公开(公告)号：WO2009058694A3

公开(公告)日：2010-04-08

申请号：PCT/US2008081209

申请日：2008-10-24

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  TROLLSAS MIKAEL O ,  NGO MICHAEL HUY ,  SHERMAN DAVID J ,  HOSSAINY SYED F A

Inventor： TROLLSAS MIKAEL O ,  NGO MICHAEL HUY ,  SHERMAN DAVID J ,  HOSSAINY SYED F A

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/33 ,  A61K31/436 ,  A61K31/497 ,  A61K31/56 ,  A61K38/13 ,  A61K38/446 ,  A61K45/06 ,  A61K47/34 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  C08L71/02 ,  C08L67/04

Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

Abstract translation: 本发明提供具有包含缓慢溶解性聚合物或材料的涂层的可植入装置及其制造和使用方法。

公开(公告)号：WO2009070209A3

公开(公告)日：2009-07-16

申请号：PCT/US2008012767

申请日：2008-11-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  MURASE KATSUYUKI ,  HOSSAINY SYED F A ,  ASTAFIEVA IRINA ,  ZHAO LI ,  MA HONG

Inventor： MURASE KATSUYUKI ,  HOSSAINY SYED F A ,  ASTAFIEVA IRINA ,  ZHAO LI ,  MA HONG

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/17

CPC classification number: C07K7/08 ,  A61F2/95 ,  A61K9/1075 ,  A61K9/127 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/25 ,  A61L2300/802 ,  A61M25/1011 ,  A61M2025/0086 ,  A61M2025/105 ,  A61M2025/1075 ,  C07K7/06 ,  C07K14/775

Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

公开(公告)号：WO2007146049A3

公开(公告)日：2009-01-22

申请号：PCT/US2007013396

申请日：2007-06-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  HOSSAINY SYED F A ,  TANG FUH-WEI ,  KLEINER LOTHAR ,  GLAUSER THIERRY ,  TANG YIWEN ,  ROORDA WOUTER ,  PACETTI STEPHEN ,  ZHANG GINA ,  CHEN YUNG-MING ,  MCNIVEN ANDREW F ,  MCNIVEN SEAN A ,  YOE BRANDON J

Inventor： HOSSAINY SYED F A ,  TANG FUH-WEI ,  KLEINER LOTHAR ,  GLAUSER THIERRY ,  TANG YIWEN ,  ROORDA WOUTER ,  PACETTI STEPHEN ,  ZHANG GINA ,  CHEN YUNG-MING ,  MCNIVEN ANDREW F ,  MCNIVEN SEAN A ,  YOE BRANDON J

IPC: A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：WO2007146228A3

公开(公告)日：2008-10-02

申请号：PCT/US2007013687

申请日：2007-06-08

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  HOSSAINY SYED F A ,  TROLLSAS MIKAEL ,  GLAUSER THIERRY ,  TANG YIWEN

Inventor： HOSSAINY SYED F A ,  TROLLSAS MIKAEL ,  GLAUSER THIERRY ,  TANG YIWEN

IPC: C08H1/00 ,  A61L31/04 ,  C07K7/00

CPC classification number: A61L31/10 ,  A61K38/08 ,  A61K38/39 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/047 ,  A61L31/16 ,  A61L2300/25 ,  A61L2420/02 ,  B05D3/007 ,  C07K14/001 ,  C08H1/00 ,  Y10T428/3154 ,  Y10T428/31909

Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.

Abstract translation: 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。

公开(公告)号：WO2006023672A2

公开(公告)日：2006-03-02

申请号：PCT/US2005/029443

申请日：2005-08-17

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed, F., A. ,  PACETTI, Stephen, D. ,  GALE, David

Inventor： HOSSAINY, Syed, F., A. ,  PACETTI, Stephen, D. ,  GALE, David

CPC classification number: A61L31/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/606 ,  C08G63/06 ,  C08G63/08 ,  C08G64/0208 ,  C08G64/0241 ,  C09D167/04 ,  C09D169/00 ,  C08L67/04

Abstract: Polymers that can form the substrate of an implantable medical device and form coatings for implantable medical devices and methods for their fabrication are disclosed, the coatings comprising polymers that are hydrolyzed at a substantially constant rate or that have been pre-pared so that they degrade at a rate closer to constant.

