公开(公告)号：WO2003090910A1

公开(公告)日：2003-11-06

申请号：PCT/SE2003/000655

申请日：2003-04-23

Applicant: GAMBRO LUNDIA AB ,  FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG e.V. ,  MÜLLER, Michael ,  OEHR, Christian ,  MALTHANER, Heinrich ,  GOEHL, Hermann ,  DEPPISCH, Reinhold ,  STORR, Markus

Inventor： MÜLLER, Michael ,  OEHR, Christian ,  MALTHANER, Heinrich ,  GOEHL, Hermann ,  DEPPISCH, Reinhold ,  STORR, Markus

IPC: B01D63/02

CPC classification number: B01D67/009 ,  A61M1/3475 ,  A61M1/3486 ,  B01D67/0093 ,  B01D69/02 ,  B01J20/28004 ,  B01J20/28014 ,  B01J20/28021 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28097 ,  B01J20/3242 ,  G01N33/6878 ,  G01N33/6881

Abstract: A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.

Abstract translation: 公开了一种制备具有区域选择性亲和力的微孔亲和膜的方法，所述微孔亲和膜还包括在血液或所述流体纯化期间除去的血液或其它生物活性流体中的化合物，以及由所述方法生产的微孔亲和膜， 这样的微孔亲和膜，以及这种微孔亲和膜的使用。

公开(公告)号：WO2011131534A1

公开(公告)日：2011-10-27

申请号：PCT/EP2011/055798

申请日：2011-04-13

Applicant: GAMBRO LUNDIA AB ,  STORR, Markus ,  KRAUSE, Bernd ,  GOEHL, Hermann ,  ERTL, Thomas ,  GEKELER, Alexander

Inventor： STORR, Markus ,  KRAUSE, Bernd ,  GOEHL, Hermann ,  ERTL, Thomas ,  GEKELER, Alexander

IPC: A61M1/16 ,  A61M1/34 ,  B01D67/00

CPC classification number: B01D67/0009 ,  A61M1/16 ,  A61M1/1696 ,  A61M2210/1071 ,  B01D69/08 ,  B01D69/087 ,  B01D71/68 ,  B01D2325/20

Abstract: The present disclosure relates to an improved system for liver dialysis, which makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein bound toxins from the blood of a person in need. The specific hollow fiber membrane has the potential to improve the removal of albumin bound toxins and of inflammatory mediators. The present disclosure also relates to a high cut-off hemodialysis membrane for the treatment of liver failure.

Abstract translation: 本公开涉及一种用于肝脏透析的改进系统，其利用高截止血液透析膜从所需人的血液中除去水溶性和蛋白质结合的毒素。 特定的中空纤维膜具有改善白蛋白结合毒素和炎性介质的去除的潜力。 本公开还涉及用于治疗肝衰竭的高截止血液透析膜。

公开(公告)号：WO2004056460A1

公开(公告)日：2004-07-08

申请号：PCT/SE2003/001993

申请日：2003-12-18

Applicant: GAMBRO LUNDIA AB ,  BUCK, Reinhold ,  GOEHL, Hermann

Inventor： BUCK, Reinhold ,  GOEHL, Hermann

IPC: B01D69/08

CPC classification number: B01D67/0002 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  B01D67/0006 ,  B01D69/08 ,  B01D2325/02 ,  D01D5/24

Abstract: The present invention relates to a permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer. Further, the present invention relates to a process for the preparation of such a membrane, and the use of said membrane in hemodialysis, hemodiafiltration and hemofiltration for treatment of toxic mediator related diseases.

Abstract translation: 本发明涉及一种用于将有毒介质与血液分离的选择性不对称中空纤维膜，由至少一种疏水性聚合物和至少一种亲水性聚合物组成。 此外，本发明涉及一种制备这种膜的方法，以及所述膜在血液透析，血液透析滤过和血液滤过中用于治疗有毒介质相关疾病的用途。

公开(公告)号：WO2005044340A1

公开(公告)日：2005-05-19

申请号：PCT/EP2004/012277

申请日：2004-10-29

Applicant: GAMBRO LUNDIA AB ,  DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco

Inventor： DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco

IPC: A61M1/36

CPC classification number: A61M1/3627 ,  A61M1/1008 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12 ,  B01D61/30 ,  B01D63/02

Abstract: A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.

