-
1.发明申请SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN 审中-公开作为NAV1.7的磺胺衍生物用于治疗疼痛的抑制剂
公开(公告)号：WO2012007883A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/053030
申请日：2011-07-07
Applicant: PFIZER LIMITED , BELL, Andrew, Simon , BROWN, Alan, Daniel , DE GROOT, Marcel, John , LEWTHWAITE, Russell, Andrew , MARSH, Ian, Roger , MILLAN, David, Simon , PEREZ PACHECO, Manuel , RAWSON, David, James , SCIAMMETTA, Nunzio , STORER, Robert, Ian , STUPPLE, Paul, Anthony , SWAIN, Nigel, Alan
Inventor： BELL, Andrew, Simon , BROWN, Alan, Daniel , DE GROOT, Marcel, John , LEWTHWAITE, Russell, Andrew , MARSH, Ian, Roger , MILLAN, David, Simon , PEREZ PACHECO, Manuel , RAWSON, David, James , SCIAMMETTA, Nunzio , STORER, Robert, Ian , STUPPLE, Paul, Anthony , SWAIN, Nigel, Alan
IPC: C07C311/00 , A61P29/00
CPC classification number: C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):or a pharmaceutically acceptable salt thereof, wherein Ar 1 , X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Ar1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
公开(公告)号：WO2012007868A2
公开(公告)日：2012-01-19
申请号：PCT/IB2011052940
申请日：2011-07-04
Applicant: PFIZER LTD , BROWN ALAN DANIEL , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
Inventor： BROWN ALAN DANIEL , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
IPC: C07C311/51
CPC classification number: C07C311/04 , A61K31/18 , A61K31/277 , A61K31/415 , A61K31/4245 , A61K31/451 , A61K31/495 , A61K31/50 , A61K45/06 , C07C311/51 , C07D211/22 , C07D231/12 , C07D237/08 , C07D241/04 , C07D271/06
Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中X，Ar1，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
3.发明申请N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS 审中-公开N-磺酰苯胺衍生物作为电压门式通道抑制剂有用
公开(公告)号：WO2012007861A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/052797
申请日：2011-06-24
Applicant: PFIZER LIMITED , BELL, Andrew, Simon , BROWN, Alan, Daniel , DE GROOT, Marcel, John , GAULIER, Steven, Matthieu , LEWTHWAITE, Russell, Andrew , MARSH, Ian, Roger , MILLAN, David, Simon , PEREZ PACHECO, Manuel , RAWSON, David, James , SCIAMMETTA, Nunzio , STORER, Robert, Ian , SWAIN, Nigel, Alan
Inventor： BELL, Andrew, Simon , BROWN, Alan, Daniel , DE GROOT, Marcel, John , GAULIER, Steven, Matthieu , LEWTHWAITE, Russell, Andrew , MARSH, Ian, Roger , MILLAN, David, Simon , PEREZ PACHECO, Manuel , RAWSON, David, James , SCIAMMETTA, Nunzio , STORER, Robert, Ian , SWAIN, Nigel, Alan
IPC: C07D213/63 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04 , C07B59/00 , A61K31/44
CPC classification number: C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
Abstract: The invention relates to sulfonamide derivatives, to their use i n medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het 1 , X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及磺酰胺衍生物，其药物用途，含有它们的组合物，其制备方法和用于此类方法的中间体。 更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Het1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
公开(公告)号：WO2010131147A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/051879
申请日：2010-04-29
Applicant: PFIZER LIMITED , ACIRO, Caroline , BAGAL, Sharanjeet Kaur , HARVEY, John Wilson , JONES, Lyn Howard , MOWBRAY, Charles Eric , OWEN, Robert McKenzie , SABNIS, Yogesh Anil , STORER, Robert Ian , YEAP, Siew Kuen
Inventor： ACIRO, Caroline , BAGAL, Sharanjeet Kaur , HARVEY, John Wilson , JONES, Lyn Howard , MOWBRAY, Charles Eric , OWEN, Robert McKenzie , SABNIS, Yogesh Anil , STORER, Robert Ian , YEAP, Siew Kuen
IPC: C07D213/74 , C07D237/22 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D513/04 , A61K31/443 , A61K31/4412 , A61K31/50 , A61K31/501 , A61P11/06
CPC classification number: C07D213/85 , C07D213/74 , C07D401/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds of the formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly inflammatory conditions.
