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1.发明申请
公开(公告)号：WO2007071402A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012322
申请日：2006-12-20
IPC分类号： A61K31/14
CPC分类号： A61K31/14
摘要： The present invention relates of the use of certain inner ionic (zwitter ionic) phospholipids, phosphonolipids and phosphate derivatives for the preparation of a pharmaceutical composition for the treatment, prevention and/or amelioration of an immunological disorder related to mast cell sensitization and/or activation. Preferred in this context are Edelfosine, Miltefosine and Perifosine. In a particularly preferred embodiment, the present invention relates to the use of Miltefosine for the preparation of a pharmaceutical composition for the treatment, prevention and/or amelioration of allergic diseases, in particular acute hyperallergic diseases, like asthma, atopic dermatitis and mastocytosis.
摘要翻译： 本发明涉及某些内离子（两性离子）磷脂，磷脂酰脂和磷酸酯衍生物在制备用于治疗，预防和/或改善与肥大细胞致敏和/或激活相关的免疫学障碍的药物组合物中的用途 。 在本文中优选的是Edelfosine，Miltefosine和Perifosine。 在特别优选的实施方案中，本发明涉及用于制备用于治疗，预防和/或改善过敏性疾病，特别是急性高过敏性疾病如哮喘，特应性皮炎和肥大细胞增多症的药物组合物的用途。
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公开(公告)号：WO2006002909A2
公开(公告)日：2006-01-12
申请号：PCT/EP2005007033
申请日：2005-06-29
申请人： JADOLABS GMBH , MAX PLANCK GESELLSCHAFT , UNIV DRESDEN TECH , BRAXMEIER TOBIAS , FRIEDRICHSON TIM , FROEHNER WOLFGANG , JENNINGS GARY , SCHLECHTINGEN GEORG , SCHROEDER CORNELIA , KNOELKER HANS-JOACHIM , SIMONS KAI , ZERIAL MARINO , KURZCHALIA TEYMURAS
发明人： BRAXMEIER TOBIAS , FRIEDRICHSON TIM , FROEHNER WOLFGANG , JENNINGS GARY , SCHLECHTINGEN GEORG , SCHROEDER CORNELIA , KNOELKER HANS-JOACHIM , SIMONS KAI , ZERIAL MARINO , KURZCHALIA TEYMURAS
IPC分类号： A61K31/133 , A61P11/06 , A61P31/12 , A61P37/08
CPC分类号： A61K31/133
摘要： The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及作为药物组合物的特定鞘脂/鞘脂衍生物及其在制备用于治疗，预防和/或改善与脂筏中的病理过程有关的疾病的药物中的用途。
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公开(公告)号：WO2006002908A1
公开(公告)日：2006-01-12
申请号：PCT/EP2005/007032
申请日：2005-06-29
申请人： JADOLABS GMBH , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN , TECHNISCHE UNIVERSITÄT DRESDEN , BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
发明人： BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , Y02A50/475
摘要： The present invention relates to the use of specific carbazole derivatives in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及特定咔唑衍生物在制备用于治疗，预防和/或改善与脂筏病理过程有关的疾病的药物中的用途。
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4.发明申请USE OF STEROID-DERIVED PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS RELATING TO PATHOLOGICAL PROCESSES IN LIPID RAFTS 审中-公开使用甾体衍生的药物组合物治疗与脂肪毒性相关的病理过程的疾病
公开(公告)号：WO2006002907A1
公开(公告)日：2006-01-12
申请号：PCT/EP2005/007031
申请日：2005-06-29
申请人： JADOLABS GMBH , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , TECHNISCHE UNIVERSITÄT DRESDEN , BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
发明人： BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , Y02A50/475
摘要： The present invention relates to the use of specific steroid derivatives in the preparation of medicaments for the treatment or prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及特定类固醇衍生物在制备用于治疗或预防和/或改善与脂筏中的病理过程有关的疾病的药物中的用途。
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5.发明申请TRIPARTITE CONJUGATES CONTAINING A STRUCTURE INTERACTING WITH CELL MEMBRANE RAFTS AND THEIR USE 审中-公开包含与细胞膜相关的结构的三联结合物及其使用
公开(公告)号：WO2005097199A1
公开(公告)日：2005-10-20
申请号：PCT/EP2005/003740
申请日：2005-04-08
申请人： JADOLABS GMBH , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , TECHNISCHE UNIVERSITÄT DRESDEN , BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , MUNICK, Michael , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
发明人： BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , MUNICK, Michael , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
IPC分类号： A61K47/48
CPC分类号： A61K47/554 , A61K47/543
摘要： The present invention relates to a compound comprising a tripartite structure in the format C-B-A or C'-B'-A' wherein moiety A and moiety A' is a raftophile, moiety B and moiety B' is a linker, moiety C and moiety C' is a pharmacophore; and wherein moiety B and B' is a linker which has a backbone of at least 8 carbon atoms and wherein one or more of said carbon atoms may be replaced by nitrogen, oxygen or sulfur. Furthermore, specific medical and pharmaceutical uses of the compounds of the invention are disclosed.
