公开(公告)号：WO2012040853A1

公开(公告)日：2012-04-05

申请号：PCT/CA2011/050609

申请日：2011-09-28

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  SCHAFER, Laurel L. ,  LAUZON, Jean Michel P. ,  AYINLA, Rashidat O. ,  EISENBERGER, Patrick

发明人： SCHAFER, Laurel L. ,  LAUZON, Jean Michel P. ,  AYINLA, Rashidat O. ,  EISENBERGER, Patrick

IPC分类号： C07C217/76 ,  C07B37/00 ,  C07B43/04 ,  C07C217/48 ,  C07C227/00 ,  C07C227/32 ,  C07F9/00 ,  B01J31/36

CPC分类号： C07F9/005 ,  B01J31/1805 ,  B01J31/2217 ,  B01J2231/32 ,  B01J2531/58 ,  C07B37/02 ,  C07B2200/07 ,  C07C209/68 ,  C07C213/08 ,  C07C233/07 ,  C07C233/58 ,  C07C233/65 ,  C07C303/38 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D211/96 ,  C07D215/06 ,  C07D265/30 ,  C07D279/12 ,  C07D491/10 ,  C07C211/48 ,  C07C217/84 ,  C07C311/16

摘要： The present invention provides Group 5 metal complexes useful for amine functionalization and synthetic process for manufacture thereof. Provided in this application are halo group 5 metal-amidate complexes having the structure of Formula I: I wherein: M is a group 5 metal, such as Ta, Nb or V; X is a halo substituent, such as CI, F, I or Br; n = 1 or 2,; s = 1 or 2; R 1 and R 2 are each independently H; a C 1 - C 25 substituted or unsubstituted, linear, branched or cyclic alkyl; or substituted or unsubstituted aryl or heterocyclic groups; R' is independently a C 1 - C 25 substituted or unsubstituted, linear, branched or cyclic alkyl; a substituted or unsubstituted aryl; a substituted or unsubstituted heterocyclic group; or NR 3 2 ; and each R 3 is independently a C 1 - C 25 substituted or unsubstituted, linear, branched or cyclic alkyl; a substituted or unsubstituted aryl; or substituted or unsubstituted heterocyclic group, and a process for synthesis thereof. Also provided are the corresponding metallaaziridine complexes. The metal complex of Formula I, and the corresponding metallaaziridine complex are useful as a catalysts in ct-alkylation of secondary amines and, therefore, also provided are methods of using the metal complex of Formula I, and the corresponding metallaaziridine complex in o-alkylation of secondary amines. This application also provides methods of using the corresponding non-halo group 5 metal-amidate complexes and metallaaziridine complexes in α-alkylation of heterocycles.

摘要翻译： 本发明提供了可用于胺官能化的第5族金属络合物及其制造方法。 本申请中提供了具有式I结构的卤代基5金属 - 酰胺化物络合物：其中：M是第5族金属，如Ta，Nb或V; X是卤素取代基，例如Cl，F，I或Br; n = 1或2 s = 1或2; R1和R2各自独立地为H; C1-C25取代或未取代的直链，支链或环状烷基; 或取代或未取代的芳基或杂环基; R'独立地为C 1 -C 25取代或未取代的直链，支链或环状烷基; 取代或未取代的芳基; 取代或未取代的杂环基; 或NR3 2 并且每个R 3独立地为C 1 -C 25取代或未取代的直链，支链或环状烷基; 取代或未取代的芳基; 或取代或未取代的杂环基，及其合成方法。 还提供了相应的喹唑啉复合物。 式I的金属络合物和相应的金氮idine啶络合物可用作仲胺烷基化中的催化剂，因此还提供了使用式I的金属络合物和相应的金属氮杂环丁烷络合物在邻烷基化中的方法 的仲胺。 本申请还提供了在杂环烷基化中使用相应的非卤代基团5金属 - 酰胺化物络合物和金属氮杂环丁烷配合物的方法。