Abstract translation: 本发明涉及式（I）化合物：因此可药用盐和所述化合物和盐的药学上可接受的溶剂合物，其中取代基在本文中定义; 含有这些化合物的组合物; 以及这些化合物在治疗各种疾病，特别是炎性病症中的用途。
-
公开(公告)号：WO2012095781A1
公开(公告)日：2012-07-19
申请号：PCT/IB2012/050102
申请日：2012-01-09
Applicant: PFIZER LIMITED , BELL, Andrew Simon , DE GROOT, Marcel John , LEWTHWAITE, Russell Andrew , MARSH, Ian Roger , SCIAMMETTA, Nunzio , STORER, Robert Ian , SWAIN, Nigel Alan
Inventor： BELL, Andrew Simon , DE GROOT, Marcel John , LEWTHWAITE, Russell Andrew , MARSH, Ian Roger , SCIAMMETTA, Nunzio , STORER, Robert Ian , SWAIN, Nigel Alan
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D451/04 , C07D487/08 , A61K31/4439 , A61P25/00
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D451/04 , C07D487/08
Abstract: The invention relates to acyl sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new acyl sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein U, V, W, X, Y, R° and R 1 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及酰基磺酰胺衍生物，其在医药中的用途，含有它们的组合物，其制备方法和用于此类方法的中间体。 更具体地，本发明涉及式（I）的新的酰基磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中U，V，W，X，Y，R 1和R 1如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
Patent Agency Ranking
公开(公告)号：WO2012004706A2
公开(公告)日：2012-01-12
申请号：PCT/IB2011/052840
申请日：2011-06-28
Applicant: PFIZER LIMITED , ICAGEN, INC. , MARKWORTH, Christopher John , MARRON, Brian Edward , RAWSON, David James , STORER, Robert Ian , SWAIN, Nigel Alan , WEST, Christopher William , ZHOU, Shulan
Inventor： MARKWORTH, Christopher John , MARRON, Brian Edward , RAWSON, David James , STORER, Robert Ian , SWAIN, Nigel Alan , WEST, Christopher William , ZHOU, Shulan
IPC: C07D417/12 , C07D417/14 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , A61P25/04
CPC classification number: C07D417/14 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D401/12 , C07D417/12
Abstract: The invention relates to new sulfonamide Nav1.7 inhibitors and pharmaceutically acceptable salts thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及新型磺酰胺Nav1.7抑制剂及其药学上可接受的盐在药物中的用途，含有它们的组合物，其制备方法和用于该方法的中间体。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
公开(公告)号：WO2010131146A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/051878
申请日：2010-04-29
Applicant: PFIZER LIMITED , ACIRO, Caroline , BAGAL, Sharanjeet Kaur , HARVEY, John Wilson , JONES, Lyn Howard , MOWBRAY, Charles Eric , OWEN, Robert McKenzie , SABNIS, Yogesh Anil , STORER, Robert Ian , YEAP, Siew Kuen
Inventor： ACIRO, Caroline , BAGAL, Sharanjeet Kaur , HARVEY, John Wilson , JONES, Lyn Howard , MOWBRAY, Charles Eric , OWEN, Robert McKenzie , SABNIS, Yogesh Anil , STORER, Robert Ian , YEAP, Siew Kuen
IPC: C07D401/12 , C07D417/12 , C07D513/04 , C07D213/74 , C07D213/85 , A61K31/50 , A61K31/501 , A61K31/443 , A61K31/4412 , A61P11/06
CPC classification number: C07D213/85 , C07D213/74 , C07D401/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds of the formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly inflammatory conditions.
-
8.发明申请PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS 审中-公开PYRIMIDO [4，5-D] AZEPINE衍生物作为5-HT2C激动剂
公开(公告)号：WO2008117169A1
公开(公告)日：2008-10-02
申请号：PCT/IB2008/000731
申请日：2008-03-14
Applicant: PFIZER LIMITED , ANDREWS, Mark, David , BLAGG, Julian , BRENNAN, Paul, Edward , FISH, Paul, Vincent , ROBERTS, Lee, Richard , STORER, Robert, Ian , WHITLOCK, Gavin, Alistair
Inventor： ANDREWS, Mark, David , BLAGG, Julian , BRENNAN, Paul, Edward , FISH, Paul, Vincent , ROBERTS, Lee, Richard , STORER, Robert, Ian , WHITLOCK, Gavin, Alistair
IPC: C07D487/04 , A61K31/55 , A61P15/00 , A61P25/00
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I): wherein R 1 , R 2 , R 3a , R 3b , R 3c , R 3d and R 100 are as defined in the specification. These compounds act as 5-HT 2C agonists.
Abstract translation: 本发明涉及式（I）的化合物：其中R 1，R 2，R 3a，R SUP， > 3b，R 3c，R 3d和R 100如说明书中所定义。 这些化合物起5-HT 2C激动剂的作用。
-
9.发明申请
公开(公告)号：WO2012004714A3
公开(公告)日：2012-03-01
申请号：PCT/IB2011052920
申请日：2011-07-01
Applicant: PFIZER LTD , ICAGEN INC , GREENER BENJAMIN SCOTT , MARRON BRIAN EDWARD , MILLAN DAVID SIMON , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
Inventor： GREENER BENJAMIN SCOTT , MARRON BRIAN EDWARD , MILLAN DAVID SIMON , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
IPC: C07D285/08 , A61K31/433 , A61K31/4427 , A61K31/501 , A61P25/04 , C07D285/135 , C07D401/12 , C07D417/12
CPC classification number: C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D285/08 , C07D401/12 , C07D417/12
Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y1, Y2, Z, R1, R2 and R3 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中X，Y1，Y2，Z，R1，R2和R3如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
公开(公告)号：WO2012007877A2
公开(公告)日：2012-01-19
申请号：PCT/IB2011/052998
申请日：2011-07-06
Applicant: PFIZER LIMITED , BELL, Andrew Simon , BROWN, Alan Daniel , LEWTHWAITE, Russell Andrew , PEREZ PACHECO, Manuel , RAWSON, David James , STORER, Robert Ian , SWAIN, Nigel Alan
Inventor： BELL, Andrew Simon , BROWN, Alan Daniel , LEWTHWAITE, Russell Andrew , PEREZ PACHECO, Manuel , RAWSON, David James , STORER, Robert Ian , SWAIN, Nigel Alan
IPC: C07D213/64
CPC classification number: A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Abstract translation: 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式10（I）的新型磺酰胺Nav1.7抑制剂：（I）或其药学上可接受的盐，其中Z，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.024 seconds)
