公开(公告)号：WO2019005631A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039135

申请日：2018-06-22

Applicant: VITAWORKS IP, LLC

Inventor： HU, Songzhou

IPC: C07C227/00 ,  C07C209/86 ,  C07C51/48 ,  C07C51/47 ,  C07C51/43 ,  B01D3/36 ,  B01D9/02

Abstract: There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) cooling the hydrolysis solution to crystallize and separate alkali salt of long chain dibasic acid to provide an aqueous solvent solution; (2) distilling the aqueous solvent solution of step (1) to recover the solvent and to recover alkylamine; (3) cooling the residual solution of step (2) to precipitate and separate alkali salt of long chain amino acid to provide a mother liquor; (4) adding an acid to the mother liquor of step (3) to yield alkanoic acid; (5) adding an acid to an aqueous solution of the alkali salt of long chain dibasic acid of step (1) to obtain long chain dibasic acid; and (6) neutralizing the alkali salt of long chain amino acid of step (3) with an acid to obtain long chain amino acid.

公开(公告)号：WO2019005628A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039125

申请日：2018-06-22

Applicant: VITAWORKS IP, LLC

Inventor： HU, Songzhou

IPC: C07C227/00 ,  C07C209/86 ,  C07C51/48 ,  C07C51/46 ,  C07C51/43 ,  C07C227/38

Abstract: There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine by distilling or by extracting with an extractant solvent; (2) adding an acid and an extractant solvent to the aqueous solution of step (1) to form an acidic salt of long chain amino acid to extract long chain dibasic acid; (3) separating the mixture of step (2) into an aqueous phase and an extractant phase; (4) neutralizing the aqueous phase of step (3) with an alkali hydroxide or ammonium hydroxide to obtain a crystalline solid of long chain amino acid; (5) cooling the extractant phase of step (3) to crystallize the long chain dibasic acid and recovering the dibasic acid by solid-liquid separation; and (6) recovering the extractant solvent of step (5) and isolating the alkanoic acid by distillation.

公开(公告)号：WO2015005298A1

公开(公告)日：2015-01-15

申请号：PCT/JP2014/068101

申请日：2014-07-08

Applicant: 第一三共株式会社

Inventor： 中村　嘉孝 ,  鵜飼　和利 ,  北脇　隆文 ,  中島　工 ,  北川　豊 ,  古屋　幸人 ,  今井　誠 ,  沼上　英治 ,  若山　雅一 ,  齋藤　亜矢子

IPC: C07C205/50 ,  C07C201/12 ,  C07C201/16 ,  C07C227/00 ,  C07C227/42 ,  C07C229/32 ,  C07C253/10 ,  C07C253/30 ,  C07C253/34 ,  C07C255/47 ,  C07B57/00 ,  C07B61/00

CPC classification number: C07D319/06 ,  C07B2200/07 ,  C07C67/00 ,  C07C67/343 ,  C07C69/608 ,  C07C201/12 ,  C07C201/16 ,  C07C205/50 ,  C07C211/27 ,  C07C227/04 ,  C07C227/42 ,  C07C229/32 ,  C07C253/00 ,  C07C253/10 ,  C07C253/30 ,  C07C253/34 ,  C07C255/47 ,  C07C2602/20

Abstract: 　本発明では、光学活性な二環性γ－アミノ酸誘導体を、高純度で提供することを目的とする。　その解決手段は、一般式（Ｉ）及び一般式（Ｉ'）を有する化合物の混合物、又は、化合物（Ｉ）を経由して、一般式（ＶＩＩ）を有する化合物、又は、その塩を製造する方法である。 式（Ｉ）（Ｉ'）［式中、Ｒ １ 及びＲ ２ は、Ｃ１－６アルキル基等を示し、Ｒ ３ は、シアノ基等を示す。］ 式（ＶＩＩ）

Abstract translation: 本发明的目的是提供高纯度光学活性双环γ-氨基酸衍生物。 用于实现该目的的方法是通过通式（I）和通式（I'）表示的化合物的混合物或通过方法制备由通式（VII）表示的化合物或其盐的方法 的化合物（I）。 式（I）和（I'）[在式中，R 1和R 2各自表示C 1-6烷基等，R 3表示氰基等。

