公开(公告)号：WO2011084884A1

公开(公告)日：2011-07-14

申请号：PCT/US2011/000018

申请日：2011-01-05

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

Inventor： BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

IPC: G06Q30/00

CPC classification number: G01S13/88 ,  A61B5/1102 ,  A61B5/113 ,  G01S7/412 ,  G01S7/415 ,  G01S13/04 ,  G06Q30/02 ,  G06Q30/0269 ,  H04H60/45

Abstract: A micro-impulse radar (MIR) may be configured to provide information about at least one person in a region. A media output device may be driven responsive to the information to output media content to the at least one person.

Abstract translation: 微脉冲雷达（MIR）可以被配置为提供关于区域中的至少一个人的信息。 可以响应于该信息来驱动媒体输出设备，以向至少一个人输出媒体内容。

公开(公告)号：WO2008130706A3

公开(公告)日：2009-02-05

申请号：PCT/US2008005173

申请日：2008-04-21

Applicant: SEARETE LLC ,  BANGERA MAHALAXMI GITA ,  BOYDEN EDWARD S ,  HYDE RODERICK A ,  ISHIKAWA MURIEL Y ,  JUNG EDWARD K Y ,  LEUTHARDT ERIC C ,  RIVET DENNIS J ,  SMITH MICHAEL A ,  SWEENEY ELIZABETH A ,  TEGREENE CLARENCE T ,  WOOD LOWELL L JR ,  WOOD VICTORIA Y H

Inventor： BANGERA MAHALAXMI GITA ,  BOYDEN EDWARD S ,  HYDE RODERICK A ,  ISHIKAWA MURIEL Y ,  JUNG EDWARD K Y ,  LEUTHARDT ERIC C ,  RIVET DENNIS J ,  SMITH MICHAEL A ,  SWEENEY ELIZABETH A ,  TEGREENE CLARENCE T ,  WOOD LOWELL L JR ,  WOOD VICTORIA Y H

IPC: A61B5/05

CPC classification number: A61B17/085 ,  A61B17/0401 ,  A61B17/0466 ,  A61B17/06166 ,  A61B17/3474 ,  A61B34/10 ,  A61B90/39 ,  A61B90/96 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00867 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/081 ,  A61B2017/086 ,  A61B2017/320052 ,  A61B2034/101 ,  A61B2034/256 ,  A61B2090/363 ,  A61B2090/366 ,  A61B2090/3937 ,  A61B2090/395 ,  A61B2090/3987

Abstract: Fiducial markings are placed on a patient to identify surgical parameters such as locations for an incision or a surgical closure.

Abstract translation: 将基准标记放置在患者身上以识别手术参数，例如切口或手术闭合的位置。

公开(公告)号：WO2010030382A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/005112

申请日：2009-09-10

Applicant: SEARETE, LLC ,  BANGERA, Mahalaxmi, Gita ,  HARLOW, Ed ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  RIVET, Dennis, J. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

Inventor： BANGERA, Mahalaxmi, Gita ,  HARLOW, Ed ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  RIVET, Dennis, J. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

IPC: C12M1/34 ,  C12N1/00 ,  B82B3/00

CPC classification number: C07K16/32 ,  A61K38/1703 ,  A61K38/1732 ,  A61K47/60 ,  A61K47/6871 ,  A61K47/6901 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B21/0648 ,  C01B32/168 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  C01P2004/13 ,  Y02A50/473 ,  Y10S977/743 ,  Y10S977/75 ,  Y10S977/762 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/848 ,  Y10S977/896 ,  Y10S977/915

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract translation: 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置，组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。

公开(公告)号：WO2010030381A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/005111

申请日：2009-09-10

Applicant: SEARETE, LLC ,  BANGERA, Mahalaxmi, Gita ,  HARLOW, Ed ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  RIVET, Dennis, J. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

Inventor： BANGERA, Mahalaxmi, Gita ,  HARLOW, Ed ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  RIVET, Dennis, J. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

IPC: C12N1/00

CPC classification number: C07K16/32 ,  A61K38/1703 ,  A61K38/1732 ,  A61K47/60 ,  A61K47/6871 ,  A61K47/6901 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B21/0648 ,  C01B32/168 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  C01P2004/13 ,  Y02A50/473 ,  Y10S977/743 ,  Y10S977/75 ,  Y10S977/762 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/848 ,  Y10S977/896 ,  Y10S977/915

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g. , mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.

Abstract translation: 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，被配置为在细胞器官的脂质双层膜中形成孔，并且至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。

公开(公告)号：WO2008130707A1

公开(公告)日：2008-10-30

申请号：PCT/US2008/005174

申请日：2008-04-21

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi, Gita ,  BOYDEN, Edward, S. ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K.Y. ,  LEUTHARDT, Eric, C. ,  NUGENT, Elizabeth, E. ,  RIVET, Dennis, J. ,  SMITH, Michael, A. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y.H

Inventor： BANGERA, Mahalaxmi, Gita ,  BOYDEN, Edward, S. ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K.Y. ,  LEUTHARDT, Eric, C. ,  NUGENT, Elizabeth, E. ,  RIVET, Dennis, J. ,  SMITH, Michael, A. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y.H

IPC: A61B17/04

CPC classification number: A61B17/10 ,  A61B17/085 ,  A61B34/10 ,  A61B2017/081 ,  A61B2017/086

Abstract: An opening in a fascia is closed by inserting a cannula through the fascia, and attaching a tissue anchor to the fascia from the exterior or through a side of the cannula

Abstract translation: 通过将插管穿过筋膜将面板中的开口封闭，并将组织锚固件从外部或穿过套管的一侧附接到筋膜

公开(公告)号：WO2012054086A1

公开(公告)日：2012-04-26

申请号：PCT/US2011/001789

申请日：2011-10-20

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi, Gita ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  TUCKERMAN, David, B. ,  WEAVER, Thomas, Allan ,  WOOD, JR., Lowell, L. ,  WOOD, Victoria, Y., H.

