METHOD OF TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING USING ZONISAMIDE AND MEANS FOR CARRYING OUT THE METHOD
    3.
    发明申请
    METHOD OF TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING USING ZONISAMIDE AND MEANS FOR CARRYING OUT THE METHOD 审中-公开
    治疗和诊断使用松果酸的睡眠障碍性呼吸的方法和实施方法的手段

    公开(公告)号:WO2005077362A1

    公开(公告)日:2005-08-25

    申请号:PCT/SE2005/000196

    申请日:2005-02-15

    CPC classification number: A61K31/423 Y10S514/923

    Abstract: A method of treating or preventing Obstructive Sleep Apnea (OSA) comprises the administration of a pharmacologically effective amount of zonisamide to a patient in need thereof, with the proviso that OSA caused by external mechanical obstruction of the airways, such as by mucus, is excluded. Also disclosed is the use of zonisamide for the manufacture of a medicament useful in the treatment; a protective patch comprising zonisamide and a pharmaceutically acceptable carrier for transdermal or transmucosal administration to a person suffering from OSA; and the use of zonisamide for the manufacture of a diagnostic device, kit or composition for the diagnosis of sleep disordered breathing.

    Abstract translation: 治疗或预防阻塞性睡眠呼吸暂停(OSA)的方法包括向有需要的患者施用药理学有效量的唑尼沙胺,条件是由气道的外部机械阻塞(例如通过粘液)引起的OSA被排除 。 还公开了使用唑尼沙胺制造用于治疗的药物; 包含唑尼沙星和药物学上可接受的载体的保护性片剂,用于向患有OSA的人透皮或经粘膜给药; 以及使用唑尼沙胺制造用于诊断睡眠呼吸障碍的诊断装置,试剂盒或组合物。

    PHARMACOLOGIC MANAGEMENT OF SNORING
    5.
    发明申请
    PHARMACOLOGIC MANAGEMENT OF SNORING 审中-公开
    动物的药理学管理

    公开(公告)号:WO1996020700A1

    公开(公告)日:1996-07-11

    申请号:PCT/US1995017062

    申请日:1995-12-29

    Abstract: A method of pharmaceutically managing snoring is provided by the instillation intranasally of a solution containing 1-20 % methylsulfonylmethane by weight dissolved in water so as to saturate the nasal mucous membranes. Preferably, the solution has between 10 %-16 % by weight methylsulfonylmethane. The solution may be buffered, and/or a mild analgesic may be included. The method prefers that instillation occur as close to the sleep event as possible, and it should be at least within one hour before a person retires for sleep. The solution may be introduced by spray or drop-wise, and a product packaging the solution in a suitable container is described.

    Abstract translation: 通过鼻内滴入含有溶解在水中的重量为1-20%的甲基磺酰基甲烷的溶液以使鼻粘膜饱和来提供药物学打鼾的方法。 优选地,该溶液具有10重量%-16重量%的甲基磺酰基甲烷。 溶液可以被缓冲,和/或可以包括温和的止痛剂。 该方法倾向于尽可能接近睡眠事件发生滴注,并且应至少在一个人退休睡眠前一小时内。 该溶液可以通过喷雾或滴落式引入,并且将溶液包装在合适的容器中进行描述。

    METHOD OF TREATING SLEEPLESSNESS WITH MELATONIN ON AN ACUTE BASIS
    9.
    发明申请
    METHOD OF TREATING SLEEPLESSNESS WITH MELATONIN ON AN ACUTE BASIS 审中-公开
    在急性基础上用MELATONIN治疗无症状的方法

    公开(公告)号:WO2004028533A1

    公开(公告)日:2004-04-08

    申请号:PCT/US2003/030878

    申请日:2003-09-19

    Inventor: ROSENTHAL, Holly

    CPC classification number: A61K31/40 Y10S514/923

    Abstract: A method of treating sleeplessness in a human comprising administering to said human suffering from said sleeplessness an effective sleep-inducing amount of not greater than about 5 mg of melatonin or a pharmaceutically acceptable salt thereof, said administration being at a point in time after said human attempts to go to sleep until no less than one hour prior to said patient's desired awakening time.

    Abstract translation: 一种治疗人类失眠的方法,包括给所述患有所述失眠的人施用不大于约5mg褪黑素或其药学上可接受的盐的有效睡眠诱导量,所述给药在所述人之后的时间点 试图在所述患者期望的唤醒时间之前不少于1小时进入睡眠状态。

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