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1.发明申请INCREASING THE PERFUSION SIGNAL TO NOISE RATIO (SNR) IN VELOCITY SELECTIVE ARTERIAL SPIN LABELING (VSASL) IN MAGNETIC RESONANCE IMAGING 审中-公开在磁共振成像中增加速度信号选择性旋转标记（VSASL）中的噪声信噪比（SNR）
公开(公告)号：WO2012145687A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/034537
申请日：2012-04-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GUO, Jia , WONG, Eric, C.
Inventor： GUO, Jia , WONG, Eric, C.
IPC: A61B5/055
CPC classification number: G01R33/4838 , G01R33/56366
Abstract: Techniques, systems computer program products are disclosed increasing tagging efficiency in velocity selective arterial spin labeling using multiple velocity selective saturation modules. In one aspect, a magnetic resonance imaging method for tagging arterial blood includes using two or more velocity selective saturation (VSS) modules to tag arterial blood. The tagged arterial blood is imaged.
Abstract translation: 公开了一种技术，系统计算机程序产品，其使用多个速度选择性饱和模块来增加速度选择性动脉自旋标记中的标签效率。 一方面，用于标记动脉血的磁共振成像方法包括使用两个或更多个速度选择饱和（VSS）模块来标记动脉血。 标记的动脉血液被成像。
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2.发明申请ANTIRETROVIRAL CYCLONUCLEOSIDE COMPOSITIONS AND METHODS AND ARTICLES OF MANUFACTURE THEREWITH 审中-公开抗狂犬病毒环糖核苷组合物及其制备方法和制备方法
公开(公告)号：WO2012100017A3
公开(公告)日：2012-09-27
申请号：PCT/US2012021817
申请日：2012-01-19
Applicant: LENTX INC , HAWLEY TODD W , WU YUNTAO , GUO JIA
Inventor： HAWLEY TODD W , WU YUNTAO , GUO JIA
IPC: A61K31/519 , A61K31/495 , A61K31/505 , A61K48/00 , A61P31/00 , A61P31/18
CPC classification number: A61K31/519 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/7072 , A61K45/06 , C12N2740/16011 , A61K2300/00
Abstract: Aspects of embodiments relate to methods of treating human immunodeficiency virus (HIV) infection. Further aspects of embodiments also relate to constellations of compositions for treating HIV infection. Still additional aspects of embodiments relate to a many methods of making compositions useful in the treatment of HIV infection.
Abstract translation: 实施例的各方面涉及治疗人免疫缺陷病毒（HIV）感染的方法。 实施方案的其他方面还涉及用于治疗HIV感染的组合物的星座。 实施方案的其他方面涉及制备用于治疗HIV感染的组合物的许多方法。
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3.发明申请
公开(公告)号：WO2012145765A3
公开(公告)日：2013-01-24
申请号：PCT/US2012034720
申请日：2012-04-23
Applicant: UNIV CALIFORNIA , WONG ERIC C , GUO JIA
Inventor： WONG ERIC C , GUO JIA
IPC: A61B5/055
CPC classification number: A61B5/055 , A61B5/0042
Abstract: Techniques, systems computer program products are disclosed for mapping of vascular perfusion territories by applying a train of pseudo-continuous radio frequency tagging pulses to modulate a first magnetization of one or more blood vessels that supply blood to one or more vascular perfusion territories, applying an encoding scheme using unipolar transverse gradient pulses to modulate a second magnetization of blood vessels of the vascular perfusion territories, obtaining efficiency for each blood vessel based on the applied encoding scheme and separating the vascular perfusion territories by using the obtained tagging efficiency in a decoding process.
