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    SYSTEMS AND METHODS FOR THERMAL CYCLING CROSS-REFERENCE
    3.
    发明申请
    SYSTEMS AND METHODS FOR THERMAL CYCLING CROSS-REFERENCE 审中-公开
    用于热循环交叉参考的系统和方法

    公开(公告)号：WO2015176674A1

    公开(公告)日：2015-11-26

    申请号：PCT/CN2015/079499

    申请日：2015-05-21

    Applicant: COYOTE BIOSCIENCE CO., LTD.

    Inventor： LI, Xiang ,  LI, Chen ,  HAN, Yuguang ,  FENG, Huiying

    IPC: C12M1/38

    CPC classification number: B01L7/52 ,  B01L2200/18 ,  B01L2300/0654

    Abstract: Systems and methods for low voltage power thermal cycling are provided. A nucleic acid amplification device (500) comprising a thermal cycler (510) and a detector (520) is capable of operating using a low operating voltage, such as 12 V. The nucleic acid amplification device (500) may include a portable energy storage device (530) that can provide operating power. The nucleic acid amplification device (500) may be powered by a vehicle (1120) and deployed to remote locations.

    Abstract translation: 提供了低压功率热循环的系统和方法。 包括热循环仪（510）和检测器（520）的核酸扩增装置（500）能够使用诸如12V的低工作电压进行操作。核酸扩增装置（500）可以包括便携式能量储存器 设备（530），其可以提供操作功率。 核酸扩增装置（500）可以由车辆（1120）供电并且部署到远程位置。

    DETECTION OF NUCLEIC ACID MOLECULES USING NANOPORES AND TAGS
    6.
    发明申请
    DETECTION OF NUCLEIC ACID MOLECULES USING NANOPORES AND TAGS 审中-公开
    使用纳米和标签检测核酸分子

    公开(公告)号：WO2016106689A1

    公开(公告)日：2016-07-07

    申请号：PCT/CN2014/095907

    申请日：2014-12-31

    Applicant: COYOTE BIOSCIENCE CO., LTD.

    Inventor： LI, Xiang ,  YANG, Kun

    IPC: G01N27/406 ,  G01N27/414 ,  G01N27/417 ,  C12Q1/68

    CPC classification number: C12Q1/6869 ,  G01N33/48721 ,  C12Q2525/204 ,  C12Q2531/113 ,  C12Q2531/143 ,  C12Q2535/122 ,  C12Q2563/107 ,  C12Q2563/119 ,  C12Q2565/631 ,  C12Q2563/116 ,  C12Q2563/179

    Abstract: The present disclosure provides methods and systems for assaying the presence of a target nucleic acid molecule in a sample having or suspected of having the target nucleic acid molecule. A method of assaying the presence of the target nucleic acid molecule comprises facilitating the flow of the sample through at least one nanopore in a membrane disposed adjacent or in proximity to an electrode that detects a current or current change upon movement of the target nucleic acid molecule through the nanopore. The target nucleic acid molecule， if present， can have a tag coupled at a terminal end thereof that increases a dwell time of the target nucleic acid molecule in the nanopore. The presence of the target nucleic acid molecule in the sample is assayed based on an increase in dwell time of the target nucleic acid molecule from measurements of the current or current change.

    Abstract translation: 本公开提供了用于测定具有或怀疑具有靶核酸分子的样品中靶核酸分子的存在的方法和系统。 测定靶核酸分子的存在的方法包括促进样品流过设置在电极附近或附近的膜中的至少一个纳米孔，其检测靶核酸分子移动时的当前或当前变化 通过纳米孔。 靶核酸分子（如果存在）可以具有在其末端偶联的标签，其增加靶核酸分子在纳米孔中的停留时间。 基于当前或当前变化的测量，靶核酸分子的停留时间的增加来测定样品中靶核酸分子的存在。

    APPARATUS AND METHODS FOR CONDUCTING CHEMICAL REACTIONS
    9.
    发明申请
    APPARATUS AND METHODS FOR CONDUCTING CHEMICAL REACTIONS 审中-公开
    用于引导化学反应的装置和方法

    公开(公告)号：WO2016106717A1

    公开(公告)日：2016-07-07

    申请号：PCT/CN2014/095987

    申请日：2014-12-31

    Applicant: COYOTE BIOSCIENCE CO., LTD.

    Inventor： LI, Xiang ,  MU, Xiaobing ,  LI, Chen ,  FENG, Huiying

    IPC: C12M1/38

    CPC classification number: B01L7/52 ,  B01L9/523 ,  B01L2200/026 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/027 ,  B01L2300/0829

    Abstract: An apparatus and a method for conducting a chemical reaction in a sample contained in a sample holder, said reaction requiring cycling between at least two target temperature levels. The method comprises: (a) placing said sample holder in thermal contact with a first overshooting thermal zone to achieve a first target temperature level; (b) placing said sample holder in thermal contact with a second overshooting thermal zone to achieve a second target temperature level; and optionally repeating steps (a) and (b); wherein said first overshooting thermal zone is at a higher temperature than said first target temperature level, and said second overshooting thermal zone is at a lower temperature than said second target temperature level. One or more rotating arms is programmed to place said sample holder in thermal contact with one or more of said thermal zones. Said reaction is a polymerase chain reaction (PCR).

    Abstract translation: 用于在包含在样品架中的样品中进行化学反应的装置和方法，所述反应需要在至少两个目标温度水平之间循环。 该方法包括：（a）将所述样品保持器与第一过冲热区热接触以达到第一目标温度水平; （b）将所述样品保持器与第二过冲热区热接触以达到第二目标温度水平; 并且可选地重复步骤（a）和（b）; 其中所述第一过冲热区处于比所述第一目标温度水平更高的温度，并且所述第二过冲热区处于比所述第二目标温度水平低的温度。 编程一个或多个旋转臂以使所述样品保持器与一个或多个所述热区热接触。 所述反应是聚合酶链反应（PCR）。

    ELECTROPHORESIS APPARATUS
    10.
    发明申请
    ELECTROPHORESIS APPARATUS 审中-公开
    电泳装置

    公开(公告)号：WO2016019482A1

    公开(公告)日：2016-02-11

    申请号：PCT/CN2014/000752

    申请日：2014-08-06

    Applicant: COYOTE BIOSCIENCE CO., LTD.

    Inventor： YU, Fei ,  LI, Xiang ,  MU, Xiaobing

    IPC: G01N27/447

    CPC classification number: G01N27/44713 ,  G01N27/44704 ,  G01N27/44747

    Abstract: An apparatus for performing electrophoresis on a sample comprises: a frame comprising a bottom plate and a plurality of side walls; an electrophoresis gel retained in said frame and an electrical component that produces an electric field through the electrophoresis gel to cause at least a portion of the sample to migrate through the gel, wherein the electrical component is powered by no more than 12 V. A method for performing electrophoresis is also disclosed. The apparatus is suited for portability, low power consumption, integrated operation, and remote monitoring.

    Abstract translation: 用于对样品进行电泳的装置包括：框架，包括底板和多个侧壁; 保留在所述框架中的电泳凝胶和通过电泳凝胶产生电场以使至少一部分样品迁移穿过凝胶的电气部件，其中电气部件由不超过12V的电力供电。一种方法 用于进行电泳也被公开。 该设备适用于便携性，低功耗，集成操作和远程监控。

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