摘要翻译： 本发明涉及一种化合物，其包含CBA或C'-B'-A'形式的三方结构，其中部分A和部分A'为拉夫方，部分B和部分B'为连接基，部分C和部分C “是药效团; 并且其中部分B和B'是具有至少8个碳原子的主链的连接体，并且其中一个或多个所述碳原子可被氮，氧或硫代替。 此外，公开了本发明化合物的具体医药用途。
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6.发明申请USE OF GANGLIOSIDES AND OTHER SUBSTANCES FOR MODULATING SPHINGOLIPID-CHOLESTEROL MICRODOMAINS 审中-公开神经节苷脂和其他物质用于调制鞘脂胆固醇微区USE
公开(公告)号：WO0122957A3
公开(公告)日：2002-06-27
申请号：PCT/EP0009588
申请日：2000-09-29
IPC分类号： A61K31/575 , A61K31/7032 , A61K31/70
CPC分类号： A61K31/7032 , A61K31/575
摘要： The invention relates to the use of gangliosides and other substances for producing an agent for modulating sphingolipid-cholesterol microdomains.
摘要翻译： 它是用于制造药剂的用于描述鞘脂胆固醇微区的调制使用神经节苷脂和其他物质。
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7.发明申请
公开(公告)号：WO2012160188A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059813
申请日：2012-05-25
申请人： JADO TECHNOLOGIES GMBH , TECHNISCHE UNIVERSITÄT DRESDEN , SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
发明人： SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
IPC分类号： C07C237/08 , A61K31/164
CPC分类号： A61K31/164 , A61K45/06 , C07C237/08
摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
摘要翻译： 本发明涉及羟基取代的氨基和铵衍生物，特别是式（1）或（2）的化合物及其医疗用途，包括其用于治疗，预防或改善炎症，自身免疫和/或 过敏性疾病或增殖性，肿瘤性或发育异常性疾病或病症。
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8.发明申请AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE 审中-公开氨基酸或含氨酸的硫酸，磷酸和羧酸衍生物及其医疗用途
公开(公告)号：WO2012160187A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059812
申请日：2012-05-25
申请人： JADO TECHNOLOGIES GMBH , TECHNISCHE UNIVERSITÄT DRESDEN , SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
发明人： SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
IPC分类号： A61K31/205 , C07C309/14 , A61P17/06 , A61P37/08 , A61P37/00 , A61P29/00 , A61P1/04 , A61P27/00 , A61P27/06 , A61P27/14 , A61P17/10 , A61P11/06 , A61P11/16 , A61P19/02 , A61P19/04 , A61P25/28 , C07D211/14 , C07D211/46
CPC分类号： C07F9/4006 , A61K31/205 , A61K31/4425 , A61K31/662 , C07C229/12 , C07C309/14 , C07D211/06 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/037 , C07F9/3808
摘要： The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
摘要翻译： 本发明涉及含氨基或铵的磺酸，膦酸和羧酸衍生物，特别是式1，2，3，4，5或6的化合物及其医疗用途，包括它们在治疗中的用途 ，预防或改善炎症，自身免疫和/或过敏性疾病。
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9.发明申请OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE 审中-公开含氧氨基或含氨酸的硫酸，磷酸和羧酸衍生物及其医学用途
公开(公告)号：WO2012160186A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059810
申请日：2012-05-25
申请人： JADO TECHNOLOGIES GMBH , TECHNISCHE UNIVERSITÄT DRESDEN , SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
发明人： SCHLECHTINGEN, Georg , KNÖLKER, Hans-Joachim , FRIEDRICHSON, Tim , JENNINGS, Gary , BRAXMEIER, Tobias
IPC分类号： C07C309/14 , A61K31/205 , A61P17/06 , A61P37/08 , A61P37/00 , A61P29/00 , A61P1/04 , A61P27/00 , A61P27/06 , A61P27/14 , A61P17/10 , A61P11/06 , A61P11/16 , A61P19/02 , A61P19/04 , A61P25/28 , A61P35/00
CPC分类号： C07C309/14 , A61K31/205
摘要： The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
摘要翻译： 本发明涉及含氧氨基或铵的磺酸，膦酸和羧酸衍生物，特别是式1,2,3,4,5或6的化合物及其医疗用途，包括它们在治疗中的用途 ，预防或改善炎症，自身免疫和/或过敏性疾病，或增殖性，肿瘤性或发育异常性疾病或病症。
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公开(公告)号：WO2006002909A3
公开(公告)日：2006-01-12
申请号：PCT/EP2005/007033
申请日：2005-06-29
申请人： JADOLABS GMBH , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , TECHNISCHE UNIVERSITÄT DRESDEN , BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
发明人： BRAXMEIER, Tobias , FRIEDRICHSON, Tim , FRÖHNER, Wolfgang , JENNINGS, Gary , SCHLECHTINGEN, Georg , SCHROEDER, Cornelia , KNÖLKER, Hans-Joachim , SIMONS, Kai , ZERIAL, Marino , KURZCHALIA, Teymuras
IPC分类号： A61K31/133 , A61P11/06 , A61P31/18 , A61P31/12 , A61P37/08
摘要： The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
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