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公开(公告)号：WO2012149356A3
公开(公告)日：2012-11-01
申请号：PCT/US2012/035502
申请日：2012-04-27
Applicant: APEXIGEN, INC. , ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
Inventor： ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
IPC: C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.
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公开(公告)号：WO2008133643A8
公开(公告)日：2011-10-06
申请号：PCT/US2007021987
申请日：2007-10-12
Applicant: MONSANTO TECHNOLOGY LLC , ALLEN EDWARDS , GOLDMAN BARRY S , GUO LIANG , HEISEL SARA E , HUANG SHIHSHIEH , IVASHUTA SERGEY I , KRIEGER ELYSIA K , ROBERTS JAMES K , ZHANG YUANJI I
Inventor： ALLEN EDWARDS , GOLDMAN BARRY S , GUO LIANG , HEISEL SARA E , HUANG SHIHSHIEH , IVASHUTA SERGEY I , KRIEGER ELYSIA K , ROBERTS JAMES K , ZHANG YUANJI I
CPC classification number: C12N15/113 , C12N15/8216 , C12N15/8218 , C12N15/8238 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/8286 , C12N2310/141 , C12N2320/50 , Y02A40/146 , Y02A40/162
Abstract: This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.
Abstract translation: 本发明公开了新的微小RNA及其前体，以及重组DNA构建体，包括这样的新型miRNA，miRNA前体，miRNA启动子和对应于miRNA的miRNA识别位点。 包括显示营养反应表达的新型miRNA和miRNA前体。 还公开了miRNA诱饵序列。 还提供了非天然转基因植物细胞，植物和种子，在其基因组中含有本发明的重组DNA构建体和使用本发明的重组DNA构建体控制基因表达的方法。
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3.发明申请ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开来自大豆的分离的新型核酸和蛋白质分子以及使用这些分子生产具有增强的农业条件的转基因植物的方法
公开(公告)号：WO2009099580A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/000655
申请日：2009-02-02
Applicant: MONSANTO TECHNOLOGY, LLC , KOVALIC, David , TABASKA, Jack , QIU, Bo-xing , WU, Wei , GUO, Liang
Inventor： KOVALIC, David , TABASKA, Jack , QIU, Bo-xing , WU, Wei , GUO, Liang
IPC: A01H5/00
CPC classification number: C12N15/8218 , A01H5/10 , C07K14/415 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12N15/8278
Abstract: This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants.
Abstract translation: 本公开提供了纯化的核酸和多肽。 还提供了转基因植物，种子和含有用于表达可用于赋予转基因作物植物增强的农学性状的蛋白质的DNA的植物细胞，以及制造这种植物的方法以及制造包括种子和杂交种子在内的农产品的方法 从这样的植物。
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公开(公告)号：WO2008039087A3
公开(公告)日：2008-08-14
申请号：PCT/NZ2007000285
申请日：2007-09-28
Applicant: AUCKLAND UNISERVICES LTD , STRIBBLING STEPHEN MARK , MOUNTJOY KATHLEEN GRACE , TERCEL MOANA , WILSON WILLIAM ROBERT , DENNY WILLIAM ALEXANDER , STEVENSON RALPH JAMES , LU GUO-LIANG
Inventor： STRIBBLING STEPHEN MARK , MOUNTJOY KATHLEEN GRACE , TERCEL MOANA , WILSON WILLIAM ROBERT , DENNY WILLIAM ALEXANDER , STEVENSON RALPH JAMES , LU GUO-LIANG
IPC: C07D403/12 , A61K31/395 , A61K31/403 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , C07D209/56
CPC classification number: C07D209/60 , C07D403/12
Abstract: The present invention relates to compounds which are indoline derivatives of formula (I), wherein Rl, R2, R3, R4 and n are as defined in the specification, intermediates used in their synthesis and pharmaceutical compositions containing these compounds. The invention is also concerned with methods utilising these compounds in prophylactic or therapeutic treatment of obesity, weight gain, metabolic disorders resulting in obesity or weight gain and associated conditions such as high blood glucose and triglycerides, and Type II diabetes.