公开(公告)号：WO2013092579A2

公开(公告)日：2013-06-27

申请号：PCT/EP2012/075939

申请日：2012-12-18

Applicant: BASF SE ,  BASF SCHWEIZ AG

Inventor： BAUMANN, Robert ,  BIEL, Markus, Christian ,  FRANZKE, Axel ,  OFTRING, Alfred ,  TEICH, Friedhelm ,  KLINGELHOEFER, Paul ,  HENZE, Guido ,  SCHRÖTER, Marie, Katrin ,  KISTER, Olesya ,  BORCHERS, Sabine ,  TUZINA, Pavel ,  DEIMLING, Beate ,  LEIDEL, Udo

IPC: B01J23/00 ,  C07C227/00

CPC classification number: B01J23/72 ,  B01J21/066 ,  B01J35/002 ,  B01J35/1014 ,  B01J35/1019 ,  B01J37/031 ,  B01J37/033 ,  B01J37/18 ,  C07C227/02 ,  C07C229/04

Abstract: Verfahren zur Herstellung eines oder mehrerer Komplexbildner, ausgewählt aus Methylglycindiessigsäure, Glutaminsäurediessigsäure und deren Salzen, durch katalytische Dehydrierung von N,N-Bis-(2-hydroxyethyl)-alanin und/oder N,N-Bis-(2-hydroxyethyl)-glutaminsäure bzw. deren Salzen in Gegenwart von Alkalihydroxid, wobei ein Katalysator enthaltend Kupfer und Zirkoniumdioxid eingesetzt wird, dessen Aktivierung eine Reduktion ist, dadurch gekennzeichnet, dass die Vorstufe des betreffenden Katalysators einen Kristallisationsgrad K, definiert als (I) im Bereich von 0 bis 50 % aufweist.

Abstract translation:

一种用于制备一种或多种络合剂，选定＆AUML过程;从Methylglycindiessigs＆AUML HLT;酸，谷氨酸＆AUML; urediessigs BEAR酸和它们的盐，通过N催化脱氢，N-双（2-羟乙基）丙氨酸 和/或N，N-双（2-羟乙基）-glutamins BEAR酸或它们的盐中的碱金属氢氧化物的存在下，使用含有铜和二氧化锆的催化剂，其激活为还原，其特征在于，所述前体 催化剂具有结晶度K，定义为（I）在0至50％范围内

公开(公告)号：WO2006017455A2

公开(公告)日：2006-02-16

申请号：PCT/US2005/027308

申请日：2005-07-29

Applicant: MERCK & CO., INC. ,  MERCK FROSST CANADA LTD. ,  CHEN, Cheng Yi ,  DEVINE, Paul, N. ,  FOSTER, Bruce, S. ,  HUGHES, Greg ,  O'SHEA, Paul

Inventor： CHEN, Cheng Yi ,  DEVINE, Paul, N. ,  FOSTER, Bruce, S. ,  HUGHES, Greg ,  O'SHEA, Paul

IPC: C07C227/00

CPC classification number: C07C227/32 ,  C07B2200/07 ,  C07C227/04 ,  C07C227/18 ,  C07C229/14 ,  C07C229/20 ,  C07C229/36 ,  C07C249/02 ,  C07C315/04 ,  C07C317/32 ,  C07C251/24

Abstract: This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.

Abstract translation: 本发明描述了还原胺化方法，其中全氟化酮或缩酮在碱性条件下与α-氨基酯组合以形成金属羧酸盐。 取决于还原条件，金属羧酸盐的非对映选择性还原使得能够获得两种非对映异构体。

公开(公告)号：WO2005020930A2

公开(公告)日：2005-03-10

申请号：PCT/US2004028424

申请日：2004-09-01

Applicant: KNOBLOCK KEN ,  SHAH PANKAJ

Inventor： KNOBLOCK KEN ,  SHAH PANKAJ

IPC: A61K20060101 ,  C07C53/00 ,  C07C205/00 ,  C07C227/00 ,  A61K

CPC classification number: C07D331/04 ,  C07K5/06113

Abstract: The present invention relates to an improved synthesis of alitame (3-L-alpha-aspartyl-D-alanylamido-2,2,4,4-tetramethylthietanylamine) in which residual iodine species formed during the deodorization step are eliminated, resulting in an improved yield and a purer, more consistent product.

