公开(公告)号：WO2008067639A1

公开(公告)日：2008-06-12

申请号：PCT/CA2007/002132

申请日：2007-11-27

Applicant: H3 FORMULATIONS LTD. ,  HEUER, Marvin A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken

Inventor： HEUER, Marvin A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken

IPC: A61K36/754 ,  A61K31/205 ,  A61K31/175 ,  A61K31/7072 ,  A61K36/185 ,  A61K36/76 ,  A61K36/82 ,  A61P3/04

CPC classification number: A61K36/185 ,  A61K31/175 ,  A61K31/205 ,  A61K31/7072 ,  A61K36/74 ,  A61K36/754

Abstract: A nutritional composition and method is provided for promoting weight loss or weight maintenance in an individual by supporting and enhancing thermogenesis and lipid oxidation comprising therapeutically effective amounts of yohimbine from the bark of the tree Corynanthe yohimbe , an effective amount of Evodia rutaecarpia extract and a source of an effective amount of L-carnitine The composition further comprising at least one of Yerba mate , black tea, white tea, Theobromo cacao , caffeine and white willow bark.

Abstract translation: 提供营养组合物和方法，用于通过支持和增强生热和脂质氧化来促进个体的体重减轻或体重维持，其包括来自树Corynanthe yohimbe的树皮的治疗有效量的育亨宾，有效量的Evodia rutaecarpia提取物和来源 的有效量的L-肉碱该组合物还包含Yerba伴侣，红茶，白茶，Theobromo可可，咖啡因和白柳树皮中的至少一种。

公开(公告)号：WO2007095717A1

公开(公告)日：2007-08-30

申请号：PCT/CA2006/001345

申请日：2006-08-16

Applicant: H3 FORMULATIONS LTD. ,  HEUER, Marvin, A. ,  CLEMENT, Ken ,  CHAUDHURI, Shan

Inventor： HEUER, Marvin, A. ,  CLEMENT, Ken ,  CHAUDHURI, Shan

IPC: A61K31/52 ,  A23L1/29 ,  A23K1/16 ,  A23L3/00 ,  A23P1/02 ,  A61K31/198 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K36/539 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A23L33/16 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/0095 ,  A61K9/14 ,  A61K9/20 ,  A61K9/2072 ,  A61K31/122 ,  A61K31/185 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K31/4045 ,  A61K31/455 ,  A61K31/555 ,  A61K31/715 ,  A61K33/24 ,  A61K33/42 ,  A61K36/185 ,  A61K36/53 ,  A61K36/752 ,  A61K36/76 ,  A61K36/84 ,  A61K36/889 ,  H01L21/28273 ,  H01L29/42324 ,  H01L29/788 ,  H01L29/7884 ,  Y10S514/923 ,  A61K2300/00 ,  A23V2200/20 ,  A23V2250/0606 ,  A23V2250/7046 ,  A23V2200/326 ,  A23V2200/316 ,  A23V2250/06 ,  A23V2250/0644 ,  A23V2250/21

Abstract: The present invention relates to a dietary supplement and method for a rapidly dissolving and disintegrating solid oral dosage form. Specifically, the present invention provides dietary supplements and methods for the delivery of dietary supplements comprising Arginine or derivatives thereof and Xanthinol Nicotinate or derivatives thereof. By way of oral administration to an individual of said solid oral dosage form, a method of rapidly increasing nitric oxide activity in an individual is also provided.

Abstract translation: 本发明涉及一种快速溶解和崩解固体口服剂型的膳食补充剂和方法。 具体地，本发明提供了用于递送包含精氨酸或其衍生物和烟酸黄豆醇或其衍生物的膳食补充剂的膳食补充剂和方法。 通过口服给予所述固体口服剂型的个体，也提供了个体中一氧化氮活性快速增加的方法。

公开(公告)号：WO2009079741A1

公开(公告)日：2009-07-02

申请号：PCT/CA2007/002371

申请日：2007-12-21

Applicant: H3 FORMULATIONS LTD. ,  MOLINO, Michele ,  MACDOUGALL, Joseph ,  APONG, Phil