Abstract translation: 本发明涉及作为式（I）的二氢吲哚衍生物的化合物，其中R1，R2，R3，R4和n如本说明书中所定义，在其合成中使用的中间体和含有这些化合物的药物组合物。 本发明还涉及利用这些化合物在预防或治疗肥胖症，体重增加，导致肥胖或体重增加的代谢紊乱以及相关病症如高血糖和甘油三酸酯以及II型糖尿病中的方法。
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公开(公告)号：WO2007123765A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/008021
申请日：2007-03-30
Applicant: HUMAN GENOME SCIENCES INC. , YU, Guo-liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen , CHEVRIER, Marc
Inventor： YU, Guo-liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen , CHEVRIER, Marc
Abstract: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2004022715A2
公开(公告)日：2004-03-18
申请号：PCT/US2003/027913
申请日：2003-09-08
Applicant: THE OHIO STATE UNIVERSITY , WANG, Guo-liang
Inventor： WANG, Guo-liang
IPC: C12N
CPC classification number: C12N15/8282 , C07K14/415
Abstract: Compositions and methods for enhancing or creating plant disease resistance to plant pests are provided. Transforming a plant with a novel rice Pi2-like disease resistance gene of the invention enhances disease resistance of the plant. Transformed plants, plant cells, tissues, and seed having enhanced disease resistance are also provided.
Abstract translation: 提供了用于增强或产生对植物害虫的植物病害抗性的组合物和方法。 用本发明的新型水稻Pi2样抗病基因转化植物提高了植物的抗病性。 还提供了具有增强的抗病性的转化植物，植物细胞，组织和种子。
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公开(公告)号：WO03013227A9
公开(公告)日：2003-07-03
申请号：PCT/US0225805
申请日：2002-08-09
Applicant: MENDEL BIOTECHNOLOGY INC , RATCLIFFE OLIVER , RIECHMANN JOSE LUIS , ADAM LUC J , DUBELL ARNOLD N , HEARD JACQUELINE E , PILGRIM MARSHA L , JIANG CAI-ZHONG , REUBER T LYNNE , CREELMAN ROBERT A , PINEDA OMAIRA , YU GUO-LIANG , BROUN PIERRE E
Inventor： RATCLIFFE OLIVER , RIECHMANN JOSE LUIS , ADAM LUC J , DUBELL ARNOLD N , HEARD JACQUELINE E , PILGRIM MARSHA L , JIANG CAI-ZHONG , REUBER T LYNNE , CREELMAN ROBERT A , PINEDA OMAIRA , YU GUO-LIANG , BROUN PIERRE E
IPC: A01H5/10 , C07K14/415 , C12N15/29 , C12N15/82 , A01H
CPC classification number: A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
Abstract translation: 本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自各种植物物种的同系物，以及使用多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。 与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法，并且也被公开。
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公开(公告)号：WO03014327A3
公开(公告)日：2003-05-30
申请号：PCT/US0226966
申请日：2002-08-09
Applicant: MENDEL BIOTECHNOLOGY INC , REUBER T LYNNE , RIECHMANN JOSE LUIS , HEARD JACQUELINE E , JIANG CAI-ZHONG , ADAM LUC J , DUBELL ARNOLD N , RATCLIFFE OLIVER , PINEDA OMAIRA , YU GUO LIANG , BROUN PIERRE E
Inventor： REUBER T LYNNE , RIECHMANN JOSE LUIS , HEARD JACQUELINE E , JIANG CAI-ZHONG , ADAM LUC J , DUBELL ARNOLD N , RATCLIFFE OLIVER , PINEDA OMAIRA , YU GUO LIANG , BROUN PIERRE E
CPC classification number: A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
Abstract translation: 本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自多种植物物种的同源物，以及使用该多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。 与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法中，并且也被公开。
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公开(公告)号：WO2003014327A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/026966
申请日：2002-08-09
Applicant: MENDEL BIOTECHNOLOGY, INC. , REUBER, T., Lynne , RIECHMANN, Jose Luis , HEARD, Jacqueline, E. , JIANG, Cai-Zhong , ADAM, Luc, J. , DUBELL, Arnold, N. , RATCLIFFE, Oliver , PINEDA, Omaira , YU, Guo, Liang , BROUN, Pierre, E.
Inventor： REUBER, T., Lynne , RIECHMANN, Jose Luis , HEARD, Jacqueline, E. , JIANG, Cai-Zhong , ADAM, Luc, J. , DUBELL, Arnold, N. , RATCLIFFE, Oliver , PINEDA, Omaira , YU, Guo, Liang , BROUN, Pierre, E.
IPC: C12N
CPC classification number: A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
Abstract translation: 本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自各种植物物种的同系物，以及使用多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。 与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法，并且也被公开。
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公开(公告)号：WO0196528A3
公开(公告)日：2002-08-08
申请号：PCT/US0119026
申请日：2001-06-14
Applicant: HUMAN GENOME SCIENCES INC , YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
Inventor： YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
IPC: A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K16/28 , G01N33/564 , C12Q1/68 , A61K38/00 , C07H21/02
CPC classification number: A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
Abstract translation: 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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