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    TEST APPARATUS
    1.
    发明申请
    TEST APPARATUS 审中-公开
    测试仪器

    公开(公告)号：WO2012126898A2

    公开(公告)日：2012-09-27

    申请号：PCT/EP2012054839

    申请日：2012-03-19

    Applicant: ITI SCOTLAND LTD ,  WIERCIGROCH MARIAN

    Inventor： WIERCIGROCH MARIAN

    CPC classification number: E21B7/24

    Abstract: Provided is an apparatus for testing a resonance enhanced rotary drilling module, which apparatus comprises: (i) a resonance enhanced rotary drilling module comprising an oscillator; (ii) a fixed frame for fixing the apparatus to a base surface; (iii) a movable frame for moving the rotary drilling module in an axial direction relative to a sample; (iv) a means for generating relative rotary motion between the drilling module and a sample; and (v) a torsion restraint unit for reducing the torsional loading on the oscillator.

    Abstract translation: 提供了一种用于测试共振增强旋转钻井模块的装置，该装置包括：（i）包括振荡器的共振增强旋转钻井模块; （ii）用于将所述装置固定到基面的固定框架; （iii）可移动框架，用于相对于样本沿轴向方向移动所述旋转钻井模块; （iv）用于在钻井模块和样品之间产生相对旋转运动的装置; 和（v）用于减小振荡器上的扭转载荷的扭转约束单元。

    USES OF REAGENTS IN SAMPLE COLLECTION AND CARTRIDGE SYSTEMS
    3.
    发明申请
    USES OF REAGENTS IN SAMPLE COLLECTION AND CARTRIDGE SYSTEMS 审中-公开
    样品采集和采集系统中试剂的使用

    公开(公告)号：WO2009115608A3

    公开(公告)日：2009-12-03

    申请号：PCT/EP2009053327

    申请日：2009-03-20

    Applicant: ITI SCOTLAND LTD ,  DEHAL PRABHJYOT ,  PRITCHARD DAVID ,  GEEKIE CLAIRE

    Inventor： DEHAL PRABHJYOT ,  PRITCHARD DAVID ,  GEEKIE CLAIRE

    IPC: B01L3/00 ,  B01L3/14 ,  C12Q1/68 ,  G01N33/543

    CPC classification number: B01L3/523 ,  B01L3/502715 ,  B01L3/5082 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0832 ,  G01N33/54326

    Abstract: Provided is a sample collection container comprising one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent. Further provided is a cartridge system comprising: (a) a reagent component for storing one or more reagents; and (b) a processing component for processing the one or more reagents in an assay; wherein one or more of the components comprise one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent; and further wherein the reagent component and the processing component are configured to be coupled together to form a cartridge, and wherein the reagent component and/or the processing component comprise at least one compartment configured to accept waste from the assay, the reagent component not taking part in processing the reagents in the assay, except to accept waste from the processing component.

    Abstract translation: 提供了一种样品收集容器，其包含一个或多个试剂体，其中每个体包含一个或多个限制剂限制的试剂，其中所述抑制剂能够被分解以释放一种或多种试剂，并且其中所述一种或多种试剂 更多的试剂通过约束剂分散。 还提供了一种盒系统，包括：（a）用于存储一种或多种试剂的试剂组分; 和（b）用于在测定中处理所述一种或多种试剂的处理组分; 其中一种或多种组分包含一种或多种试剂体，其中每个体包含限制剂限制的一种或多种试剂，其中所述抑制剂能够分解以释放所述一种或多种试剂，并且其中所述一种或多种试剂 或更多的试剂通过约束剂分散; 并且其中所述试剂组分和所述处理组分被配置为耦合在一起以形成盒，并且其中所述试剂组分和/或所述处理组分包含至少一个隔室，其被配置为接受来自所述测定的废物，所述试剂组分不服用 部分处理试剂中的试剂，除了接受处理组分的废物。

    SCREENING FOR NON-GENOTOXIC CARCINOGENS
    4.
    发明申请
    SCREENING FOR NON-GENOTOXIC CARCINOGENS 审中-公开
    筛选非致病性致癌因子

    公开(公告)号：WO2009109769A2

    公开(公告)日：2009-09-11

    申请号：PCT/GB2009000642

    申请日：2009-03-09

    Applicant: ITI SCOTLAND LTD ,  WOLF CHARLES ROLAND ,  ELCOMBE CLIFFORD ROY

    Inventor： WOLF CHARLES ROLAND ,  ELCOMBE CLIFFORD ROY

    IPC: A01K67/027

    CPC classification number: G01N33/5014 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/07 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/47 ,  C07K14/70567 ,  C12N15/8509

    Abstract: The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARa, and in which the endogenous equivalent genes have been rendered inoperable.

