公开(公告)号：WO2012007877A2

公开(公告)日：2012-01-19

申请号：PCT/IB2011/052998

申请日：2011-07-06

Applicant: PFIZER LIMITED ,  BELL, Andrew Simon ,  BROWN, Alan Daniel ,  LEWTHWAITE, Russell Andrew ,  PEREZ PACHECO, Manuel ,  RAWSON, David James ,  STORER, Robert Ian ,  SWAIN, Nigel Alan

Inventor： BELL, Andrew Simon ,  BROWN, Alan Daniel ,  LEWTHWAITE, Russell Andrew ,  PEREZ PACHECO, Manuel ,  RAWSON, David James ,  STORER, Robert Ian ,  SWAIN, Nigel Alan

IPC: C07D213/64

CPC classification number: A61K31/444 ,  A61K31/18 ,  A61K31/4164 ,  A61K31/4418 ,  A61K45/06 ,  C07C311/13 ,  C07C311/51 ,  C07D213/64 ,  C07D213/65 ,  C07D213/69 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D401/12

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract translation: 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式10（I）的新型磺酰胺Nav1.7抑制剂：（I）或其药学上可接受的盐，其中Z，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

公开(公告)号：WO2007017752A1

公开(公告)日：2007-02-15

申请号：PCT/IB2006/002225

申请日：2006-07-31

Applicant: PFIZER LIMITED ,  BROWN, Alan, Daniel ,  CALABRESE, Andrew, Antony ,  ELLIS, David ,  SCIAMMETTA, Nunzio

Inventor： BROWN, Alan, Daniel ,  CALABRESE, Andrew, Antony ,  ELLIS, David ,  SCIAMMETTA, Nunzio

IPC: C07D401/14 ,  A61K31/497 ,  A61P15/12

CPC classification number: C07D401/14

Abstract: The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

Abstract translation: 本发明涉及一类具有活性作为催产素拮抗剂的式（I）的取代三唑，其用途，其制备方法和含有所述抑制剂的组合物。 这些抑制剂可用于各种治疗领域，包括性功能障碍，特别是早泄（P.E.）。

公开(公告)号：WO2005080313A9

公开(公告)日：2006-08-31

申请号：PCT/IB2005000086

申请日：2005-01-12

Applicant: PFIZER LTD ,  PFIZER ,  BROWN ALAN DANIEL ,  BUNNAGE MARK EDWARD ,  GLOSSOP PAUL ALAN ,  JAMES KIM ,  LANE CHARLOTTE ALICE LOUISE ,  LEWTHWAITE RUSSELL ANDREW ,  MOSES IAN BRIAN ,  PRICE DAVID ANTHONY ,  THOMSON NICHOLAS MURRAY

Inventor： BROWN ALAN DANIEL ,  BUNNAGE MARK EDWARD ,  GLOSSOP PAUL ALAN ,  JAMES KIM ,  LANE CHARLOTTE ALICE LOUISE ,  LEWTHWAITE RUSSELL ANDREW ,  MOSES IAN BRIAN ,  PRICE DAVID ANTHONY ,  THOMSON NICHOLAS MURRAY

IPC: C07C311/08 ,  C07D217/06

CPC classification number: C07C311/08 ,  A61K31/18 ,  A61K31/352 ,  A61K31/522 ,  C07C2602/08 ,  C07D217/06

Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Abstract translation: 本发明涉及式（1）化合物及其制备方法，含有这些衍生物的用途和用途。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

公开(公告)号：WO2005090287A3

公开(公告)日：2006-02-16

申请号：PCT/IB2005000640

申请日：2005-03-10

Applicant: PFIZER LTD ,  PFIZER ,  BROWN ALAN DANIEL ,  BUNNAGE MARK EDWARD ,  GLOSSOP PAUL ALAN ,  JAMES KIM ,  LANE CHARLOTTE ALICE LOUISE ,  LEWTHWAITE RUSSELL ANDREW ,  LUNN GRAHAM ,  PRICE DAVID ANTHONY

Inventor： BROWN ALAN DANIEL ,  BUNNAGE MARK EDWARD ,  GLOSSOP PAUL ALAN ,  JAMES KIM ,  LANE CHARLOTTE ALICE LOUISE ,  LEWTHWAITE RUSSELL ANDREW ,  LUNN GRAHAM ,  PRICE DAVID ANTHONY

IPC: A61K31/165 ,  A61K31/472 ,  C07C237/20 ,  C07D217/06

CPC classification number: C07D217/06

Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Abstract translation: 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

公开(公告)号：WO2005092861A1

公开(公告)日：2005-10-06

申请号：PCT/IB2005/000536

申请日：2005-03-01

Applicant: PFIZER LIMITED ,  PFIZER INC. ,  BROWN, Alan, Daniel ,  GLOSSOP, Paul, Alan ,  LANE, charlotte, Alice, Louise

Inventor： BROWN, Alan, Daniel ,  GLOSSOP, Paul, Alan ,  LANE, charlotte, Alice, Louise

IPC: C07D215/26

CPC classification number: C07D215/26 ,  C07D401/12

Abstract: The invention relates to compounds of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Abstract translation: 本发明涉及式（I）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎性，过敏和呼吸道疾病，病症和病症。

公开(公告)号：WO2005092860A1

公开(公告)日：2005-10-06

申请号：PCT/IB2005/000669

申请日：2005-03-11

Applicant: PFIZER LIMITED ,  PFIZER INC ,  BROWN, Alan, Daniel ,  BUNNAGE, Mark, Edward ,  GLOSSOP, Paul, Alan ,  JAMES, Kim ,  LANE, Charlotte, Alice, Louise ,  LEWTHWAITE, Russell, Andrew ,  PRICE, David, Anthony

