公开(公告)号：WO2009020936A3

公开(公告)日：2009-12-17

申请号：PCT/US2008072152

申请日：2008-08-04

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KLEINER LOTHAR WALTER ,  DESNOYER JESSICA RENEE ,  MASLANKA BOZENA ZOFIA ,  TROLLSAS MIKAEL O ,  HOSSAINY SYED F A ,  TANG YIWEN ,  GLAUSER THIERRY ,  NGO MICHAEL H

Inventor： KLEINER LOTHAR WALTER ,  DESNOYER JESSICA RENEE ,  MASLANKA BOZENA ZOFIA ,  TROLLSAS MIKAEL O ,  HOSSAINY SYED F A ,  TANG YIWEN ,  GLAUSER THIERRY ,  NGO MICHAEL H

IPC: A61L31/16

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2420/06

Abstract: Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same.

Abstract translation: 本文公开了一种涂层，其具有包括基质相和在基质相中基本上不混溶的分散相的层及其使用方法。

公开(公告)号：WO2008088456A3

公开(公告)日：2008-10-23

申请号：PCT/US2007024304

申请日：2007-11-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KLEINER LOTHAR W ,  HOSSAINY SYED ,  ASTAFIEVA IRINA ,  PACETTI STEPHEN ,  GLAUSER THIERRY ,  DESNOYER JESSICA ,  LUDWIG FLORIAN N

Inventor： KLEINER LOTHAR W ,  HOSSAINY SYED ,  ASTAFIEVA IRINA ,  PACETTI STEPHEN ,  GLAUSER THIERRY ,  DESNOYER JESSICA ,  LUDWIG FLORIAN N

IPC: A61L31/16 ,  A61K9/14 ,  A61K9/16 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61K9/143 ,  A61K9/0019 ,  A61K9/1611 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08L67/04

Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.

Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。 另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。

公开(公告)号：WO2008088456A2

公开(公告)日：2008-07-24

申请号：PCT/US2007/024304

申请日：2007-11-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KLEINER, Lothar, W. ,  HOSSAINY, Syed ,  ASTAFIEVA, Irina ,  PACETTI, Stephen ,  GLAUSER, Thierry ,  DESNOYER, Jessica ,  LUDWIG, Florian, N.

Inventor： KLEINER, Lothar, W. ,  HOSSAINY, Syed ,  ASTAFIEVA, Irina ,  PACETTI, Stephen ,  GLAUSER, Thierry ,  DESNOYER, Jessica ,  LUDWIG, Florian, N.

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/10

CPC classification number: A61K9/143 ,  A61K9/0019 ,  A61K9/1611 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08L67/04

Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.

Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可装载处理剂和任选的图像增强剂，并涂有缓释包衣以递送至闭塞血管并受影响 组织和/或器官通过递送装置。

公开(公告)号：WO2007097875A3

公开(公告)日：2008-04-17

申请号：PCT/US2007002124

申请日：2007-01-26

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  GLAUSER THIERRY ,  PACETTI STEPHEN D ,  CONSIGNY PAUL

Inventor： GLAUSER THIERRY ,  PACETTI STEPHEN D ,  CONSIGNY PAUL

IPC: A61L31/16 ,  A61L31/10

CPC classification number: A61K33/00 ,  A61K45/06 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606

Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide attached to the medical device and methods of treating a vascular condition using the devices are provided.

Abstract translation: 提供了具有能够催化附着于医疗装置的一氧化氮的产生的催化剂的医疗装置和使用该装置治疗血管状态的方法。

公开(公告)号：WO2006112932A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/005690

申请日：2006-02-15

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  ASTAFIEVA, Irina ,  GLAUSER, Thierry ,  HOSSAINY, Syed Faiyaz Ahmed

Inventor： ASTAFIEVA, Irina ,  GLAUSER, Thierry ,  HOSSAINY, Syed Faiyaz Ahmed

CPC classification number: A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/40

Abstract: Provided herein is a coating that includes a chemo-attractant for endothelial cells and methods of making and using the same.

Abstract translation: 本文提供的是包含内皮细胞的化学引诱剂的涂层及其制备和使用方法。

公开(公告)号：WO2006036558A3

公开(公告)日：2006-08-10

申请号：PCT/US2005032754

申请日：2005-09-12

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  PACETTI STEPHEN D ,  GLAUSER THIERRY

Inventor： PACETTI STEPHEN D ,  GLAUSER THIERRY

IPC: A61L31/04 ,  A61L27/16 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L33/10

Abstract: A polymer for a medical device, particularly for a drug eluting stent, is described. The polymer can be derived from n-butyl methacrylate and can have a degree of an elongation at failure from about 20 % to about 500 %.

Abstract translation: 描述了用于医疗装置的聚合物，特别是用于药物洗脱支架的聚合物。 聚合物可以衍生自甲基丙烯酸正丁酯，并且可以具有约20％至约500％的失效伸长率。

公开(公告)号：WO2005118018A1

公开(公告)日：2005-12-15

申请号：PCT/US2005/017811

申请日：2005-05-19

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  GLAUSER, Thierry ,  MICHAL, Eugene ,  CLAUDE, Charles ,  PACETTI, Stephen, D.

Inventor： GLAUSER, Thierry ,  MICHAL, Eugene ,  CLAUDE, Charles ,  PACETTI, Stephen, D.

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  C08L1/00 ,  C08L33/14 ,  C08L2666/26

Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：WO2005092406A1

公开(公告)日：2005-10-06

申请号：PCT/US2005/008844

申请日：2005-03-17

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DING, Ni

Inventor： GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DING, Ni

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/40 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  C08L33/14

Abstract: ABSTRACT A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 摘要一种包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含聚合物和任选的生物活性剂的涂层，其包含该涂层，以及使用该装置的方法 用于治疗人类疾病。

公开(公告)号：WO2013022851A2

公开(公告)日：2013-02-14

申请号：PCT/US2012/049775

申请日：2012-08-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  STEICHEN, Bethany ,  PACETTI, Stephen, D. ,  GADA, Manish ,  GLAUSER, Thierry ,  KLEINER, Lothar, W. ,  WANG, Yunbing ,  OBERHAUSER, James, P. ,  DING, Ni

Inventor： STEICHEN, Bethany ,  PACETTI, Stephen, D. ,  GADA, Manish ,  GLAUSER, Thierry ,  KLEINER, Lothar, W. ,  WANG, Yunbing ,  OBERHAUSER, James, P. ,  DING, Ni

IPC: B29C47/10 ,  B29B13/06 ,  B29C47/92 ,  B29C47/76

CPC classification number: B29C47/0078 ,  B29B13/06 ,  B29B13/065 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/1018 ,  B29C47/1072 ,  B29C47/76 ,  B29C47/92 ,  B29C2947/922 ,  B29C2947/92228 ,  B29C2947/92342 ,  B29C2947/92695 ,  B29C2947/92704 ,  B29C2947/92723 ,  B29K2995/006

Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

公开(公告)号：WO2011133436A1

公开(公告)日：2011-10-27

申请号：PCT/US2011/032790

申请日：2011-04-15

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HOSSAINY, Syed F.A. ,  TANG, Yiwen ,  MICHAL, Eugene, T. ,  GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  DESNOYER, Jessica

Inventor： HOSSAINY, Syed F.A. ,  TANG, Yiwen ,  MICHAL, Eugene, T. ,  GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  DESNOYER, Jessica

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61F2250/0067 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/148 ,  A61L31/16 ,  A61L2420/00 ,  A61L2420/02 ,  A61L2420/06 ,  C08L67/04

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。