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1.发明申请DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开可溶性荧光核素的设计和合成作为合成DNA序列的可逆终止子
公开(公告)号：WO2009051807A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011891
申请日：2008-10-17
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , CAO, Huanyan , LI, Zengmin , MENG, Qinglin , GUO, Jia , ZHANG, Shenglong , YU, Lin
Inventor： JU, Jingyue , CAO, Huanyan , LI, Zengmin , MENG, Qinglin , GUO, Jia , ZHANG, Shenglong , YU, Lin
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q2525/301 , C12Q2537/157
Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
Abstract translation: 本发明提供了具有附着于其上的可检测标记的脱氧核苷酸类似物的新型叠氮基连接体。
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2.发明申请DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS 审中-公开使用非荧光核苷酸可逆终止子和可清除标签的DNA序列修饰核酸酶终止子
公开(公告)号：WO2009054922A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/011913
申请日：2008-10-17
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KIM, Dae, H. , GUO, Jia , MENG, Qinglin , LI, Zengmin , CAO, Huanyan
Inventor： JU, Jingyue , KIM, Dae, H. , GUO, Jia , MENG, Qinglin , LI, Zengmin , CAO, Huanyan
CPC classification number: C12Q1/6874 , A61K31/70 , C07H19/04 , C12Q1/6869 , C12Q1/6876 , C12Q2523/107 , C12Q2523/319 , C12Q2535/101 , C12Q2535/113 , C12Q2563/107
Abstract: This invention provides a process for sequencing nucleic acids using 3' modified deoxynucleotide analogues or 3' modified deoxyinosine triphosphate analogues, and 3' modified dideoxynucleotide analogues having a detectable marker attached thereto.
Abstract translation: 本发明提供了使用3'修饰的脱氧核苷酸类似物或3'修饰的脱氧蛋白三磷酸酯类似物以及具有连接其上的可检测标记的3'修饰的双脱氧核苷酸类似物来测序核酸的方法。
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