Abstract translation: 技术，系统计算机程序产品被公开用于通过应用一连串的伪连续射频标签脉冲来映射血管灌注区域，以调制向一个或多个血管灌注区域供应血液的一个或多个血管的第一磁化， 编码方案，使用单极横向梯度脉冲来调制血管灌注区域的血管的第二磁化，基于所应用的编码方案获得每个血管的效率，并通过在解码过程中使用获得的标记效率来分离血管灌注区域。
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4.发明申请INCREASING THE PERFUSION SIGNAL TO NOISE RATIO (SNR) IN VELOCITY SELECTIVE ARTERIAL SPIN LABELING (VSASL) IN MAGNETIC RESONANCE IMAGING 审中-公开在磁共振成像中增加速度信号选择性旋转标记（VSASL）中的噪声信噪比（SNR）
公开(公告)号：WO2012145687A3
公开(公告)日：2013-02-14
申请号：PCT/US2012034537
申请日：2012-04-20
Applicant: UNIV CALIFORNIA , GUO JIA , WONG ERIC C
Inventor： GUO JIA , WONG ERIC C
IPC: A61B5/055
CPC classification number: G01R33/4838 , G01R33/56366
Abstract: Techniques, systems computer program products are disclosed increasing tagging efficiency in velocity selective arterial spin labeling using multiple velocity selective saturation modules. In one aspect, a magnetic resonance imaging method for tagging arterial blood includes using two or more velocity selective saturation (VSS) modules to tag arterial blood. The tagged arterial blood is imaged.
Abstract translation: 公开了一种技术，系统计算机程序产品，其使用多个速度选择性饱和模块来增加速度选择性动脉自旋标记中的标签效率。 一方面，用于标记动脉血的磁共振成像方法包括使用两个或更多个速度选择饱和（VSS）模块来标记动脉血。 标记的动脉血液被成像。
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公开(公告)号：WO2012145765A9
公开(公告)日：2012-10-26
申请号：PCT/US2012/034720
申请日：2012-04-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WONG, Eric, C. , GUO, Jia
Inventor： WONG, Eric, C. , GUO, Jia
IPC: A61B5/055
Abstract: Techniques, systems computer program products are disclosed for mapping of vascular perfusion territories by applying a train of pseudo-continuous radio frequency tagging pulses to modulate a first magnetization of one or more blood vessels that supply blood to one or more vascular perfusion territories, applying an encoding scheme using unipolar transverse gradient pulses to modulate a second magnetization of blood vessels of the vascular perfusion territories, obtaining efficiency for each blood vessel based on the applied encoding scheme and separating the vascular perfusion territories by using the obtained tagging efficiency in a decoding process.
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Patent Agency Ranking
公开(公告)号：WO2010051550A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/063016
申请日：2009-11-02
Applicant: UNIVERSITY OF ROCHESTER , GUO, Jia , LIN, Xin , GEORAS, Steve , SIME, Patricia
Inventor： GUO, Jia , LIN, Xin , GEORAS, Steve , SIME, Patricia
IPC: C12Q1/68
CPC classification number: G01N33/6875 , A61K31/7088 , A61K31/713 , A61K38/44 , A61K39/395 , A61K39/39533 , A61K39/39583 , A61K45/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y114/11027 , G01N2800/10 , G01N2800/52
Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.
Abstract translation: 本发明涉及在哺乳动物受试者中诊断和治疗纤维化病症的方法。 这些方法包括测量组蛋白-3的赖氨酸残基27处的三甲基化水平和/或测量EZH2或YY-1的表达水平。 还公开了可用于治疗纤维化或纤维化病症的药剂。
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7.发明申请DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS 审中-公开使用非荧光核苷酸可逆终止子和可清除标签的DNA序列修饰核酸酶终止子
公开(公告)号：WO2009054922A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/011913
申请日：2008-10-17
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KIM, Dae, H. , GUO, Jia , MENG, Qinglin , LI, Zengmin , CAO, Huanyan
Inventor： JU, Jingyue , KIM, Dae, H. , GUO, Jia , MENG, Qinglin , LI, Zengmin , CAO, Huanyan
CPC classification number: C12Q1/6874 , A61K31/70 , C07H19/04 , C12Q1/6869 , C12Q1/6876 , C12Q2523/107 , C12Q2523/319 , C12Q2535/101 , C12Q2535/113 , C12Q2563/107
Abstract: This invention provides a process for sequencing nucleic acids using 3' modified deoxynucleotide analogues or 3' modified deoxyinosine triphosphate analogues, and 3' modified dideoxynucleotide analogues having a detectable marker attached thereto.
