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公开(公告)号：WO2012087966A3
公开(公告)日：2013-01-17
申请号：PCT/US2011065902
申请日：2011-12-19
Applicant: DU PONT , DICOSIMO ROBERT , CUNNINGHAM SCOTT D , FAHNESTOCK STEPHEN R , GRUBER TANJA MARIA , PAYNE MARK S , ROUVIERE PIERRE E , SOLOMON LINDA JANE , WANG HONG
Inventor： DICOSIMO ROBERT , CUNNINGHAM SCOTT D , FAHNESTOCK STEPHEN R , GRUBER TANJA MARIA , PAYNE MARK S , ROUVIERE PIERRE E , SOLOMON LINDA JANE , WANG HONG
CPC classification number: C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
Abstract: Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
Abstract translation: 本文公开了将酶过氧酸生产靶向靶表面的组合物和方法。 由靶向的水解酶产生的过酸有益剂可用于各种应用，例如漂白，增白，消毒，脱色，除臭及其组合。 特别地，包含过水解酶和至少一种对靶表面（不包括体表和口腔护理表面）具有亲和力的肽组分的融合蛋白与合适的底物和过氧源组合使用以在 靠近目标材料的表面。 在优选的方面，目标表面是纤维素材料。
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2.发明申请IN SITU EXPRESSION OF LIPASE FOR ENZYMATIC PRODUCTION OF ALCOHOL ESTERS DURING FERMENTATION 审中-公开在发酵期间用于生产酒精饮料的脂肪酶的实际表达
公开(公告)号：WO2012173658A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/000288
申请日：2012-06-15
Applicant: BUTAMAX (TM) ADVANCED BIOFUELS LLC , DICOSIMO, Robert , KRUCKEBERG, Arthur, Leo , VAN AKEN, Thomas, Edwin
Inventor： DICOSIMO, Robert , KRUCKEBERG, Arthur, Leo , VAN AKEN, Thomas, Edwin
Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.
Abstract translation: 本文公开了在发酵期间通过提供产生醇的微生物来生产醇酯的方法，其进一步包含编码具有脂肪酶活性的多肽的工程化多核苷酸。
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公开(公告)号：WO2012087968A3
公开(公告)日：2012-11-22
申请号：PCT/US2011065908
申请日：2011-12-19
Applicant: DU PONT , CHISHOLM DEXTER A , CUI XIUMIN , CUNNINGHAM SCOTT D , DICOSIMO ROBERT , FAHNESTOCK STEPHEN R , GRUBER TANJA MARIA , HUANG YONGQING , JIANG XUEPING , PARTHASARATHY ANJU , PAYNE MARK S , ROUVIERE PIERRE E , WANG HONG
Inventor： CHISHOLM DEXTER A , CUI XIUMIN , CUNNINGHAM SCOTT D , DICOSIMO ROBERT , FAHNESTOCK STEPHEN R , GRUBER TANJA MARIA , HUANG YONGQING , JIANG XUEPING , PARTHASARATHY ANJU , PAYNE MARK S , ROUVIERE PIERRE E , WANG HONG
CPC classification number: A61K8/66 , A61K8/22 , A61K8/38 , A61K8/64 , A61K38/46 , A61K38/465 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61Q15/00 , A61Q19/00 , A61Q19/02
Abstract: Disclosed herein are compositions and methods to treat hair with a peracid-based benefit agent. The peracid benefit agent can be used for hair bleaching, hair weakening, hair removal, hair waiving, hair straightening or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a hair-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the hair surface.