Inventor： MOLINO, Michele ,  MACDOUGALL, Joseph ,  APONG, Phil

IPC: A61K31/36 ,  A23L1/30 ,  A61K31/7048 ,  A61P21/06

CPC classification number: A61K31/36 ,  A23L33/10 ,  A23L33/105

Abstract: Mammalian cells express heat shock proteins (HSPs) in response to various stresses, such as exercise. Recent studies suggest that expression of heat shock proteins in general, and HSP72 in particular, play a role in muscular hypertrophy. The present invention is directed to nutritional compositions comprising a synergistic combination of a compound which activates heat shock protein transcription factors, and a compound which increases the production of oxidants from cyotochrome P-450 metabolism (indirectly influencing HSP functionality), and methods of using said compositions for improving muscle building. In a preferred embodiment, the transcription factor activator is selected from the group consisting of geranylgeranylacetone, paeoniflorin, derivatives of the preceding, and mixtures of the preceding, and the P- 450 metabolic enhancer is Schisandrin B.

Abstract translation: 哺乳动物细胞响应各种应激（如运动）表达热休克蛋白（HSP）。 最近的研究表明，一般来说，热休克蛋白的表达，特别是HSP72在肌肉肥大中起作用。 本发明涉及包含活化热休克蛋白转录因子的化合物的协同组合的营养组合物和增加由细胞色素P-450代谢（间接影响HSP功能性）的氧化剂产生的化合物，以及使用所述 用于改善肌肉建设的组合物。 在优选的实施方案中，转录因子活化剂选自香叶基香叶基丙酮，芍药苷，前述的衍生物，前述的混合物和P-450代谢增强剂是五味子二

公开(公告)号：WO2007006135A1

公开(公告)日：2007-01-18

申请号：PCT/CA2006/001110

申请日：2006-07-07

Applicant: H3 FORMULATIONS LTD. ,  HEUER, Marvin, A. ,  MOLINO, Michele

Inventor： HEUER, Marvin, A. ,  MOLINO, Michele

IPC: A61K31/575 ,  A61K31/352

CPC classification number: A61K36/424 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A23L33/17 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/205 ,  A61K31/353 ,  A61K31/685 ,  A61K31/70 ,  A61K31/702 ,  A61K31/7048 ,  A61K2300/00 ,  A23V2200/316 ,  A23V2250/214 ,  A23V2250/306 ,  A23V2250/0634 ,  A23V2250/06 ,  A23V2250/2132 ,  A23V2250/21 ,  A23V2250/54 ,  A23V2200/33

Abstract: A dietary supplement and method for enhancing skeletal muscle mass, decreasing muscle protein degradation, downregulation of muscle catabolism pathways, and decreasing catabolism of muscle cells an individual, the supplement comprising at least source of Creatine or derivatives thereof, a source of Gypenosides or Phanoside or derivatives thereof, Creatinol-O- phosphate, and a source of Epigallocatechin Gallate or derivatives thereof. The dietary supplement may further comprise N-acetyl cysteine, astaxanthin, a protein or a carbohydrate. A method of enhancing GLUT4 translocation to the plasma membrane in non-adipose cells, decreasing muscle protein degradation, downregulation of the ATP-dependent ubiquination pathway of muscle catabolism, and decreasing catabolism of muscle cells through reducing the activation of NF-κβ is also provided.

Abstract translation: 一种用于增强骨骼肌质量，减少肌肉蛋白质降解，肌肉分解代谢途径下调以及降低个体肌肉细胞分解代谢的膳食补充剂和方法，所述补充剂至少包含肌酸或其衍生物来源，Gypenosides或Phanoside的来源或 其衍生物，肌醇-O-磷酸酯，以及表没食子儿茶素镓酸盐的来源或其衍生物。 膳食补充剂还可以包含N-乙酰半胱氨酸，虾青素，蛋白质或碳水化合物。 增加GLUT4易位于非脂肪细胞中的质膜的方法，减少肌肉蛋白质降解，ATP依赖性泛素化途径的肌肉分解代谢的下调，以及通过降低NF-κB的活化降低肌细胞的分解代谢也是 提供。

