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    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS
    2.
    发明申请
    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS 审中-公开
    高效率异质途径的组合设计

    公开(公告)号：WO2012045088A2

    公开(公告)日：2012-04-05

    申请号：PCT/US2011/054650

    申请日：2011-10-03

    申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  ZHAO, Huimin ,  KIM, Byoungjin ,  DU, Jing ,  YUAN, Yongbo ,  ERIKSEN, Dawn ,  SI, Tong

    发明人： ZHAO, Huimin ,  KIM, Byoungjin ,  DU, Jing ,  YUAN, Yongbo ,  ERIKSEN, Dawn ,  SI, Tong

    IPC分类号： C12N15/52

    CPC分类号： C12P7/06 ,  C07K14/39 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/2445 ,  C12N15/1093 ,  C12N15/52 ,  C12N15/81 ,  C12P7/10 ,  C12Y101/01009 ,  C12Y101/0101 ,  C12Y101/01307 ,  C12Y207/01017 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

    摘要： The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars.

    摘要翻译： 本公开涉及通过鉴定有利的酶和/或启动子组合而在宿主细胞中产生高效异源途径。 特别地，本公开提供了用于从真菌酶库组装和选择多步骤木糖和阿拉伯糖/木糖利用途径的方法。 本公开内容进一步提供了含有有利的酶组合的组合物，以及表达这种组合的重组酵母，以及用于生物转化戊糖的方法。 还提供了涉及利用不同强度的启动子组合鉴定的有利表达模式的组合物和方法。 本文提供了用于从不同强度的启动子文库组装和选择多步骤木糖，阿拉伯糖/木糖和纤维二糖利用途径的方法。 本发明进一步提供了在有利启动子控制下含有异源酶编码多核苷酸的组合物，以及表达这些酶的重组酵母，以及它们用于生物转化戊糖和/或己糖的方法。

    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS
    5.
    发明申请
    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS 审中-公开
    高效率异常路径的组合设计

    公开(公告)号：WO2012045088A9

    公开(公告)日：2012-07-26

    申请号：PCT/US2011054650

    申请日：2011-10-03

    申请人： UNIV ILLINOIS ,  ZHAO HUIMIN ,  KIM BYOUNGJIN ,  DU JING ,  YUAN YONGBO ,  ERIKSEN DAWN ,  SI TONG

    发明人： ZHAO HUIMIN ,  KIM BYOUNGJIN ,  DU JING ,  YUAN YONGBO ,  ERIKSEN DAWN ,  SI TONG

    IPC分类号： C12N15/52

    CPC分类号： C12P7/06 ,  C07K14/39 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/2445 ,  C12N15/1093 ,  C12N15/52 ,  C12N15/81 ,  C12P7/10 ,  C12Y101/01009 ,  C12Y101/0101 ,  C12Y101/01307 ,  C12Y207/01017 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

    摘要： The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars.

    摘要翻译： 本公开涉及通过鉴定有利的酶和/或启动子组合在宿主细胞中产生高效的异源途径。 特别地，本公开提供了从真菌酶文库中组装和选择多步木糖和阿拉伯糖/木糖利用途径的方法。 本公开进一步提供含有有利的酶组合的组合物，以及表达这种组合的重组酵母以及用于戊糖的生物转化的方法。 还提供了包括通过利用不同强度的启动子的组合鉴定的有利的表达模式的组合物和方法。 本文提供了用于从不同强度的启动子文库中组装和选择多步木糖，阿拉伯糖/木糖和纤维二糖利用途径的方法。 本公开进一步提供了含有有利启动子控制的异源酶编码多核苷酸的组合物，以及表达这些酶的重组酵母，以及它们用于戊糖和/或己糖的生物转化的方法。

    PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF
    6.
    发明申请
    PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF 审中-公开
    吡嗪衍生物，其制备方法及其用途

    公开(公告)号：WO2012003784A1

    公开(公告)日：2012-01-12

    申请号：PCT/CN2011/076756

    申请日：2011-07-01

    申请人： JINAN UNIVERSITY ,  WANG, Yuqiang ,  SUN, Yewei ,  YU, Pei ,  DU, Jing ,  ZHANG, Gaoxiao