    Abstract translation: 本发明涉及在动物模型中筛选非遗传毒性致癌物的作用的方法。 本发明还涉及适用于这种方法的动物模型，以及衍生自这些动物的细胞系用于体外筛选目的。 更具体地说，本发明涉及已被人源化为核转录因子CAR，PXR和PPARa的转基因啮齿类动物，其中内源等效基因已被使得不可操作。

    AUTHENTICATION METHOD AND FRAMEWORK
    5.
    发明申请
    AUTHENTICATION METHOD AND FRAMEWORK 审中-公开
    认证方法和框架

    公开(公告)号：WO2009044174A3

    公开(公告)日：2009-06-25

    申请号：PCT/GB2008003383

    申请日：2008-10-06

    Applicant: ITI SCOTLAND LTD ,  MCDIARMUID ALISDAIR ,  IRVINE JAMES

    Inventor： MCDIARMUID ALISDAIR ,  IRVINE JAMES

    IPC: H04L29/06

    CPC classification number: H04L63/08 ,  H04L63/0892

    Abstract: Authentication in an ad-hoc network is established between a first device (for example a service-requesting device) and a second device (for example a service-providing device) using a third device (a peer device). An authentication request is transmitted from the first device to the second device. The second device transmits a query message to at least one third device (i.e. peer device). If the peer device has previously been authenticated with the first device, the peer device sends an authentication credential, for example an authentication key, to the first and second devices. Upon receiving the authentication credential, the first device sends the authentication credential to the second device. The second device then compares the authentication credential received from the first device with the authentication credential received from the third device, and authenticates the first device with the second device if the authentication credentials match. Preferably the authentication credential from the third (peer) device to the first device is encrypted.

    Abstract translation: 使用第三设备（对等设备）在第一设备（例如服务请求设备）和第二设备（例如服务提供设备）之间建立自组织网络中的认证。 认证请求从第一设备传输到第二设备。 第二设备向至少一个第三设备（即，对等设备）发送查询消息。 如果对等设备先前已经被第一设备认证，则对等设备向第一和第二设备发送认证凭证，例如认证密钥。 在接收到认证凭证后，第一设备将认证凭证发送给第二设备。 然后，第二设备将从第一设备接收到的认证证书与从第三设备接收到的认证证书进行比较，并且如果认证证书匹配，则向第二设备认证第一设备。 优选地，从第三（对等）设备到第一设备的认证证书被加密。

    CARTRIDGE SYSTEM
    7.
    发明申请
    CARTRIDGE SYSTEM 审中-公开
    墨盒系统

    公开(公告)号：WO2008037995A2

    公开(公告)日：2008-04-03

    申请号：PCT/GB2007003666

    申请日：2007-09-26

    Applicant: ITI SCOTLAND LTD ,  BARRAULT DENISE ,  POLWART STUART ,  THOMSON DAVID ,  SALMON JONATHAN

    Inventor： BARRAULT DENISE ,  POLWART STUART ,  THOMSON DAVID ,  SALMON JONATHAN

    IPC: B01L3/00

    CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0672 ,  B01L2300/0819 ,  Y10T436/143333

    Abstract: Provided is a cartridge system comprising: (a) a reagent component for storing one or more reagents; and (b) a processing component for processing the one or more reagents in an assay; wherein the reagent component and the processing component are configured to be coupled together to form a cartridge, and wherein the reagent component and/or the processing component comprise at least one compartment configured to accept waste from the assay, the reagent component not taking part in processing the reagents in the assay, except to accept waste from the processing component. Further provided is a cartridge system comprising: (a) a reagent component for storing one or more reagents; (b) a processing component for processing one or more reagents in an assay; and (c) a sensing component comprising at least one sensing element for detecting an analyte; wherein the reagent component, the processing component and the sensing component are separate components configured to be coupled together to form a cartridge. Still further provided is a cartridge system comprising: (a) a reagent component for storing one or more reagents; (b) a processing component for processing one or more reagents in an assay; and (c) a sample preparation component for preparing a sample for the assay; wherein the reagent component and the processing component are configured to be coupled together to form a cartridge.

