公开(公告)号：WO2010011356A3

公开(公告)日：2010-01-28

申请号：PCT/US2009/004364

申请日：2009-07-27

Applicant: AUREON LABORATORIES, INC. ,  DONOVAN, Michael ,  KHAN, Faisal ,  FERNANDEZ, Gerardo ,  TABESH, Ali ,  MESA-TEJADA, Ricardo ,  CARDON-CARDO, Carlos ,  COSTA, Jose ,  FOGARASI, Stephen ,  VENGRENYUK, Yevgen

Inventor： DONOVAN, Michael ,  KHAN, Faisal ,  FERNANDEZ, Gerardo ,  TABESH, Ali ,  MESA-TEJADA, Ricardo ,  CARDON-CARDO, Carlos ,  COSTA, Jose ,  FOGARASI, Stephen ,  VENGRENYUK, Yevgen

IPC: G06F19/00

Abstract: Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts risk of prostate cancer progression in a patient, where the model is based on features including one or more (e.g., all) of preoperative PSA, dominant Gleason Grade, Gleason Score, at least one of a measurement of expression of AR in epithelial and stromal nuclei and a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of average edge length in the minimum spanning tree (MST) of epithelial nuclei, and a morphometric measurement of area of non-lumen associated epithelial cells relative to total tumor area. In some embodiments, the morphometric information is based on image analysis of tissue subject to multiplex immunofluorescence and may include characteristic(s) of a minimum spanning tree (MST) and/or a fractal dimension observed in the images.

公开(公告)号：WO2008144425A2

公开(公告)日：2008-11-27

申请号：PCT/US2008/063754

申请日：2008-05-15

Applicant: PASSPORT SYSTEMS, INC. ,  BERTOZZI, William ,  DONOVAN, Michael ,  KLIMENKO, Alexei ,  KORBLY, Stephen, E. ,  PARK, William

Inventor： BERTOZZI, William ,  DONOVAN, Michael ,  KLIMENKO, Alexei ,  KORBLY, Stephen, E. ,  PARK, William

IPC: H01J5/18

CPC classification number: H05G2/00 ,  H01J35/12 ,  H01J2235/08 ,  H01J2235/1204 ,  H05H6/00

Abstract: Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.

Abstract translation: 用于产生具有在前方角度的窄锥体中增强的光子通量的bre致辐射的方法和系统利用诸如金的高Z材料的薄靶作为散热器，其支撑在诸如钛的低Z材料的管上，该管包含 诸如水的循环流体，其作为冷却剂并且还可以吸收入射的电子束。

公开(公告)号：WO2007087205A1

公开(公告)日：2007-08-02

申请号：PCT/US2007/001180

申请日：2007-01-17

Applicant: GENERAL ELECTRIC COMPANY ,  RAMARAJU, Deepak ,  RAVI, Gomatam, Raghavan ,  STARKEY, Kyle, Patrick ,  DONOVAN, Michael, Stephen ,  AGARWAL, Parminder

Inventor： RAMARAJU, Deepak ,  RAVI, Gomatam, Raghavan ,  STARKEY, Kyle, Patrick ,  DONOVAN, Michael, Stephen ,  AGARWAL, Parminder

IPC: C08G63/78

CPC classification number: C08G63/46 ,  C08G63/181 ,  C08G63/82

Abstract: A process to make a polyester is described wherein said polyester comprises, a) substituted or unsubstituted diacid or diester; b) substituted or unsubstituted diol; wherein said diol comprises at least about 0.5 mole percent of butanediol; and c) 0.01 weight percent to about 15 weight percent based on the total weight of the composition a reactive organic compound wherein said organic compound comprises of at least one functional group.

Abstract translation: 描述了制备聚酯的方法，其中所述聚酯包括：a）取代或未取代的二酸或二酯; b）取代或未取代的二醇; 其中所述二醇包含至少约0.5摩尔％的丁二醇; 和c）基于组合物的总重量为0.01重量％至约15重量％的反应性有机化合物，其中所述有机化合物包含至少一个官能团。

公开(公告)号：WO2006107940A3

公开(公告)日：2006-11-23

申请号：PCT/US2006012454

申请日：2006-04-04

Applicant: GEN ELECTRIC ,  SHAIKH ABBAS ALLI GHUDUBHAI ,  WAGLE GOVIND SUBBANNA ,  RAJESWARAN RAMESH ,  KANNAN GANESH ,  STARKEY KYLE PATRICK ,  DONOVAN MICHAEL STEPHEN