    发明人： WANG, Yuqiang ,  SUN, Yewei ,  YU, Pei ,  DU, Jing ,  ZHANG, Gaoxiao

    IPC分类号： C07D295/00 ,  C07D403/12 ,  A61K31/495 ,  A61P9/00 ,  A61P35/00 ,  A61P1/00 ,  A61P3/00 ,  A61P5/00 ,  A61P11/00 ,  A61P25/00 ,  A61P31/00 ,  A61P27/00

    CPC分类号： C07D241/12 ,  C07D241/24 ,  C07D241/42 ,  C07D495/04

    摘要： Pyrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the designation of R 1 , R 2 , R 3 and R 4 are provided herein. Syntheses for preparation of such compounds are disclosed. Methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments are disclosed. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

    摘要翻译： 公开了式（I）的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。 公开了制备这些化合物的合成。 公开了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。 这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物 自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS
    8.
    发明申请
    COMBINATORIAL DESIGN OF HIGHLY EFFICIENT HETEROLOGOUS PATHWAYS 审中-公开
    高效率异质途径的组合设计

    公开(公告)号：WO2012045088A3

    公开(公告)日：2012-09-13

    申请号：PCT/US2011054650

    申请日：2011-10-03

    申请人： UNIV ILLINOIS ,  ZHAO HUIMIN ,  KIM BYOUNGJIN ,  DU JING ,  YUAN YONGBO ,  ERIKSEN DAWN ,  SI TONG

    发明人： ZHAO HUIMIN ,  KIM BYOUNGJIN ,  DU JING ,  YUAN YONGBO ,  ERIKSEN DAWN ,  SI TONG

    IPC分类号： C12N15/52 ,  C12N9/02 ,  C12N9/04 ,  C12N9/12 ,  C12N15/10 ,  C12P7/06 ,  C12P7/08

    CPC分类号： C12P7/06 ,  C07K14/39 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/2445 ,  C12N15/1093 ,  C12N15/52 ,  C12N15/81 ,  C12P7/10 ,  C12Y101/01009 ,  C12Y101/0101 ,  C12Y101/01307 ,  C12Y207/01017 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

    摘要： The present disclosure relates to the production of highly efficient heterologous pathways in host cells by identifying favorable enzyme and/or promoter combinations. In particular the present disclosure provides methods for assembly and selection of multi-step xylose and arabinose/xylose utilization pathways from a library of fungal enzymes. The present disclosure further provides compositions containing favorable enzyme combinations, as well as recombinant yeast expressing such combinations, and methods of use for bioconversion of pentose sugars. Also provided are compositions and methods involving favorable expression patterns identified by utilization of combinations of promoters of varying strengths. Provided herein are methods for assembly and selection of multi-step xylose, arabinose/xylose, and cellobiose utilization pathways from a library of promoters of varying strengths. The present disclosure further provides compositions containing heterologous enzyme-coding polynucleotides under the control of favorable promoters, as well as recombinant yeast expressing such enzymes, and methods of their use for bioconversion of pentose and/or hexose sugars.

    摘要翻译： 本公开涉及通过鉴定有利的酶和/或启动子组合来在宿主细胞中产生高效异源途径。 特别地，本公开提供了用于从真菌酶库组装和选择多步骤木糖和阿拉伯糖/木糖利用途径的方法。 本公开内容进一步提供了含有有利的酶组合的组合物，以及表达这种组合的重组酵母，以及用于生物转化戊糖的方法。 还提供了涉及利用不同强度的启动子组合鉴定的有利表达模式的组合物和方法。 本文提供了用于从不同强度的启动子文库组装和选择多步骤木糖，阿拉伯糖/木糖和纤维二糖利用途径的方法。 本发明进一步提供了在有利启动子控制下含有异源酶编码多核苷酸的组合物，以及表达这些酶的重组酵母，以及它们用于生物转化戊糖和/或己糖的方法。