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    PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF
    2.
    发明申请
    PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF 审中-公开
    吡嗪衍生物，其制备方法及其用途

    公开(公告)号：WO2012003784A1

    公开(公告)日：2012-01-12

    申请号：PCT/CN2011/076756

    申请日：2011-07-01

    申请人： JINAN UNIVERSITY ,  WANG, Yuqiang ,  SUN, Yewei ,  YU, Pei ,  DU, Jing ,  ZHANG, Gaoxiao

    发明人： WANG, Yuqiang ,  SUN, Yewei ,  YU, Pei ,  DU, Jing ,  ZHANG, Gaoxiao

    IPC分类号： C07D295/00 ,  C07D403/12 ,  A61K31/495 ,  A61P9/00 ,  A61P35/00 ,  A61P1/00 ,  A61P3/00 ,  A61P5/00 ,  A61P11/00 ,  A61P25/00 ,  A61P31/00 ,  A61P27/00

    CPC分类号： C07D241/12 ,  C07D241/24 ,  C07D241/42 ,  C07D495/04

    摘要： Pyrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the designation of R 1 , R 2 , R 3 and R 4 are provided herein. Syntheses for preparation of such compounds are disclosed. Methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments are disclosed. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

    摘要翻译： 公开了式（I）的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。 公开了制备这些化合物的合成。 公开了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。 这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物 自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

    FIBER-OPTIC SENSING APPARATUS, SYSTEM AND METHOD FOR CHARACTERIZING METAL IONS IN SOLUTION
    4.
    发明申请
    FIBER-OPTIC SENSING APPARATUS, SYSTEM AND METHOD FOR CHARACTERIZING METAL IONS IN SOLUTION 审中-公开

    公开(公告)号：WO2020238830A1

    公开(公告)日：2020-12-03

    申请号：PCT/CN2020/092011

    申请日：2020-05-25

    申请人： JINAN UNIVERSITY

    发明人： GUO, Tuan ,  YUAN, Yong ,  LI, Kaiwei ,  XIAO, Gaozhi

    IPC分类号： G01N21/25 ,  G01N27/26

    摘要： A fiber-optic sensing apparatus, system, and method for characterizing at least one metal ion in a solution. The sensing apparatus (100) includes a fiber-optic sensor (50) and a controller (80). The sensor (50) includes an optical fiber with tilted grating in its core (10), and includes a conductive and surface plasmon resonance (SPR) -active coating assembly (30) that allows the sensor (50) to also serve as an electrochemical working electrode. The controller (80) is electrically connected with the sensor (50), configured to provide an adjustable potential such that when the coating assembly (30) is in contact with the solution (S), redox reactions of each of the at least one metal ion (H1) occur on an outer surface thereof, resulting in a detectable change of the surface plasmon waves generated in the fiber-optic sensor (50). Based on the change thus detected, identities and/or concentration of the at least one metal ion (H1) in the solution (S) can be determined with high accuracy and sensitivity.

    METHODS AND SYSTEM FOR IN OPERANDO BATTERY STATE MONITORING
    6.
    发明申请
    METHODS AND SYSTEM FOR IN OPERANDO BATTERY STATE MONITORING 审中-公开

    公开(公告)号：WO2022037589A1

    公开(公告)日：2022-02-24

    申请号：PCT/CN2021/113083

    申请日：2021-08-17

    申请人： JINAN UNIVERSITY

    发明人： GUO, Tuan ,  MAI, Yaohua ,  HUANG, Jiaqiang ,  LU, Xihong ,  LI, Kaiwei ,  ZHONG, Hai ,  TARASCON, Jean-Marie

    IPC分类号： H01M10/42

    摘要： A method and system for in operando, in situ, and real-time monitoring the state of an electrochemical device, e.g. battery, is provided, which is by means of an optical fiber probe inside the electrochemical device. The method includes: shedding an input light into the optical fiber probe and detecting an output light transmitted therefrom; and determining state of health of the electrochemical device based on the output light. The determination step can be based on a change of the refractive index or of the cladding mode or the surface plasmon resonance, all derived from the output light, in the instant state compared to a prior state. The method can simultaneously detect other parameters including state of charge, temperature, pressure, strain, displacement, vibration, or gas release inside the electrochemical device. With a core mode for correction, the determination of these parameters can also realize a high accuracy.

    ELECTRODE MATERIALS, AND METHODS OF MANUFACTURING AND USE THEREOF
    9.
    发明申请
    ELECTRODE MATERIALS, AND METHODS OF MANUFACTURING AND USE THEREOF 审中-公开

    公开(公告)号：WO2021098435A1

    公开(公告)日：2021-05-27

    申请号：PCT/CN2020/122193

    申请日：2020-10-20

    申请人： JINAN UNIVERSITY

    发明人： MAI, Yaohua ,  ZENG, Shuaibo

    IPC分类号： H01M4/36 ,  H01M10/052

    摘要： An electrode material, its manufacturing method, and its use as a cathode material in batteries are provided. The electrode material comprises a plurality of nanoparticles, each having a diameter of approximately 100-400 nm and comprising a core and a shell encapsulating the core. The shell comprises carbon and nitrogen, respectively having a mass fraction of approximately 70-90%and approximately 5-20%relative to a total mass of the shell. The core comprises sulfur, having a mass fraction of approximately 40-97%relative to a total mass of the core. The core has a mass fraction of approximately 50-90%relative to a total mass of each nanoparticle. The electrode material can be used in a cathode of a Li-S battery, which has a good energy storage capacity, a high electrochemical stability, and a low capacity decay.

    A METHOD FOR CONTINUOUS DETECTION OF MULTI-CHANNEL GAS SAMPLES
    10.
    发明申请
    A METHOD FOR CONTINUOUS DETECTION OF MULTI-CHANNEL GAS SAMPLES 审中-公开

    公开(公告)号：WO2021089024A1

    公开(公告)日：2021-05-14

    申请号：PCT/CN2020/127302

    申请日：2020-11-06

    申请人： O'GRANDS INNOVATION INC. ,  JINAN UNIVERSITY

    发明人： LI, Xue ,  YIN, Zhihong ,  XU, Michael, Jun

    IPC分类号： G01N1/22 ,  G01N1/02

    摘要： A method for continuous detection of multi-channel gas samples, includes following steps:a plurality of gas samples are sequentially entered into the sampling path of a detection device (40) from a multi-channel gas path automatic switching unit (30), and the interval gas delays the diffusion of each gas sample and makes the samples enter the detection device (40)for analysis without cross interference as much as possible, so as to achieve continuous detection of multiple real-time online or offline gas samples to effectively improve sample throughput and detection efficiency.