公开(公告)号：WO2007024485A8

公开(公告)日：2007-05-18

申请号：PCT/US2006031053

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORP ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

Inventor： HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

IPC: G01L3/02

CPC classification number: B01F13/0059 ,  B01F5/0646 ,  B01F5/0647 ,  Y10T29/494

Abstract: Microfluidic Systems, Devices and Methods for Reducing Diffusion and Compliance Effects at a Fluid Mixing Region. According to one embodiment, a microfluidic device is provided for combining fluids in a mixing region. The microfluidic device can include a fluid mixing region connected to a first and second microscale channel. The microscale channels can advance fluids to the fluid mixing region. The microscale channels can include constricted flow portions. According to another embodiment, the microscale channels can be connected to waste channels for removing fluid diffused into one of the channels from the other channel. According to yet another embodiment, a microfluidic system is provided for controlling the flow of fluids through the microscale channels for reducing or eliminating diffusion between the channels.

Abstract translation: 用于减少流体混合区域的扩散和顺从效应的微流体系统，装置和方法。 根据一个实施例，提供了用于在混合区域中组合流体的微流体装置。 微流体装置可以包括连接到第一和第二微型通道的流体混合区域。 微型通道可将流体推进到流体混合区域。 微型通道可以包括收缩的流动部分。 根据另一个实施例，微型通道可以连接到废物通道，用于去除从另一个通道扩散到一个通道中的流体。 根据又一个实施例，提供了一种微流体系统，用于控制流体通过微型通道的流动，以减少或消除通道之间的扩散。

公开(公告)号：WO2007021815A2

公开(公告)日：2007-02-22

申请号：PCT/US2006/031164

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORPORATION ,  HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  KUNG, Pang-jen, Craig ,  PEETIGREW, Kenneth, I. ,  WARRINGTON, Brian, Harbert ,  CRENSHAW, Hugh, C.

Inventor： HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  KUNG, Pang-jen, Craig ,  PEETIGREW, Kenneth, I. ,  WARRINGTON, Brian, Harbert ,  CRENSHAW, Hugh, C.

IPC: C12M3/00

CPC classification number: B01L3/502715 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N2021/0346 ,  G02B6/10 ,  G02B6/1228 ,  G02B6/305 ,  G02B6/3636 ,  G02B6/3644 ,  G02B6/3652 ,  G02B6/3688 ,  G02B6/3692 ,  G02B6/3696 ,  Y10T29/49885

Abstract: Microfluidic Chip Apparatuses, Systems, and Methods having Fluidic and Fiber Optic Interconnections. According to one embodiment, apparatuses and methods are provided for connecting a light-guiding conduit to a microfluidic channel. First and second substrates with first surfaces can be provided, wherein the first surfaces of the first and second substrates form a microfluidic channel and a connection channel when the first surfaces are positioned together, and wherein the connection channel extends from an edge of the first surface of the first or second substrate to the microfluidic channel. The apparatus and method can also include bonding the first surfaces of the first and second substrates to form the microfluidic channel and the connection channel. A light-guiding conduit can be inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel and filling an area between the light-guiding conduit and the connection channel for forming a liquid-tight seal between the light-guiding conduit and the connection channel.

Abstract translation: 具有流体和光纤互连的微流控芯片装置，系统和方法。 根据一个实施例，提供了用于将导光管连接到微流体通道的装置和方法。 可以提供具有第一表面的第一和第二基底，其中第一和第二基底的第一表面在第一表面位于一起时形成微流体通道和连接通道，并且其中连接通道从第一表面的边缘延伸 的第一或第二基底到微流体通道。 该装置和方法还可以包括粘合第一和第二基底的第一表面以形成微流体通道和连接通道。 导光管可以插入连接通道中，使得导光管连接到微流体通道并且填充导光管和连接通道之间的区域，以在导光管之间形成液密密封 导管和连接通道。

公开(公告)号：WO2007021811A2

公开(公告)日：2007-02-22

申请号：PCT/US2006031160

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORP ,  WYRICK DAVID W ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  PATEL MEHUL ,  POLLACK MICHAEL G ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

Inventor： WYRICK DAVID W ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  PATEL MEHUL ,  POLLACK MICHAEL G ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

IPC: C12M3/00

CPC classification number: B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00961 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/565 ,  B01L7/00 ,  B01L9/527 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0487 ,  F28F3/02

Abstract: An actively temperature regulated microfluidic chip assembly includes a first thermally conductive body, a second thermally conductive body attached to the first thermally conductive body, a microfluidic chip encapsulated between the first and second thermally conductive bodies, and a temperature regulating element mounted to the first thermally conductive body for adding heat to or alternately removing heat from the chip. The temperature of the chip and thus the liquid contained and/or flowing therein can be regulated by measuring the temperature of the liquid and operating the temperature regulating element to establish a thermal gradient toward or alternately away from the liquid based on the measured temperature and in comparison with a desired set point temperature.

