYLAN PHARMACEUTICALS, INC. ,  BHAT, Pavan ,  CHATTARAJ, Sarat, C. ,  SHAW, Andrew, A.

Inventor： BHAT, Pavan ,  CHATTARAJ, Sarat, C. ,  SHAW, Andrew, A.

IPC: A61K9/50

CPC classification number: A61K31/138 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5084

Abstract: Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.

Abstract translation: 提供了包含持续释放颗粒的药物制剂，其各自具有包含活性药物成分的内芯珠，基本上围绕内芯珠的中间涂层，以及基本上围绕包含pH独立聚合物的中间涂层的外涂层。 还提供了包含两个珠粒的药物制剂，其中第一和第二珠粒中的每一个具有不同的药物释放曲线。 还提供了制备包含一个或多个珠粒的延长释放剂量组合物的方法。

公开(公告)号：WO2006054117A2

公开(公告)日：2006-05-26

申请号：PCT/GB2005/050203

申请日：2005-11-16

Applicant: EVANESCO Ltd ,  SHAW, Andrew Mark

Inventor： SHAW, Andrew Mark

IPC: G01F23/292

CPC classification number: G01F23/292

Abstract: This invention is generally concerned with methods and apparatus for optical monitoring of fluid level and quality, in particular by means of evanescent wave techniques such as cavity ring-down spectroscopy. We describe a fuel monitoring system, comprising: an evanescent wave fuel sensor for monitoring said fuel, the sensor comprising a light source and a transducer for providing an electrical signal in response to light from said light source, and having a light path between said light source and said transducer including an evanescent wave sensing region; and a processor coupled to said fuel sensor, for converting said electrical signal from said transducer into a signal characterising said monitored fuel; and an output coupled to said processor, for outputting a signal responsive to said fuel characterising signal. We further describe apparatus for jointly determining depth of fluid in a tank and characterising the fluid according to depth, and a fluid storage tank having a three dimensional structure for containing fluid, and a three-dimensional array of fibre-optic sensors integrated into said tank structure.

Abstract translation: 本发明通常涉及用于液体水平和质量的光学监测的方法和装置，特别是通过诸如空腔衰减光谱的ev逝波技术。 我们描述一种燃料监测系统，包括：用于监测所述燃料的ev逝波燃料传感器，所述传感器包括光源和用于响应于来自所述光源的光提供电信号的换能器，并且在所述光 源和所述换能器包括ev逝波感测区域; 以及耦合到所述燃料传感器的处理器，用于将来自所述换能器的所述电信号转换成表征所述监测燃料的信号; 以及耦合到所述处理器的输出，用于响应于所述燃料特性信号输出信号。 我们进一步描述了用于共同确定罐中流体深度和根据深度表征流体的装置，以及具有用于容纳流体的三维结构的流体储存罐和集成到所述罐中的光纤传感器的三维阵列 结构体。

公开(公告)号：WO2005007818A8

公开(公告)日：2006-03-16

申请号：PCT/US2004021723

申请日：2004-07-07

Applicant: GENENCOR INT ,  DANISCO ,  BERG CASPER TUNE ,  BOJSEN KIRSTEN ,  DERKX PATRICK M F ,  FIORESI CAROL ,  GERRITSE GIJSBERT ,  KRAGH KARSTEN M ,  LIU WEI ,  SHAW ANDREW ,  THOUDAHL CHARLOTTE R

Inventor： BERG CASPER TUNE ,  BOJSEN KIRSTEN ,  DERKX PATRICK M F ,  FIORESI CAROL ,  GERRITSE GIJSBERT ,  KRAGH KARSTEN M ,  LIU WEI ,  SHAW ANDREW ,  THOUDAHL CHARLOTTE R

IPC: A21D8/02 ,  A21D8/04 ,  A23L1/03 ,  A23L1/09 ,  A23L1/305 ,  C07H21/04 ,  C11D3/386 ,  C12N1/21 ,  C12N9/28 ,  C12N9/32 ,  C12N15/74 ,  C12N

CPC classification number: C12N9/2417 ,  A21D8/042 ,  A23L29/06 ,  A23L29/35 ,  A23L33/17 ,  A23V2002/00 ,  A23V2300/21

Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.

Abstract translation: 本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。 本发明的淀粉酶已被设计成具有更多的有益品质。 具体地说，本发明的淀粉酶表现出改变的促进作用。