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公开(公告)号：WO2006091470A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005487
申请日：2006-02-15
Applicant: CODEXIS, INC. , GAVRILOVIC, Vesna , DAVIS, S., Christopher , FOX, Richard, John , HUISMAN, Gjalt, W. , MUNDORFF, Emily, C. , NEWMAN, Lisa, M. , FOX, Richard
Inventor： DAVIS, S., Christopher , FOX, Richard, John , HUISMAN, Gjalt, W. , MUNDORFF, Emily, C. , NEWMAN, Lisa, M. , FOX, Richard
Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Abstract translation: 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：WO2002029079A3
公开(公告)日：2002-04-11
申请号：PCT/US2001/031273
申请日：2001-10-04
Applicant: MAXYGEN, INC. , RAMER, Sandra, W. , HUISMAN, Gjalt , MILLIS, Jim , SHELDON, Roger , DEL CARDAYRE, Stephen , TOBIN, Matthew , COX, Anthony , DAVIS, S., Christopher
Inventor： RAMER, Sandra, W. , HUISMAN, Gjalt , MILLIS, Jim , SHELDON, Roger , DEL CARDAYRE, Stephen , TOBIN, Matthew , COX, Anthony , DAVIS, S., Christopher
IPC: C12P13/00
Abstract: Enantioselective or enantiospecific nitrilases and nitrile hydratases are used to produce R or S enantiomers of amides, and carboxylic acids. R-amino acids and S-amino acids are produced using such enantioselective enzymes. In addition, methods of producing and screening enantioselective nitrilases and nitrile hydratases are provided.
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公开(公告)号：WO0229079A2
公开(公告)日：2002-04-11
申请号：PCT/US0131273
申请日：2001-10-04
Applicant: MAXYGEN INC , RAMER SANDRA W , HUISMAN GJALT , MILLIS JIM , SHELDON ROGER , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , COX ANTHONY , DAVIS S CHRISTOPHER
Inventor： RAMER SANDRA W , HUISMAN GJALT , MILLIS JIM , SHELDON ROGER , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , COX ANTHONY , DAVIS S CHRISTOPHER
CPC classification number: C12P13/04 , C12N9/88 , C12P13/02 , C12P41/006
Abstract: Enantioselective or enantiospecific nitrilases and nitrile hydratases are used to produce R or S enantiomers of amides, and carboxylic acids. R-amino acids and S-amino acids are produced using such enantioselective enzymes. In addition, methods of producing and screening enantioselective nitrilases and nitrile hydratases are provided.
Abstract translation: 对映选择性或对映体特异性腈水解酶和腈水合酶用于产生酰胺和羧酸的R或S对映异构体。 使用这种对映选择性酶产生R-氨基酸和S-氨基酸。 另外，提供了生产和筛选对映选择性腈水解酶和腈水合酶的方法。
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公开(公告)号：WO2006091470A8
公开(公告)日：2012-11-29
申请号：PCT/US2006005487
申请日：2006-02-15
Applicant: CODEXIS INC , DAVIS S CHRISTOPHER , FOX RICHARD JOHN , HUISMAN GJALT W , GAVRILOVIC VESNA , MUNDORFF EMILY C , NEWMAN LISA M , FOX RICHARD
Inventor： DAVIS S CHRISTOPHER , FOX RICHARD JOHN , HUISMAN GJALT W , MUNDORFF EMILY C , NEWMAN LISA M , FOX RICHARD
IPC: C12N9/88 , C07H21/04 , C12N1/21 , C12N9/04 , C12N9/14 , C12N15/60 , C12N15/74 , C12P21/06 , C12Q1/68
Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Abstract translation: 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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5.发明申请
公开(公告)号：WO0210750A2
公开(公告)日：2002-02-07
申请号：PCT/US0124182
申请日：2001-07-31
Applicant: MAXYGEN INC , MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
Inventor： MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
CPC classification number: C12N9/1252 , C12N15/1055 , C12P19/34 , C12Q1/6888
Abstract: Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.