Abstract translation: 一种用于通过体外血液处理装置引导和监测来自和来自患者的流体循环的流体分配模块（1），包括连接到连接结构（10）的脱气装置（11）。 脱气装置（11）包括具有用于液体的下入口（13）的第一室（12）和具有由疏水膜（78）和出口（15）封闭的上开口（79）的第二室（14） ）用于排出液体。 连接结构（10）具有至少限定在其中的第一和第二导管（20,21），其中第一导管（20）包括用于从治疗装置连接到放电管（7）的第一端和第二导管 端部连接到脱气装置（11）的第一室（12）的入口（13），并且第二管道（21）包括连接到第二室（14）的出口（15）的第一端 脱气装置（11）和用于连接到患者的血液回流管（6）的第二端。

公开(公告)号：WO2011110600A1

公开(公告)日：2011-09-15

申请号：PCT/EP2011/053549

申请日：2011-03-09

Applicant: GAMBRO LUNDIA AB ,  KRAUSE, Bernd ,  GOEHL, Hermann ,  STORR, Markus ,  MENDA, Ralf ,  HERZ, Hans-Georg ,  WILLIARDT, Joerg

Inventor： KRAUSE, Bernd ,  GOEHL, Hermann ,  STORR, Markus ,  MENDA, Ralf ,  HERZ, Hans-Georg ,  WILLIARDT, Joerg

IPC: C08G81/02 ,  C08L81/06 ,  B01D71/68 ,  B01D71/78

CPC classification number: C08F271/02 ,  B01D67/0011 ,  B01D67/0016 ,  B01D71/44 ,  B01D71/68 ,  B01D71/78 ,  B01D2323/08 ,  B01D2323/38 ,  C08G81/024 ,  C08L39/06 ,  C08L81/06 ,  C08L2666/04

Abstract: The present disclosure relates to graft copolymers of hydrophobic polymers and hydrophilic polymers, to a method for their preparation, and their use in membranes for medical treatments like hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and membranes for bio-processing.

Abstract translation: 本公开涉及疏水性聚合物和亲水性聚合物的接枝共聚物，其制备方法，以及它们在血液透析，血液透析滤过和血液滤过等用于医疗处理的膜中的用途，用于水净化的膜和用于生物处理的膜。

公开(公告)号：WO2005053772A1

公开(公告)日：2005-06-16

申请号：PCT/EP2004/012372

申请日：2004-11-02

Applicant: GAMBRO LUNDIA AB ,  DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco

Inventor： DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco

IPC: A61M1/36

CPC classification number: A61M1/16 ,  A61M1/3627 ,  A61M2205/12 ,  B01D2313/21

Abstract: A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).

Abstract translation: 脱气装置（203）包括具有用于液体的入口的第一室（21）和具有由疏水膜（24）封闭的开口（23）的第二室（22）和用于排出 液体。 第一室（21）具有在第二室（22）内部分地延伸并与通道（28）连通的下游部分。 第二室（22）具有在通道（28）下方延伸并且不对称地包围第一室（21）的下游部分的下游部分。

公开(公告)号：WO2005044341A1

公开(公告)日：2005-05-19

申请号：PCT/EP2004/012528

申请日：2004-11-05

Applicant: GAMBRO LUNDIA AB ,  DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco ,  SEIDLER, Björn Frederik ,  JÖNSSON, Lennart ,  NILSSON, Eddie

Inventor： DANNENMAIER, Jürgen ,  GOEHL, Hermann ,  ERTL, Thomas ,  CHEVALLET, Jacques ,  RIBOLZI, Francesco ,  SEIDLER, Björn Frederik ,  JÖNSSON, Lennart ,  NILSSON, Eddie

IPC: A61M1/36

CPC classification number: A61M1/3627 ,  A61M1/1008 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12 ,  B01D61/30 ,  B01D63/02

Abstract: An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.

Abstract translation: 集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。 用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16） （4）以形成环路。 脱气装置（30）连接到第二端帽（5）。 在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。

公开(公告)号：WO2003077966A1

公开(公告)日：2003-09-25

申请号：PCT/IB2003/000934

申请日：2003-03-07

Applicant: GAMBRO LUNDIA AB ,  MALAGOLI, Marcello ,  DELNEVO, Annalisa ,  GOEHL, Hermann ,  HANNA, Martin

Inventor： MALAGOLI, Marcello ,  DELNEVO, Annalisa ,  GOEHL, Hermann ,  HANNA, Martin

IPC: A61L29/04

CPC classification number: A61M1/367 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M2205/12 ,  Y10T428/139

Abstract: A tube (1, 3, 7) for medical applications comprises a chlorine-free material and has a layer (2, 4, 8) defining an outer surface (2a, 4a, 8a) of the tube (1, 3, 7) and is manufactured from a polymer material having a solubility parameter within the range 9.9 ± 1.5 (cal/cm 3 ) ½ .

Abstract translation: 用于医疗应用的管（1,3,7）包括无氯材料并且具有限定管（1,3,7）的外表面（2a，4a，8a）的层（2,4,8） 并且由溶解度参数在9.9±1.5（cal / cm 3）1/2范围内的聚合物材料制成。