Inventor： BANGERA, Mahalaxmi, Gita ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  TUCKERMAN, David, B. ,  WEAVER, Thomas, Allan ,  WOOD, JR., Lowell, L. ,  WOOD, Victoria, Y., H.

IPC: H04H60/33

CPC classification number: A61B5/0507 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/113 ,  A61B5/165 ,  A61B5/7253 ,  G01S7/412 ,  G01S7/415 ,  G01S13/0209 ,  G01S13/52 ,  G01S13/867 ,  G01S13/88 ,  G01S13/887

Abstract: One or more computers are configured to determine a human stress condition corresponding to one or more physical or physiological parameters extracted from one or more micro-impulse radar (MIR) signals.

Abstract translation: 一个或多个计算机被配置为确定对应于从一个或多个微脉冲雷达（MIR）信号提取的一个或多个物理或生理参数的人类应激条件。

公开(公告)号：WO2012036753A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/001629

申请日：2011-09-19

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

Inventor： BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

IPC: G01S13/00

CPC classification number: G01S13/0209 ,  G01S7/415 ,  G01S13/04 ,  G06F3/017 ,  H04N21/42201 ,  H04N21/44218

Abstract: A computer or entertainment system is configured to respond to data received from a micro impulse radar configured to detect movement, physiology, presence, and/or absence of a person in one or more regions near the computer or entertainment system.

Abstract translation: 计算机或娱乐系统被配置为响应从配置成检测计算机或娱乐系统附近的一个或多个区域中的人的移动，生理，存在和/或不存在的微脉冲雷达接收的数据。

公开(公告)号：WO2008130706A2

公开(公告)日：2008-10-30

申请号：PCT/US2008/005173

申请日：2008-04-21

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi, Gita ,  BOYDEN, Edward, S. ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K.y. ,  LEUTHARDT, Eric, C. ,  RIVET, Dennis, J. ,  SMITH, Michael, A. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

Inventor： BANGERA, Mahalaxmi, Gita ,  BOYDEN, Edward, S. ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K.y. ,  LEUTHARDT, Eric, C. ,  RIVET, Dennis, J. ,  SMITH, Michael, A. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  WOOD, Lowell, L., Jr. ,  WOOD, Victoria, Y., H.

IPC: A61B17/08

CPC classification number: A61B17/085 ,  A61B17/0401 ,  A61B17/0466 ,  A61B17/06166 ,  A61B17/3474 ,  A61B34/10 ,  A61B90/39 ,  A61B90/96 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00867 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/081 ,  A61B2017/086 ,  A61B2017/320052 ,  A61B2034/101 ,  A61B2034/256 ,  A61B2090/363 ,  A61B2090/366 ,  A61B2090/3937 ,  A61B2090/395 ,  A61B2090/3987

Abstract: Fiducial markings are placed on a patient to identify surgical parameters such as locations for an incision or a surgical closure.

Abstract translation: 将基准标记放置在患者身上以识别手术参数，例如切口或手术闭合的位置。

公开(公告)号：WO2012082159A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/001985

申请日：2011-12-16

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WEAVER, Thomas Allan ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

Inventor： BANGERA, Mahalaxmi Gita ,  HYDE, Roderick A. ,  ISHIKAWA, Muriel Y. ,  JUNG, Edward K.Y. ,  KARE, Jordin T. ,  LEUTHARDT, Eric C. ,  MYHRVOLD, Nathan P. ,  SWEENEY, Elizabeth A. ,  TEGREENE, Clarence T. ,  TUCKERMAN, David B. ,  WEAVER, Thomas Allan ,  WOOD, JR., Lowell L. ,  WOOD, Victoria Y.H.

IPC: G01S13/89

CPC classification number: G06Q30/02 ,  A61B5/0507 ,  A61B5/0816 ,  A61B5/165 ,  A61B5/7253 ,  G01S7/412 ,  G01S7/415 ,  G01S13/52 ,  G01S13/88

Abstract: One or more human attributes extracted from a micro-impulse radar (MIR) signal is correlated to a temporary identity or phenotypic identity of a person.

Abstract translation: 从微脉冲雷达（MIR）信号提取的一个或多个人类属性与人的临时身份或表型身份相关。

公开(公告)号：WO2012054087A1

公开(公告)日：2012-04-26

申请号：PCT/US2011/001790

申请日：2011-10-20

Applicant: SEARETE LLC ,  BANGERA, Mahalaxmi, Gita ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  TUCKERMAN, David, B. ,  WEAVER, Thomas, Allan ,  WOOD, JR., Lowell, L. ,  WOOD, Victoria, Y., H.

Inventor： BANGERA, Mahalaxmi, Gita ,  HYDE, Roderick, A. ,  ISHIKAWA, Muriel, Y. ,  JUNG, Edward, K., Y. ,  KARE, Jordin, T. ,  LEUTHARDT, Eric, C. ,  MYHRVOLD, Nathan, P. ,  SWEENEY, Elizabeth, A. ,  TEGREENE, Clarence, T. ,  TUCKERMAN, David, B. ,  WEAVER, Thomas, Allan ,  WOOD, JR., Lowell, L. ,  WOOD, Victoria, Y., H.

IPC: G06Q30/00

CPC classification number: G06Q30/0251 ,  G06Q30/0261

Abstract: One or more micro-impulse radars (MIRs) are configured to determine the movement of at least one person. Media can be output to the person responsive to the movement.

Abstract translation: 一个或多个微脉冲雷达（MIR）被配置为确定至少一个人的移动。 可以将响应于移动的媒体输出给人。