公开(公告)号：WO2008074139A1

公开(公告)日：2008-06-26

申请号：PCT/CA2007/002303

申请日：2007-12-18

Applicant: H3 FORMULATIONS LTD. ,  SCALISI, Vincent ,  HEUER, Marvin, A. ,  CLEMENT, Ken

Inventor： SCALISI, Vincent ,  HEUER, Marvin, A. ,  CLEMENT, Ken

IPC: A61L9/14 ,  A23L1/00 ,  A23L1/30 ,  B65B31/04

CPC classification number: A23L33/175 ,  A23L27/00 ,  A23P10/40 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/306 ,  A23V2250/0606 ,  A23V2250/0628 ,  A23V2250/5114 ,  A23V2200/254

Abstract: The present invention relates to a method for producing a sensory stimulating effect upon the opening of a vessel containing a nutritional or dietary supplement. The sensory stimulating effect occurs each time the vessel is opened and without shaking or disturbance of the vessel prior to said opening. At least some of the nutritional or dietary supplement is fine-milled to produce particles of an effective size and an effective weight to provide the desired effect upon opening the vessel.

Abstract translation: 本发明涉及一种在含有营养或膳食补充剂的容器打开时产生感觉刺激作用的方法。 每次打开容器并且在所述打开之前不会摇晃或扰动容器时，都会发生感觉刺激作用。 至少一些营养或膳食补充剂被精细研磨以产生有效尺寸和有效重量的颗粒，以在打开容器时提供期望的效果。

公开(公告)号：WO2008067641A1

公开(公告)日：2008-06-12

申请号：PCT/CA2007/002134

申请日：2007-11-27

Applicant: H3 FORMULATIONS LTD. ,  HEUER, Marvin A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken ,  MOLINO, Michele

Inventor： HEUER, Marvin A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken ,  MOLINO, Michele

IPC: A61K36/734 ,  A61K31/198 ,  A61K31/352 ,  A61K31/522 ,  A61K36/15 ,  A61K36/258 ,  A61K36/28 ,  A61K36/424 ,  A61K36/537 ,  A61P9/02

CPC classification number: A61K36/15 ,  A61K31/198 ,  A61K31/352 ,  A61K31/522 ,  A61K36/258 ,  A61K36/28 ,  A61K36/424 ,  A61K36/537 ,  A61K36/734

Abstract: A nutritional composition and method is provided for increasing blood flow to skeletal muscle leading to increased vasolidation in an individual by supporting the biological activity of nitric oxide comprising L-arginine, Crataegus extract and Artichoke flavonoids. Increased vasolidation assists in the transport of metabolic products during skeletal muscle exercise.

Abstract translation: 提供一种营养组合物和方法，用于通过支持包含L-精氨酸，山楂提取物和朝鲜蓟酮类黄酮的一氧化氮的生物活性来增加对骨骼肌的血液，导致个体中增加的血管融合。 增加血管巩固有助于骨骼肌运动中代谢产物的运输。

公开(公告)号：WO2008067640A1

公开(公告)日：2008-06-12

申请号：PCT/CA2007/002133

申请日：2007-11-27

Applicant: H3 FORMULATIONS LTD. ,  HEUER, Marvin, A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken

Inventor： HEUER, Marvin, A. ,  CHAUDHURI, Shan ,  CLEMENT, Ken

IPC: A61K31/506 ,  A61K31/16 ,  A61K31/198 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/661

CPC classification number: A61K31/4375 ,  A61K31/16 ,  A61K31/198 ,  A61K31/435 ,  A61K31/506 ,  A61K31/661 ,  A61K2300/00

Abstract: A nutritional composition and method is provided for enhancing cognition, providing nootropic effects to improve concentration in an individual by supporting the biological activity of the neurotransmitters comprising therapeutically effective amounts of Sulbutiamine or derivatives thereof, an effective amount of Huperzine-A or derivatives thereof and an effective amount of Tyrosine or derivatives thereof.

Abstract translation: 提供了一种营养组合物和方法，用于增强认知，通过支持神经递质的生物活性来提供益智效应以提高个体的浓度，所述神经递质包括治疗有效量的苏必比胺或其衍生物，有效量的石杉碱甲或其衍生物，以及 有效量的酪氨酸或其衍生物。