Abstract translation: 提供使用生物聚合物阵列感测测试刺激的方法。 提供了生物聚合物，核酸变体和由核酸变体编码的表达产物的文库。 提供了可重用库数组及其使用方法。
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Patent Agency Ranking
公开(公告)号：WO2003075129A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006551
申请日：2003-03-03
Applicant: MAXYGEN, INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
Inventor： GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
IPC: G01N33/48
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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公开(公告)号：WO2006091470A3
公开(公告)日：2008-11-27
申请号：PCT/US2006005487
申请日：2006-02-15
Applicant: CODEXIS INC , GAVRILOVIC VESNA , DAVIS S CHRISTOPHER , FOX RICHARD JOHN , HUISMAN GJALT W , MUNDORFF EMILY C , NEWMAN LISA M , FOX RICHARD
Inventor： DAVIS S CHRISTOPHER , FOX RICHARD JOHN , HUISMAN GJALT W , MUNDORFF EMILY C , NEWMAN LISA M , FOX RICHARD
IPC: C12N9/88 , C07H21/04 , C12N1/21 , C12N9/04 , C12N9/14 , C12N15/60 , C12N15/74 , C12P21/06 , C12Q1/68
Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Abstract translation: 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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8.发明申请ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES 审中-公开用于生产4-取代的3-羟基丁酸衍生物的酶法
公开(公告)号：WO2004015132A3
公开(公告)日：2005-04-14
申请号：PCT/US0325263
申请日：2003-08-11
Applicant: CODEXIS INC , DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
Inventor： DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
CPC classification number: C12P13/002 , C12N9/14 , C12P13/02
Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.
Abstract translation: 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物制备4-卤代-3-羟基丁酸衍生物的方法和组合物。
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9.发明申请ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES AND VICINAL CYANO, HYDROXY SUBSTITUTED CARBOXYLIC ACID ESTERS 审中-公开用于生产4-取代的3-羟基丁酸衍生物和邻氰基的羟基取代的羧酸酯的酶法
公开(公告)号：WO2005018579A2
公开(公告)日：2005-03-03
申请号：PCT/US2004004819
申请日：2004-02-18
Applicant: CODEXIS INC , DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
Inventor： DAVIS S CHRISTOPHER , GRATE JOHN H , GRAY DAVID R , GRUBER JOHN M , HUISMAN GJALT W , MA STEVEN K , NEWMAN LISA M , SHELDON ROGER , WANG LI A
CPC classification number: C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
Abstract: The present invention provides methods and composition for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3ketobutyric acid derivatives. The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
Abstract translation: 本发明提供了通过卤代醇脱卤素酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明进一步提供了通过酮还原酶催化的4-卤代-3-酮丁酸衍生物的转化制备4-卤代-3-羟基丁酸衍生物的方法和组合物。 本发明还提供了用于制备邻位氰基，羟基取代的羧酸酯的方法和组合物。
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10.发明申请ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES 审中-公开用于生产4-取代的3-羟基丁酸衍生物的酶法
公开(公告)号：WO2004015132A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025263
申请日：2003-08-11
Applicant: CODEXIS, INC. , DAVIS, S., Christopher , GRATE, John, H. , GRAY, David, R. , GRUBER, John, M. , HUISMAN, Gjalt, W. , MA, Steven, K. , NEWMAN, Lisa, M. , SHELDON, Roger , WANG, Li, A.
Inventor： DAVIS, S., Christopher , GRATE, John, H. , GRAY, David, R. , GRUBER, John, M. , HUISMAN, Gjalt, W. , MA, Steven, K. , NEWMAN, Lisa, M. , SHELDON, Roger , WANG, Li, A.
IPC: C12Q
CPC classification number: C12P13/002 , C12N9/14 , C12P13/02
Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.
Abstract translation: 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物制备4-卤代-3-羟基丁酸衍生物的方法和组合物。
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