Abstract translation: 本文公开了用基于过酸的有益剂处理头发的组合物和方法。 过酸有益剂可以用于头发漂白，头发弱化，脱毛，免除头发，拉直头发或其任何组合。 过酸可以使用具有过水解活性的酶（过水解酶）在过氧源存在下从羧酸酯底物酶促产生。 包含偶联至头发结合结构域的过水解酶的融合蛋白，可以直接或通过任选的接头，用于靶向头发表面的过水解活性。
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4.发明申请PRODUCTION OF ALCOHOL ESTERS IN SITU USING ALCOHOLS AND FATTY ACIDS PRODUCED BY MICROORGANISMS 审中-公开利用微生物生产的酒精和脂肪酸生产酒精饮料
公开(公告)号：WO2012109221A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024117
申请日：2012-02-07
Applicant: E. I. du Pont de Nemours and Company , DAUNER, Michael , DICOSIMO, Robert , PATNAIK, Ranjan
Inventor： DAUNER, Michael , DICOSIMO, Robert , PATNAIK, Ranjan
CPC classification number: C12P7/6436 , C12P7/649 , C12P39/00 , Y02E50/13
Abstract: Fatty acid alcohol esters that may be used as biodiesel are synthesized from microbially produced alcohol and fatty acids using an in situ process. The process utilizes a catalyst capable of esterifying the alcohol and fatty acid products of microorganisms, which are produced from renewable resources.
Abstract translation: 可用作生物柴油的脂肪酸醇酯由原位生产的微生物醇和脂肪酸合成。 该方法利用能够使可再生资源生产的微生物的醇和脂肪酸产物酯化的催化剂。
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5.发明申请ENZYMATIC PERACID GENERATION FOR USE IN ORAL CARE PRODUCTS 审中-公开用于口腔护理产品的ENZYMATIC PERACID GENERATION
公开(公告)号：WO2012087970A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/065912
申请日：2011-12-19
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , BUTTERICK, Lisa, A. , CUNNINGHAM, Scott, D. , DICOSIMO, Robert , FOSSER, Kari, A. , GRUBER, Tanja, Maria , HAYNIE, Sharon, L. , PAYNE, Mark, S. , ROUVIERE, Pierre, E. , WANG, Hong
Inventor： BUTTERICK, Lisa, A. , CUNNINGHAM, Scott, D. , DICOSIMO, Robert , FOSSER, Kari, A. , GRUBER, Tanja, Maria , HAYNIE, Sharon, L. , PAYNE, Mark, S. , ROUVIERE, Pierre, E. , WANG, Hong
Abstract: Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.
Abstract translation: 本文公开了用基于过酸的有益剂治疗口腔表面的组合物和方法。 过酸有益剂可用于口腔表面漂白，增白，消毒，脱色，除臭，减少或除去生物膜及其组合。 使用具有过水解活性的CE-7碳水化合物酯酶（过水解酶），在过氧化物源的存在下，由羧酸酯底物酶促产生过酸。 包含偶联于对口腔表面具有亲和力的肽组分的过水解酶的融合蛋白可以直接或通过任选的连接体用于靶向口腔表面的过水解活性。
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Patent Agency Ranking
公开(公告)号：WO2012087966A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/065902
申请日：2011-12-19
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , DICOSIMO, Robert , CUNNINGHAM, Scott, D. , FAHNESTOCK, Stephen, R. , GRUBER, Tanja, Maria , PAYNE, Mark, S. , ROUVIERE, Pierre, E. , SOLOMON, Linda, Jane , WANG, Hong
Inventor： DICOSIMO, Robert , CUNNINGHAM, Scott, D. , FAHNESTOCK, Stephen, R. , GRUBER, Tanja, Maria , PAYNE, Mark, S. , ROUVIERE, Pierre, E. , SOLOMON, Linda, Jane , WANG, Hong
CPC classification number: C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
Abstract: Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
Abstract translation: 本文公开了将酶过氧酸生产靶向靶表面的组合物和方法。 由靶向的水解酶产生的过酸有益剂可用于各种应用，例如漂白，增白，消毒，脱色，除臭及其组合。 特别地，包含过水解酶和至少一种对靶表面（不包括身体表面和口腔护理表面）具有亲和性的肽成分的融合蛋白与合适的底物和过氧源组合使用以在其上或 靠近目标材料的表面。 在优选的方面，目标表面是纤维素材料。
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公开(公告)号：WO2007149401A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014208
申请日：2007-06-15
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , D'AMORE, Michael, B. , MANZER, Leo, Ernest , MILLER, JR., Edward, S. , DICOSIMO, Robert , KNAPP, Jeffrey, P.