Inventor： BROWN, Alan, Daniel ,  BUNNAGE, Mark, Edward ,  GLOSSOP, Paul, Alan ,  JAMES, Kim ,  LANE, Charlotte, Alice, Louise ,  LEWTHWAITE, Russell, Andrew ,  PRICE, David, Anthony

IPC: C07D213/65

CPC classification number: C07D401/12 ,  C07D213/65

Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Abstract translation: 本发明涉及式（1）的化合物和用于制备用于制备含有这些衍生物的组合物和其用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎性，变应性和呼吸系统疾病，病症和病症。

公开(公告)号：WO2005082866A2

公开(公告)日：2005-09-09

申请号：PCT/IB2005/000313

申请日：2005-02-07

Applicant: PFIZER LIMITED ,  PFIZER INC. ,  BROWN, Alan, Daniel ,  CALABRESE, Andrew, Anthony ,  ELLIS, David ,  SMITH, Christopher, Ronald

Inventor： BROWN, Alan, Daniel ,  CALABRESE, Andrew, Anthony ,  ELLIS, David ,  SMITH, Christopher, Ronald

IPC: C07D249/08

CPC classification number: C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

Abstract translation: 本发明涉及一类具有活性作为催产素拮抗剂的式（I）的取代三唑，其用途，其制备方法和含有所述抑制剂的组合物。 这些抑制剂可用于各种治疗领域，包括性功能障碍，特别是早泄（P.E.）。

公开(公告)号：WO2012007868A3

公开(公告)日：2012-01-19

申请号：PCT/IB2011/052940

申请日：2011-07-04

Applicant: PFIZER LIMITED ,  BROWN, Alan, Daniel ,  RAWSON, David, James ,  STORER, Robert, Ian ,  SWAIN, Nigel, Alan

Inventor： BROWN, Alan, Daniel ,  RAWSON, David, James ,  STORER, Robert, Ian ,  SWAIN, Nigel, Alan

IPC: C07C311/51 ,  A61K31/18 ,  A61P25/04

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar 1 , R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

公开(公告)号：WO2011151807A1

公开(公告)日：2011-12-08

申请号：PCT/IB2011/052446

申请日：2011-06-03

Applicant: PFIZER VACCINES LLC ,  ANASTASIOU, Nickolas ,  BHATTACHARYA, Keshab ,  BROWN, Alan, Daniel ,  DAVIS, Heather, Lynn ,  FINNEMAN, Jari, Ilmari ,  GERVAIS, David, P. ,  JONES, Lyn, Howard ,  KOLHE, Parag, Ashok ,  MCCLUSKIE, Michael, John ,  MEHELIC, Paul, Robert ,  MERSON, James, Richard ,  PARSONS, Erin, Kristen ,  PRYDE, David, Cameron ,  STEAD, David, Robert ,  THORN, Jennifer, Marie

Inventor： ANASTASIOU, Nickolas ,  BHATTACHARYA, Keshab ,  BROWN, Alan, Daniel ,  DAVIS, Heather, Lynn ,  FINNEMAN, Jari, Ilmari ,  GERVAIS, David, P. ,  JONES, Lyn, Howard ,  KOLHE, Parag, Ashok ,  MCCLUSKIE, Michael, John ,  MEHELIC, Paul, Robert ,  MERSON, James, Richard ,  PARSONS, Erin, Kristen ,  PRYDE, David, Cameron ,  STEAD, David, Robert ,  THORN, Jennifer, Marie

IPC: A61K47/48 ,  A61P25/30 ,  A61K31/465 ,  C07D213/82

CPC classification number: A61K39/385 ,  A61K31/465 ,  A61K39/39 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/6012 ,  A61K2039/6037 ,  A61K2039/627 ,  C07D401/04 ,  C07K14/34 ,  Y02A50/473

Abstract: The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.

Abstract translation: 本发明部分地涉及式（III）的尼古丁衍生的半抗原 - 载体共轭物：其中m，n，W， - （间隔基） - ，X *和Y如说明书中所定义。 在某些实施方案中，所述尼古丁衍生的半抗原 - 载体缀合物可用于制备用于治疗和/或预防尼古丁成瘾的疫苗。

公开(公告)号：WO2010067286A3

公开(公告)日：2010-08-05

申请号：PCT/IB2009055508

申请日：2009-12-04

Applicant: PFIZER VACCINES LLC ,  BROWN ALAN DANIEL ,  CHAMPION BRIAN ROBERT ,  CHRISTY CLARE ,  GERVAIS DAVID PAUL ,  JONES LYN HOWARD ,  KJERRSTROM ANNE MARIA KRISTINA ,  PRYDE DAVID CAMERON ,  ROBERTS LEE RICHARD ,  WYATT DAVID MICHAEL

Inventor： BROWN ALAN DANIEL ,  CHAMPION BRIAN ROBERT ,  CHRISTY CLARE ,  GERVAIS DAVID PAUL ,  JONES LYN HOWARD ,  KJERRSTROM ANNE MARIA KRISTINA ,  PRYDE DAVID CAMERON ,  ROBERTS LEE RICHARD ,  WYATT DAVID MICHAEL

IPC: A61K39/00 ,  A61P37/08 ,  C07K16/00

CPC classification number: A61K47/48338 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/627

Abstract: The present invention relates to the provision of immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract translation: 本发明涉及提供免疫原，其包含优选与免疫原性载体连接的抗原性IgE肽，用于预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在医药中的应用。