Abstract translation: 本发明涉及消除除臭步骤期间形成的残留碘物质的阿利替酮（3-L-α-天冬氨酰-D-丙氨酰氨基-2,2,4,4-四甲基硫杂环丁胺）的改进合成， 产量和更纯净，更一致的产品。

公开(公告)号：WO9902484A3

公开(公告)日：1999-04-01

申请号：PCT/US9813245

申请日：1998-06-26

Applicant: DOW CHEMICAL CO ,  ST GEORGE GEORGE M ,  WILSON DAVID A

Inventor： ST GEORGE GEORGE M ,  WILSON DAVID A

IPC: C07C227/00 ,  C07C227/18 ,  C07C227/44 ,  C07C229/76

CPC classification number: C07C227/18 ,  C07C229/76

Abstract: A process for producing a ferric aminopolycarboxylic acid chelate with improved long term stability is disclosed. The process involves heating a mixture of iron oxide, ammonia and aminopolycarboxylic acid chelant at an elevated temperature for a sufficient time to improve the stability of the formed chelate.

Abstract translation: 公开了一种具有改进的长期稳定性的三价氨基多羧酸螯合物的制备方法。 该方法包括在升高的温度下加热氧化铁，氨和氨基多羧酸螯合剂的混合物足够的时间以改善形成的螯合物的稳定性。

公开(公告)号：WO8700521A3

公开(公告)日：1987-03-12

申请号：PCT/EP8600406

申请日：1986-07-10

Applicant: BOEHRINGER MANNHEIM GMBH ,  WOLFF HANS PETER ,  WITTE ERNST CHRISTIAN ,  KUEHNLE HANS FRIEDER

Inventor： WOLFF HANS PETER ,  WITTE ERNST-CHRISTIAN ,  KUEHNLE HANS-FRIEDER

IPC: C07C69/736 ,  A61K31/19 ,  A61K31/215 ,  A61K31/255 ,  A61K31/275 ,  A61K31/49 ,  C07C20060101 ,  C07C51/00 ,  C07C59/125 ,  C07C59/215 ,  C07C59/64 ,  C07C59/68 ,  C07C59/76 ,  C07C59/88 ,  C07C67/00 ,  C07C69/65 ,  C07C69/708 ,  C07C69/738 ,  C07C227/00 ,  C07C227/08 ,  C07C227/16 ,  C07C229/22 ,  C07C229/30 ,  C07C229/36 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/45 ,  C07C233/47 ,  C07C233/51 ,  C07C233/63 ,  C07C233/65 ,  C07C233/81 ,  C07C235/20 ,  C07C237/06 ,  C07C237/22 ,  C07C253/00 ,  C07C255/32 ,  C07C309/29 ,  C07C309/63 ,  C07C309/65 ,  C07C309/77 ,  C07C311/00 ,  C07C311/02 ,  C07C311/03 ,  C07C311/06 ,  C07C311/15 ,  C07C311/19 ,  C07C313/00 ,  C07C317/00 ,  C07C317/04 ,  C07C317/14 ,  C07C317/44 ,  C07C317/46 ,  C07C323/52 ,  C07C323/56

CPC classification number: C07C317/00 ,  A61K31/19 ,  A61K31/215 ,  A61K31/255 ,  A61K31/275 ,  C07C59/64 ,  C07C59/68 ,  C07C59/88 ,  C07C309/00 ,  C07C323/00

