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公开(公告)号：WO2003090691A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012943
申请日：2003-04-25
申请人： GILEAD SCIENCES, INC. , BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： C12Q1/34
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
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2.发明申请
公开(公告)号：WO2005064008A9
公开(公告)日：2006-09-28
申请号：PCT/US2004042991
申请日：2004-12-22
申请人： GILEAD SCIENCES INC , ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
发明人： ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
IPC分类号： C12N9/99 , C12Q1/44 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译： 提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。 可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。 还提供了与GS-7340酯水解酶有关的组合物和方法。
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3.发明申请
公开(公告)号：WO2004096818A3
公开(公告)日：2005-04-07
申请号：PCT/EP0312423
申请日：2003-11-06
申请人： GILEAD SCIENCES INC , BIRKUS GABRIEL , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , EISENBERG EUGENE J , HATADA MARCOS , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , MCDERMOTT MARTIN J , SWAMINATHAN SUNDARAMOORTHI
发明人： BIRKUS GABRIEL , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , EISENBERG EUGENE J , HATADA MARCOS , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , MCDERMOTT MARTIN J , SWAMINATHAN SUNDARAMOORTHI
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及用于鉴定具有针对人类免疫缺陷病毒（HIV）的治疗活性的化合物的方法和组合物。
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4.发明申请
公开(公告)号：WO2005064008A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/042991
申请日：2004-12-22
申请人： Gilead Sciences, Inc. , ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
发明人： ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
IPC分类号： C12Q1/44
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译： 提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。 可以任选地使用新型GS-7340酯水解酶来筛选这些化合物的文库。 还提供了与GS-7340酯水解酶有关的组合物和方法。
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5.发明申请
公开(公告)号：WO2004096818A2
公开(公告)日：2004-11-11
申请号：PCT/EP2003/012423
申请日：2003-11-06
申请人： GILEAD SCIENCES, INC. , BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： C07F9/40
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及用于鉴定具有针对人类免疫缺陷病毒（HIV）的治疗活性的化合物的方法和组合物。
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6.发明申请
公开(公告)号：WO2003090691A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012943
申请日：2003-04-25
申请人： GILEAD SCIENCES, INC. , BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： A61K
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译： 提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。 可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。 还提供了与GS-7340酯水解酶有关的组合物和方法。
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