Abstract translation: 公开了可形成可植入医疗装置的基底并形成用于可植入医疗装置的涂层的聚合物及其制造方法，所述涂层包含以基本上恒定的速率水解的或已被预处理使得它们在 一个接近常数的比率。

公开(公告)号：WO2005118681A2

公开(公告)日：2005-12-15

申请号：PCT/US2005017690

申请日：2005-05-18

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  PACETTI STEPHEN D ,  CLAUDE CHARLES ,  GLAUSER THIERRY ,  DESNOYER JESSICA R ,  HOSSAINY SYED F A

Inventor： PACETTI STEPHEN D ,  CLAUDE CHARLES ,  GLAUSER THIERRY ,  DESNOYER JESSICA R ,  HOSSAINY SYED F A

IPC: A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C08G69/44

CPC classification number: C08G69/44 ,  A61L31/10 ,  C08L77/12

Abstract: Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.

Abstract translation: 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。

公开(公告)号：WO2005097220A1

公开(公告)日：2005-10-20

申请号：PCT/US2005/009881

申请日：2005-03-24

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  TANG, Yiwen ,  HOSSAINY, Syed, F., A. ,  TUNG, Andrew, C. ,  PACETTI, Stephen, D.

Inventor： TANG, Yiwen ,  HOSSAINY, Syed, F., A. ,  TUNG, Andrew, C. ,  PACETTI, Stephen, D.

IPC: A61L27/34

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L2420/06 ,  C08L67/04

Abstract: A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.

Abstract translation: 公开了一种医疗用品，其包含生物降解性AB嵌段共聚物和能够在平衡和室温下吸收少于约5质量％水的生物可降解聚合物。

公开(公告)号：WO2010019721A2

公开(公告)日：2010-02-18

申请号：PCT/US2009/053623

申请日：2009-08-12

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  CHEN, Jin ,  DUGAN, Stephen ,  STEWART, Gordon ,  ZHANG, Gina ,  KIRSTEN, Nancy ,  CONSIGNY, Paul ,  FEEZOR, Christopher ,  PARK, Gene ,  ROORDA, Wouter ,  HOSSAINY, Syed, F., A.

Inventor： CHEN, Jin ,  DUGAN, Stephen ,  STEWART, Gordon ,  ZHANG, Gina ,  KIRSTEN, Nancy ,  CONSIGNY, Paul ,  FEEZOR, Christopher ,  PARK, Gene ,  ROORDA, Wouter ,  HOSSAINY, Syed, F., A.

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K31/4745 ,  A61K31/56 ,  A61K31/573 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/45 ,  A61K2300/00

Abstract: A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2- hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2- hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1 - tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).

Abstract translation: 提供了包括至少100μg依维莫司和氯倍他索的药物递送系统，使得依维莫司与氯倍他索的比例至少为10:1（w / w）或依维莫司的量按 体重至少是氯倍他索的10倍。 该系统可以是支架。 还提供了治疗血管再狭窄或易损斑块的方法，所述方法包括局部给予患者选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，temsirolimus，匹美莫司， zotarolimus（ABT-578），40-O-（2-羟基）乙基雷帕霉素（依维莫司），40-0-（3-羟基）丙基雷帕霉素，40-0- [2-（2-羟基）乙氧基]乙基雷帕霉素， O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且向患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100μg，并且其中 第一种药物与第二种药物的比例为例如10:1至100:1（w / w）。

公开(公告)号：WO2008002636A2

公开(公告)日：2008-01-03

申请号：PCT/US2007014988

申请日：2007-06-26

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  HUANG BIN ,  CASTRO DANIEL ,  GALE DAVID C ,  HOSSAINY SYED F A

Inventor： HUANG BIN ,  CASTRO DANIEL ,  GALE DAVID C ,  HOSSAINY SYED F A

IPC: B29C45/72 ,  A61F2/86

CPC classification number: B29C45/7207 ,  A61F2/86 ,  B29C45/0001 ,  B29L2031/7532

Abstract: Methods of fabricating polymer stents using injection molding are disclosed.

Abstract translation: 公开了使用注射成型制造聚合物支架的方法。

公开(公告)号：WO2006058122A3

公开(公告)日：2006-10-05

申请号：PCT/US2005042541

申请日：2005-11-21

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  HOSSAINY SYED F A ,  PACETTI STEPHEN D

Inventor： HOSSAINY SYED F A ,  PACETTI STEPHEN D

IPC: C09D177/00 ,  A61L31/00 ,  A61L31/08 ,  A61L31/10 ,  A61L31/12 ,  C08L77/00 ,  C08L77/12 ,  C09D177/12

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/608 ,  C08L77/12

Abstract: A derivatized poly(ester amide) (D-PEA) and coatings and medical devices formed therefrom are provided. The coatings and medical devices may optionally include a biobeneficial material and/or a biocompatible polymer and/or a bioactive agent. The medical devices can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供衍生的聚（酯酰胺）（D-PEA）和由其形成的涂层和医疗装置。 涂层和医疗装置可以可选地包括生物有益材料和/或生物相容性聚合物和/或生物活性剂。 医疗装置可植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖和 人造移植物，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。