公开(公告)号：WO2008097819A3

公开(公告)日：2008-11-13

申请号：PCT/US2008052735

申请日：2008-02-01

Applicant: SMITHKLINE BEECHAM CORP ,  COFFIN AARON ,  EVINDAR GHOTAS ,  YAO GANG

Inventor： COFFIN AARON ,  EVINDAR GHOTAS ,  YAO GANG

IPC: C07D207/12 ,  C07D207/16

CPC classification number: A61K31/403 ,  C07D207/12 ,  C07D207/16 ,  C07F9/5532 ,  C07F9/568 ,  C07F9/5722 ,  C07F9/592 ,  C07F9/65583

Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

Abstract translation: 本发明提供了式I化合物，其制备方法及其作为药物活性免疫抑制剂用于治疗自身免疫病症，器官移植排斥反应，与激活的免疫系统相关的病症以及由淋巴细胞减少症或S1P受体调节的其他病症的用途。

公开(公告)号：WO2008016692A3

公开(公告)日：2008-03-20

申请号：PCT/US2007017282

申请日：2007-08-01

Applicant: PRAECIS PHARM INC ,  EVINDAR GHOTAS ,  DENG HONGFENG ,  BERNIER SYLVIE ,  YAO GANG ,  COFFIN AARON ,  YANG HONGFANG

Inventor： EVINDAR GHOTAS ,  DENG HONGFENG ,  BERNIER SYLVIE ,  YAO GANG ,  COFFIN AARON ,  YANG HONGFANG

IPC: C07D213/38 ,  A61K31/425 ,  A61K31/433 ,  A61K31/44 ,  A61K31/505 ,  A61P37/00 ,  C07D261/08 ,  C07D271/10 ,  C07D277/28 ,  C07D285/12 ,  C07D417/12 ,  C07F9/6539

CPC classification number: C07D277/28 ,  C07D213/38 ,  C07D261/08 ,  C07D271/10 ,  C07D285/12 ,  C07D417/12 ,  C07F9/582 ,  C07F9/65033 ,  C07F9/65122 ,  C07F9/653 ,  C07F9/65312 ,  C07F9/65318 ,  C07F9/6539 ,  C07F9/65395

Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

Abstract translation: 本发明提供式I化合物及其制备方法及其作为药物活性免疫抑制剂用于治疗自身免疫疾病，器官移植排斥，与活化的免疫系统相关的病症以及由淋巴细胞减少或S1P受体调节的其它病症的用途。

公开(公告)号：WO2008016674A1

公开(公告)日：2008-02-07

申请号：PCT/US2007/017243

申请日：2007-08-01

Applicant: PRAECIS PHARMACEUTICALS INCORPORATED ,  DENG, Hongfeng ,  EVINDAR, Ghotas ,  BERNIER, Sylvie ,  YAO, Gang ,  COFFIN, Aaron ,  YANG, Hongfang ,  ACHARYA, Raksha, A.

Inventor： DENG, Hongfeng ,  EVINDAR, Ghotas ,  BERNIER, Sylvie ,  YAO, Gang ,  COFFIN, Aaron ,  YANG, Hongfang ,  ACHARYA, Raksha, A.

IPC: C07D277/28 ,  C07D285/12 ,  C07F9/09 ,  A61K31/426 ,  A61K31/433 ,  A61K31/661 ,  A61P25/28

CPC classification number: C07D285/12 ,  C07D277/28 ,  C07F9/6539 ,  C07F9/65395

Abstract: The invention provides compounds of formula I and formula II, their preparation, a their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

Abstract translation: 本发明提供式I和式II化合物及其制备，它们作为药物活性免疫抑制剂用于治疗自身免疫性疾病，器官移植排斥，与活化的免疫系统相关的病症，以及由淋巴细胞减少或其它调节的其它疾病 S1P受体。

公开(公告)号：WO2008016692A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/017282

申请日：2007-08-01

Applicant: PRAECIS PHARMACEUTICALS INCORPORATED ,  EVINDAR, Ghotas ,  DENG, Hongfeng ,  BERNIER, Sylvie ,  YAO, Gang ,  COFFIN, Aaron ,  YANG, Hongfang

Inventor： EVINDAR, Ghotas ,  DENG, Hongfeng ,  BERNIER, Sylvie ,  YAO, Gang ,  COFFIN, Aaron ,  YANG, Hongfang

IPC: C07D213/38 ,  C07D239/26 ,  C07D261/08 ,  C07D271/10 ,  C07D277/28 ,  C07D285/12 ,  C07D417/12 ,  C07F9/6539 ,  A61K31/425 ,  A61K31/433 ,  A61K31/44 ,  A61K31/505 ,  A61P37/00

CPC classification number: C07D277/28 ,  C07D213/38 ,  C07D261/08 ,  C07D271/10 ,  C07D285/12 ,  C07D417/12 ,  C07F9/582 ,  C07F9/65033 ,  C07F9/65122 ,  C07F9/653 ,  C07F9/65312 ,  C07F9/65318 ,  C07F9/6539 ,  C07F9/65395

Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

公开(公告)号：WO2021243001A1

公开(公告)日：2021-12-02

申请号：PCT/US2021/034488

申请日：2021-05-27

Applicant: CONSTELLATION PHARMACEUTICALS, INC. ,  COFFIN, Aaron ,  LEVELL, Julian, R. ,  MEDIKONDA, Aravind, Prasad

Inventor： ZABLOCKI, Mary-Margaret ,  TAVERAS, Kennedy ,  WILSON, Jonathan, E.

IPC: C07D213/40 ,  C07D405/12 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D231/12 ,  C07D271/06 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/44

Abstract: Provided are compounds of Formula (I): (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.

公开(公告)号：WO2008097819A2

公开(公告)日：2008-08-14

申请号：PCT/US2008/052735

申请日：2008-02-01

Applicant: SMITHKLINE BEECHAM CORPORATION ,  COFFIN, Aaron ,  EVINDAR, Ghotas ,  YAO, Gang

Inventor： COFFIN, Aaron ,  EVINDAR, Ghotas ,  YAO, Gang

IPC: A61K31/403

CPC classification number: A61K31/403 ,  C07D207/12 ,  C07D207/16 ,  C07F9/5532 ,  C07F9/568 ,  C07F9/5722 ,  C07F9/592 ,  C07F9/65583

Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

Abstract translation: 本发明提供了式I化合物，其制备以及它们作为药物活性免疫抑制剂用于治疗自身免疫病症，器官移植排斥，与激活的免疫系统相关的病症以及其他病症的用途 受淋巴细胞减少或S1P受体调节。