公开(公告)号：WO2008021124A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/017619

申请日：2007-08-07

Applicant: ABBOTT LABORATORIES ,  BURKE, Sandra E. ,  CROMACK, Keith R. ,  MACK, Matthew ,  TONER, John L.

Inventor： BURKE, Sandra E. ,  CROMACK, Keith R. ,  MACK, Matthew ,  TONER, John L.

IPC: A61K45/06 ,  A61K9/127 ,  A61L31/14 ,  A61L31/16 ,  A61P7/10

CPC classification number: A61K45/06 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/337 ,  A61K31/4745 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45

Abstract: The present invention provides for drug-delivery systems and compositions comprising zotarolimus and paclitaxel, or derivatives, prodrugs or salts thereof, as well as methods of treatment using such systems and compositions, wherein the drugs complement each other in effect and/or activity. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and drug-delivery systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 本发明提供了包含佐他莫司和紫杉醇或其衍生物，前药或盐的药物递送系统和组合物，以及使用此类系统和组合物的治疗方法，其中药物彼此互补 实际上和/或活动。 公开了包括支撑结构的医疗装置，所述支撑结构包括至少一种药学上可接受的载体或赋形剂，所述载体或赋形剂可以包括一种或多种治疗剂或物质，其中所述载体在其表面上包含至少一个涂层， 与治疗物质，例如药物一起使用。 适用于本发明的医疗装置的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和药物递送系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂， 分化抑制剂，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

公开(公告)号：WO2007047473A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/040155

申请日：2006-10-12

Applicant: ABBOTT LABORATORIES ,  TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew

Inventor： TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew

IPC: A61F2/82 ,  A61K31/4745 ,  A61K31/192

CPC classification number: A61L31/16 ,  A61K31/192 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/256 ,  A61L2300/416

Abstract: A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on its surface, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures suitable for use include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative, anti-platelet, anti-inflammatory and anti-thrombotic agents; cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

Abstract translation: 包含能够包含或承载药学上可接受的载体或赋形剂的支撑结构的医疗装置，所述载体或赋形剂可包含一种或多种治疗剂或物质，其中所述载体在其表面上包含涂层 以及包含治疗物质的涂层，例如药物。 适合使用的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可以与另一种药物联合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂和抗血栓形成剂的药物; 细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗血液流变药物，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

公开(公告)号：WO2007046935A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/031879

申请日：2006-08-15

Applicant: ABBOTT LABORATORIES ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew ,  TONER, John, L.

Inventor： BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew ,  TONER, John, L.

IPC: A61F2/82 ,  A61K31/4745 ,  A61K31/192

CPC classification number: A61L31/16 ,  A61K31/192 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/256 ,  A61L2300/416

Abstract: A system and compositions including zotarolimus and paditaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including antiproliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de- differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 公开了一种包含唑他罗莫司和帕台他汀的系统和组合物，以及递送方法，其中药物具有彼此补充的作用。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞分解抑制剂，抗 脂质体药物，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：WO2010093800A3

公开(公告)日：2011-05-12

申请号：PCT/US2010023910

申请日：2010-02-11

Applicant: ABBOTT LAB ,  TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  OEPEN RANDOLF VON

Inventor： TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  OEPEN RANDOLF VON

IPC: A61L29/16 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2/958 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606 ,  A61M25/10 ,  A61M2025/105

Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

Abstract translation: 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

公开(公告)号：WO2010093799A1

公开(公告)日：2010-08-19

申请号：PCT/US2010/023907

申请日：2010-02-11

Applicant: ABBOTT LABORATORIES ,  TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  OEPEN, Randolf, Von

Inventor： TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  OEPEN, Randolf, Von

IPC: A61L31/00 ,  A61L31/16 ,  A61K31/4745 ,  A61K9/00 ,  A61F2/82 ,  A61F2/06

CPC classification number: A61M25/104 ,  A61F2/958 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K31/4745 ,  A61K45/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1088

Abstract: Disclosed is a method for delivery of at least one therapeutic agent, in particular Zotarolimus (ABT 578) from an angioplasty balloon for treating vascular disease at a bifurcated vessel.. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces.