Abstract translation: 主动温度调节的微流体芯片组件包括第一导热体，连接到第一导热体的第二导热体，封装在第一和第二导热体之间的微流体芯片，以及安装在第一导热体上的温度调节元件 导电体，用于向芯片加热或交替地从芯片中去除热量。 可以通过测量液体的温度和操作温度调节元件来调节芯片的温度，从而使其中含有和/或流过的液体的温度基于测量的温度来建立朝向或者远离液体的热梯度，并且在 与所需设定点温度进行比较。

公开(公告)号：WO2007021755A3

公开(公告)日：2007-10-11

申请号：PCT/US2006031054

申请日：2006-08-10

Applicant: EKSIGENT TECHNOLOGIES LLC ,  CRENSHAW HUGH C ,  COLONELL JENNIFER ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  WYRICK DAVID W

Inventor： CRENSHAW HUGH C ,  COLONELL JENNIFER ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  WYRICK DAVID W

IPC: C12M3/00

CPC classification number: B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/5027 ,  Y10T137/0329 ,  Y10T137/86131 ,  Y10T137/87249

Abstract: Microfluidic Systems, Devices and Methods for Reducing Noise Generated by Mechanical Instabilities. According to one embodiment, a microfluidic device is provided for reducing noise in a fluid mix. The microfluidic device can include microscale channels for passage of fluids to a mixing junction. The mixing channel can be adapted to combine the fluids into a common fluid flow. The microfluidic device can also include a connector channel including first and second ends. The first end of the connector channel can be connected to the mixing junction. The microfluidic device can also include an expansion channel having connection to the second end of the connector channel. The expansion channel can be adapted for passage of the fluid mix through the expansion channel to reduce concentration gradient noise of the fluid mix by dispersion of the fluid mix as the fluid mix passes through the expansion channel.

Abstract translation: 微流控系统，降低机械不稳定噪声的设备和方法。 根据一个实施例，提供了用于减少流体混合物中的噪声的微流体装置。 微流体装置可以包括用于将流体通过混合结的微细通道。 混合通道可适于将流体组合成公共的流体流。 微流体装置还可以包括包括第一端和第二端的连接器通道。 连接器通道的第一端可以连接到混合连接点。 微流体装置还可以包括具有连接到连接器通道的第二端的扩张通道。 膨胀通道可适于使流体混合物通过膨胀通道，以在流体混合物通过膨胀通道时通过流体混合物的分散来减小流体混合物的浓度梯度噪声。

公开(公告)号：WO2007021815A3

公开(公告)日：2009-04-23

申请号：PCT/US2006031164

申请日：2006-08-10

Applicant: EKSIGENT TECHNOLOGIES LLC ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  KUNG PANG-JEN CRAIG ,  PEETIGREW KENNETH I ,  WARRINGTON BRIAN HARBERT ,  CRENSHAW HUGH C

Inventor： HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  KUNG PANG-JEN CRAIG ,  PEETIGREW KENNETH I ,  WARRINGTON BRIAN HARBERT ,  CRENSHAW HUGH C

IPC: G02B6/00 ,  G02B6/10 ,  G02B6/12

CPC classification number: B01L3/502715 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N2021/0346 ,  G02B6/10 ,  G02B6/1228 ,  G02B6/305 ,  G02B6/3636 ,  G02B6/3644 ,  G02B6/3652 ,  G02B6/3688 ,  G02B6/3692 ,  G02B6/3696 ,  Y10T29/49885

Abstract: Apparatuses and method are provided for connecting a light-guiding conduit (FO1, F02, F03) to a microfluidic channel (MC1). First and second substrates with first surfaces are provided, wherein the first surfaces of the substrates form microfluidic channel (MC1) and a connection channel (CCl, CC2, CC3, CC4,CC5, CC6, CC7) when the surfaces are positioned together, wherein the connection channel extends from an edge of the first surface of one of the substrates (100) to the microfluidic channel (MC1). The apparatus and method includes bonding the first surfaces of the substrates to form the microfluidic channel and the connection channel. A light-guiding conduit (FO1, F02, F03) is inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel (MC1) and an area between the light-guiding conduit and the connection channel is filled forming a liquid-tight seal between the light-guiding conduit and the connection channel.