Abstract translation: 本发明提供了使用3'修饰的脱氧核苷酸类似物或3'修饰的脱氧蛋白三磷酸酯类似物以及具有连接其上的可检测标记的3'修饰的双脱氧核苷酸类似物来测序核酸的方法。
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8.发明申请
公开(公告)号：WO2012145765A2
公开(公告)日：2012-10-26
申请号：PCT/US2012034720
申请日：2012-04-23
Applicant: UNIV CALIFORNIA , WONG ERIC C , GUO JIA
Inventor： WONG ERIC C , GUO JIA
IPC: A61B5/055
CPC classification number: A61B5/055 , A61B5/0042
Abstract: Techniques, systems computer program products are disclosed for mapping of vascular perfusion territories by applying a train of pseudo-continuous radio frequency tagging pulses to modulate a first magnetization of one or more blood vessels that supply blood to one or more vascular perfusion territories, applying an encoding scheme using unipolar transverse gradient pulses to modulate a second magnetization of blood vessels of the vascular perfusion territories, obtaining efficiency for each blood vessel based on the applied encoding scheme and separating the vascular perfusion territories by using the obtained tagging efficiency in a decoding process.
Abstract translation: 技术，系统计算机程序产品被公开用于通过应用一连串的伪连续射频标签脉冲来映射血管灌注区域，以调制向一个或多个血管灌注区域供应血液的一个或多个血管的第一磁化， 编码方案，使用单极横向梯度脉冲来调制血管灌注区域的血管的第二磁化，基于所应用的编码方案获得每个血管的效率，并通过在解码过程中使用获得的标记效率来分离血管灌注区域。
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9.发明申请ANTIRETROVIRAL CYCLONUCLEOSIDE COMPOSITIONS AND METHODS AND ARTICLES OF MANUFACTURE THEREWITH 审中-公开抗生素环孢素组合物及其制备方法及其制备方法
公开(公告)号：WO2012100017A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021817
申请日：2012-01-19
Applicant: LENTX, INC. , HAWLEY, Todd, W. , WU, Yuntao , GUO, Jia
Inventor： HAWLEY, Todd, W. , WU, Yuntao , GUO, Jia
IPC: A61K31/519 , A61K31/505 , A61K31/495 , A61K48/00 , A61P31/18 , A61P31/00
CPC classification number: A61K31/519 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/7072 , A61K45/06 , C12N2740/16011 , A61K2300/00
Abstract: Aspects of embodiments relate to methods of treating human immunodeficiency virus (HIV) infection. Further aspects of embodiments also relate to constellations of compositions for treating HIV infection. Still additional aspects of embodiments relate to a many methods of making compositions useful in the treatment of HIV infection.
Abstract translation: 实施方案涉及治疗人类免疫缺陷病毒（HIV）感染的方法。 实施方案的其它方面还涉及用于治疗HIV感染的组合物的星座。 实施方案的另外的方面涉及制备可用于治疗HIV感染的组合物的许多方法。
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10.发明申请DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开可溶性荧光核素的设计和合成作为合成DNA序列的可逆终止子
公开(公告)号：WO2009051807A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011891
申请日：2008-10-17
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , CAO, Huanyan , LI, Zengmin , MENG, Qinglin , GUO, Jia , ZHANG, Shenglong , YU, Lin
Inventor： JU, Jingyue , CAO, Huanyan , LI, Zengmin , MENG, Qinglin , GUO, Jia , ZHANG, Shenglong , YU, Lin
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q2525/301 , C12Q2537/157
Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
Abstract translation: 本发明提供了具有附着于其上的可检测标记的脱氧核苷酸类似物的新型叠氮基连接体。
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