Inventor： D'AMORE, Michael, B. , MANZER, Leo, Ernest , MILLER, JR., Edward, S. , DICOSIMO, Robert , KNAPP, Jeffrey, P.
Abstract: The present invention relates to a process for making dibutyl ethers using dry 1-butanol derived from fermentation broth. The dibutyl ethers so produced are useful in transportation fuels.
Abstract translation: 本发明涉及使用来自发酵液的干燥的1-丁醇制备二丁醚的方法。 如此生产的二丁醚可用于运输燃料。
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公开(公告)号：WO2007149400A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014207
申请日：2007-06-15
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , D'AMORE, Michael, B. , MANZER, Leo, Ernest , MILLER, JR., Edward, S. , DICOSIMO, Robert , KNAPP, Jeffrey, P.
Inventor： D'AMORE, Michael, B. , MANZER, Leo, Ernest , MILLER, JR., Edward, S. , DICOSIMO, Robert , KNAPP, Jeffrey, P.
Abstract: The present invention relates to a catalytic process for making dibutyl ethers using a reactant comprising 1-butanol and water. The dibutyl ethers so produced are useful in transportation fuels.
Abstract translation: 本发明涉及使用包含1-丁醇和水的反应物制备二丁醚的催化方法。 如此生产的二丁醚可用于运输燃料。
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9.发明申请
公开(公告)号：WO2006069114A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046273
申请日：2005-12-21
Applicant: E.I. DUPONT DE NEMOURS AND COMPANY , DICOSIMO, Robert , FOO, Thomas , PAYNE, Mark, S. , PANOVA, Anna , O'KEEFE, Daniel, P. , THOMPSON, Jeffrey, Scott , GALLAGHER, F., Glenn , LI, Xu
Inventor： DICOSIMO, Robert , FOO, Thomas , PAYNE, Mark, S. , PANOVA, Anna , O'KEEFE, Daniel, P. , THOMPSON, Jeffrey, Scott , GALLAGHER, F., Glenn , LI, Xu
CPC classification number: C12P7/42
Abstract: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
Abstract translation: 提供从甲醛和氰化氢生产乙醇酸的方法。 更具体地，将热处理的甲醛和氰化氢反应以制备具有低浓度杂质的乙醇腈。 随后使用具有源自Acidovorax facilis 72W（ATCC 57746）的腈水解酶活性的酶催化剂将乙醇腈转化为乙醇酸铵水溶液。 使用本文所述的各种方法，从乙醇酸水溶液中以酸或盐的形式回收乙醇酸。
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公开(公告)号：WO2006069110A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046269
申请日：2005-12-21
Applicant: E.I. DUPONT DE NEMOURS AND COMPANY , DICOSIMO, Robert , PAYNE, Mark, S. , PANOVA, Anna , O'KEEFE, Daniel, P. , THOMPSON, Jeffrey, Scott
Inventor： DICOSIMO, Robert , PAYNE, Mark, S. , PANOVA, Anna , O'KEEFE, Daniel, P. , THOMPSON, Jeffrey, Scott
Abstract: Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of Acidovorax facilis 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.
Abstract translation: 提供了各种从乙醇腈生产乙醇酸的方法。 这些方法包括：1）使用敏捷食酸菌72W腈水解酶突变体，其具有提高的腈水解酶活性以将乙醇腈转化为乙醇酸，以及2）提高催化剂稳定性和/或生产率的方法。 提高催化剂稳定性/生产率的方法包括使用反应稳定剂，在基本上无氧的条件下进行反应，并控制反应混合物中底物的浓度。
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