Abstract translation: 提供了用于将光导管（FO1，F02，F03）连接到微流体通道（MC1）的装置和方法。 提供具有第一表面的第一和第二基板，其中当表面位于一起时，基板的第一表面形成微流体通道（MC1）和连接通道（CCl，CC2，CC3，CC4，CC5，CC6，CC7），其中 连接通道从一个基板（100）的第一表面的边缘延伸到微流体通道（MC1）。 该装置和方法包括粘合基板的第一表面以形成微流体通道和连接通道。 光导管（FO1，F02，F03）被插入到连接通道中，使得导光管连接到微流体通道（MC1），并且导光管和连接通道之间的区域被填充形成 光导管和连接通道之间的液密密封。

公开(公告)号：WO2007024485A3

公开(公告)日：2008-01-03

申请号：PCT/US2006031053

申请日：2006-08-10

Applicant: EKSIGENT TECHNOLOGIES LLC ,  HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

Inventor： HARTMANN DANIEL M ,  NEVILL JOSHUA T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

IPC: B01D11/00 ,  G01N15/06

CPC classification number: B01F13/0059 ,  B01F5/0646 ,  B01F5/0647 ,  Y10T29/494

Abstract: Micro fluidic Systems, Devices and Methods for Reducing Diffusion and Compliance Effects at a Fluid Mixing Region (110). According to one embodiment, a micro fluidic device is provided for combining fluids in a mixing region. The micro fluidic device can include a fluid-mixing region connected to a first and second micro scale channel. The micro scale channels can advance fluids to the fluid-mixing region. The micro scale channels can include constricted flow portions. According to another embodiment, the micro scale channels can be connected to waste channels for removing fluid diffused into one of the channels from the other channel. According to yet another embodiment, a micro fluidic system is provided for controlling the flow of fluids through the micro scale channels for reducing or eliminating diffusion between the channels (108).

Abstract translation: 微流体系统，用于在流体混合区域减少扩散和依从性效应的装置和方法（110）。 根据一个实施例，提供微流体装置用于在混合区域中组合流体。 微流体装置可以包括连接到第一和第二微尺度通道的流体混合区域。 微量级通道可以将流体推进到流体混合区域。 微尺度通道可以包括收缩的流动部分。 根据另一个实施例，微尺度通道可以连接到废物通道，用于从另一个通道去除扩散到一个通道中的流体。 根据另一个实施例，提供微流体系统用于控制通过微尺度通道的流体的流动，以减少或消除通道（108）之间的扩散。

公开(公告)号：WO2007021817A2

公开(公告)日：2007-02-22

申请号：PCT/US2006031166

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORP ,  VOTAW GREGORY A ,  BUCKNER CHARLES A ,  HARTMANN DANIEL M ,  KARSH WILLIAM ,  MONTEFUSCO FRANK ANTHONY ,  NEVIL JOSHUA T ,  PATEL MEHUL ,  WYRICK DAVID W ,  CRENSHAW HUGH C

Inventor： VOTAW GREGORY A ,  BUCKNER CHARLES A ,  HARTMANN DANIEL M ,  KARSH WILLIAM ,  MONTEFUSCO FRANK ANTHONY ,  NEVIL JOSHUA T ,  PATEL MEHUL ,  WYRICK DAVID W ,  CRENSHAW HUGH C

IPC: F04B17/00

CPC classification number: F04B19/006 ,  B01J2219/0081 ,  B01J2219/00891 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/565 ,  B01L7/52 ,  B01L2300/0896 ,  B01L2400/0478 ,  B82Y30/00 ,  F04B9/02 ,  F04B23/06 ,  G01N2035/00158

Abstract: Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/min range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.

Abstract translation: 以纳米级速率处理流体的装置和方法。 线性排量泵产生低至nl / min范围内的非脉动液体流速。 泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。 微流体互连装置可以联接到枪管。 这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置 在与泵的桶或桶相对的一侧与导热体接触。

公开(公告)号：WO2007021811A3

公开(公告)日：2007-02-22

申请号：PCT/US2006/031160

申请日：2006-08-10

Applicant: EKSIGENT TECHNOLOGIES, LLC ,  WYRICK, David, W. ,  HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  PATEL, Mehul ,  POLLACK, Michael, G. ,  VOTAW, Gregory, A. ,  CRENSHAW, Hugh, C.