Inventor： SHAIKH ABBAS ALLI GHUDUBHAI ,  WAGLE GOVIND SUBBANNA ,  RAJESWARAN RAMESH ,  KANNAN GANESH ,  STARKEY KYLE PATRICK ,  DONOVAN MICHAEL STEPHEN

IPC: C08G63/193 ,  C08G63/547

CPC classification number: C08G63/547

Abstract: A polyarylate composition comprising: structural units derived at least one substituted or unsubstituted diacid, at least one aromatic dihydroxy compound, and an unsaturated compound. The composition possesses good optical properties, flow, stability and mechanical property. Also disclosed is a process to prepare these compositions and articles therefrom.

Abstract translation: 一种多芳基化合物组合物，其包含：衍生至少一种取代或未取代的二酸，至少一种芳族二羟基化合物和不饱和化合物的结构单元。 该组合物具有良好的光学性能，流动性，稳定性和机械性能。 还公开了由其制备这些组合物和制品的方法。

公开(公告)号：WO2014036267A1

公开(公告)日：2014-03-06

申请号：PCT/US2013/057301

申请日：2013-08-29

Applicant: CORNING INCORPORATED ,  DONOVAN, Michael Patrick ,  FURSTOSS, Anthony John ,  HOFF, Kyle C

Inventor： DONOVAN, Michael Patrick ,  FURSTOSS, Anthony John ,  HOFF, Kyle C

IPC: C03C15/00 ,  C03C21/00

CPC classification number: C03C21/002 ,  C03C3/091 ,  C03C3/093 ,  C03C15/00 ,  C03C15/02 ,  Y10T428/315

Abstract: A strengthened glass article has a chemically-etched edge and a compressive stress layer formed in a surface region thereof. The compressive stress layer has a compressive stress and a depth of layer. A product of the compressive stress and depth of layer is greater than 21,000 μm-MPa. A method of making the strengthened glass article includes creating the compressive stress layer in a glass sheet, separating the glass article from the glass sheet, and chemically etching at least one edge of the glass article.

Abstract translation: 强化的玻璃制品在其表面区域中形成化学蚀刻的边缘和​​压应力层。 压应力层具有压应力和层的深度。 压应力和层深度的乘积大于21,000mum-MPa。 制造强化玻璃制品的方法包括在玻璃板中形成压应力层，将玻璃制品与玻璃板分离，并化学蚀刻玻璃制品的至少一个边缘。

公开(公告)号：WO2013163524A1

公开(公告)日：2013-10-31

申请号：PCT/US2013/038381

申请日：2013-04-26

Applicant: CORNING INCORPORATED ,  AKARAPU, Ravindra Kumar ,  DONOVAN, Michael Patrick ,  LI, Aize

Inventor： AKARAPU, Ravindra Kumar ,  DONOVAN, Michael Patrick ,  LI, Aize

IPC: C03C15/02 ,  C03C19/00 ,  C09K13/08 ,  B24B9/10

CPC classification number: C03C15/00 ,  B24B9/10 ,  C03C15/02 ,  Y10T428/24488 ,  Y10T428/24777 ,  Y10T428/315

Abstract: A strengthened glass sheet or article having an edge profile that provides improved edge strength, particularly when the strengthened glass sheet is subjected to a four point bend test, and a method of making a glass sheet having such an edge. The edge is formed by cutting or other separation methods and then ground to a predetermined profile such as a pencil or bullet profile, a bull nose profile, or the like. In some embodiments, the edge is polished and/or etched following grinding to reduce flaw size.

Abstract translation: 具有提高边缘强度的边缘轮廓的强化玻璃板或制品，特别是当加强玻璃板进行四点弯曲试验时，以及制造具有这种边缘的玻璃板的方法。 边缘通过切割或其它分离方法形成，然后研磨成预定的轮廓，例如铅笔或子弹轮廓，牛鼻轮廓等。 在一些实施例中，边缘在研磨之后被抛光和/或蚀刻以减少缺陷尺寸。