Abstract translation: 公开了一种用于从血管成形术球囊递送至少一种治疗剂，特别是佐他莫司（ABT578）的方法，用于在分叉血管处理血管疾病。本发明还涉及将有益药物加载到气囊上的方法，以及 该装置以及从单独表面递送试剂的方法。 本发明还涉及一种将多种有益剂装载到球囊表面上的方法。

公开(公告)号：WO2007111885A3

公开(公告)日：2007-12-06

申请号：PCT/US2007006916

申请日：2007-03-19

Applicant: ABBOTT LAB ,  CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

Inventor： CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

IPC: A61L31/16

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604

Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical including : a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

Abstract translation: 一种用于递送与医学相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数至少在统计学上显着至少 约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至 学科。 此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

公开(公告)号：WO2007047416A3

公开(公告)日：2007-11-08

申请号：PCT/US2006040027

申请日：2006-10-12

Applicant: ABBOTT LAB ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW ,  TONER JOHN L

Inventor： BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW ,  TONER JOHN L

IPC: A61F2/00 ,  A61K31/44

CPC classification number: A61L31/16 ,  A61K31/192 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/256 ,  A61L2300/416

Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 公开了包含紫杉醇和第二种药物如雷帕霉素，其类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或承载药学上可接受的载体或赋形剂的载体结构的医疗器械，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，并且包含治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂 ，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

公开(公告)号：WO2007032777A3

公开(公告)日：2007-10-25

申请号：PCT/US2006010700

申请日：2006-03-22

Applicant: ABBOTT LAB ,  TONER JOHN K ,  BURKE SANDRA E ,  CROMACK KEITH R

Inventor： TONER JOHN K ,  BURKE SANDRA E ,  CROMACK KEITH R

IPC: A61F2/06 ,  A61K31/56

CPC classification number: A61L31/16 ,  A61L2300/416 ,  A61L2300/602

Abstract: Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效且产生更少的炎症。 包含能够容纳或承载药学上可接受的载体或赋形剂的支撑结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体在其表面上包含涂层，并且所述涂层具有治疗性化合物， 包括例如药物。 医疗器械的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂 ，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

公开(公告)号：WO2007111925A2

公开(公告)日：2007-10-04

申请号：PCT/US2007/007090

申请日：2007-03-21

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R.

Inventor： TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R.

IPC: A61K31/00 ,  A61K9/00 ,  A61F2/06

CPC classification number: A61K9/0019 ,  A61F2/91 ,  A61K31/192 ,  A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/602

Abstract: Abstract of the Disclosure Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 公开了公开的系统和组合物，其包含与雷帕霉素和紫杉醇系统相比更安全，更有效并且产生更少炎症的唑他莫司。 医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的支持结构，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层， 包括例如药物。 适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎药，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其它药物的组合。

公开(公告)号：WO2006102359A3

公开(公告)日：2007-05-10

申请号：PCT/US2006010307

申请日：2006-03-22

Applicant: ABBOTT LAB ,  CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

Inventor： CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

IPC: A61L27/54

CPC classification number: A61L31/10 ,  A61F2/04 ,  A61F2/82 ,  A61F2002/044 ,  A61F2002/047 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/606

Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

Abstract translation: 一种用于递送与医疗装置相关联的亲脂性试剂的设备和系统，所述设备和系统包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的传递系数的量在统计学上显着为 其中所述第一亲脂试剂与所述医疗装置相关联，其中所述第一亲脂试剂/医疗装置放置在所述体腔附近，并且其中将治疗有效量的所述第一亲脂试剂递送至所述医疗装置内的期望区域 课程。 此外，本发明涉及一种用于改善受试者中的开放的方法，该方法涉及将医疗装置放置在体腔中以用于治疗和/或预防相邻疾病或维持体腔的开放。