Inventor： WYRICK, David, W. ,  HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  PATEL, Mehul ,  POLLACK, Michael, G. ,  VOTAW, Gregory, A. ,  CRENSHAW, Hugh, C.

IPC: G01N25/20

Abstract: An actively temperature regulated microfluidic chip assembly includes a first thermally conductive body, a second thermally conductive body attached to the first thermally conductive body, a microfluidic chip encapsulated between the first and second thermally conductive bodies, and a temperature regulating element mounted to the first thermally conductive body for adding heat to or alternately removing heat from the chip. The temperature of the chip and thus the liquid contained and/or flowing therein can be regulated by measuring the temperature of the liquid and operating the temperature regulating element to establish a thermal gradient toward or alternately away from the liquid based on the measured temperature and in comparison with a desired set point temperature.

公开(公告)号：WO2007021809A2

公开(公告)日：2007-02-22

申请号：PCT/US2006031158

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORP ,  NEVILL JOSHUA T ,  HARTMANN DANIEL M ,  ESPENHAHN ERIC T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

Inventor： NEVILL JOSHUA T ,  HARTMANN DANIEL M ,  ESPENHAHN ERIC T ,  VOTAW GREGORY A ,  CRENSHAW HUGH C

IPC: C12M3/00

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2300/12 ,  G01N21/6428 ,  G01N21/6458

Abstract: According to one embodiment, a microfluidic system and method is disclosed for reducing autofluorescence. The microfluidic system can include a light source for generating an excitation light. The microfluidic system can also include a microscope having an objective for focusing the excitation light on a fluid inside a microfluidic channel of a microfluidic chip. Further, the microfluidic system can include a detector for rejecting out-of-focus light emitted from the microfluidic chip.

Abstract translation: 根据一个实施方案，公开了用于减少自发荧光的微流体系统和方法。 微流体系统可以包括用于产生激发光的光源。 微流体系统还可以包括具有将激发光聚焦在微流体芯片的微流体通道内的流体的目的的显微镜。 此外，微流体系统可以包括用于拒绝从微流控芯片发射的离焦光的检测器。

公开(公告)号：WO2007021755A2

公开(公告)日：2007-02-22

申请号：PCT/US2006/031054

申请日：2006-08-10

Applicant: SMITHKLINE BEECHAM CORPORATION ,  CRENSHAW, Hugh, C. ,  COLONELL, Jennifer ,  HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  WYRICK, David, W.

Inventor： CRENSHAW, Hugh, C. ,  COLONELL, Jennifer ,  HARTMANN, Daniel, M. ,  NEVILL, Joshua, T. ,  WYRICK, David, W.

IPC: C12M3/00

CPC classification number: B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/5027 ,  Y10T137/0329 ,  Y10T137/86131 ,  Y10T137/87249

Abstract: Microfluidic Systems, Devices and Methods for Reducing Noise Generated by Mechanical Instabilities. According to one embodiment, a microfluidic device is provided for reducing noise in a fluid mix. The microfluidic device can include microscale channels for passage of fluids to a mixing junction. The mixing channel can be adapted to combine the fluids into a common fluid flow. The microfluidic device can also include a connector channel including first and second ends. The first end of the connector channel can be connected to the mixing junction. The microfluidic device can also include an expansion channel having connection to the second end of the connector channel. The expansion channel can be adapted for passage of the fluid mix through the expansion channel to reduce concentration gradient noise of the fluid mix by dispersion of the fluid mix as the fluid mix passes through the expansion channel.

Abstract translation: 用于降低由机械不稳定性产生的噪声的微流体系统，装置和方法 根据一个实施例，提供了一种用于减少流体混合物中的噪声的微流体装置。 微流体装置可以包括用于流体通过混合接头的微型通道。 混合通道可以适用于将流体组合成共同的流体流动。 微流体装置还可以包括包括第一端和第二端的连接器通道。 连接器通道的第一端可连接到混合接点。 微流体装置还可以包括具有连接到连接器通道的第二端的扩展通道。 膨胀通道可以适用于流体混合物通过膨胀通道，以在流体混合物通过膨胀通道时通过流体混合物的分散降低流体混合物的浓度梯度噪声。