公开(公告)号：WO2012016242A3

公开(公告)日：2012-02-02

申请号：PCT/US2011/046149

申请日：2011-08-01

Applicant: AUREON BIOSCIENCES, INC. ,  AJEMBA, Peter ,  SCOTT, Richard ,  RAMACHANDRAN, Janakiramanan ,  ZEINEH, Jack ,  DONOVAN, Michael ,  AL-KOFAHI, Yousef ,  FERNANDEZ, Gerardo ,  SAPIR, Marina ,  LIU, Qiuhua ,  KHAN, Faisal

Inventor： AJEMBA, Peter ,  SCOTT, Richard ,  RAMACHANDRAN, Janakiramanan ,  ZEINEH, Jack ,  DONOVAN, Michael ,  AL-KOFAHI, Yousef ,  FERNANDEZ, Gerardo ,  SAPIR, Marina ,  LIU, Qiuhua ,  KHAN, Faisal

IPC: G06T5/30 ,  G06T7/00

Abstract: Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.

公开(公告)号：WO2012016242A2

公开(公告)日：2012-02-02

申请号：PCT/US2011046149

申请日：2011-08-01

Applicant: AUREON BIOSCIENCES INC ,  AJEMBA PETER ,  SCOTT RICHARD ,  RAMACHANDRAN JANAKIRAMANAN ,  ZEINEH JACK ,  DONOVAN MICHAEL ,  AL-KOFAHI YOUSEF ,  FERNANDEZ GERARDO ,  SAPIR MARINA ,  LIU QIUHUA ,  KHAN FAISAL

Inventor： AJEMBA PETER ,  SCOTT RICHARD ,  RAMACHANDRAN JANAKIRAMANAN ,  ZEINEH JACK ,  DONOVAN MICHAEL ,  AL-KOFAHI YOUSEF ,  FERNANDEZ GERARDO ,  SAPIR MARINA ,  LIU QIUHUA ,  KHAN FAISAL

IPC: G06T5/30

CPC classification number: G06K9/00147 ,  G06T5/008 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T7/45 ,  G06T2207/10056 ,  G06T2207/20041 ,  G06T2207/20212 ,  G06T2207/30024

Abstract: Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.

Abstract translation: 提供装置，方法和计算机可读介质用于分组，处理（例如，预处理和/或后处理）和/或从诸如例如核和/或细胞质的图像的组织图像的特征提取。 可以通过苏木精和曙红（H＆E）染色，免疫荧光（IF）检测，免疫组织化学（IHC），类似和/或相关的染色过程和/或其它过程产生由本文描述的各种实施方案处理的组织图像。 本文所述的预测特征可以被提供用于例如用于治疗，诊断和/或预测一种或多种医学病症（例如癌症或其他）的发生（例如复发）的一种或多种预测模型 疾病类型

公开(公告)号：WO2011070005A1

公开(公告)日：2011-06-16

申请号：PCT/EP2010/069058

申请日：2010-12-07

Applicant: EUROPATH BIOSCIENCES, S.L. ,  DONOVAN, Michael J. ,  COLOMER VALERO, Anna ,  ERILL SAGALÉS, Nadina ,  FERRER ABIZANDA, Isidre ,  BOLUDA CASAS, Susana

Inventor： DONOVAN, Michael J. ,  COLOMER VALERO, Anna ,  ERILL SAGALÉS, Nadina ,  FERRER ABIZANDA, Isidre ,  BOLUDA CASAS, Susana

IPC: C12Q1/68

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/71 ,  G01N2333/916 ,  G01N2800/52 ,  G01N2800/56

Abstract: The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy / amplification levels of EGFR gene in a sample from said patients.

Abstract translation: 本发明涉及基于PTEN基因的LOH水平以及来自所述患者的样品中EGFR基因的表达水平或多重/扩增水平来预测脑癌患者的临床结果的方法。

公开(公告)号：WO2011005570A2

公开(公告)日：2011-01-13

申请号：PCT/US2010/039648

申请日：2010-06-23

Applicant: AUREON LABORATORIES INC. ,  DONOVAN, Michael ,  KHAN, Faisal ,  POWELL, Doug

Inventor： DONOVAN, Michael ,  KHAN, Faisal ,  POWELL, Doug

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/533 ,  G06F19/00

CPC classification number: G01N33/57415 ,  G01N2800/52

Abstract: This present invention systems and methods of accessing/monitoring the responsiveness of a breast cancer to a therapeutic compound.

Abstract translation: 本发明访问/监测乳腺癌对治疗性化合物的响应性的系统和方法。