Abstract: New carboxylic acide derivatives having general formula (I) in which R1 is a possibly substituted aryl or aryloxy residue; R2 is hydrogen, a lower alkyl residue or the group R1-A-, as well as in the case where X represents the cyano group, an acylamino or amino group; A is a group of straight-chain or branched-chain, saturated or unsaturated alkyl group with 3 to 8 carbon atoms, which has a chain length of at least 3 carbon atoms; X represents the cyano group or a group of the formula -B-R3 or -D-NR4R5, in which B is O, S, SO, SO2, O(CO), OSO2, NHCO, NHSO2 or CO; D represents a valency dash, SO2 or CO; R3 is an alkyl, trifluoromethyl, cycloalkyl, aralkyl-, aralkenyl- or aryl group, in which the respective aryl residue can possibly be substituted; R4 is hydrogen, a lower alkyl residue, a possibly substituted aryl or aralkyl residue; R5 is hydrogen, a lower alkyl residue or R4 and R5 together are an alkyl chain with 4 to 6 carbon atoms which may be interrupted by O, S or NR6, and R6 is hydrogen, a lower alkyl residue or possibly a substituted phenyl or benzyl residue. Also described are their physiologically neutral salts, esters, amides and nitriles provided that in the case where: a) A is an alkyl group with 3 carbon atoms; a1) in all cases the aryl residue of the group R1 is not the unsubstituted phenyl residue and a2) X may not represent the groups -CN, NHCOR3 and NR4R5; b) where X is a residue of the formula -SCH3, R2 may not represent methyl; c) where X is the -NH2 or -NHCOCH3 group R1A- may not represent 4-phenylbutyl or 4-(4-methoxyphenyl)butyl; d) where X is the 2,4-dinitrophenyl group, R1A may not represent 4-phenylbutyl or 5-phenylpentyl; e) where X is the -COCH3 group, R1A may not represent 3-(2-chlorphenyl)propyl or 5-(4-methoxyphenyl)-pentyl. These compounds are used as medicines for lowering the sugar-level in the blood.

公开(公告)号：WO2017220308A1

公开(公告)日：2017-12-28

申请号：PCT/EP2017/063285

申请日：2017-06-01

Applicant: BASF SE

Inventor： MUELLER, Michael Klemens ,  STAMM, Armin ,  JAEKEL, Frank ,  SUELING, Carsten

IPC: C11D3/33 ,  C07C227/00 ,  C07C229/16 ,  C11D11/00 ,  C11D11/02

Abstract: Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250°C, (b) withdrawing powder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fines from said powder or granules, wherein said fines have a maximum particle diameter of 350 µm, (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 µm or more, (e) milling said lumps to a maximum particle diameter of 500 µm, (f) re-introducing said fines from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20 % by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).

Abstract translation: 制备含有至少一种选自甲基甘氨酸二乙酸（MGDA）和谷氨酸二乙酸（GLDA）和亚氨基二琥珀酸（IDS）的碱金属盐的螯合剂的粉末或颗粒的方法，所述方法 包括以下步骤：（a）将各自螯合剂（A）的水溶液或含水浆料引入喷雾干燥器或喷雾造粒机中，并且通过喷雾干燥或使用气体喷雾造粒除去大部分所述水 （b）分别从喷雾干燥器或喷雾造粒机中分别取出粉末或颗粒，（c）分离所述粉末或颗粒中的细粒，其中所述细粒具有最大颗粒 （d）从所述粉末或颗粒中分离出块状物，其中所述块状物的粒径为1,500微米或更大，（e）将所述块状物研磨至最大粒径为500微米 ，（f）将来自步骤（c）的所述细粒再次引入， 并将来自步骤（e）的块状物研磨到喷雾干燥器或喷雾造粒机中，其中细粒的份额为在步骤（b）中提取的总螯合剂（A）的0.5-20重量％ 研磨块的份额在步骤（b）中提取的总螯合剂（A）的5至60重量％的范围内。

公开(公告)号：WO2017132178A3

公开(公告)日：2017-08-03

申请号：PCT/US2017/014791

申请日：2017-01-24

Applicant: ZHAO, Ming ,  ZHOU, Li-Ming

Inventor： ZHAO, Ming ,  ZHOU, Li-Ming

IPC: C07C227/00 ,  A61K31/197 ,  C07C229/22

Abstract: The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares.

Abstract translation: 本公开提供5-氨基乙酰丙酸（5-ALA）的新盐和5-ALA酯的新盐，其制备，制剂和作为光敏剂在光动力治疗，诊断和美容护理中的用途