    Abstract translation: 提供一种药筒系统，其包括：（a）用于储存一种或多种试剂的试剂组分; 和（b）用于在测定中处理所述一种或多种试剂的处理组件; 其中所述试剂组分和所述处理组分构造成联接在一起以形成盒，并且其中所述试剂组分和/或所述处理组分包括至少一个隔室，所述隔室被配置为接受来自所述化验的废物，所述试剂组分不参与 处理测定中的试剂，除了接受来自处理组件的废物。 还提供了一种盒体系统，其包括：（a）用于储存一种或多种试剂的试剂组分; （b）用于处理测定中的一种或多种试剂的处理组件; 和（c）感测组件，其包括用于检测分析物的至少一个感测元件; 其中所述试剂组分，所述处理组分和所述感测组分是分离的组分，所述分离的组分被配置为联接在一起以形成盒。 还提供了一种盒系统，其包括：（a）用于储存一种或多种试剂的试剂组分; （b）用于处理测定中的一种或多种试剂的处理组件; 和（c）用于制备用于测定的样品的样品制备组分; 其中所述试剂组分和所述处理部件被配置为联接在一起以形成盒。

    TECHNIQUES FOR PROGRAM EXECUTION
    8.
    发明申请
    TECHNIQUES FOR PROGRAM EXECUTION 审中-公开
    节目执行技巧

    公开(公告)号：WO2008003930A3

    公开(公告)日：2008-03-13

    申请号：PCT/GB2007002398

    申请日：2007-06-27

    Applicant: ITI SCOTLAND LTD ,  RICHARDS ANDREW ,  COOK ANDREW ,  RUSSELL GEORGE

    Inventor： RICHARDS ANDREW ,  COOK ANDREW ,  RUSSELL GEORGE

    IPC: G06F9/45 ,  G06F9/44

    CPC classification number: G06F11/3664 ,  G06F9/522 ,  G06F9/546

    Abstract: The present application relates to techniques for handling the execution of a computer software program comprising a plurality of distinct program components. In particular, the application describes techniques relating to the interaction between distinct components of a computer program and seeks to allow program components to execute with a high degree of determinism. An execution environment is described which is operable such that the execution of one or more components of a computer program is carried out in a plurality of sequential frames of execution, wherein the execution environment is further operable to: i) allow communication between one said component and another said component in different frames of execution; and ii) to prevent communication between one said component and another said component in the same frame of execution. A debugger which utilises the execution environment is also described.

    Abstract translation: 本申请涉及用于处理包括多个不同程序组件的计算机软件程序的执行的技术。 具体而言，该申请描述了涉及计算机程序的不同组件之间的交互的技术，并且试图允许程序组件以高度确定性执行。 描述了可操作的执行环境，使得计算机程序的一个或多个组件的执行在多个连续的执行帧中执行，其中执行环境还可操作以：i）允许一个所述组件 和另一个所述组件在不同的执行框架中; 和ii）防止在同一个执行框架中的一个所述组件和另一个所述组件之间的通信。 还描述了利用执行环境的调试器。

    TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY
    10.
    发明申请
    TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
    用于评估药物代谢和毒性的转基因动物

    公开(公告)号：WO2006064197A3

    公开(公告)日：2006-09-28

    申请号：PCT/GB2005004772

    申请日：2005-12-13

    Applicant: ITI SCOTLAND LTD ,  WOLF CHARLES ROLAND ,  SCHEER NICO ,  FAUST NICOLE

    Inventor： WOLF CHARLES ROLAND ,  SCHEER NICO ,  FAUST NICOLE

    IPC: A01K67/027 ,  C12N15/09 ,  G01N33/50

    CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/0393 ,  C07K14/721 ,  C07K14/80 ,  C12N15/8509

    Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

    Abstract translation: 本发明涉及转基因非人动物，由其衍生的组织或细胞及其制备方法。 转基因非人动物或组织或由其衍生的细胞提供了能够表达负责药物代谢的人蛋白质代替同源内源性非人动物蛋白质和用于引入动物的人基因的受控表达的系统， 人类基因的表达以与人体内所见相似的方式进行调节。

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